Translational Cell Therapy
- Technology that optimizes the cell source and transplantation
- Methods that enhance the transplantation therapeutic effect
- Better safety and control of the immune response
- Development of new cell transplantation medicines
- Development of new cell transplantation technologies
Advanced cell transplantation medicine
Major innovations in artificial organs have revolutionized medical treatment. Dialysis has been instrumental in improving the quality of life (QOL) of renal failure patients, while the cardiopulmonary pump has proven indispensable for heart surgery. Despite these innovations, artificial devices that can restore or replace the damaged tissue remain unavailable.
The idea of tissue engineering comes from Robert Langer of MIT and Charles Vacanti of Harvard University. In tissue engineering, a new tissue is constructed by culturing cells with scaffold materials and growth factors. Tissue engineering is considered instrumental in the development of artificial organs that function just like natural organs. Progress in the field depends on the integration of a wide range of subjects, including developmental biology, stem cell research, gene therapy, DDS (drug delivery system), biomaterials and others, which is the focus of our laboratory.
To obtain full function, we are also researching cellular transplantation medicine. Cellular medicine exploits the multifunctional capacity of human cells to achieve high therapeutic potential. However, current cell transplantations show suboptimal therapeutic effects and risk rejection. We are investigating ways that solve these problems for a new generation of medical care. This effort involves academic and industrial collaborations on regenerative medicine and cellular transplantations, with the aim of early clinical trials and new drug candidates.