現在教室には周産期、内分泌、免疫、病理の4つの研究グループがあり、
研究の創造性、国際性をモットーに総勢40名で研究を行っている。

●不妊症の診断治療 ●抗精子抗体検査 ●GIFT、 IVF-ET、顕微受精 ●習慣性流産患者の診断治療 ●絨毛性腫瘍 免疫学的観点から妊娠を捉え、（1）抗精子抗体の対応抗原、（2）抗リン脂質抗体による流早産発症機序（3）胎児・胎盤が母体から免疫学的拒絶を免れている妊娠維持機構�C胎盤や子宮内膜で産生されるサイトカインの生物学的意義等の解明について研究を行っている。生殖医学領域では陣痛発来機序と絨毛性腫瘍について分子生物学的解析を行っている。陣痛発来に関してはオキシトシン・レセプターのcDNA及びゲノムのクローニングを行い、絨毛性腫瘍については腫瘍と宿主のDNA finger printing, gene imprintingを比較することにより腫瘍の発生病理の解明に努めている。

●排卵障害 ●内分泌疾患の診断治療 ●子宮内膜症の内分泌療法 生殖現象における分子内分泌学のテーマの下、生殖生理では、受精における卵と精子間の認識・結合・融合の機構について表層顆粒分泌と低分子量G蛋白との関連を中心に研究を進めている。さらに生殖腺の生理について細胞増殖因子の発現とその役割を分子内分泌学的手法で研究を行っている。また内分泌細胞における細胞内情報伝達機構を明らかにすべく内分泌細胞の増殖、分化およびホルモン分泌機構におけるG蛋白の活性化機構、イノシトール燐脂質代謝と細胞内カルシウムの動態、Tyrosine Kinaseの燐酸化機構等の細胞内情報伝達の経路を中心に、研究を進めている。

● 合併症妊娠の管理、妊娠中毒症の治療と管理 ● 胎児疾患の診断と管理 ● 胎児疾患の胎内治療 臨床的研究として、甲状腺疾患・糖尿病・自己免疫疾患を合併する妊娠での母体管理と胎児への影響に関する研究、ならびに超音波血流計測を用いた胎児循環動態と肺呼吸機能の評価に関する研究を行っている。産科的基礎研究としては、動物実験モデルを用いた胎仔脳障害の発生メカニズムに関する研究と、胎仔循環異常と静脈血流波形の相関に関する研究が行っている。

●婦人科腫瘍の病理診断 ●婦人科腫瘍の遺伝子診断 ●婦人科腫瘍の遺伝子変異の解析 ●婦人科腫瘍の浸潤転移機構の解析 婦人科腫瘍における癌遺伝子、癌抑制遺伝子・癌関連遺伝子の異常を蛋白及び遺伝子レベルで系統的に解析し、癌化に伴う遺伝子変化を形態との関連に於いて検討している。また、癌の浸潤、転移機構の分子生物学的機序の解明を行い、効果的分子標的治療法開発を試みている。関連病院を含めた他施設共同の婦人科腫瘍の集学的治療の計画的立案と解析を行っている。

論文業績（2011.1月−12月）

産科学婦人科学教室から2011年には73報の英文原著、総説を掲載することができました。この中の半数以上が実験を使わない、臨床データーの報告です。まだまだレベル�Vのエビデンスを示す臨床研究や症例報告です。しかし、教室員がこのような試みを続けていくことでやがて高いレベルの臨床研究も可能になると思っています。その一方で留学・国内共同研究などを含めて最先端の基礎研究の成果を世に問う論文も増えてきました。今後も臨床研究と基礎研究をバランスよく行い、産科学・婦人科学の発展と妊婦の皆さん、患者の皆さんの安全と幸福に寄与してゆきたいと思っています。このようなダイナミックな研究に参加してくださる大学院生をひろく募集しています。興味のある方は jimu@gyne.med.osaka-u.ac.jpまでご連絡ください。

