大阪大学・呼吸器内科(8研)
大阪大学大学院医学系研究科 呼吸器・免疫アレルギー内科学
Dept. of Respiratory Medicine, Allergy and Rheumatic Disease, Graduate School of Medicine, Osaka University.
HOME
研究業績
HOME > 研究業績
2016年 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 〜2005
 <英文>
  1. Koyama S, Akbay EA, Li YY, Aref AR, Skoulidis F, Herter-Sprie GS, Buczkowski KA, Liu Y, Awad MM, Denning WL, Diao L, Wang J, Parra-Cuentas ER, Wistuba II, Soucheray M, Thai T, Asahina H, Kitajima S, Altabef A, Cavanaugh JD, Rhee K, Gao P, Zhang H, Fecci PE, Shimamura T, Hellmann MD, Heymach JV, Hodi FS, Freeman GJ, Barbie DA, Dranoff G, Hammerman PS, Wong KK. STK11/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T-cell activity in the lung tumor microenvironment. Cancer Res. 2016 Mar 1;76(5):999-1008.
  2. Tsuchisaka A, Numata S, Teye K, Natsuaki Y, Kawakami T, Takeda Y, Wang W, Ishikawa K, Goto M, Koga H, Sogame R, Ishii N, Takamori S, Hoshino T, Brandt O, Pas HH, Fujiwara S, Hashimoto T. Epiplakin is a paraneoplastic pemphigus autoantigen and related to bronchiolitis obliterans in Japanese patients. J Invest Dermatol. J Invest Dermatol. 2016 Feb;136(2):399-408.
  3. Koyama S, Akbay EA, Li YY, Herter-Sprie GS, Buczkowski KA, Richards WG, Gandhi L, Redig AJ, Rodig SJ, Asahina H, Jones RE, Kulkarni MM, Kuraguchi M, Palakurthi S, Fecci PE, Johnson BE, Janne PA, Engelman JA, Gangadharan SP, Costa DB, Freeman GJ, Bueno R, Hodi FS, Dranoff G, Wong KK, Hammerman PS. Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. Nat Commun. 2016 Feb 17;7:10501.
  4. Higashiguchi M, Kijima T, Morimura O, Osa A, Suzuki H, Inoue T, Kagawa H, Ueno K, Hirashima T, Kumagai T, Imamura F, Mori M, Tanio Y, Kawase I. Assessment of chemotherapy strategy using bevacizumab for non-squamous non-small cell lung cancer in a real world setting: A multi-institutional observational study. Cancer Treat Commun. 2016;5:1-10
 <和文>
  1. 木島貴志.「次世代のがん治療薬・診断のための研究開発 免疫チェックポイント阻害剤の臨床と併用療法の模索: 肺がんにおける免疫チェックポイントを標的とした治療戦略」 がん (技術情報協会編).2016:153-8.
  2. 玄山 宗到, 平田 陽彦, 武田 吉人.「COPDにおける慢性炎症」 呼吸と循環.2016;64(2):137-43.
  3. 中西香織, 玄山宗到, 武田吉人.「COPDとアディポネクチン」 Respiratory Trends Vol6, No1, 12-17, 2016
2015年 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 〜2005
 <英文>
  1. Takeda Y, Suzuki M, Jin Y, Tachibana I. Preventive Role of Tetraspanin CD9 in Systemic Inflammation of Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2015 Dec;53(6):751-60.
  2. Sun J, Wang J, Pefanis E, Chao J, Rothschild G, Tachibana I, Chen JK, Ivanov II, Rabadan R, Takeda Y, Basu U. Transcriptomics Identify CD9 as a marker of murine IL-10-competent regulatory B cells. Cell Rep. 2015 Nov 10;13(6):1110-7.
  3. Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS. Development of selective covalent Janus kinase 3 inhibitors. J Med Chem. 2015 Aug 27;58(16):6589-606.
