教室紹介
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教授あいさつ
スタッフ紹介
研究室紹介
研究室紹介

現在教室には周産期、内分泌、免疫、病理の4つの研究グループがあり、
研究の創造性、国際性をモットーに総勢40名で研究を行っている。


免疫研究室
妊娠高血圧症候群の予知因子の探索
 治療方法の開発

分娩発来の機序の解明
妊娠におけるユビキチンの機能解明精
不妊モデルマウス、流産モデルマウス
 の作製
不妊症の新規診断方法の開発
絨毛性腫瘍
悪性腫瘍に対する新規抗腫瘍薬の開発
上記テーマに対し、独創的な研究を行っている。臨床にフィードバックできる研究を常に心がけている。臨床面では、一般不妊外来と高度生殖医療外来を担当している
内分泌研究室
卵巣癌の腹膜播種のメカニズムの解析と
 新規治療法の開発
子宮頸がんの増悪因子の解明と新規治療
 法の開発
骨髄由来抑制細胞に焦点を当てた子宮
 頸がんの治療法の開発
子宮内膜症、子宮筋腫などの新しい分子
 標的治療の検討
早産のサイトカインに着目した新治療法
 の開発

当研究室では、上にあげた産婦人科に関わる研究テーマに対して、分子機構の解明をおこない、それを標的とした新治療法の開発につながる基礎研究を研究室員一同で取り組んでいます。臨床面では、健康維持外来、思春期外来、UAE 外来を担当し、女性のホルモンに関わる様々な疾患に対して、最新のEBM に基づいた診療を行っています。

内分泌研究室のFacebookのリンクはこちら

周産期研究室
早産の予防
妊娠高血圧症候群の治療と管理
胎児疾患の診断と管理
胎児疾患の胎内治療
臨床的研究として、早産の予防および妊娠高血圧症候群の予知に関する多施設共同研究ならびに生理学的パラメーターを用いた妊娠高血圧および分娩管理に関する研究を行っています。基礎研究としては、動物実験モデルを用いた胎仔脳障害の発生メカニズムに関する研究や、骨髄間葉系細胞移植による胎児免疫寛容の誘導および妊娠高血圧症候群の治療に関する研究を行っています。
病理研究室
婦人科腫瘍の病理診断
希な腫瘍の遺伝子診断
子宮頸部初期病変の基礎的および臨床的
  研究
婦人科腫瘍の抗癌剤耐性機序の解明
病理研究室は治療の出発点となる病理診断の知識を習得し、産科婦人科の全病理標本について病理部とともに診断をしています。また専門外来として子宮頸部初期病変の診断・治療を行う腫瘍外来(月曜午前)を担当し、毎週、コルポスコープ診・生検を行っています。
基礎研究では、治療上問題となる悪性腫瘍の抗癌剤耐性の機序を解明し治療に役立てることを目標に研究を行っています。また、予後不良な希少腫瘍に関しては治療の標準化が困難であり、個々の症例を詳細に検討し治療の突破口を探る必要がありますが、現在は子宮頸部小細胞癌・子宮体部大細胞癌・子宮体部肉腫に焦点をあてて、癌遺伝子・癌抑制遺伝子・癌関連遺伝子の異常を蛋白質及び遺伝子レベルで系統的に解析し、癌化に関連した遺伝子変化を解析しています。


2017年に刊行された教室からの研究成果をリストアップします。○は大学院生が書いた論文です。基礎研究・臨床研究がバランスよく展開できる教室になりました。臨床現場での疑問点を基礎研究を用いて解決した研究や、あるいはガイドラインに基づく医療を行うと予後が良くないグループを抽出した上での臨床試験の成果が多くなってきました。教室で活躍している各自が「こうなればいいな・これが知りたいな」、と夢を見て、行動を起こし、その結果を良く考えて、祈りながら世に問うた成果が出ていると思います(私が学生の時の大阪大学総長 山村雄一先生が卒業アルバムに書いて下さった言葉が「夢見て、行い、考えて、祈る」でした。私はこの順番が大好きです)。教室から今後ますますレベルの高い研究と臨床の成果を発表して行きたいと思います。(文責・木村 正)

【産科・周産期領域】

1)Pathophysiology of preeclampsia: an angiogenic imbalance and long-lasting systemic vascular dysfunction. Tomimatsu T, Mimura K, Endo M, Kumasawa K, Kimura T.           
Hypertens Res. 2016 Nov 10. doi: 10.1038/hr.2016.152

○2) Successful conservative management of placenta percreta: Investigation by serial magnetic resonance imaging of the clinical course and a literature review.
Sawada M, Matsuzaki S, Mimura K, Kumasawa K, Endo M, Kimura T.
J Obstet Gynaecol Res. 2016 Dec;42(12):1858-1863.

○3) Placenta accreta following hysteroscopic myomectomy.
Tanaka M, Matsuzaki S, Matsuzaki S, Kakigano A, Kumasawa K, Ueda Y, Endo M, Kimura T.
Clin Case Rep. 2016 Apr 20;4(6):541-4.

4) Guillain-Barré syndrome after trivalent influenza vaccination during pregnancy.
Tomimatsu T, Sugihara M, Nagai T, Sunada Y, Kimura T, Shimoya K.
Eur J Obstet Gynecol Reprod Biol. 2016 Jun;201:225-6

○5) Cervical varix complicated by placenta previa: A case report and literature review.
Tanaka M, Matsuzaki S, Kumasawa K, Suzuki Y, Endo M, Kimura T.
J Obstet Gynaecol Res. 2016 Jul;42(7):883-889.

○6) Expression levels of ABCG2 on cord red blood cells and study of fetal anemia associated with anti-Jr(a).
Fujita S, Kashiwagi H, Tomimatsu T, Ito S, Mimura K, Kanagawa T, Endo M, Miyoshi T, Okamura Y, Tani Y, Tomiyama Y, Kimura T.
Transfusion. 2016 May;56(5):1171-81.

○7) Targeting Inhibitor of κB Kinase β Prevents Inflammation-Induced Preterm Delivery by Inhibiting IL-6 Production from Amniotic Cells.
Toda A, Sawada K, Fujikawa T, Wakabayashi A, Nakamura K, Sawada I, Yoshimura A, Nakatsuka E, Kinose Y, Hashimoto K, Mabuchi S, Tokuhira A, Nakayama M, Itai A, Kurachi H, Kimura T.
Am J Pathol. 2016 Mar;186(3):616-29.

【婦人科腫瘍】

8) Phase I Clinical Study of Irinotecan Plus S-1 in Patients With Advanced or Recurrent Cervical Cancer Previously Treated With Platinum-Based Chemotherapy. Mabuchi S, Yokoi E, Owa T, Kozasa K, Yamashita M, Kobayashi E, Tomimatsu T, Yoki T, Tsutui T, Kimura T. Int J Gynecol Cancer. 2016 Sep;26(7):1281-7.
○9) Clinical relevance of circulating cell-free microRNAs in ovarian cancer.
Nakamura K, Sawada K, Yoshimura A, Kinose Y, Nakatsuka E, Kimura T.
Mol Cancer. 2016 Jun 24;15(1):48

10) Single-dose intra-arterial neoadjuvant chemotherapy while waiting for radical hysterectomy for stage IB-IIB cervical cancer.
Yoshino K, Hosoi A, Osuga K, Enomoto T, Ueda Y, Sawada K, Mabuchi S, Kobayashi E, Matsuo K, Kimura T.
Mol Clin Oncol. 2016 Jun;4(6):1068-1072

○11) Soluble VEGF receptor 1 (sFLT1) induces non-apoptotic death in ovarian and colorectal cancer cells.
Miyake T, Kumasawa K, Sato N, Takiuchi T, Nakamura H, Kimura T.
Sci Rep. 2016 Apr 22;6:24853.

12) Clear cell carcinoma of the ovary: molecular insights and future therapeutic perspectives.
Mabuchi S, Sugiyama T, Kimura T.
J Gynecol Oncol. 2016 May;27(3):e31.

○13) Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary.
Takahashi R, Mabuchi S, Kawano M, Sasano T, Matsumoto Y, Kuroda H, Kozasa K, Hashimoto K, Sawada K, Kimura T.
PLoS One. 2016 Mar 17;11(3):e0151050.

○14) The Novel IκB Kinase β Inhibitor, IMD-0560, Has Potent Therapeutic Efficacy in Ovarian Cancer Xenograft Model Mice.
Sawada I, Hashimoto K, Sawada K, Kinose Y, Nakamura K, Toda A, Nakatsuka E, Yoshimura A, Mabuchi S, Fujikawa T, Itai A, Kimura T.
Int J Gynecol Cancer. 2016 May;26(4):610-8.