（文責　木村　正）

【産科・周産期・胎児】

Nicotine restores endothelial dysfunction caused by excess sFlt1 and sEng in an in vitro model of preeclamptic vascular endothelium: a possible therapeutic role of nicotinic acetylcholine receptor (nAChR) agonists for preeclampsia
Mimura, K. Tomimatsu, T. Sharentuya, N. Tskitishvili, E. Kinugasa-Taniguchi, Y. Kanagawa, T. Kimura, T.
Am J Obstet Gynecol 202:464.e1-6, 2010

The effect of tumor-associated protein RCAS1 gene silencing on blood pressure and urinary protein excretion in pregnant mouse: a pilot study
Tskitishvili, E. Nakamura, H. Kinugasa-Taniguchi, Y. Kanagawa, T. Shimoya, K. Tomimatsu, T. Kimura, T.
Am J Obstet Gynecol 203:364.e6-364.e12, 2010

A case of complete hydatidiform mole with coexistent fetus: conclusive diagnosis of androgenesis of the molar placenta by variation of paternal acrocentric short arms
Koyama, S. Tomimatsu, T. Sawada, K. Kanagawa, T. Isobe, A. Kinugasa, Y. Tsutsui, T. Kimura, T.
Am J Perinatol 27:143-149, 2010

Temporal and spatial expression of tumor-associated antigen RCAS1 in pregnant mouse uterus
Tskitishvili, E. Nakamura, H. Kinugasa-Taniguchi, Y. Kanagawa, T. Kimura, T. Tomimatsu, T. Shimoya, K.
Am J Reprod Immunol 63:137-143, 2010

Maternal blood serum and plasma human tumor-associated antigen RCAS1 during the course of uncomplicated pregnancies: a prospective study
Tskitishvili, E. Sharentuya, N. Tsubouchi, H. Kinugasa-Taniguchi, Y. Kanagawa, T. Shimoya, K. Tomimatsu, T. Kimura, T.
Am J Reprod Immunol 64:218-224, 2010

A retrospective analysis of ovarian endometriosis during pregnancy
Ueda, Y. Enomoto, T. Miyatake, T. Fujita, M. Yamamoto, R. Kanagawa, T. Shimizu, H. Kimura, T.
Fertil Steril 94:78-84, 2010

Spinal subarachnoid hematoma following spinal anesthesia in a patient with HELLP syndrome
Koyama, S. Tomimatsu, T. Kanagawa, T. Sawada, K. Tsutsui, T. Kimura, T. Chang, Y.S. Wasada, K. Imai, S. Murata, Y.
Int J Obstet Anesth 19:87-91, 2010

Pseudomyxoma peritonei originating from colorectal cancer during pregnancy
Koyama, S. Tomimatsu, T. Sawada, K. Kanagawa, T. Tsutsui, T. Kimura, T.
J Obstet Gynaecol Res 2010

Cervical insufficiency following cesarean delivery after prolonged second stage of labor: experiences of two cases
Koyama, S. Tomimatsu, T. Kanagawa, T. Sawada, K. Tsutsui, T. Kimura, T.
J Obstet Gynaecol Res 36:411-413, 2010

Current status of negative treatment decision-making for fetuses with a prenatal diagnosis of neonatal surgical disease at a single Japanese institution
Usui, N. Kanagawa, T. Kamiyama, M. Tani, G. Kinugasa-Taniguchi, Y. Kimura, T. Fukuzawa, M.
J Pediatr Surg 45:2328-2333, 2010

Oxidative stress-induced S100B protein from placenta and amnion affects soluble Endoglin release from endothelial cells
Tskitishvili, E. Sharentuya, N. Temma-Asano, K. Mimura, K. Kinugasa-Taniguchi, Y. Kanagawa, T. Fukuda, H. Kimura, T. Tomimatsu, T. Shimoya, K.
Mol Hum Reprod 16:188-199, 2010