  4. Van Allen EM, Golay HG, Liu Y, Koyama S, Wong K, Taylor-Weiner A, Giannakis M, Harden M, Rojas-Rudilla V, Chevalier A, Thai T, Lydon C, Mach S, Avila AG, Wong JA, Rabin AR, Helmkamp J, Sholl L, Carter SL, Oxnard G, Janne P, Getz G, Lindeman N, Hammerman PS, Garraway LA, Hodi FS, Rodig SJ, Dranoff G, Wong KK, Barbie DA. Long-term benefit of PD-L1 blockade in lung cancer associated with JAK3 activation. Cancer Immunol Res. 2015 Aug;3(8):855-63.
  5. Kinehara Y, Kijima T, Inoue K, Hirata H, Takeuchi Y, Fukushima K, Hayama Y, Higashiguchi M, Morimura O, Miyake K, Minami T, Nagatomo I, Takeda Y, Kida H, Kumanogoh A. Dapsone hypersensitivity syndrome-related lung injury without eosinophilia in the bronchoalveolar lavage fluid. Intern Med. 2015;54(7):827-31.
  6. Otsuka T, Mori M, Yano Y, Uchida J, Nishino K, Kaji R, Hata A, Hattori Y, Urata Y, Kaneda T, Tachihara M, Imamura F, Katakami N, Negoro S, Morita S, Yokota S. Effectiveness of tyrosine kinase inhibitors in Japanese patients with non-small cell lung cancer harboring minor epidermal growth factor receptor mutations: Results from a multicenter retrospective study (HANSHIN Oncology Group 0212). Anticancer Res. 2015;35:3885-91.
  7. Kuroyama M, Kagawa H, Kitada S, Maekura R, Mori M, Hirano H. Exogenous lipoid pneumonia caused by repeated sesame oil pulling: A report of two cases. BMC Pulm Med. 2015 Oct 30;15:135.
 <和文>
  1. 小山正平,木島貴志,熊ノ郷 淳.「肺がん免疫療法とバイオマーカー」 呼吸器内科.2015;28(6):494-8.
  2. 竹内美子,西川博嘉.「免疫療法におけるバイオマーカーと個別化医療」 がん分子標的治療. 2015;13: 20-23.
  3. 竹内美子,西川博嘉.「がん免疫療法における制御性T細胞の意義」 腫瘍内科.2015;16(4):360-6.
  4. 竹内美子,西川博嘉.「抗PD-1抗体ニボルマブの基礎と臨床効果」 医学のあゆみ.2015;254(9):777-83.
  5. 武田吉人.「呼吸器疾患における新規メッセンジャー:エクソソーム」 分子呼吸器病.2015;19(1):13-6.
  6. 武田吉人.「分子オーガナイザー:テトラスパニンからみた呼吸器疾患(肺気腫、肺線維症から老化まで)」 呼吸. Vol34, No1. 92-98, 2015
2014年 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 〜2005
 <英文>
  1. Takeda Y, Tsujino K, Kijima T, Kumanogoh A. Efficacy and safety of pirfenidone for idiopathic pulmonary fibrosis. Patient Preference and Adherence. 2014 Mar 21;8:361-70.
  2. Development of microscopic polyangiitis-related pulmonary fibrosis in a patient with autoimmune pulmonary alveolar proteinosis.Kinehara Y, Kida H, Inoue Y, Hirose M, Nakabayashi A, Takeuchi Y, Hayama Y,Fukushima K, Hirata H, Inoue K, Minami T, Nagatomo I, Takeda Y, Funakoshi T,Kijima T, Kumanogoh A.BMC Pulm Med. 2014 Nov 4;14:172.
  3. Opioid switch from low dose of oral oxycodone to transdermal fentanylmatrix patch for patients with stable thoracic malignancy-related pain.Minami S, Kijima T, Nakatani T, Yamamoto S, Ogata Y, Hirata H, Shiroyama T,Koba T, Komuta K.BMC Palliat Care. 2014 Oct 8;13:46.
 <和文>
  1. 北岡裕子,平田陽彦,木島貴志.大きくかわる呼吸機能検査データの解釈:動態イメージングと流体力学に基づいた換気力学の再構築.アレルギーの臨床.vol.34, No.3, 64-69, 2014
  2. 武田吉人,熊ノ郷 淳.セマフォリンと呼吸器疾患.Annual Reviews呼吸器病.2014 p45-50.