○15) Similar protein expression profiles of ovarian and endometrial high-grade serous carcinomas.
Hiramatsu K, Yoshino K, Serada S, Yoshihara K, Hori Y, Fujimoto M, Matsuzaki S, Egawa-Takata T, Kobayashi E, Ueda Y, Morii E, Enomoto T, Naka T, Kimura T.
Br J Cancer. 2016 Mar 1;114(5):554-61.

16) A phase II study of postoperative concurrent carboplatin and paclitaxel combined with intensity-modulated pelvic radiotherapy followed by consolidation chemotherapy in surgically treated cervical cancer patients with positive pelvic lymph nodes.
Mabuchi S, Isohashi F, Yokoi T, Takemura M, Yoshino K, Shiki Y, Ito K, Enomoto T, Ogawa K, Kimura T.
Gynecol Oncol. 2016 May;141(2):240-6.

○17) Drug screening and grouping by sensitivity with a panel of primary cultured cancer spheroids derived from endometrial cancer.
Kiyohara Y, Yoshino K, Kubota S, Okuyama H, Endo H, Ueda Y, Kimura T, Kimura T, Kamiura S, Inoue M.
Cancer Sci. 2016 Apr;107(4):452-60.

○18) Predictors of Survival in Patients With FIGO Stage IVB Cervical Cancer.
Sasano T, Mabuchi S, Kuroda H, Takahashi R, Kozasa K, Isohashi F, Yoshioka Y, Ogawa K, Kimura T.
Int J Gynecol Cancer. 2016 Mar;26(3):528-33.

19) Utility of an Internal Retractor (EndoGrab) for the Management of the Vesicouterine Ligament during Laparoscopic Radical Hysterectomy.
Kobayashi E, Kakuda M, Tanaka Y, Morimoto A, Egawa-Takata T, Matsuzaki S, Ueda Y, Yoshino K, Kimura T.
Gynecol Obstet Invest. 2016;81(4):363-6.

○20) Clinical outcomes of abnormal cervical cytology and human papillomavirus-related lesions in patients with organ transplantation: 11-year experience at a single institution.
Tanaka Y, Ueda Y, Kakuda M, Kubota S, Matsuzaki S, Nakagawa S, Egawa-Takata T, Matsuzaki S, Kobayashi E, Yoshino K, Kimura T.
Int J Clin Oncol. 2016 Aug;21(4):730-4.

○21) Early metabolic change in (18)F-FDG-PET by measuring the single largest lesion predicts chemotherapeutic effects and patients' survival: PEACH study.
Tanaka Y, Ueda Y, Egawa-Takata T, Matsuzaki S, Kobayashi E, Yoshino K, Enomoto T, Tatsumi M, Kimura T.
Cancer Chemother Pharmacol. 2016 Jan;77(1):121-6.

○22) Long-term survival in small-cell carcinoma of the endometrium with liver and brain metastases.
Sawada M, Matsuzaki S, Yoshino K, Ueda Y, Yoshida S, Kimura T, Ogita K.
Anticancer Drugs. 2016 Feb;27(2):138-43.


【婦人科一般】

23) Development of an efficient strategy to improve HPV immunization coverage in Japan.   Yagi A, Ueda Y, Egawa-Takata T, Tanaka Y, Morimoto A, Terai Y, Ohmichi M, Ichimura T, Sumi T, Murata H, Okada H, Nakai H, Mandai M, Yoshino K, Kimura T, Saito J, Kudoh R, Sekine M, Enomoto T, Hirai K, Horikoshi Y, Takagi T, Shimura K. BMC Public Health. 2016 Sep 23;16(1):1013

24) Project conducted in Hirakata to improve cervical cancer screening rates in 20-year-old Japanese: Influencing parents to recommend that their daughters undergo cervical cancer screening. Yagi A, Ueda Y, Egawa-Takata T, Tanaka Y, Terai Y, Ohmichi M, Ichimura T, Sumi T, Murata H, Okada H, Nakai H, Mandai M, Matsuzaki S, Kobayashi E, Yoshino K, Kimura T, Saito J, Hori Y, Morii E, Nakayama T, Suzuki Y, Motoki Y, Sukegawa A, Asai-Sato M, Miyagi E, Yamaguchi M, Kudo R, Adachi S, Sekine M, Enomoto T, Horikoshi Y, Takagi T, Shimura K. J Obstet Gynaecol Res. 2016 Dec;42(12):1802-1807.

○25) Efficacies of uterine artery embolization for symptomatic uterine fibroids using gelatin sponge: a single-center experience and literature review.
Toda A, Sawada K, Osuga K, Maeda N, Higashihara H, Sasano T, Tomiyama N, Kimura T.
Int J Womens Health. 2016 Aug 12;8:397-404.

○26) Outcomes for girls without HPV vaccination in Japan.
Tanaka Y, Ueda Y, Egawa-Takata T, Yagi A, Yoshino K, Kimura T.
Lancet Oncol. 2016 Jul;17(7):868-9.

27) Mothers' attitudes in Japan regarding cervical cancer screening correlates with intention to recommend cervical cancer screening for daughters. Egawa-Takata T, Ueda Y, Tanaka Y, Morimoto A, Kubota S, Yagi A, Terai Y, Ohmichi M, Ichimura T, Sumi T, Murata H, Okada H, Nakai H, Mandai M, Yoshino K, Kimura T, Saito J, Kudo R, Sekine M, Enomoto T, Horikoshi Y, Takagi T, Shimura K.
Int J Clin Oncol. 2016 Oct;21(5):962-968.

28) Postoperative administration of dienogest for suppressing recurrence of disease and relieving pain in subjects with ovarian endometriomas.
Adachi K, Takahashi K, Nakamura K, Otake A, Sasamoto N, Miyoshi Y, Shioji M, Yamamoto Y, Fujitani M, Wakimoto A, Tokuhira A, Kobayashi E, Yoshimura A, Sawada K, Kimura T.
Gynecol Endocrinol. 2016 Aug;32(8):646-649.


【生殖医学・内分泌医学】

他科との共同研究
29) Longitudinal observation of serum anti-Müllerian hormone in three girls after cancer treatment. Miyoshi Y, Yasuda K, Tachibana M, Yoshida H, Miyashita E, Miyamura T, Hashii Y, Hashimoto K, Kimura T, Ozono K. Clin Pediatr Endocrinol. 2016 Oct;25(4):119-126.

30) Salvage high-dose-rate brachytherapy for isolated vaginal recurrence of endometrial cancer. Baek S, Isohashi F, Yamaguchi H, Mabuchi S, Yoshida K, Kotsuma T, Yamazaki H, Tanaka E, Sumida I, Tamari K, Otani K, Seo Y, Suzuki O, Yoshioka Y, Kimura T, Ogawa K. Brachytherapy. 2016 Nov - Dec;15(6):812-816.

31) Dose-volume analysis of predictors for chronic gastrointestinal complications in patients with cervical cancer treated with postoperative concurrent chemotherapy and whole-pelvic radiation therapy.
Isohashi F, Mabuchi S, Akino Y, Yoshioka Y, Seo Y, Suzuki O, Tamari K, Yoshino K, Sawada K, Ueda Y, Kobayashi E, Sumida I, Mizuno H, Okubo H, Kimura T, Ogawa K.
J Radiat Res. 2016 Nov;57(6):668-676.

32) Prognostic significance of a component of the Hippo pathway, TAZ, in human uterine endometrioid adenocarcinoma.
Zhan M, Ikeda JI, Wada N, Hori Y, Nojima S, Tahara SI, Ueda Y, Yoshino K, Kimura T, Morii E.
Oncol Lett. 2016 Jun;11(6):3611-3616

33) Significance of histologic pattern of carcinoma and sarcoma components on survival outcomes of uterine carcinosarcoma.
Matsuo K, Takazawa Y, Ross MS, Elishaev E, Podzielinski I, Yunokawa M, Sheridan TB, Bush SH, Klobocista MM, Blake EA, Takano T, Matsuzaki S, Baba T, Satoh S, Shida M, Nishikawa T, Ikeda Y, Adachi S, Yokoyama T, Takekuma M, Fujiwara K, Hazama Y, Kadogami D, Moffitt MN, Takeuchi S, Nishimura M, Iwasaki K, Ushioda N, Johnson MS, Yoshida M, Hakam A, Li SW, Richmond AM, Machida H, Mhawech-Fauceglia P, Ueda Y, Yoshino K, Yamaguchi K, Oishi T, Kajiwara H, Hasegawa K, Yasuda M, Kawana K, Suda K, Miyake TM, Moriya T, Yuba Y, Morgan T, Fukagawa T, Wakatsuki A, Sugiyama T, Pejovic T, Nagano T, Shimoya K, Andoh M, Shiki Y, Enomoto T, Sasaki T, Fujiwara K, Mikami M, Shimada M, Konishi I, Kimura T, Post MD, Shahzad MM, Im DD, Yoshida H, Omatsu K, Ueland FR, Kelley JL, Karabakhtsian RG, Roman LD.
Ann Oncol. 2016 Jul;27(7):1257-66.