Prenatal diagnosis of fetal intracranial hemorrhage in pregnancy complicated by idiopathic thrombocytopenic purpura
Koyama, S. Tomimatsu, T. Sawada, K. Kanagawa, T. Isobe, A. Taniguchi, Y. Wada, T. Kimura, T. Arahori, H. Kitabatake, Y. Wada, K.
Prenat Diagn 30:489-491, 2010

Prenatal diagnosis of polysplenia syndrome associated with increased nuchal translucency
Koyama, S. Tomimatsu, T. Kanagawa, T. Morimoto, A. Kimura, T.
Prenat Diagn 30:1005-1006, 2010

Human C-reactive protein enhances vulnerability of immature rats to hypoxic-ischemic brain damage: a preliminary study
Kinugasa-Taniguchi, Y. Tomimatsu, T. Mimura, K. Kanagawa, T. Shimoya, K. Murata, Y. Kimura, T.
Reprod Sci 17:419-425, 2010

Nicotine suppresses interleukin-6 production from vascular endothelial cells: a possible therapeutic role of nicotine for preeclampsia
Sharentuya, N. Tomimatsu, T. Mimura, K. Tskitishvili, E. Kinugasa-Taniguchi, Y. Kanagawa, T. Kimura, T.
Reprod Sci 17:556-563, 2010

Fetal and neonatal anemia associated with anti-Jr(a) : a case report showing a poorly hemolytic mechanism
Sasamoto, N. Tomimatsu, T. Nagamine, K. Oshida, M. Kashiwagi, H. Koyama, S. Kanagawa, T. Arahori, H. Tomiyama, Y. Kimura, T.
J Obstet Gynaecol Res 37:1132-6, 2011

Successful pregnancy after simultaneous pancreas-kidney transplantation from a brain-dead donor: the first case report in Japan
Koyama, S. Tomimatsu, T. Kanagawa, T. Daimon, E. Kimura, T. Kuroda, A. Tanemura, M. Doki, Y. Ito, T.
J Obstet Gynaecol Res 37:1711-6, 2011

Impaired delivery outcomes in pregnancies following myomectomy compared to myoma-complicated pregnancies
Kinugasa-Taniguchi, Y. Ueda, Y. Hara-Ohyagi, C. Enomoto, T. Kanagawa, T. Kimura, T.
J Reprod Med 56:142-148, 2011

The prognostic factors and the outcome of primary isolated fetal ascites
Nose, S. Usui, N. Soh, H. Kamiyama, M. Tani, G. Kanagawa, T. Kimura, T. Arahori, H. Nose, K. Kubota, A. Fukuzawa, M.
Pediatr Surg Int 27:799-804, 2011

Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model
Kumasawa, K. Ikawa, M. Kidoya, H. Hasuwa, H. Saito-Fujita, T. Morioka, Y. Takakura, N. Kimura, T. Okabe, M.
Proc Natl Acad Sci U S A 108:1451-5, 2011

【婦人科腫瘍】

Endometrial carcinoma with extra-abdominal metastasis: improved prognosis following cytoreductive surgery
Ueda, Y. Enomoto, T. Miyatake, T. Egawa-Takata, T. Ugaki, H. Yoshino, K. Fujita, M. Kimura, T.
Ann Surg Oncol 17:1111-1117, 2010

Early reduction of glucose uptake after cisplatin treatment is a marker of cisplatin sensitivity in ovarian cancer
Egawa-Takata, T. Endo, H. Fujita, M. Ueda, Y. Miyatake, T. Okuyama, H. Yoshino, K. Kamiura, S. Enomoto, T. Kimura, T. Inoue, M.
Cancer Sci 101:2171-2178, 2010

Concurrent weekly nedaplatin, external beam radiotherapy and high-dose-rate brachytherapy in patients with FIGO stage IIIb cervical cancer: a comparison with a cohort treated by radiotherapy alone
Mabuchi, S. Ugaki, H. Isohashi, F. Yoshioka, Y. Temma, K. Yada-Hashimoto, N. Takeda, T. Yamamoto, T. Yoshino, K. Nakajma, R. Kuragaki, C. Morishige, K. Enomoto, T. Inoue, T. Kimura, T.
Gynecol Obstet Invest 69:224-232, 2010