  3. 武田吉人,立花 功、熊ノ郷 淳 細胞膜4回貫通型蛋白ファミリー:テトラスパニンによる肺気腫と肺線維症の病態解明.分子呼吸器病学.2014 Vol18, No1, 158-62.
  4. 木田博 IL-6 / STAT3シグナルと肺癌 分子呼吸器病学.2014 Vol18, No1, 20-23.
  5. 鉄本訓史、武田吉人、木島貴志、立花 功、熊ノ郷 淳 呼吸器疾患と動物モデル 呼吸器学会雑誌 3(5): 630-635, 2014.
  6. 三宅浩太郎、福島清春、竹内美子、葉山善友、甲原雄平、南 俊行、平田陽彦、長友 泉、井上幸治、武田吉人、木島貴志 スイッチ・オブリーク法により肺野末梢小病変の直視下生検に成功した一例 気管支学.2014; 36(5): 481-6.
2013年 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 〜2005
 <英文>
  1. Minami S, Kijima T, Komuta K, Kumagai T, Imamura F, Yokota S, Takeuchi Y, Nakatani T, Tachibana I, Kawase I. Phase II trial of pemetrexed continuation--maintenance after carboplatin-based induction in untreated non-squamous non-small cell lung cancer. Anticancer Res. 2013 Dec;33(12):5535-42.
  2. Nishino K, Imamura F, Morita S, Mori M, Komuta K, Kijima T, Namba Y, Kumagai T, Yamamoto S, Tachibana I, Nakazawa Y, Uchida J, Minami S, Takahashi R, Yano Y, Okuyama T, Kumanogoh A. A retrospective analysis of 335 Japanese lung cancer patients who responded to initial gefitinib treatment. Lung Cancer. 2013 Nov;82(2):299-304.
  3. Minami S, Kijima T, Hamaguchi M, Nakatani T, Koba T, Takahashi R, Takeuchi Y, Kida H, Nagatomo I, Yamamoto S, Tachibana I, Komuta K, Kawase I. Phase II study of pemetrexed plus intermittent erlotinib combination therapy for pretreated advanced non-squamous non-small cell lung cancer with documentation of epidermal growth factor receptor mutation status. Lung Cancer. 2013 Nov;82(2):271-5.
  4. Fukushima K, Doi H, Hamaguchi S, Tomono K. Fulminant pneumonia caused by nontypable haemophilus influenzae. Intern Med. 2013;52(15):1755.
  5. Tetsumoto S, Takeda Y, Imai H, Kimura A, Jin Y, Nakanishi K, Maeda Y, Kuhara H, Tsujino K, Iwasaki T, Shigeta H, Kondo Y, Ito M, Minami T, Hirata H, Takahashi R, Kohmo S, Nagatomo I, Inoue K, Kida H, Kijima T, Tachibana I, Maeda N, Funahashi T, Shimomura I, Fujiwara H, Kumanogoh A. Validation of noninvasive morphological and diffusion imaging in mouse emphysema by micro-computed tomography and hyperpolarized (129)Xe magnetic resonance imaging. Am J Respir Cell Mol Biol. 2013 Oct;49(4):592-600.
  6. Jin Y, Tachibana I, Takeda Y, He P, Kang S, Suzuki M, Kuhara H, Tetsumoto S, Tsujino K, Minami T, Iwasaki T, Nakanishi K, Kohmo S, Hirata H, Takahashi R, Inoue K, Nagatomo I, Kida H, Kijima T, Ito M, Saya H, Kumanogoh A. Statins decrease lung inflammation in mice by upregulating tetraspanin CD9 in macrophages. PLoS One. 2013 Sep 9;8(9):e73706.
  7. Minami T, Kijima T, Kohmo S, Arase H, Otani Y, Nagatomo I, Takahashi R, Miyake K, Higashiguchi M, Morimura O, Ihara S, Tsujino K, Hirata H, Inoue K, Takeda Y, Kida H, Tachibana I, Kumanogoh A. Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis. Sci Rep. 2013;3:2669.
  8. Kitaoka H, Koc S, Tetsumoto S, Koumo S, Hirata H, Kijima T. 4D model generator of the human lung, "Lung4Cer". Conf Proc IEEE Eng Med Biol Soc. 2013;2013:453-6.