34) Prenatal and Postnatal Clinical Course of an Urachus Identified as an Allantoic Cyst in the Umbilical Cord.
Umeda S, Usui N, Kanagawa T, Yamamichi T, Nara K, Ueno T, Owari M, Uehara S, Oue T, Kimura T, Okuyama H.
Eur J Pediatr Surg. 2016 Apr;26(2):200-2.



論文業績(2012.1月-2014.12月)

2012-2014年に私たち阪大産婦人科の教室員が発表した英文原著と総説を掲載します。私たちの教室では細胞や動物を使った基礎研究からヒトの臨床情報や検体を用いた臨床研究、トランスレーショナルリサーチまでを幅広く活発に行っています。臨床業績はまだ症例報告や後方視的観察研究が主ですが、前向き介入研究も始まっており、これからが期待できます。教室員の国内外での留学先、あるいは教授として赴任された教室、関連病院などとの共同研究の成果や他の部門との共同研究の成果も掲載しました。


私たちは大学院生として、あるいはスタッフとしてこれらの研究に参加する人材を広く求めています。大学院では産婦人科医のみならず医師ではない経歴の方の入学も歓迎しています。
興味をお持ちの方は阪大産婦人科医局jimu@gyne.med.osaka-u.ac.jpまでメールでご連絡ください。


(太字は教室関係者、星印は学位論文)

文責:木村 正

【産科・周産期・胎児】

Reliable predictors of neonatal immune thrombocytopenia in pregnant women with idiopathic thrombocytopenic purpura
Koyama, S. Tomimatsu, T. Kanagawa, T. Kumasawa, K. Tsutsui, T. Kimura, T.
 
Am J Hematol 87:15-21, 2012  1月

Balloon tamponade during cesarean section is useful for severe post-partum hemorrhage due to placenta previa
Ishii, T. Sawada, K. Koyama, S. Isobe, A. Wakabayashi, A. Takiuchi, T. Kanagawa, T. Tomimatsu, T. Ogita, K. Kimura, T.
J Obstet Gynaecol Res
38:102-107, 2012  1月

Central aortic blood pressure and augmentation index during normal pregnancy
Fujime, M. Tomimatsu, T. Okaue, Y. Koyama, S. Kanagawa, T. Taniguchi, T. Kimura, T.
Hypertens Res
35:633-638, 2012  6月

Maternal hyperventilation during labor revisited: its effects on fetal oxygenation
Tomimatsu, T. Kakigano, A. Mimura, K. Kanayama, T. Koyama, S. Fujita, S. Taniguchi, Y. Kanagawa, T. Kimura, T.
Reprod Sci
19:1169-1174, 2012  11月

☆ Hypoxic preconditioning increases triiodothyronine (T3) level in the developing rat brain
Minato, K. Tomimatsu, T. Mimura, K. Jugder, O. Kakigano, A. Kanayama, T. Fujita, S. Taniguchi, Y. Kanagawa, T. Endo, M. Kimura, T.
Brain Res
1501:89-97, 2013  3月

Normalisation of angiogenic imbalance after intra-uterine transfusion for mirror syndrome caused by parvovirus B19
Goa, S. Mimura, K. Kakigano, A. Tomimatsu, T. Kinugasa-Taniguchi, Y. Endo, M. Kanagawa, T. Kimura, T.
Fetal Diagn Ther
34:176-179, 2013  Epub 5月

Maternal arterial stiffness in normotensive pregnant women who subsequently deliver babies that are small for gestational age
Tomimatsu, T. Fujime, M. Kanayama, T. Mimura, K. Koyama, S. Kanagawa, T. Kimura, T.
Eur J Obstet Gynecol Reprod Biol
169:24-27, 2013  7月

Imbalance of angiogenic factors and avascular edematous cystic villi in a trisomy 13 pregnancy: a case report
Kakigano, A. Mimura, K. Kanagawa, T.
Nakayama, M. Kanayama, T. Fujita, S. Kinugasa-Taniguchi, Y. Endo, M. Tomimatsu, T. Kimura, T.
Placenta
34:628-630, 2013  7月

☆Short-term treatment of caffeine attenuates hypoxic ischemic brain damage in neonatal rats
Otgonbaatar, J. Kanagawa, T. Minato, K. Mimura, K. Kinugasa-Taniguchi, Y. Endo, M. Tomimatsu, T. Kimura, T.
Medical Journal of Osaka University
55:1-4, 2013  8月

Disease flare-ups and obstetric outcomes in pregnant women with systemic lupus erythematosus
Takahashi, K. Mimura, K. Kanagawa, T. Kinugasa-Taniguchi, Y. Endo, M. Matsuzaki, S. Kumasawa, K. Hashimoto, K. Tomimatsu, T. Kimura, T.
Hypertens Res Pregnancy
1:103-107, 2013  10月

☆ Targeting interleukin-6 receptor inhibits preterm delivery induced by inflammation
Wakabayashi, A. Sawada, K.
Nakayama, M. Toda, A. Kimoto, A. Mabuchi, S. Kinose, Y. Nakamura, K. Takahashi, K. Kurachi, H. Kimura, T.
Mol Hum Reprod
19:718-726, 2013  11月

Challenges in diagnosis of pseudo vasa previa
Kajimoto, E. Shinya Matsuzaki Satoko Matsuzaki Tanaka, Y. Kinugasa-Taniguchi, Y. Mimura, K. Kanagawa, T. Kimura, T.
Case Rep Obstet Gynecol
2014:903920, 2014  Epub 5月

Interstitial pregnancy resulting in a viable infant coexistent with massive perivillous fibrin deposition: a case report and literature review
Tanaka, Y. Mimura, K. Kanagawa, T.
Nakayama, M. Matsuzaki, S. Kinugasa-Taniguchi, Y. Endo, M. Kimura, T.
AJP Rep
4:29-32, 2014 5月

Placenta percreta with a vaginal fistula after successful management by uterine transverse fundal incision and subsequent cesarean hysterectomy
Satoko Matsuzaki Shinya Matsuzaki Ueda, Y. Egawa-Takata, T. Mimura, K. Kanagawa, T.
Morii, E. Kimura, T.
Obstet Gynecol Sci
57:397-400, 2014 9

Abnormal pressure-wave reflection in pregnant women with chronic hypertension: association with maternal and fetal outcomes
Tomimatsu, T. Fujime, M. Kanayama, T. Mimura, K. Koyama, S. Kanagawa, T. Endo, M. Shimoya, K. Kimura, T.
Hypertens Res
37:989-92, 2014 11月

Three-dimensional sonography in the differential diagnosis of interstitial, angular, and intrauterine pregnancies in a septate uterus
Tanaka, Y. Mimura, K. Kanagawa, T. Kajimoto, E. Takahashi, K. Kakigano, A. Fujita, S. Kinugasa-Taniguchi, Y. Endo, M. Kimura, T.
J Ultrasound Med
33:2031-2035, 2014 11月

Placenta percreta managed by transverse uterine fundal incision with retrograde cesarean hysterectomy: a novel surgical approach
Matsuzaki, S. Yoshino, K. Kumasawa, K. Satou, N. Mimura, K. Kanagawa, T. Ueda, Y. Kimura, T.
Clin Case Rep
2:260-264, 2014 12月

Successful management of placenta percreta by cesarean hysterectomy with transverse uterine fundal incision
Matsuzaki, S. Yoshino, K. Kajimoto, E. Tanaka, Y. Mimura, K. Kanagawa, T. Kimura, T.
IJRCOG
3(2):447-449, 2014 

【 婦人科腫瘍 】

The prognostic significance of multiple pelvic node metastases in cervical cancer patients treated with radical hysterectomy plus adjuvant chemoradiotherapy
Okazawa, M. Mabuchi, S.
Isohashi, F. Suzuki, O. Ohta, Y. Fujita, M. Yoshino, K. Enomoto, T. Kamiura, S. Kimura, T.
Int J Gynecol Cancer
22:490-497, 2012  3月