Amputation of uterine corpus as the intraoperative modification during cesarean radical hysterectomy for invasive cervical cancer during pregnancy
Matsuo, K. Enomoto, T. Yamasaki, M.
Int J Clin Oncol 15:77-81, 2010

Endometrial carcinoma: better prognosis for asymptomatic recurrences than for symptomatic cases found by routine follow-up
Ueda, Y. Enomoto, T. Egawa-Takata, T. Miyatake, T. Yoshino, K. Fujita, M. Matsuzaki, S. Yokoyama, T. Miyoshi, Y. Kimura, T.
Int J Clin Oncol 15:406-412, 2010

Squamous cell carcinoma of the uterine cervix producing granulocyte colony-stimulating factor: a report of 4 cases and a review of the literature
Matsumoto, Y. Mabuchi, S. Muraji, M. Morii, E. Kimura, T.
Int J Gynecol Cancer 20:417-21, 2010

Prognostic factors for survival in patients with recurrent cervical cancer previously treated with radiotherapy
Mabuchi, S. Isohashi, F. Yoshioka, Y. Temma, K. Takeda, T. Yamamoto, T. Enomoto, T. Morishige, K. Inoue, T. Kimura, T.
Int J Gynecol Cancer 20:834-40, 2010

The first 2 cases of granulocyte colony-stimulating factor producing adenocarcinoma of the uterine cervix
Mabuchi, S. Matsumoto, Y. Morii, E. Morishige, K. Kimura, T.
Int J Gynecol Pathol 29:483-7, 2010

Carboplatin and paclitaxel as an initial treatment in patients with stage IVb cervical cancer: a report of 7 cases and a review of the literature
Mabuchi, S. Morishige, K. Enomoto, T. Kimura, T.
J Gynecol Oncol 21:93-6, 2010

Diagnostic performance of fluorodeoxyglucose positron emission tomography/magnetic resonance imaging fusion images of gynecological malignant tumors: comparison with positron emission tomography/computed tomography
Nakajo, K. Tatsumi, M. Inoue, A. Isohashi, K. Higuchi, I. Kato, H. Imaizumi, M. Enomoto, T. Shimosegawa, E. Kimura, T. Hatazawa, J.
JPN J Radiol 28:95-100, 2010

Vascular endothelial growth factor is a promising therapeutic target for the treatment of clear cell carcinoma of the ovary
Mabuchi, S. Kawase, C. Altomare, D. A. Morishige, K. Hayashi, M. Sawada, K. Ito, K. Terai, Y. Nishio, Y. Klein-Szanto, A. J. Burger, R. A. Ohmichi, M. Testa, J. R. Kimura, T.
Mol Cancer Ther 9:2411-22, 2010

Prognostic significance of CUB domain containing protein expression in end ometrioid adenocarcinoma
Mamat, S. Ikeda, J. Enomoto, T. Ueda, Y. Rahadiani, N. Tian, T. Wang, Y. Qiu, Y. Kimura, T. Aozasa, K. Morii, E.
Oncol Rep 23:1221-1227, 2010

(Review) Serum biomarkers for early detection of gynecologic cancers
Ueda, Y. Enomoto, T. Kimura, Toshihiro Miyatake, T. Yoshino, K. Fujita, M. Kimura, T.
Cancers 2:1312-1327, 2010

(Review) Use of monoclonal antibodies in the treatment of ovarian cancer
Mabuchi, S. Morishige, K. Kimura, T.
Curr Opin Obstet Gynecol 22:3-8, 2010

(Review) Treatment of ovarian cancer by monoclonal antibodies
Mabuchi, S. Kimura, T.
Discov Med 9:197-203, 2010

