- Development and clinical application of the cancer panel
- Technology for clinical implementation of cell-free DNA analysis
- Identification of biomarkers using intestinal microbiome assays
- Application of single cell sequencing to study intractable diseases
- Pathognesis of neoplastic and inflammatory diseases by genomic approaches
Taking genome science to the clinic
The 21st Century has seen remarkable progress in genome science. Especially, next generation sequencers have allowed us to identify gene abnormalities associated with disease. The impact of these advances has been felt in cancer research, as they have led to new understandings about tumor development in different organs. Now, genome science tools such as next generation sequencing are standard for cancer diagnosis. Besides diagnosis, researchers want to apply these tools to therapeutic strategies to combat the cancer. One example is clinical sequencing to detect causal genetic abnormalities, which can then be used as targets for drug candidates.
Today, we have massive data on genetic abnormalities associated with cancer. Current urgent challenges include sorting the data useful for clinical application and developing analysis tools to gather these data. To solve these problems, we are conducting genomic pathology research towards genome medicine. Ultimately, we want to improve both cancer diagnosis and cancer treatment. As a first step, we are establishing our cancer panel and will apply it to examine clinical samples.
One of the main themes of genome science is cancer research. However, our group is looking at other diseases, too. The microbiome has received growing attention for its role in disease. Genome science has also been applied to the study of immune cells and their role in inflammatory diseases. We are performing single-cell sequencing to study related intractable diseases.
Overall, our lab is combining genomics, pathology and clinical medicine research to study diseases that builds a bridge between basic research and clinical application.