Prediction of progression-free survival and response to Paclitaxel plus Carboplatin in patients with recurrent or advanced cervical cancer
Hisamatsu, T. Mabuchi, S. Yoshino, K. Fujita, M. Enomoto, T.
Hamasaki, T. Kimura, T.
Int J Gynecol Cancer
22:623-629, 2012  3月

Prediction, based on resection margins, of long-term outcome of cervical intraepithelial neoplasia 3 treated by Shimodaira-Taniguchi conization
Miyoshi, Y. Miyatake, T. Ueda, Y. Morimoto, A. Yokoyama, T. Matsuzaki, S. Toshihiro Kimura Yoshino, K. Fujita, M.
Ohashi, H. Morii, E. Enomoto, T. Kimura, T.
Arch Gynecol Obstet
285:1427-1432, 2012  5月

Investigating the relative efficacies of combination chemotherapy of paclitaxel/carboplatin, with or without anthracycline, for endometrial carcinoma
Fujiwara, K. Egawa-Takata, T. Ueda, Y. Toshihiro Kimura Yoshino, K. Fujita, M. Miyatake, T. Ohta, Y. Kamiura, S. Enomoto, T. Kimura, T.
Arch Gynecol Obstet
285:1447-1453, 2012 5月

Enormous cystic tumor of peritoneal psammocarcinoma exhibiting complete response to Cisplatin and cyclophosphamide after suboptimal cytoreduction: case report and review of the literature
Takahashi, R. Ueda, Y.
Shioji, M. Adachi, S. Ohashi, H. Morii, E. Aozasa, K. Yoshino, K. Fujita, M. Enomoto, T. Kimura, T. Tokuhira, A.
Gynecol Obstet Invest
74:165-170, 2012  Epub5月

Primary retroperitoneal mucinous cystadenocarcinoma with mural nodules: a case report and literature review
Kanayama, T. Yoshino, K. Enomoto, T.
Ohashi, H. Fujita, M. Ueda, Y. Toshihiro Kimura, Kobayashi, E. Morii, E. Kimura, T.
Int J Clin Oncol
17:407-411, 2012  8月

Salvage Chemotherapy Using Gemcitabine for Taxane/Platinum-resistant Recurrent Ovarian Cancer: A Single Institutional Experience
Yoshino, K. Hiramatsu, K. Enomoto, T. Fujita, M. Ueda, Y. Toshihiro Kimura Kobayashi, E. Kiyohara, Y. Tsutsui, T. Kimura, T.
Anticancer Res
32:4029-4033, 2012  9月

Cervical non-squamous carcinoma: an effective combination chemotherapy of taxane, anthracycline and platinum for advanced or recurrent cases
Toshihiro Kimura, Miyatake, T. Ueda, Y. Ohta, Y. Enomoto, T. Kimura, T. Kamiura, S.
Eur J Obstet Gynecol Reprod Biol
164:200-204, 2012  10月

Impact of histological subtype on survival of patients with surgically-treated stage IA2-IIB cervical cancer: adenocarcinoma versus squamous cell carcinoma
Mabuchi, S. Okazawa, M. Matsuo, K. Kawano, M. Suzuki, O. Miyatake, T. Enomoto, T. Kamiura, S. Ogawa, K. Kimura, T.
Gynecol Oncol
127:114-120, 2012  10月

Comparison of the prognoses of FIGO stage I to stage II adenosquamous carcinoma and adenocarcinoma of the uterine cervix treated with radical hysterectomy
Mabuchi, S. Okazawa, M. Kinose, Y. Matsuo, K. Fujiwara, M.
Suzuki, O. Morii, E. Kamiura, S. Ogawa, K. Kimura, T.
Int J Gynecol Cancer
22:1389-1397, 2012  10月

Elevated white blood cell count at the time of recurrence diagnosis is an indicator of short survival in patients with recurrent cervical cancer
Mabuchi, S. Matsumoto, Y. Hamasaki, T. Kawano, M. Hisamatsu, T. Mutch, D. G. Kimura, T.
Int J Gynecol Cancer
22:1545-1551, 2012  11月

G-CSF induces focal intense bone marrow FDG uptake mimicking multiple bone metastases from uterine cervical cancer: a case report and review of the literature
Mabuchi, S. Morimoto, A. Fujita, M. Isohashi, K. Kimura, T.
Eur J Gynaecol Oncol
33:316-317, 2012  不明

Calcaneal metastasis in uterine cervical cancer: a case report and a review of the literature
Kanayama, T. Mabuchi, S. Fujita, M. Kimura, T.
Eur J Gynaecol Oncol
33:524-525, 2012 

A retrospective analysis of endometrial carcinoma cases surgically treated with or without para-aortic lymph node dissection followed by adjuvant chemotherapy
Okazawa, M. Ueda, Y. Enomoto, T. Yoshino, K. Kono, K. Mabuchi, S. Kimura, T. Nagamatsu, M.
Eur J Gynaecol Oncol
33:620-624, 2012 

☆Plasma membrane proteomics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer
Yokoyama, T. Enomoto, T.
Serada, S. Morimoto, A. Matsuzaki, S. Ueda, Y. Yoshino, K. Fujita, M. Kyo, S. Iwahori, K. Fujimoto, M. Kimura, T. Naka, T.
Int J Cancer 132:472-484, 2013  1月

Salvage chemotherapy for recurrent or persistent clear cell carcinoma of the ovary: a single-institution experience for a series of 20 patients
Yoshino, K. Enomoto, T. Fujita, M. Ueda, Y. Toshihiro Kimura, Kobayashi, E. Tsutsui, T. Kimura, T.
Int J Clin Oncol
18:148-153, 2013  2月

Impact of the addition of concurrent chemotherapy to pelvic radiotherapy in surgically treated stage IB1-IIB cervical cancer patients With intermediate-risk or high-risk factors: A 13-year experience
Okazawa, M. Mabuchi, S.
Isohashi, F. Suzuki, O. Yoshioka, Y. Sasano, T. Ohta, Y. Kamiura, S. Ogawa, K. Kimura, T.
Int J Gynecol Cancer 23:567-575, 2013  3月

WT1 peptide immunotherapy for gynecologic malignancies resistant to conventional therapies: a phase II trial
Miyatake, T. Ueda, Y. Morimoto, A. Enomoto, T.
Nishida, S. Shirakata, T. Oka, Y. Tsuboi, A. Oji, Y. Hosen, N. Nakatsuka, S. Morita, S. Sakamoto, J. Sugiyama, H. Kimura, T.
J Cancer Res Clin Oncol
139:457-463, 2013  3月

Utility of risk-weighted surgical-pathological factors in early-stage cervical cancer
Matsuo, K
. Mabuchi, S. Okazawa, M. Matsumoto, Y. Tsutsui, T. Fujita, M. Kamiura, S.
Ogawa, K. Morrow, C. P. Kimura, T.
Br J Cancer
108:1348-1357, 2013  4月

☆miR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrin alpha5 Expression
Ohyagi-Hara, C. Sawada, K. Kamiura, S.
Tomita, Y. Isobe, A. Hashimoto, K. Kinose, Y. Mabuchi, S. Hisamatsu, T. Takahashi, T. Kumasawa, K. Nagata, S. Morishige, K. I. Lengyel, E. Kurachi, H. Kimura, T.
Am J Pathol
182:1876-1889, 2013  5月

Grave outcome of granulocyte colony-stimulating factor-producing endometrial cancer: A case report and literature review
Yamamoto, K. Mabuchi, S. Yamasaki, M. Yoshimura, M. Murata, Y.
J Obstet Gynaecol Res
39:1107-1110, 2013  5月

Taxane-sensitivity of ovarian carcinomas previously treated with paclitaxel and carboplatin
Ueda, Y. Enomoto, T. Matsuzaki, S. Kobayashi, E. Toshihiro Kimura, Yoshino, K. Fujita, M. Tsutsui, T. Kimura, T.
Cancer Chemother Pharmacol
71:1411-1416, 2013  6月

Conization using the Shimodaira-Taniguchi procedure for adenocarcinoma in situ of the uterine cervix
Hiramatsu, K. Ueda, Y. Yoshino, K. Fujita, M.
Morii, E. Enomoto, T. Kimura, T.
Eur J Obstet Gynecol Reprod Biol
168:218-221, 2013  6月