(Review) Targeting annexin A4 to counteract chemoresistance in clear cell carcinoma of the ovary
Kim, A. Serada, S. Enomoto, T. Naka, T.
Expert Opin Ther Targets 14:963-971, 2010

Recurrent endometrial carcinoma: prognosis for patients with recurrence within 6 to 12 months is worse relative to those relapsing at 12 months or later
Miyake, T. Ueda, Y. Egawa-Takata, T. Matsuzaki, S. Yokoyama, T. Miyoshi, Y. Toshihiro Kimura Yoshino, K. Fujita, M. Yamasaki, M. Enomoto, T. Kimura, T
Am J Obstet Gynecol 204:535 e1-5, 2011

Dissection of unsuspicious para-aortic lymph nodes does not improve prognosis of advanced endometrial carcinoma with intra- or extra-abdominal metastasis
Ueda, Y. Okazawa, M. Enomoto, T. Egawa-Takata, T. Toshihiro Kimura Yoshino, K. Fujita, M. Ohta, Y. Kamiura, S. Kimura, T.
Anticancer Res 31:4513-7, 2011

Salvage chemotherapy for ovarian carcinoma recurring during or after consolidation chemotherapy with Paclitaxel
Miyoshi, Y. Ueda, Y. Morimoto, A. Yokoyama, T. Matsuzaki, S. Kobayashi, E. Toshihiro Kimura Yoshino, K. Fujita, M. Enomoto, T. Kimura, T.
Anticancer Res 31:4613-7, 2011

Investigating the relative efficacies of combination chemotherapy of paclitaxel/carboplatin, with or without anthracycline, for endometrial carcinoma
Fujiwara, K. Egawa-Takata, T. Ueda, Y. Toshihiro Kimura Yoshino, K. Fujita, M. Miyatake, T. Ohta, Y. Kamiura, S. Enomoto, T. Kimura, T.
Arch Gynecol Obstet 2011

Prediction, based on resection margins, of long-term outcome of cervical intraepithelial neoplasia 3 treated by Shimodaira-Taniguchi conization
Miyoshi, Y. Miyatake, T. Ueda, Y. Morimoto, A. Yokoyama, T. Matsuzaki, S. Toshihiro Kimura Yoshino, K. Fujita, M. Ohashi, H. Morii, E. Enomoto, T. Kimura, T.
Arch Gynecol Obstet 2011

Usefulness of computed tomography in predicting cytoreductive surgical outcomes for ovarian cancer
Fujwara, K. Yoshino, K. Enomoto, T. Fujita, M. Ueda, Y. Miyatake, T. Toshihiro Kimura Muraji, M. Fujita, H. Hori, M. Kimura, T.
Arch Gynecol Obstet 284:1501-7, 2011

Second-line chemotherapy for advanced or recurrent endometrial carcinoma previously treated with paclitaxel and carboplatin, with or without epirubicin
Ueda, Y. Miyake, T. Egawa-Takata, T. Miyatake, T. Matsuzaki, S. Yokoyama, T. Yoshino, K. Fujita, M. Enomoto, T. Kimura, T.
Cancer Chemother Pharmacol 67:829-35, 2011

Chemotherapy for endometrial carcinoma (GOGO-EM1 study): TEC (paclitaxel, epirubicin, and carboplatin) is an effective remission-induction and adjuvant therapy
Egawa-Takata, T. Ueda, Y. Kuragaki, C. Miyake, T. Miyatake, T. Fujita, M. Yoshino, K. Nakashima, R. Okazawa, M. Tsutsui, T. Morishige, K. Kimura, T. Yamasaki, M. Nishizaki, T. Nagamatsu, M. Ito, K. Asada, M. Ogita, K. Wakimoto, A. Yamamoto, T. Nishio, Y. Enomoto, T.
Cancer Chemother Pharmacol 68:1603-1610, 2011