  9. Nishida T, Hiramatsu N, Mizuki M, Nagatomo I, Kida H, Tazumi K, Shinzaki S, Miyazaki M, Yakushijin T, Tatsumi T, Iijima H, Kiso S, Kanto T, Tsujii M, Takehara T. Managing hepatitis B virus carriers with systemic chemotherapy or biologic therapy in the outpatient clinic. Hepatol Res 2013 Apr;43(4):339-46.
  10. He P, Kuhara H, Tachibana I, Jin Y, Takeda Y, Tetsumoto S, Minami T, Kohmo S, Hirata H, Takahashi R, Inoue K, Nagatomo I, Kida H, Kijima T, Naka T, Morii E, Kawase I, Kumanogoh A. Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin CD9. FEBS Open Bio. 2013 May 10;3:225-30.
  11. Tetsumoto S, Takeda Y, Imai H, Kimura A, Jin Y, Nakanishi K, Maeda Y, Kuhara H, Tsujino K, Iwasaki T, Shigeta H, Kondo Y, Ito M, Minami T, Hirata H, Takahashi R, Kohmo S, Nagatomo I, Inoue K, Kida H, Kijima T, Tachibana I, Maeda N, Funahashi T, Shimomura I, Fujiwara H, Kumanogoh A. Validation of Non-Invasive Morphological and Diffusion Imaging in Mouse Emphysema by Micro-CT and Hyperpolarized 129Xe MRI. Am J Respir Cell Mol Biol. 2013 May 13.
  12. Takimoto T, Kijima T, Otani Y, Nonen S, Namba Y, Mori M, Yokota S, Minami S, Komuta K, Uchida J, Imamura F, Furukawa M, Tsuruta N, Fujio Y, Azuma J, Tachibana I, Kumanogoh A. Polymorphisms of CYP2D6 Gene and Gefitinib-Induced Hepatotoxicity. Clin Lung Cancer. 2013 May 9.
  13. Uenami T, Kijima T, Ayata M, Hayama Y, Tsuruta N, Saito Y, Niju T, Higaki N, Ikeda T. A 46-year-old woman with atelectasis from an endobronchial tumor. Chest. 2013 Apr;143(4):1170-3.
  14. Minami S, Kijima T, Shiroyama T, Okafuji K, Hirashima T, Uchida J, Imamura F, Osaki T, Nakatani T, Ogata Y, Yamamoto S, Namba Y, Otsuka T, Tachibana I, Komuta K, Kawase I. Randomized phase II trial of paclitaxel and carboplatin followed by gemcitabine switch-maintenance therapy versus gemcitabine and carboplatin followed by gemcitabine continuation-maintenance therapy in previously untreated advanced non-small cell lung cancer. BMC Res Notes. 2013 Jan 3;6:3. doi: 10.1186/1756-0500-6-3
  15. Kida H, Ihara S, Kumanogoh A. Involvement of STAT3 in immune evasion during lung tumorigenesis. OncoImmunology Vol.2 (1) 2013; 2:eLocationID: e22653
  16. Tetsumoto S, Kijima T, Morii E, Goya S, Minami T, Hirata H, Takahashi R, Kohmo S, Inoue K, Nagatomo I, Takeda Y, Kida H, Tachibana I, Kumanogoh A. Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangement in congenital pulmonary airway malformation. Clin Lung Cancer 2013; in press.
  17. Hirata H, Tetsumoto S, Kijima T, Kida H, Kumagai T, Takahashi R, Otani Y, Inoue K, Kuhara H, Shimada K, Nagatomo I, Takeda Y, Goya S, Yoshizaki K, Kawase I, Tachibana I, Kishimoto T, Kumanogoh A. Favorable responses to tocilizumab in 2 patients with cancer-related cachexia. J Pain Symptom Manage 2013; in press.