Potential role of mTORC2 as a therapeutic target in clear cell carcinoma of the ovary
Hisamatsu, T. Mabuchi, S. Matsumoto, Y. Kawano, M. Sasano, T. Takahashi, R. Sawada, K.
Ito, K. Kurachi, H. Schilder, R. J. Testa, J. R. Kimura, T.
Mol Cancer Ther
12:1367-1377, 2013  7月

A phase II study of combination chemotherapy using docetaxel and irinotecan for TC-refractory or TC-resistant ovarian carcinomas (GOGO-OV2 study) and for primary clear or mucinous ovarian carcinomas (GOGO-OV3 Study)
Ueda, Y. Miyatake, T. Nagamatsu, M. Yamasaki, M. Nishio, Y. Yoshino, K. Fujita, M. Tsutsui, T. Enomoto, T. Kimura, T.
Eur J Obstet Gynecol Reprod Biol
170:259-263, 2013  9月

Endometrial thickness measured by ultrasonography in postmenopausal patients with endometrial carcinoma has significance, irrespective of histological subtype
Hosoi, A. Ueda, Y. Shindo, M. Nakagawa, S. Matsuzaki, S. Kobayashi, E. Toshihiro Kimura Yoshino, K. Fujita, M. Kimura, T.
Int J Gynecol Cancer
23:1266-1269, 2013  9月

A phase I study of concurrent weekly carboplatin and paclitaxel combined with intensity-modulated pelvic radiotherapy as an adjuvant treatment for early-stage cervical cancer patients with positive pelvic lymph nodes
Mabuchi, S. Takahashi, R.
Isohashi, F. Yokoi, T. Ito, K. Tsutui, T. Ogata, T. Yoshioka, Y. Ogawa, K. Kimura, T.
Int J Gynecol Cancer
23:1279-1286, 2013  9月

Utility of serum squamous cell carcinoma antigen levels at the time of recurrent cervical cancer diagnosis in determining the optimal treatment choice
Shimura, K. Mabuchi, S. Yokoi, T. Sasano, T. Sawada, K.
Hamasaki, T. Kimura, T.
J Gynecol Oncol
24:321-329, 2013  10月

☆Overexpression of endogenous TIMP-2 increases the proliferation of BeWo choriocarcinoma cells through the MAPK-signaling pathway
Thang, N. M. Kumasawa, K. Tsutsui, T. Nakamura, H. Masaki, H. Ono, T. Kimura, T.
Reprod Sci
20:1184-1192, 2013  10月

Condyloma acuminata induces focal intense FDG uptake mimicking vaginal stump recurrence from uterine cervical cancer: a case report
Kishimoto, T. Mabuchi, S.
Kato, H. Kimura, T.
Eur J Gynaecol Oncol
34:99-100, 2013  

Reirradiation using high-dose-rate interstitial brachytherapy for locally recurrent cervical cancer: a single institutional experience
Mabuchi, S. Takahashi, R.
Isohashi, F. Yokoi, T. Okazawa, M. Sasano, T. Maruoka, S. Anzai, M. Yoshioka, Y. Ogawa, K. Kimura, T.
Int J Gynecol Cancer
24:141-148, 2014 1月

☆Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A
Matsuzaki, S. Enomoto, T. Serada, S. Yoshino, K. Nagamori, S. Morimoto, A. Yokoyama, T. Kim, A. Toshihiro Kimura, Ueda, Y. Fujita, M. Fujimoto, M. Kanai, Y. Kimura, T. Naka, T.
Int J Cancer
134:1796-809, 2014 4月

The impact of multiple high-risk factors on survival outcome of surgically treated early-stage cervical cancer
Matsuo, K. Mabuchi, S. Okazawa, M. Matsumoto, Y. Yoshino, K. Kamiura, S.
YG., L. LD., R. Kimura, T.
Gynecol Oncol
133:62, 2014  6月

Combination treatment with trabectedin and irinotecan or topotecan has synergistic effects against ovarian clear cell carcinoma cells
Kawano, M. Mabuchi, S. Kishimoto, T. Hisamatsu, T. Matsumoto, Y. Sasano, T. Takahashi, R. Sawada, K. Takahashi, K. Takahashi, T. Hamasaki, T. Kimura, T.
Int J Gynecol Cancer
24:829-37, 2014 6月

Perioperative venous thromboembolism in patients with gynecological malignancies: a lesson from four years of recent clinical experience
Morimoto, A. Ueda, Y. Yokoi, T.
Tokizawa, Y. Yoshino, K. Fujita, M. Toshihiro Kimura, Kobayashi, E. Matsuzaki, S. Egawa-Takata, T. Sawada, K. Tsutsui, T. . Kimura, T.
Anticancer Res
34:3589-3595, 2014 7月

Recurrent cerebral infarctions in a patient with ovarian cancer: a fatal case of trousseau's syndrome
Kuroda, H. Mabuchi, S. Shigeta, N.
Yamamoto, H. Kimura, T.
Gynecol Obstet
4:232, 2014  7月

☆Uterine cervical cancer displaying tumor-related leukocytosis: a distinct clinical entity with radioresistant feature
Mabuchi, S. Matsumoto, Y. Kawano, M.
Minami, K. Seo, Y. Sasano, T. Takahashi, R. Kuroda, H. Hisamatsu, T. Kakigano, A. Hayashi, M. Sawada, K. Hamasaki, T. Morii, E. Kurachi, H. Matsuura, N. Kimura, T.
J Natl Cancer Inst
106: 2014 7月

Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner
Morimoto, A.
Serada, S. Enomoto, T. Kim, A. Matsuzaki, S. Takahashi, T. Ueda, Y. Yoshino, K. Fujita, M. Fujimoto, M. Kimura, T. Naka, T.
Oncotarget
5:7776-7787, 2014 9月

Clear cell adenocarcinoma of the peritoneum: a case report and literature review
Shigeta, N. Yoshino, K. Matsuzaki, S.
Morii, E. Ueda, Y. Kimura, T.
J Ovarian Res
7:86, 2014  10月

Annexin A4 is a promising therapeutic target for the treatment of platinum-resistant cancers
Matsuzaki, S.
Serada, S. Morimoto, A. Ueda, Y. Yoshino, K. Kimura, T. Naka, T.
Expert Opin Ther Tar
18:403-414, 2014  

【 婦人科一般 】

Estradiol and raloxifene induce the proliferation of osteoblasts through G-protein-coupled receptor GPR30
Noda-Seino, H. Sawada, K. Hayakawa, J. Ohyagi-Hara, C. Mabuchi, S. Takahashi, K. Nishio, Y. Sakata, M. Kurachi, H. Kimura, T.
J Endocrinol Invest
36:21-27, 2013  1月

Vulvovaginal aggressive angiomyxoma mimicking lymphedema complicated with Behcet’s disease: a case report and review of the literature
Wakimoto, T. Yoshino, K.
Hori, Y. Ueda, Y. Fujita, M. Toshihiro Kimura, Kobayashi, E. Matsuzaki, S. Morii, E. Kimura, T.
Int Canc Conf J
2:76-81, 2013  4月

Pedunculated subserous leiomyosarcoma mimicking ovarian cancer: case report and review of the literature
Kobayashi, E. Yokoyama, T. Nakagawa, S. Matsuzaki, S. Toshihiro Kimura, Ueda, Y. Yoshino, K. Fujita, M.
Hori, Y. Morii, E. Kimura, T.
Gynecol Obstet
3:157, 2013  7月

Serum white blood cell count (WBC) and plasma C reactive protein (CRP) values could be markers for acute pelvic inflammatory disease
Ugaki, H. Miyatake, T. Matsuzaki, N.
Hashimoto, T. Ueda, Y. Enomoto, T.
I JGORMR
1:19-22, 2014  3月

Large uterine cervical adenomyoma excised by vaginal approach: case report, images, and literature review
Satoko Matsuzaki, Shinya Matsuzaki, Tanaka, Y. Fujita, M. Yoshino, K. Kimura, T.
J Minim Invasive Gynecol
21:954-958, 2014  9-10月

【 生殖 】

Estimation of mouse fetal weight by ultrasonography: application from clinic to laboratory
Nguyen, T. M. Nakamura, H. Wakabayashi, A. Kanagawa, T. Koyama, S. Tsutsui, T.
Hamasaki, T. Kimura, T.
Lab Anim
46:225-230, 2012  7月

Importance of optimal local uterine blood flow for implantation
Nakamura, H. Hosono, T. Minato, K.
Hamasaki, T. Kumasawa, K. Kimura, T.
J Obstet Gynaecol Res
40:1668-1673, 2014 6月