Expression of aldehyde dehydrogenase 1 (ALDH1) in endometrioid adenocarcinoma and its clinical implications
Rahadiani, N. Ikeda, J. Mamat, S. Matsuzaki, S. Ueda, Y. Umehara, R. Tian, T. Wang, Y. Enomoto, T. Kimura, T. Aozasa, K. Morii, E.
Cancer Sci 102:903-8, 2011

The activity of trabectedin as a single agent or in combination with everolimus for clear cell carcinoma of the ovary
Mabuchi, S. Hisamatsu, T. Kawase, C. Hayashi, M. Sawada, K. Mimura, K. Takahashi, K. Takahashi, T. Kurachi, H. Kimura, T.
Clin Cancer Res 17:4462-73, 2011

Targeting SRC in mucinous ovarian carcinoma
Matsuo, K. Nishimura, M. Bottsford-Miller, J. N. Huang, J. Komurov, K. Armaiz-Pena, G. N. Shahzad, M. M. Stone, R. L. Roh, J. W. Sanguino, A. M. Lu, C. Im, D. D. Rosenshien, N. B. Sakakibara, A. Nagano, T. Yamasaki, M. Enomoto, T. Kimura, T. Ram, P. T. Schmeler, K. M. Gallick, G. E. Wong, K. K. Frumovitz, M. Sood, A. K.
Clin Cancer Res 17:5367-78, 2011

(Review) Targeting mTOR signaling pathway in ovarian cancer
Mabuchi, S. Hisamatsu, T. Kimura, T.
Curr Med Chem 18:2960-8, 2011

A successful case of abdominal radical trachelectomy for cervical cancer during pregnancy
Enomoto, T. Yoshino, K. Fujita, M. Miyoshi, Y. Ueda, Y. Koyama, S. Toshihiro Kimura Tomimatsu, T. Kimura, T.
Eur J Obstet Gynecol Reprod Biol 158:365-6, 2011

Metastatic mucinous adenocarcinoma of the ovary is characterized by advanced patient age, small tumor size, and elevated serum CA125
Maeda-Taniguchi, M. Ueda, Y. Miyake, T. Miyatake, T. Toshihiro Kimura Yoshino, K. Fujita, M. Wakasa, T. Ohashi, H. Morii, E. Enomoto, T. Kimura, T.
Gynecol Obstet Invest 72:196-202, 2011

Postoperative whole pelvic radiotherapy plus concurrent chemotherapy versus extended-field irradiation for early-stage cervical cancer patients with multiple pelvic lymph node metastases
Mabuchi, S. Okazawa, M. Isohashi, F. Ohta, Y. Maruoka, S. Yoshioka, Y. Enomoto, T. Morishige, K. Kamiura, S. Kimura, T.
Gynecol Oncol 120:94-100, 2011

Pretreatment leukocytosis is an indicator of poor prognosis in patients with cervical cancer
Mabuchi, S. Matsumoto, Y. Isohashi, F. Yoshioka, Y. Ohashi, H. Morii, E. Hamasaki, T. Aozasa, K. Mutch, D. G. Kimura, T.
Gynecol Oncol 122:25-32, 2011

Radical hysterectomy with adjuvant radiotherapy versus definitive radiotherapy alone for FIGO stage IIB cervical cancer
Mabuchi, S. Okazawa, M. Isohashi, F. Matsuo, K. Ohta, Y. Suzuki, O. Yoshioka, Y. Enomoto, T. Kamiura, S. Kimura, T.
Gynecol Oncol 123:241-7, 2011

Salvage chemotherapy for recurrent or persistent clear cell carcinoma of the ovary: a single-institution experience for a series of 20 patients
Yoshino, K. Enomoto, T. Fujita, M. Ueda, Y. Toshihiro Kimura Kobayashi, E. Tsutsui, T. Kimura, T.
Int J Clin Oncol 2011 Dec 10.[Equib ahead of print]

Intraoperative frozen section assessment of myometrial invasion and histology of endometrial cancer using the revised FIGO staging system
Ugaki, H. Toshihiro Kimura Miyatake, T. Ueda, Y. Yoshino, K. Matsuzaki, S. Fujita, M. Kimura, T. Morii, E. Enomoto, T.
Int J Gynecol Cancer 21:1180-4, 2011

