特定臨床研究の成果

国際論文

■2012年〜2014年 特定臨床研究の成果として

発表者氏名 発表者の所属 題名 雑誌名
Nishimura J 血液内科 Genetic variants in C5 and poor response to eculizumab. N Engl J Med. 2014 Feb 13;370(7):632-639.
Hosomi K 脳神経外科 Daily repetitive transcranial magnetic stimulation of primary motor cortex for neuropathic pain: a randomized, multicenter, double-blind, crossover, sham-controlled trial Pain 154, 1065-1072. 2013
Nishimura J 消化器外科 Combination antiemetic therapy with aprepitant/fosaprepitant in patients with colorectal cancer receiving oxaliplatin-based chemotherapy (SENRI trial): A multicentre, randomised, controlled phase 3 trial. Eur J Cancer. 2015 Apr 24. pii: S0959-8049(15)00291-9.
Takata A 消化器外科 Randomized Phase II Study of the Anti-inflammatory Effect of Ghrelin During the Postoperative Period of Esophagectomy. Ann Surg. 2014 Oct 30.
Tomiyama Y 血液内科 A lower starting dose of eltrombopag is efficacious in Japanese patients with previously treated chronic immune thrombocytopenia. J Thromb Haemost. 2012 May;10(5):799-806.
Kato M 消化器内科 Esophageal submucosal dissection under steady pressure automatically controlled endoscopy (SPACE): a clinical feasibility study. Endoscopy 2014 Aug;46(8):680-4
Kazui H, 神経科・精神科 Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2): an open-label randomised trial. Lancet Neurol. 2015 Apr 28. pii: S1474-4422(15)00046-0..
Minamino T 循環器内科 Design and Rationale of Low-Dose Erythropoietin in Patients with ST-Segment Elevation Myocardial Infarction (EPO-AMI-II Study): A Randomized Controlled Clinical Trial Cardiovasc Drugs Ther
2012 Oct;26(5):409-16
Takiguchi S, 消化器外科 Effect of rikkunshito, a Japanese herbal medicine, on gastrointestinal symptoms and ghrelin levels in gastric cancer patients after gastrectomy. Gastric Cancer. 2013 Apr;16(2):167-74.
Masuzawa T 消化器外科 Phase I/II study of S-1 plus cisplatin combined with peptide vaccines for human vascular endothelial growth factor receptor 1 and 2 in patients with advanced gastric cancer. Int J Oncol. 2012 Oct;41(4):1297-304
Fujiwara S, 消化器外科 Clinical trial of the intratumoral administration of labeled DC combined with systemic chemotherapy for esophageal cancer. J Immunother. 2012 Jul;35(6):513-21.
Hiura Y, 消化器外科 Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients: a prospective, randomized, placebo-controlled phase 2 study. Cancer. 2012 Oct 1;118(19):4785-94.
Miyata H, 消化器外科 Randomized study of clinical effect of enteral nutrition support during neoadjuvant chemotherapy on chemotherapy-related toxicity in patients with esophageal cancer. Clin Nutr. 2012 Jun;31(3):330-6.
Takiguchi S, 消化器外科 A comparison of postoperative quality of life and dysfunction after Billroth I and Roux-en-Y reconstruction following distalgastrectomy for gastric cancer: results from a multi-institutional RCT. Gastric Cancer. Gastric Cancer. 2012 Apr;15(2):198-205.
Gomi F, 眼科 Topical bromfenac as an adjunctive treatment with intravitreal ranibizumab for exudative age-related macular degeneration. Retina. 2012;32(9):1804-10.
Oka K, 整形外科 Corrective osteotomy for malunited both bones fractures of the forearm with radial head dislocations using a custom-made surgical guide: two case reports. J Shoulder Elbow Surg.
2012 Oct;21(10):e1-8
Yanagisawa T, 脳神経外科 Regulation of motor representation by phase-amplitude coupling in the sensorimotor cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience
2012 Oct 31;32(44):15467-75
Saitoh Y 脳神経外科 Validation and the future of stimulation therapy of the primary motor cortex. Neurologia medico-chirurgica
2012;52(7):451-6
Nakaoka Y, 循環器内科 Tocilizumab for the treatment of patients with refractory Takayasu arteritis. Int Heart J. 2013;54(6):405-11.
Katakami N, 内分泌・代謝内科 Rationale, design, and baseline characteristics of a trial for prevention of diabetic atherosclerosis using a DPP-4 inhibitor: the Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A). Journal of Atherosclerosis and Thrombosis
2013;20(12):893-902
Ohishi M, 腎臓内科 Effect of tablets with a combination of telmisartan and amlodipine on patients with hypertension: the Cotalo study. Hypertension Research
2013 Jul;36(7):620-6
Tanaka K, 消化器外科 Impact of reconstruction method on visceral fat change after distal gastrectomy: results from a randomized controlled trial comparing Billroth I reconstruction and roux-en-Y reconstruction. Surgery
2014 Mar;155(3):424-31.
Eguchi H 消化器外科 A phase I trial of combination therapy using gemcitabine and S-1 concurrent with full-dose radiation for resectable pancreatic cancer. Cancer Chemother Pharmacol
2014 Feb;73(2):309-15.
