TAKEDA Junji ≪Environmental and Molecular Medicine≫ “Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization.”
Publish Nat. Med., 11; 160-166, 2005
It is known that angiotensin-converting enzyme (ACE) cleave angiotensin I and bradykinin and changes their biological activities, leading to upregulation of blood pressure. We describe a new activity for ACE: a glycosylphosphatidylinositol (GPI)-anchored protein releasing activity (GPIase activity). Moreover GPIase activity plays a crucial role in fertilization.