Bladder cancer co-existing with ovarian cancer coincidentally detected by transvaginal ultrasonography
Yoshino, K. Ohta, Y. Takezawa, K. Kinouchi, T. Kamiura, S.
J Obstet Gynaecol 31:196-7, 2011

A rare case of ovarian carcinosarcoma successfully treated with the neoadjuvant chemotherapy of paclitaxel and ifosfamide
Okazawa, M. Masuhara, K. Miyoshi, A. Fujiwara, K. Ohta, Y. Yoshino, K. Kamiura, S. Tomita, Y.
J Obstet Gynaecol 31:274-5, 2011

(Review) Two distinct pathways to development of squamous cell carcinoma of the vulva
Ueda, Y. Enomoto, T. Kimura, T. Yoshino, K. Fujita, M.
J Skin Cancer 2011:951250, 2011

Low-dose metronomic oral dosing of a prodrug of Gemcitabine (LY2334737) causes anti-tumor effects in the absence of inhibition of systemic vasculogenesis
Francia, G. Shaked, Y. Hashimoto, K. Sun, J. Yin, M. Cesta, C. Xu, P. Man, S. Hackl, C. Stewart, J. Uhlik, M. Dantzig, A. H. Foster, S. Kerbel, R. S.
Mol Cancer Ther 2011

【一般婦人科・生殖内分泌】

Aldosterone stimulates the proliferation of uterine leiomyoma cells
Isobe, A. Takeda, T. Wakabayashi, A. Tsuiji, K. Li, B. Sakata, M. Yaegashi, N. Kimura, T.
Gynecol Endocrinol 26:372-7, 2010

(Review) Endometrial receptivity and blastocyst implantation
Kimura, T. Ogita, K. Kumasawa, K. Koyama, S. Tsutsui, T. Nakamura, H.
Indian J Physiol Pharmacol 54:1-74, 2010

(Review) Two multipotential transcription factor, NF-kappaB and Stat-3, play critical and hierarchal roles for implantation
Kimura, T. Ogita, K. Kumasawa, K. Koyama, S. Tsutsui, T. Nakamura, H.
Indian J Physiol Pharmacol 54:27-32, 2010

(Review) Ovarian endometriosis: diverse modifications during pregnancy
Ueda, Y. Enomoto, T. Miyatake, T. Yoshino, K. Fujita, M. Tomimatsu, T. Kimura, T.
NOVA Science Publishers 6:123-142, 2010

Antiproliferative effect of adiponectin on rat uterine leiomyoma ELT-3 cells
Wakabayashi, A. Takeda, T. Tsuiji, K. Li, B. Sakata, M. Morishige, K. Yaegashi, N. Kimura, T.
Gynecol Endocrinol 27:33-8, 2011

Inhibitory effect of curcumin on uterine leiomyoma cell proliferation
Tsuiji, K. Takeda, T. Li, B. Wakabayashi, A. Kondo, A. Kimura, T. Yaegashi, N.
Gynecol Endocrinol 27:512-7, 2011

Effects of 4-hydroxy-2-nonenal, a major lipid peroxidation-derived aldehyde, and N-acetylcysteine on the cyclooxygenase-2 expression in human uterine myometrium
Temma-Asano, K. Tskitishvili, E. Kanagawa, T. Tomimatsu, T. Tsutsui, T. Kimura, T. Chang, Y. S. Nakamura, T. Nakai, Y. Shimoya, K.
Gynecol Obstet Invest 72:37-42, 2011

【基礎研究】（教室員留学中・国外共同研究などを含む）

CD95 promotes tumour growth
Chen, L. Park, S. M. Tumanov, A. V. Hau, A. Sawada, K. Feig, C. Turner, J. R. Fu, Y. X. Romero, I. L. Lengyel, E. Peter, M. E.
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