  18. Nishijima Y, Hirata H, Himeno A, Kida H, Matsumoto M, Takahashi R, Otani Y, Inoue K, Nagatomo I, Takeda Y, Kijima T, Tachibana I, Fujimura Y, Kumanogoh A. Drug-induced thrombotic thrombocytopenic purpura successfully treated with recombinant human soluble thrombomodulin. Intern Med 2013; in press
  19. Iwasaki T, Takeda Y, Maruyama K, Yokosaki Y, Tsujino K, Tetsumoto S, Kuhara H, Nakanishi K, Otani Y, Jin Y, Kohmo S, Hirata H, Takahashi R, Suzuki M, Inoue K, Nagatomo I, Goya S, Kijima T, Kumagai T, Tachibana I, Kawase I, Kumanogoh A.Deletion of Tetraspanin CD9 Diminishes Lymphangiogenesis in Vivo and in Vitro. J Biol Chem. 288(4):2118-31.2013
 <和文>
  1. 武田吉人,立花 功,熊ノ郷 淳.慢性閉塞性肺疾患と老化.内分泌・糖尿病・代謝内科.vol.37, No.2, 2013
2012年 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 〜2005
  1. Shiroyama T, Kijima T, Komuta K, Yamamoto S, Minami S, Ogata Y, Okafuji K, Imamura F, Hirashima T, Tachibana I, Kawase I, Kumanogoh A. Phase II tailored S-1 regimen study of first-line chemotherapy in elderly patients with advanced and recurrent non-small cell lung cancer. Cancer Chemother Pharmacol. 2012 Dec;70(6):783-9.
  2. Minami S, Kijima T, Takahashi R, Kida H, Nakatani T, Hamaguchi M, Takeuchi Y, Nagatomo I, Yamamoto S, Tachibana I, Komuta K, Kawase I. Combination chemotherapy with intermittent erlotinib and pemetrexed for pretreated patients with advanced non-small cell lung cancer: a phase I dose-finding study. BMC Cancer. 2012 Jul 18;12:296.
  3. Takimoto T, Yoshida M, Hirata H, Kashiwa Y, Takeda Y, Goya S, Kijima T, Kumagai T, Tachibana I, Kawase I. 4-Hydroxy-2-nonenal induces chronic obstructive pulmonary disease-like histopathologic changes in mice. Biochem Biophys Res Commun. 2012 Mar 30;420(1):84-90. Epub 2012 Mar 3.
  4. Takeda Y, Nakanishi K, Tachibana I, Kumanogoh A. Adiponectin: A Novel Link Between Adipocytes and COPD. Vitam Horm. 2012;90:419-35
  5. Ihara S, Kida H, Arase H, Tripathi LP, Chen YA, Kimura T, Yoshida M, Kashiwa Y, Hirata H, Fukamizu R, Inoue R, Hasegawa K, Goya S, Takahashi R, Minami T, Tsujino K, Suzuki M, Kohmo S, Inoue K, Nagatomo I, Takeda Y, Kijima T, Mizuguchi K, Tachibana I, Kumanogoh A. Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis.Cancer Res. 2012 Jun 15;72(12):2990-2999. 2012 Epub
  6. Tsujino K, Takeda Y, Arai T, Shintani Y, Inagaki R, Saiga H, Iwasaki T, Tetsumoto S, Jin Y, Ihara S, Minami T, Suzuki M, Nagatomo I, Inoue K, Kida H, Kijima T, Ito M, Kitaichi M, Inoue Y, Tachibana I, Takeda K, Okumura M, Hemler ME, Kumanogoh A.Tetraspanin CD151 Protects against Pulmonary Fibrosis by Maintaining Epithelial Integrity.Am J Respir Crit Care Med. 2012 May 16. Epub
  7. Minami T, Kijima T, Otani Y, Kohmo S, Takahashi R, Nagatomo I, Hirata H, Suzuki M, Inoue K, Takeda Y, Kida H, Tachibana I, Kumanogoh A. HER2 As Therapeutic Target for Overcoming ATP-Binding Cassette Transporter-Mediated Chemoresistance in Small Cell Lung Cancer.Mol Cancer Ther.11(4):830-41. Epub
  8. Kohmo S, Kijima T, Mori M, Minami T, Namba Y, Yano Y, Yoneda T, Takeda Y, Kitada S, Yamaguchi T, Tachibana I, Yokota S.CXCL12 as a biological marker for the diagnosis of tuberculous pleurisy.Tuberculosis (Edinb). 2012. [Epub ahead of print]