【 国内・国外留学、他の教室・研究機関との共同研究などによる業績 】


Annexin A2 in amniotic fluid: correlation with histological chorioamnionitis, preterm premature rupture of membranes, and subsequent preterm delivery
Namba, F. Ina, S. Kitajima, H. Yoshio, H. Mimura, K. Saito, S. Yanagihara, I.
J Obstet Gynaecol Res 38:137-144, 2012  1月

Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma
Wang, Y. Ikeda, J. I. Rahadiani, N. Mamat, S. Ueda, Y. Tian, T. Enomoto, T. Kimura, T. Aozasa, K. Morii, E.
Oncol Lett 3:25-29, 2012  1月

Low-dose metronomic oral dosing of a prodrug of Gemcitabine (LY2334737) causes anti-tumor effects in the absence of inhibition of systemic vasculogenesis
Francia, G. Shaked, Y. Hashimoto, K. Sun, J. Yin, M. Cesta, C. Xu, P. Man, S. Hackl, C. Stewart, J. Uhlik, M. Dantzig, A. H. Foster, S. Kerbel, R. S.
Mol Cancer Ther 11:680-689, 2012  3月

Macrophages regulate expression of alpha1,2-fucosyltransferase genes in human endometrial epithelial cells
Nakamura, H.
Jasper, M. J. Hull, M. L. Aplin, J. D. Robertson, S. A.
Mol Hum Reprod
18:204-215, 2012  4月

Early intra-amniotic gene transfer using lentiviral vector improves skin blistering phenotype in a murine model of Herlitz junctional epidermolysis bullosa
Endo, M.
Zoltick, P. W. Radu, A. Jiang, Q. Matsui, C. Marinkovich, P. M. McGrath, J. Tamai, K. Uitto, J. Flake, A. W.
Gene Ther
19:561-569, 2012  5月

Total laparoscopic hysterectomy in 1253 patients using an early ureteral identification technique
Kobayashi, E.
Nagase, T. Fujiwara, K. Hada, T. Ota, Y. Takaki, Y. Kanao, H. Andou, M.
J Obstet Gynaecol Res 38:1194-1200, 2012  9月

Significance of lymphovascular space invasion in epithelial ovarian cancer
Matsuo, K.
Sheridan, T. B. Yoshino, K. Miyake, T. Hew, K. E. Im, D. D. Rosenshein, N. B. Mabuchi, S. Enomoto, T. Kimura, T. Sood, A. K. Roman, L. D.
Cancer Med
1:156-164, 2012  10月

A case of simultaneous transvaginal NOTES gastrectomy and vaginal hysterectomy in a patient with gastric submucosal tumor and uterine prolapsed
Hirota, M. Nakajima, K. Hara, J. Takahashi, T. Yamasaki, M. Tsutsui, T. Kobayashi, E. Kurokawa, Y. Miyata, H. Takiguchi, S. Mori, M. Doki, Y.
Asian J Endosc Surg 5:168-171, 2012  11月

Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis
Serada, S. Fujimoto, M. Terabe, F. Iijima, H. Shinzaki, S. Matsuzaki, S. Ohkawara, T. Nezu, R. Nakajima, S. Kobayashi, T. Plevy, S. E. Takehara, T. Naka, T.
Inflamm Bowel Dis 18:2169-2179, 2012  11月

Low Serum Concentrations of Anti-Mullerian Hormone Are Common in 53 Female Childhood Cancer Survivors
Miyoshi, Y. Ohta, H. Namba, N. Tachibana, M. Miyamura, T. Miyashita, E. Hashii, Y. Oue, T. Isobe, A. Tsutsui, T. Kimura, T. Ozono, K.
Horm Res Paediatr 79:17-21, 2013  Epub 2012 12月

Graft-related complications and biaxial tensiometry following experimental vaginal implantation of flat mesh of variable dimensions
Manodoro, S. Endo, M. Uvin, P. Albersen, M. Vlacil, J. Engels, A. Schmidt, B. De Ridder, D. Feola, A. Deprest, J.
BJOG 120:244-250, 2013  1月

Intra-amniotic transient transduction of the periderm with a viral vector encoding TGFbeta3 prevents cleft palate in Tgfbeta3(-/-) mouse embryos
Wu, C. Endo, M. Yang, B. H. Radecki, M. A. Davis, P. F. Zoltick, P. W. Spivak, R. M. Flake, A. W. Kirschner, R. E. Nah, H. D.
Mol Ther 21:8-17, 2013  1月

Contemporary use of bevacizumab in ovarian cancer
Miyake, T.
Sood, A. K. Coleman, R. L.
Expert Opin Biol Ther
13:283-294, 2013  2月

In vitro sealing of iatrogenic fetal membrane defects by a collagen plug imbued with fibrinogen and plasma
Engels, A. C. Hoylaerts, M. F. Endo, M. Loyen, S. Verbist, G. Manodoro, S. DeKoninck, P. Richter, J. Deprest, J. A.
Prenat Diagn 33:162-167, 2013  2月

Complex Müllerian malformation without any present classification: unilateral ovarian and tubal absence with an arcuate uterus
Tanaka, Y. Koyama, S. Kobayashi, M. Kubota, S. Nakamura, R. Isobe, M. Shiki, Y.
Asian J Endosc Surg 6:55-57, 2013  2月

Laparoscopic adnexectomy with peritonectomy for an ovarian tumor adhered to the pelvic sidewall
Kobayashi, E.
Kanao, H. Andou, M.
Gynecol Obstet Invest
75:250-254, 2013  Epub 3月

Dose-volume histogram predictors of chronic gastrointestinal complications after radical hysterectomy and postoperative concurrent nedaplatin-based chemoradiation therapy for early-stage cervical cancer
Isohashi, F. Yoshioka, Y. Mabuchi, S. Konishi, K. Koizumi, M. Takahashi, Y. Ogata, T. Maruoka, S. Kimura, T. Ogawa, K.
Int J Radiat Oncol Biol Phys 85:728-734, 2013  3月

Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders
Tachibana, M. Kagitani-Shimono, K. Mohri, I. Yamamoto, T. Sanefuji, W. Nakamura, A. Oishi, M. Kimura, T. Onaka, T. Ozono, K. Taniike, M.
J Child Adolesc Psychopharmacol 23:123-127, 2013  3月

Association between soluble (Pro)renin receptor concentration in cord blood and small for gestational age birth; a cross-sectional study
Watanabe, N. Morimoto, S. Fujiwara, T. Suzuki, T. Taniguchi, K. Ando, T. Kimura, T. Sago, H. Ichihara, A.
PLOS ONE 8:1-6, 2013  3月

Prediction of gestational diabetes mellitus by soluble (Pro)renin receptor during the first trimester
Watanabe, N. Morimoto, S. Fujiwara, T. Suzuki, T. Taniguchi, K. Mori, F. Ando, T. Watanabe, D. Kimura, T. Sago, H. Ichihara, A.
J Clin Endocrin Metab 98:2528-2535, 2013  6月

Angiographic findings after vaginal gauze packing: New insight into an old technique
Koyama, S.
Maeda, M. Kobayashi, M. Tanaka, Y. Kubota, S. Nakamura, R. Isobe, M. Shiki, Y.
J Obstet Gynaecol Res
39:1212-1216, 2013  6月

Fetal echocardiography and pulsed-wave Doppler ultrasound in a rabbit model of intrauterine growth restriction
Hodges, R. Endo, M. La Gerche, A. Eixarch, E. DeKoninck, P. Ferferieva, V. D'Hooge, J. Wallace, E. M. Deprest, J.
J Vis Exp 76: 10.3791/50392., 2013  6月

Endometrial cancer: preoperative staging using three-dimensional T2-weighted turbo spin-echo and diffusion-weighted MR imaging at 3.0 T: a prospective comparative study
Hori, M. Kim, T. Onishi, H. Imaoka, I. Kagawa, Y. Murakami, T. Nakamoto, A. Ueguchi, T. Tatsumi, M. Enomoto, T. Kimura, T. Tomiyama, N.
Eur Radiol 23:2296-2305, 2013  8月

Ischemic stroke in patients with solid gynecologic tract tumors and coagulopathy
Tadokoro, Y. Sakaguchi, M. Yagita, Y. Furukado, S. Okazaki, S. Fujinaka, T. Kimura, T. Yoshimine, T. Mochizuki, H. Kitagawa, K.
Eur Neurol 70:304-307, 2013  Epub 9月

Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism
Kerr, T. A. Matsumoto, Y. Matsumoto, H. Xie, Y. Hirschberger, L. L. Stipanuk, M. H. Anakk, S. Moore, D. D. Watanabe, M. Kennedy, S. Davidson, N. O.
Hepatol Res
44: E218-228, 2014  10月

Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer
Kang, Y. Hu, W. Ivan, C. Dalton, H. J. Miyake, T. Pecot, C. V. Zand, B. Liu, T. Huang, J. Jennings, N. B. Rupaimoole, R. Taylor, M. Pradeep, S. Wu, S. Y. Lu, C. Wen, Y. Liu, J. Sood, A. K.
J Natl Cancer Inst
105:1485-1495, 2013  10月

Rupture of renal artery aneurysm during the early post-partum period
Nakamura, R. Koyama, S.
Maeda, M. Kobayashi, M. Tanaka, Y. Kubota, S. Isobe, M. Shiki, Y.
J Obstet Gynaecol Res
39:1476-1479, 2013  10月

Targeting SRC and tubulin in mucinous ovarian carcinoma
Liu, T. Hu, W. Dalton, H. J. Choi, H. J. Huang, J. Kang, Y. Pradeep, S. Miyake, T. Song, J. H. Wen, Y. Lu, C. Pecot, C. V. Bottsford-Miller, J. Zand, B. Jennings, N. B. Ivan, C. Gallick, G. E. Baggerly, K. A. Hangauer, D. G. Coleman, R. L. Frumovitz, M. Sood, A. K.
Clin Cancer Res 19:6532-6543, 2013  12月

Effects of Ureaplasma parvum lipoprotein multiple-banded antigen on pregnancy outcome in mice
Uchida, K. Nakahira, K. Mimura, K. Shimizu, T. De Seta, F. Wakimoto, T. Kawai, Y. Nomiyama, M. Kuwano, K. Guaschino, S. Yanagihara, I.
J Reprod Immunol 100:118-127, 2013  12月

Laparoscopic repair of a post-myomectomy spontaneous uterine perforation accompanied by a bizarre tumor resembling polypoid endometriosis
Koyama, S. Kobayashi, M
. Tanaka, Y. Isobe, M.
Miwa, H. Shiki, Y.
J Minim Invasive Gynecol
20:912-916, 2013  11-12月

Duplicated ureter diagnosed during total laparoscopic hysterectomy
Tanaka, Y. Koyama, S. Shiki, Y.
Gynecol Minim Invasive Ther
2:99-100, 2013

High-frequency micro-ultrasound: A novel method to assess external urethral sphincter function in rats following simulated birth injury
Hakim, L. Endo, M. Feola, A. Soebadi, D. M. Deprest, J. De Ridder, D. Albersen, M. Van der Aa, F.
Neurourol Urodyn 2014 1月

A pictorial essay on fetal rabbit anatomy using micro-ultrasound and magnetic resonance imaging
DeKoninck, P. Endo, M. Sandaite, I. Richter, J. De Catte, L. Van Calster, B. Toelen, J. Himmelreich, U. Claus, F. Deprest, J.
Prenat Diagn
34:84-89, 2014 1月

Hand-assisted laparoscopic surgery (HALS) for a mesenteric teratoma
Tanaka, Y. Koyama, S. Shiki, Y.
JSLS
18:160-164, 2014  1-3月

Functional assessment of hyperoxia-induced lung injury after preterm birth in the rabbit
Richter, J. Toelen, J. Vanoirbeek, J. Kakigano, A. Dekoninck, P. Verbeken, E. Deprest, J.
Am J Physiol Lung Cell Mol Physiol 306:L277-283, 2014 2月

Anorectal abscess during pregnancy
Koyama, S.
Hirota, M. Kobayashi, M. Tanaka, Y. Kubota, S. Nakamura, R. Isobe, M. Shiki, Y.
J Obstet Gynaecol Res
40:595-8, 2014 2月

Hepatic portal venous gas: a rare complication of malignant bowel obstruction during the administration of octreotide
Maeda, I. Tsuneto, S. Yasui, Y. Ueda, Y. Kimura, T.
J Pain Symptom Manage
47:e2-5, 2014 2月

Autocrine effects of tumor-derived complement
Cho, M. S. Vasquez, H. G. Rupaimoole, R. Pradeep, S. Wu, S. Zand, B. Han, H. D. Rodriguez-Aguayo, C. Bottsford-Miller, J. Huang, J. Miyake, T. Choi, H. J. Dalton, H. J. Ivan, C. Baggerly, K. Lopez-Berestein, G. Sood, A. K. Afshar-Kharghan, V.
Cell Rep 6:1085-95, 2014 3月

☆Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN
Takiuchi, T. Nakagawa, T. Tamiya, H. Fujita, H. Sasaki, Y. Saeki, Y. Takeda, H. Sawasaki, T. Buchberger, A. Kimura, T. Iwai, K.
Genes Cells 19:254-272, 2014 3月

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity
Wu, S. Y. Yang, X. Gharpure, K. M. Hatakeyama, H. Egli, M. McGuire, M. H. Nagaraja, A. S. Miyake, T. M. Rupaimoole, R. Pecot, C. V. Taylor, M. Pradeep, S. Sierant, M. Rodriguez-Aguayo, C. Choi, H. J. Previs, R. A. Armaiz-Pena, G. N. Huang, L. Martinez, C. Hassell, T. Ivan, C. Sehgal, V. Singhania, R. Han, H. D. Su, C. Kim, J. H. Dalton, H. J. Kovvali, C. Keyomarsi, K. McMillan, N. A. Overwijk, W. W. Liu, J. Lee, J. S. Baggerly, K. A. Lopez-Berestein, G. Ram, P. T. Nawrot, B. Sood, A. K.
Nat Commun
12:3459, 2014  3月

Endometrial adenocarcinoma arising in a Turner's syndrome patient with spontaneous menstruation: a case report
Sasamoto, N. Ueda, Y. Amemiya, K. Enomoto, T.
Morii, E. Adachi, K.
J Reprod Med
59:177-80, 2014 3-4月

Feto-maternal outcomes of pregnancy complicated by ovarian sex-cord stromal tumor: a systematic review of literature
Blake, E. A. Carter, C. M. Kashani, B. N. Kodama, M. Mabuchi, S.Yoshino, K. Matsuo, K.
Eur J Obstet Gynecol Reprod Biol 175:1-7, 2014 4月

IFN-gamma or IFN-alpha ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex
Tamiya, H. Terao, M. Takiuchi, T. Nakahara, M. Sasaki, Y. Katayama, I. Yoshikawa, H. Iwai, K.
J Immunol 192:3793-3804, 2014 4月

Spontaneous uterine rupture at 15 weeks' gestation in a patient with a history of cesarean delivery after removal of shirodkar cerclage
Kanao, S. Fukuda, A. Fukuda, H. Miyamoto, M. Marumoto, E. Furuya, K. Nishiyama, R. Ohyagi, C. Ogawa, H.
AJP Rep
4:1-4, 2014 5月

Clodronate inhibits tumor angiogenesis in mouse models of ovarian cancer
Reusser, N. M. Dalton, H. J. Pradeep, S. Gonzalez-Villasana, V. Jennings, N. B. Vasquez, H. G. Wen, Y. Rupaimoole, R. Nagaraja, A. S. Gharpure, K. Miyake, T. Huang, J. Hu, W. Lopez-Berestein, G. Sood, A. K.
Cancer Biol Ther 15:1061-7, 2014 5月

Complete cervical stenosis after conization: Timing for the minimally invasive reconstructive surgery
Koyama, S. Kobayashi, M
. Tanaka, Y. Kubota, S. Nakamura, R. Isobe, M. Shiki, Y.
Gynecol Minim Invasive Ther
3:57-60, 2014   5月

Case of uterine papillary serous carcinoma following tamoxifen treatment that could not be diagnosed during screening
Maenaka, T. Egawa-Takata, T. Hisamoto, K. Kunishige, I. Nishio, Y.
Tsujimoto, M.
J Obstet Gynaecol Res
40:1450-1454, 2014 5月

Effect of lymphovascular space invasion on survival of stage I epithelial ovarian cancer
Matsuo, K. Yoshino, K. Hiramatsu, K
. Banzai, C. Hasegawa, K. Yasuda, M. Nishimura, M. Sheridan, T. B. Ikeda, Y. Shiki, Y. Mabuchi, S. Enomoto, T. Kimura, T. Fujiwara, K. Roman, L. D. Sood, A. K.
Obstet Gynecol
123:957-965, 2014 5月