Hata T, 消化器外科 A phase II study evaluating the feasibility of a 5-week cycle of S-1 plus irinotecan (IRIS) in patients with advanced and recurrent colorectal cancer. Cancer Chemother Pharmacol
2014 Nov;44(11):2116-23
Mizushima T, 消化器外科 A phase II study of combined chemotherapy with 5-week cycles of S-1 and CPT-11 plus bevacizumab in patients with metastatic colon cancer. Oncology
2013;85(6):317-22
Takiguchi S, 消化器外科 Laparoscopy-assisted distal gastrectomy versus open distal gastrectomy. A prospective randomized single-blind study. World J Surg
2013 Oct;37(10):2379-86.
Nishii T 整形外科 Alendronate treatment for hip osteoarthritis: prospective randomized 2-year trial. Clin Rheumatol.
2013;32:1759-66
Kataoka T 整形外科 3-Dimensional prebent plate fixation in corrective osteotomy of malunited upper extremity fractures using a real-sized plastic bone model prepared by preoperative computer simulation. J Hand Surg Am
2013 May;38(5):909-19
Tanemura A, 皮膚科 Recent advances and developments in the antitumor effect of the HVJ envelope vector on malignant melanoma: from the bench to clinical application. Cancer Gene Therapy
2013 Nov;20(11):599-605
Ueda, Y. 産婦人科 A phase II study of combination chemotherapy using docetaxel and irinotecan for TC-refractory or TC-resistant ovarian carcinomas (GOGO-OV2 study) and for primary clear or mucinous ovarian carcinomas (GOGO-OV3 study) Eur J Obstet Gyn Reprod Biol,
2013 Sep;170(1):259-63
Mabuchi S, 産婦人科 A phase I study of concurrent weekly carboplatin and paclitaxel combined with intensity-modulated pelvic radiotherapy as an adjuvant treatment for early-stage cervical cancer patients with positive pelvic lymph nodes. Int J Gynecol Cancer.
2013 Sep;23(7):1279-86.
Inohara H, 耳鼻咽喉科・頭頸部外科 Phase II Study of Docetaxel, Cisplatin, and Concurrent Radiation for Technically Resectable Stage III_IV Squamous Cell Carcinoma of the Head and Neck. Int J Radiat Oncol Biol Phys
2015 Apr 1;91(5): 934-41
Oze T, 消化器内科 The prospective randomized study on telaprevir at 1500 or 2250 mg with pegylated interferon plus ribavirin in Japanese patients with HCV genotype 1 Journal of Gastroenterology:
50: 313-322, 2015
Ogata A, 免疫・アレルギー内科 Phase III study of the efficacy and safety of subcutaneous versus intravenous tocilizumab monotherapy in patients with rheumatoid arthritis. Arthritis Care and Research
2014 Mar;66(3):344-54
Yoshioka D, 心臓血管外科 Over 1200-day support with dual Jarvik 2000 biventricular assist device. Interact Cardiovasc Thorac Surg.
19(6):1083-4. 2014
Yoshioka D, 心臓血管外科 Clinical results with Jarvik 2000 axial flow left ventricular assist device: Osaka University Experience. J Artif Organs.
2014 Dec;17(4):308-14 , 2014
Nishi H, 心臓血管外科 Initial experience in Japan with HeartWare ventricular assist system. J Artif Organs.
17(2):149-56, 2014
Takata A, 消化器外科 Effects of ghrelin administration on the early postoperative inflammatory response after esophagectomy. Surg Today. 2014 Nov 8.
Hata T, 消化器外科 Safety of fondaparinux to prevent venous thromboembolism in Japanese patients undergoing colorectal cancer surgery: a multicenter study. Surg Today. 2014 Nov;44(11):2116-23.
Fujikado T, 眼科 Effect of low-addition soft contact lenses with decentered optical design on myopia progression in children: a pilot study. Clin Ophthalmol. 2014
;8:1947-56.
Kamei M, 眼科 Reperfusion of large ischemic areas associated with central retinal vein occlusion: a potential novel treatment with activated protein C. JAMA Ophthalmol. 2014;132(3):361-2.
Sawa M, 眼科 Effects of a lutein supplement on the plasma lutein concentration and macular pigment in patients with central serous chorioretinopathy. Invest Ophthalmol Vis Sci. 2014;55(8):5238-44._
Maeda A 麻酔科 Continuous subcostal oblique transversus abdominis plane block provides more effective analgesia than single-shot block after gynaecological laparotomy: A randomized controlled study.” European Journal of Anesthesiology
2014;31:1-2
Nakamura K, 産婦人科 Efficacy of raloxifene hydrochloride for the prevention of health care problems in patients who undergo surgery for endometrial cancer: a multicenter randomized clinical trial. Int J Gynecol Cancer.
2015 Feb;25(2):288-95.
Hasegawa Y, 小児科 Intractable itch relieved by 4-phenylbutyrate therapy in patients with progressive familial intrahepatic cholestasis type 1. Orphanet Journal of Rare Disease
2014 Jul 15;9:89.
Shima Y, 免疫・アレルギー内科 Expansion of range of joint motion following treatment of systemic sclerosis with tocilizumab Modern Rheumatology
2015 Jan;25(1):134-7
Nishida S, 免疫・アレルギー内科 Wilms tumor gene (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer. Journal of Immunotherapy 37 (2), p105-114, 2014