  9. Takahashi R, Hirata H, Tachibana I, Shimosegawa E, Inoue A, Nagatomo I, Takeda Y, Kida H, Goya S, Kijima T, Yoshida M, Kumagai T, Kumanogoh A, Okumura M, Hatazawa J, Kawase I., Early [18F]Fluorodeoxyglucose Positron Emission Tomography at Two Days of Gefitinib Treatment Predicts Clinical Outcome in Patients with Adenocarcinoma of the Lung.Clin Cancer Res.18(1):220-8. 2012
  10. Otani Y, Kijima T, Kohmo S, Oishi S, Minami T, Nagatomo I, Takahashi R, Hirata H, Suzuki M, Inoue K, Takeda Y, Kida H, Tachibana I, Fujii N, Kumanogoh A.,Suppression of metastases of small cell lung cancer cells in mice by a peptidic CXCR4 inhibitor TF14016. FEBS Lett.586(20):3639-44. 2012
2011年 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 〜2005
  1. Kijima T, Takeuchi K, Tetsumoto S, Shimada K, Takahashi R, Hirata H, Nagatomo I, Hoshino S, Takeda Y, Kida H, Goya S, Tachibana I, Kawase I.,Favorable response to crizotinib in three patients with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion-type oncogene-positive non-small cell lung cancer.Cancer Sci. Aug;102(8):1602-4.2011
  2. Honda H, Kida H, Yoshida M, Tomita T, Fujii M, Ihara S, Goya S, Tachibana I, Kawase I., TRecurrent allergic bronchopulmonary aspergillosis in a patient with rheumatoid arthritis treated with etanercept and tocilizumab.Mod Rheumatol. (6):660-4.2011
  3. Tetsumoto S, Osa A, Kijima T, Minami T, Hirata H, Takahashi R, Kuhara H, Nagatomo I, Takeda Y, Kida H, Goya S, Tachibana I, Kawase I. Two cases of leptomeningeal metastases from lung adenocarcinoma which progressed during gefitinib therapy but responded to erlotinib.Int J Clin Oncol. 2011 May 19.[Epub ahead of print]
  4. Takeda Y, Li Q, Kazarov AR, Epardaud M, Elpek K, Turley SJ, Hemler ME. Diminished metastasis in tetraspanin CD151 knockout mice.Blood. May 2.[Epub ahead of print]
  5. Nakanishi K, Takeda Y, Tetsumoto S, Iwasaki T, Tsujino K, Kuhara H, Jin Y, Nagatomo I, Kida H, Goya S, Kijima T, Maeda N, Funahashi T, Shimomura I, Tachibana I, Kawase I.Involvement of Endothelial Apoptosis Underlying COPD-Like Phenotype in Adiponectin-Null Mice: Implications for Therapy.Am J Respir Crit Care Med.183(9):1164-75[Epub ahead of print]
  6. Kijima T, Shimizu T, Nonen S, Furukawa M, Otani Y, Minami T, Takahashi R, Hirata H, Nagatomo I, Takeda Y, Kida H, Goya S, Fujio Y, Azuma J, Tachibana I, Kawase I. Safe and Successful Treatment With Erlotinib After Gefitinib-Induced Hepatotoxicity: Difference in Metabolism As a Possible Mechanism. J Clin Oncol. 2011 Apr 18. [Epub ahead of print]
  7. Shiroyama T, Komuta K, Imamura F, Hirashima T, Kijima T, Tachibana I, Kawase I. Phase II study of S-1 monotherapy in platinum-refractory, advanced non-small cell lung cancer. Lung Cancer.[Epub ahead of print]
2010年 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 〜2005
  1. Iwasaki T, Tachibana I, Yoshida S, Shimazu K, Takeda Y, Nagano H, Kawase I.,A 61-year-old man with a lung nodule and elevated serum IgG. Chest.137(5):1232-5.2010
  2. Kohmo S, Kijima T, Otani Y, Mori M, Minami T, Takahashi R, Nagatomo I, Takeda Y, Kida H, Goya S, Yoshida M, Kumagai T, Tachibana I, Yokota S, Kawase I. Cell surface tetraspanin CD9 mediates chemoresistance in small cell lung cancer.Cancer Res.70(20):8025-35.