Notch3 pathway alterations in ovarian cancer
Hu, W. Liu, T. Ivan, C. Sun, Y. Huang, J. Mangala, L. S. Miyake, T. Dalton, H. J. Pradeep, S. Rupaimoole, R. Previs, R. A. Han, H. D. Bottsford-Miller, J. Zand, B. Kang, Y. Pecot, C. V. Nick, A. M. Wu, S. Y. Lee, J. S. Sehgal, V. Ram, P. Liu, J. Tucker, S. L. Lopez-Berestein, G. Baggerly, K. A. Coleman, R. L. Sood, A. K.
Cancer Res 74:3282-93, 2014 6月

Estrogen receptor expression and increased risk of lymphovascular space invasion in high-grade serous ovarian carcinoma
Matsuo, K.
Sheridan, T. B. Mabuchi, S. Yoshino, K. Hasegawa, K. Studeman, K. D. Im, D. D. Rosenshein, N. B. Roman, L. D. Sood, A. K.
Gynecol Oncol
133:473-479, 2014 6月

Mesh contraction: in vivo documentation of changes in apparent surface area utilizing meshes visible on magnetic resonance imaging in the rabbit abdominal wall model
Endo, M.
Feola, A. Sindhwani, N. Manodoro, S. Vlacil, J. Engels, A. C. Claus, F. Deprest, J. A.
Int Urogynecol J 25:737-43, 2014 6月

Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition
Minakami, H. Maeda, T. Fujii, T. Hamada, H. Iitsuka, Y. Itakura, A. Itoh, H. Iwashita, M. Kanagawa, T. Kanai, M. Kasuga, Y. Kawabata, M. Kobayashi, K. Kotani, T. Kudo, Y. Makino, Y. Matsubara, S. Matsuda, H. Miura, K. Murakoshi, T. Murotsuki, J. Ohkuchi, A. Ohno, Y. Ohshiba, Y. Satoh, S. Sekizawa, A. Sugiura, M. Suzuki, S. Takahashi, T. Tsukahara, Y. Unno, N. Yoshikawa, H.
J Obstet Gynaecol Res 40:1469-1499, 2014 6月

Analysis of acquired resistance to metronomic oral topotecan chemotherapy plus pazopanib after prolonged preclinical potent responsiveness in advanced ovarian cancer
Cruz-Munoz, W. Di Desidero, T. Man, S. Xu, P. Jaramillo, M. L. Hashimoto, K. Collins, C. Banville, M. O'Connor-McCourt, M. D. Kerbel, R. S.
Angiogenesis 17:661-673, 2014 7月

Biomechanics of the rat vagina during pregnancy and postpartum: a 3-dimensional ultrasound approach
Feola, A. Endo, M. Deprest, J.
Int Urogynecol J 25:915-920, 2014 7月

Metronomic Docetaxel in PRINT Nanoparticles and EZH2 Silencing Have Synergistic Antitumor Effect in Ovarian Cancer
Gharpure, K. M. Chu, K. S. Bowerman, C. J. Miyake, T. Pradeep, S. Mangala, S. L. Han, H. D. Rupaimoole, R. Armaiz-Pena, G. N. Rahhal, T. B. Wu, S. Y. Luft, J. C. Napier, M. E. Lopez-Berestein, G. DeSimone, J. M. Sood, A. K.
Mol Cancer Ther 13:1750-7, 2014 7月

Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism
Kerr, T. A. Matsumoto, Y. Matsumoto, H. Xie, Y. Hirschberger, L. L. Stipanuk, M. H. Anakk, S. Moore, D. D. Watanabe, M. Kennedy, S. Davidson, N. O.
Hepatol Res 44:E218-228, 2014 8月

Clinical characteristics and outcomes of uterine tumors resembling ovarian sex-cord tumors (UTROSCT): a systematic review of literature
Blake, E. A. Sheridan, T. B. Wang, K. L. Takiuchi, T. Kodama, M. Sawada, K. Matsuo, K.
Eur J Obstet Gynecol Reprod Biol 181C:163-170, 2014 10月

A case of neonatal alloimmune thrombocytopenia in the presence of both anti-HPA-4b and anti-HPA-5b antibody: clinical and serological analysis of the subsequent pregnancy
Kiyokawa, T. Koh, Y. Mimura, K. Nakayama, K. Hosokawa, M. Sakuragi, M. Morikawa, T. Nakao, M. Aochi, H. Fukumori, Y. Kanagawa, T. Nagamine, K. Kimura, T. Tomiyama, Y.
Int J Hematol 100:398-401, 2014 10月

Host reaction to vaginally inserted collagen containing polypropylene implants in sheep
Feola, A. Endo, M. Urbankova, I. Vlacil, J. Deprest, T. Bettin, S. Klosterhalfen, B. Deprest, J.
Am J Obstet Gynecol 2014 11月

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Clear Cell Carcinoma of the Ovary
Okamoto, A. Glasspool, R. M. Mabuchi, S. Matsumura, N. Nomura, H. Itamochi, H. Takano, M. Takano, T. Susumu, N. Aoki, D. Konishi, I. Covens, A. Ledermann, J. Mezzazanica, D. Steer, C. Millan, D. McNeish, I. A. Pfisterer, J. Kang, S. Gladieff, L. Bryce, J. Oza, A.
Int J Gynecol Cancer 24:S20-5, 2014 11月

Association between sexual health and delivery mode
Song, M. Ishii, H. Toda, M. Tomimatsu,T. Katsuyama, H. Nakamura, T. Nakai, Y. Shimoya, K.
Sex Med 2:153-158, 2014 12月

【 総説 】

Integrin inhibitors as a therapeutic agent for ovarian cancer
Sawada, K. Ohyagi-Hara, C. Kimura, T. Morishige, K.
J Oncol
2012:915140, 2012  Epub 2011 12月

Animal models for prenatal gene therapy: rodent models for prenatal gene therapy
Roybal, J. L. Endo, M. Buckley, S. M. Herbert, B. R. Waddington, S. N. Flake, A. W.
Methods Mol Biol 891:201-218, 2012  

Biomarkers for screening, diagnosis, and monitoring of ovarian cancer
Kobayashi, E. Ueda, Y. Matsuzaki, S. Yokoyama, T. Toshihiro Kimura, Yoshino, K. Fujita, M. Kimura, T. Enomoto, T.
Cancer Epidemiol Biomarkers Prev
21:1902-1912, 2012  11月

Therapeutic strategies in epithelial ovarian cancer
Kim, A. Ueda, Y. Naka, T. Enomoto, T.
J Exp Clin Cancer Res
31:14, 2012  2月

Maternal carbon dioxide level during labor and its possible effect on fetal cerebral oxygenation: mini review
Tomimatsu, T. Kakigano, A. Mimura, K. Kanayama, T. Koyama, S. Fujita, S. Taniguchi, Y. Kanagawa, T. Kimura, T.
J Obstet Gynaecol Res
39:1-6, 2013  1月

Molecular analysis of parturition via oxytocin receptor expression
Kimura, T. Ogita, K. Kumasawa, K. Tomimatsu, T. Tsutsui, T.
Taiwan J Obstet Gynecol
52:165-170, 2013  6月

The role of microRNAs in ovarian cancer
Kinose, Y. Sawada, K. Nakamura, K. Kimura, T.
Biomed Res Int
2014:249393, 2014 Epub 9月

【 著書 】

Methods for cervical cancer screening: the differences between developing and developed countries
Nakagawa, S. Yoshino, K. Ueda, Y. Kimura, T.
Cervical cancer: screening methods, risk factors and treatment options (Edited Elit, L.), Chapter2:33-40, Nova Science Publishers Inc, 2013

Association between endometriosis and ovarian cancer: A review of epidemiologic, pathologic, genetic, and clinical data
Yokoyama, T. Yoshino, K. Ueda, Y. Enomoto, T.
Endometriosis: risk factors, symptoms and management
(Edited Tomas, M. J. L.), Chapter2:43-76, Nova Science Publishers Inc, 2013

The role of paclitaxel in ovarian cancer
Shindo, M. Yoshino, K. Ueda, Y. Kimura, T.
Paclitaxel: biosynthesis, mechanisms of action and clinical uses
(Edited Morales, D.), Chapter6:159-170, Nova Science Publishers Inc, 2013

Management of advanced stage endometrial cancer
Morimoto, A. Ueda, Y. Enomoto, T. Takata-Egawa, T. Matsuzaki, S. Kobayashi, E. Toshihiro Kimura Yoshino, K. Fujita, M. Kimura, T.
Endometrial cancer: current epidemiology, detection and management
(Edited Farghaly, S.A.), Chapter12:207-228, NOVA Science Publishers, 2014



 

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