Maeda K 心臓血管外科 Transcatheter aortic valve replacement for patients with aortic valve stenosis complicated with moyamoya disease. Ann Thorac Surg. 2014 Oct;98(4):1443-5.
Maeda K 心臓血管外科 Impact of electrocardiogram-gated multi-slice computed tomography-based aortic annular measurement in the evaluation of paravalvular leakage following transcatheter aortic valve replacement: the efficacy of the OverSized AortiC Annular ratio (OSACA ratio) in TAVR. J Card Surg. 2013 Jul;28(4):373-9.
Maeda K 心臓血管外科 Successful transcatheter aortic valve replacement for bicuspid aortic valve. Ann Thorac Cardiovasc Surg. 2014;20 Suppl:705-8.
Maeda K 心臓血管外科 Early experiences of transcatheter aortic valve replacement in Japan. Circ J. 2013;77(2):359-62. Epub 2012 Oct 13
Nishida T 消化器内科 Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan. World Journal of Gastroenterology 2014;20:4362-9.
Kanakura Y 血液内科 Phase III,single-arm study investigating the efficacy, safety, and tolerability of anagrelide as a second-line treatment in high-risk Japanese patients with essential thrombocythemia. Int J Hematol. 2014 Oct;100(4):353-360.
Kanakura Y 血液内科 Long-term efficacy and safety of eculizumab in Japanese patients with PNH: AEGIS trial. Int J Hematol. 2013 Oct;98(4):406-416.
Wataya-Kaneda M 皮膚科 A novel application of topical rapamycin formulation, an inhibitor of mTOR, for patients with hypomelanotic macules in tuberous sclerosis complex. Archives of Dermatology. 2012;148(1) :138-9
Tanaka M 皮膚科 First left-right comparative study of topical rapamycin versus vehicle for facial angiofibromas in patients with tuberous sclerosis complex. Br J Dermatol. 2013 169,1314-1318
Wataya-Kaneda M 皮膚科 Clinical and Histologic Analysis of the Efficacy of Topical Rapamycin Therapy Against Hypomelanotic Macules in Tuberous Sclerosis Complex. JAMA Dermatol
2015 Feb 18.
Hosen N 免疫アレルギー内科 Vaccination strategies to improve outcome of hematopoietic stem cell transplant in leukemia patients: early evidence and future prospects. Expert Rev Hematol. 2014 Oct;7(5):671-81.
Noguchi S 乳腺・内分泌外科 Efficacy of everolimus with exemestane versus exemestane alone in Asian patients with HER2-negative, hormone-receptor-positive breast cancer in BOLERO-2. Breast Cancer. 2014 Nov;21(6):703-14.
Sawa Y, 心臓血管外科 Safety and Efficacy of Autologous Skeletal Myoblast Sheets (TCD-51073) for the Treatment of Severe Chronic Heart Failure Due to Ischemic Heart Disease. Circ J. 2015;79(5):991-9
Sawa Y 心臓血管外科 Clinical efficacy of transcatheter aortic valve replacement for severe aortic stenosis in high-risk patients: the PREVAIL JAPAN trial. Surg Today. 2015 Jan;45(1):34-43.
Fukuda S 消化器外科 Use of double-lumen peripherally inserted central catheters for safer perioperative management of esophageal cancer patients. J Vasc Access. 2015 Apr 20;0(0):0. doi: 10.5301/jva.5000382.
Ozono K 小児科 Therapeutic use of oral sodium phosphate (phosribbon(_) combination granules) in hereditary hypophosphatemic rickets. Clin Pediatr Endocrinol. 2014 Jan;23(1):9-15.
Tachibana M 小児科 Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders. J Child Adolesc Psychopharmacol. 2013 Mar;23(2):123-7.
Oritani K 血液・腫瘍内科 A multinational, open-label, phase 2 study of ruxolitinib in Asian patients with myelofibrosis: Japanese subset analysis. Int J Hematol. 2015 Mar;101(3):295-304
Miyatake, T. 産婦人科 WT1 peptide immunotherapy for gynecologic malignancies resistant to conventional therapies: a phase II trial J Cancer Res Clin Oncol 139:457-463, 2013
Inoue T 消化器内科 Amelioration of small bowel injury by switching from nonselective nonsteroidal anti-inflammatory drugs to celecoxib in rheumatoid arthritis patients: a pilot study. Digestion 2014 89(2):124-32
Chiba Y 脳神経外科 Use of 11C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma J Neurosurg 116:835_842, 2012
Maeda T 免疫アレルギー内科 Maintenance of complete remission after allogeneic stem cell transplantation in leukemia patients treated with Wilms tumor 1 peptide vaccine. Blood Cancer J. 2013;3:e130
Nishi H 心臓血管外科 Efficacy of landiolol hydrochloride for atrial fibrillation after open heart surgery. Heart Vessels2013
28:490-496
Kashiyama N 心臓血管外科 Initial experience of EVAHEART explantation after continuous-flow LVAD off test with percutaneous occlusion balloon. J Artif Organs2014
17(4):366-9
Yoshioka D 心臓血管外科 Initial experience of conversion of Toyobo paracorporeal left ventricular assist device to DuraHeart left ventricular assist device. Circ J2014
76(2):372-6
Kazui H, 神経科・精神科 Predictors of the disappearance of triad symptoms in patients with idiopathic normal pressure hydrocephalus after shunt surgery. J Neurol Sci. 2013
;328(1-2):64-69.