  3. Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Lee CM, Mizuguchi H, Takahashi T, Ripley B, Okumura M, Kawase I, Kishimoto T, Naka T. Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma. Int J Cancer 2010 Oct 14.
2009年 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 〜2005
  1. Suzuki M, Tachibana I, Takeda Y, He P, Minami S, Iwasaki T, Kida H, Goya S, Kijima T, Yoshida M, Kumagai T, Osaki T, Kawase I. Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation. J Immunol. 2009 May 15;182(10):6485-93.2009
  2. Freudenberg JA, Wang Q, Katsumata M, Drebin J, Nagatomo I, Greene MI.,The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies. Exp Mol Pathol. 87(1):1-11.2009
  3. He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS.Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.,J Allergy Clin Immunol. 124(4):761-70.2009
2008年 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 〜2005
  1. Takeda Y, He P, Tachibana I, Zhou B, Miyado K, Kaneko H, Suzuki M, Minami S, Iwasaki T, Goya S, Kijima T, Kumagai T, Yoshida M, Osaki T, Komori T, Mekada E,Kawase I. Double deficiency of tetraspanins CD9 and CD81 Alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice.J Biol Chem. 2008 Sep 19;283(38):26089-97. Epub 2008 Jul 28.
  2. Iwahori K, Osaki T, Serada S, Fujimoto M, Suzuki H, Kishi Y, Yokoyama A, Hamada H, Fujii Y, Yamaguchi K, Hirashima T, Matsui K, Tachibana I, Nakamura Y, Kawase I, Naka T. Megakaryocyte potentiating factor as a tumor marker of malignant pleural mesothelioma: Evaluation in comparison with mesothelin. Lung Cancer. 2008 Apr 2. [Epub ahead of print]
  3. Takimoto T, Yoshida M, Hirata H, Suzuki M, Yanagita M, Kashiwa Y, Inoue K, Yano Y, Hoshino S, Takeda Y, Goya S, Kijima T, Kumagai T, Osaki T, Tachibana I, Kawase I. 4-Hydroxy-2-nonenal induces endothelial cell injury via PKCdelta and biphasic JNK activationEXCLI Journal 2008;7:71-78
2007年 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 〜2005
  1. Kijima T, Suzuki M, Ueda K, Minami S, Takeda Y, Goya S, Matsuoka H, Kumagai T, Yoshida M, Osaki T, Tachibana I, Yokota S, Kawase I.Short-term gefitinib treatment brought about a long-term regression of bronchioloalveolar carcinoma without EGFR gene alterations: a case report.Oncol Res. 2007;16(10):489-95.
  2. Yanagita M, Yoshida M, Hoshino S, Yano Y, Inoue K, Takimoto T, Hirata H, Kashiwa Y, Kumagai T, Osaki T, Kijima T, Tachibana I, Kawase I. Anti-fibrotic Effects of ONO-EF-345, a Specific Phosphodiesterase IV inhibitor, on Lung Fibroblasts. EXCLI Journal 2007;6:23 - 35
  3. Furukawa M, Nagatomo I, Kumagai T, Yamadori T, Takahashi R, Yoshimura M, Yoneda T, Takeda Y, Goya S, Matsuoka H, Kijima T, Yoshida M, Osaki T, Tachibana I, Greene MI, Kawase I. Gefitinib-sensitive EGFR lacking residues 746-750 exhibits hypophosphorylation at tyrosine residue 1045, hypoubiquitination, and impaired endocytosis. DNA Cell Biol. 2007 Mar;26(3):178-85.
  4. He P, Naka T, Serada S, Fujimoto M, Tanaka T, Hashimoto S, Shima Y, Yamadori T, Suzuki H, Hirashima T, Matsui K, Shiono H, Okumura M, Nishida T, Tachibana I, Norioka N, Norioka S, Kawase I. Proteomics-based identification of alpha-enolase as a tumor antigen in non-small lung cancer. Cancer Sci. 2007 Aug;98(8):1234-40. Epub 2007 May 15.
  5. Hoshino S, Tachibana I, Kijima T, Yoshida M, Kumagai T, Osaki T, Kamei K, Kawase I. A 60-year-old woman with cough, fever, and upper-lobe cavitary consolidation. Chest. 2007 Aug;132(2):708-10.
