OTSU Kinya ≪Cardiovascular Medicine≫ “The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.”

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Publish Nature Medicine, 13: 619-624 (2007)

Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism in starving cells. Here, we report that constitutive autophagy in the heart under baseline conditions is a homeostatic mechanism for maintaining cardiomyocyte size and global cardiac structure and function, and that upregulation of autophagy in failing hearts is an adaptive response for protecting cells from hemodynamic stress.

URL http://www.med.osaka-u.ac.jp/pub/imed1/medone/