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実用化された大阪大学発のシーズ

  • 重症心筋症に対する骨格筋筋芽細胞シート移植による治療法の開発 (心臓血管外科)
  • カスタムメイド手術ガイド及びカスタムメイド骨接合プレートを用いた上肢骨の変形を矯正するためのデバイス・インプラントの安全性及び有効性に関する臨床研究(整形外科)

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先進医療として選定されたシーズ

【先進医療A】

  • 前眼部三次元画像解析(眼科)
  • 有床義歯補綴治療における総合的咬合・咀嚼機能検査(歯学部)
  • 自家嗅粘膜移植による脊髄再生治療(整形外科)
  • 腹腔鏡下広汎子宮全摘術(産婦人科)

【先進医療B】

  • 経カテーテル大動脈弁植込み術 弁尖の硬化変性に起因する重度大動脈弁狭窄症(心臓血管外科)
  • パクリタキセル静脈内投与及びカルボプラチン腹腔内投与の併用療法 上皮性卵巣がん、卵管がん又は原発性腹膜がん(産婦人科)
  • 重症低血糖発作を伴うインスリン依存性糖尿病に対する脳死ドナー又は心停止ドナーからの膵島移植重症低血糖発作を伴うインスリン依存性糖尿病(消化器外科)
  • 術後のホルモン療法及びS-1内服投与の併用療法 原発性乳がん(乳腺内分泌外科)
  • 急性心筋梗塞に対するエポエチンベータ投与療法 急性心筋梗塞(心臓血管外科)
  • 自己口腔粘膜を用いた培養上皮細胞シートの移植術 角膜上皮幹細胞疲弊症(眼科)
  • ベペルミノゲンペルプラスミドによる血管新生療法 閉塞性動脈硬化症又はビュルガー病(老年・高血圧内科)
  • 上肢カッティングガイド及び上肢カスタムメイドプレートを用いた上肢骨変形矯正術 骨端線障害若しくは先天奇形に起因する上肢骨の変形又は上肢骨の変形治癒骨折(整形外科)

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