  6. Kitaoka H, Kawase I. A novel interpretation of closing volume based on single-breath nitrogen washout curve simulation. J Physiol Sci. 2007 Dec;57(6):367-76.
  7. Kitaoka H, Nieman GF, Fujino Y, Carney D, DiRocco J, Kawase I. A 4-dimensional model of the alveolar structure. J Physiol Sci. 2007 Jun;57(3):175-85.
  8. Kohmo S, Tachibana I, Osaki T, Goya S, Matsuoka H, Kijima T, Yoshida M, Kumagai T, Ikeda J, Aozasa K, Kawase I. Multiple organ mucosa-associated lymphoid tissue lymphoma presenting with lymphangitic pattern of spread in the lung.J Thorac Oncol. 2007 Nov;2(11):1057-9.
2006年 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 〜2005
  1. Yano Y, Yoshida M, Hoshino S, Inoue K, Kida H, Yanagita M, Takimoto T, Hirata H, Kijima T, Kumagai T, Osaki T, Tachibana I, Kawase I. Anti-fibrotic effects of theophylline on lung fibroblasts.Biochem Biophys Res Commun. 2006 Mar 17;341(3):684-90. Epub 2006
  2. Nagatomo I, Kumagai T, Yamadori T, Furukawa M, Takahashi R, Yoneda T, Ogata Y, Saito Y, Inoue K, Yano Y, Kijima T, Yoshida M, Osaki T, Tachibana I, Greene MI, Kawase I. The gefitinib-sensitizing mutant epidermal growth factor receptor enables transformation of a mouse fibroblast cell line.DNA Cell Biol. 2006 ;25(4):246-51.
  3. Overexpression of PIAS3 suppresses cell growth and restores drug sensitivity of human lung cancer cells in association with PI3-K/Akt inactivation.Ogata Y,Osaki T,Naka T,Iwahhori K,Furukawa M,Nagatomo I,Kijima T,Kumagai T,Yoshida M,Tachibana I,Kawase I. Neoplasia vol.8(10) 2006
    ↑■cover pageに掲載されています。
  4. Yoneda T, Kumagai T, Nagatomo I, Furukawa M, Yamane H, Hoshino S, Mori M, Takeda Y, Horai T, Nishida S, Watanabe D, Kijima T, Yoshida M, Osaki T, Tachibana I, Greene MI, Kawase I. The Extracellular Domain of p185(c-neu) Induces Density-Dependent Inhibition of Cell Growth in Malignant Mesothelioma Cells and Reduces Growth of Mesothelioma In Vivo.DNA Cell Biol. 2006 Sep;25(9):530-40.
  5. Saito Y, Tachibana I, Takeda Y, Yamane H, He P, Suzuki M, Minami S, Kijima T, Yoshida M, Kumagai T, Osaki T, Kawase I. Absence of CD9 Enhances Adhesion-Dependent Morphologic Differentiation, Survival, and Matrix Metalloproteinase-2 Production in Small Cell Lung Cancer Cells. Cancer Res. 2006 Oct 1;66(19):9557-65
〜2005年 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 〜2005
 <2005年>
  1. Hoshino, S. Yoshida, M. Inoue, K. Yano, Y. Yanagita, M. Mawatari, H. Yamane, H. Kijima, T. Kumagai, T. Osaki, T. Tachiba, I. Kawase, I. Cigarette smoke extract induces endothelial cell injury via JNK pathway Biochem Biophys Res Commun329(1)58-63,2005
  2. Inoue K, Yoshida M, Arai T, Hoshino S, Yano Y, Yanagita M, Kida H, Takimoto T, Hirata H, Kumagai T, Osaki T, Kijima T, Tachibana I, Kawase I. IL-10 Inhibits Transforming Growth Factor-b-Induction of Type I Collagen mRNA Expression via Both JNK and p38 Pathways in Human Lung Fibroblasts. EXCLI J ;4:49-60 2005
 <2004年>
  1. Kida, H. Yoshida, M. Hoshino, S. Inoue, K. Yano, Y. Yanagita, M. Kumagai, T. Osaki, T. Tachibana, I. Saeki, Y. Kawase, I. Protective effect of IL-6 on alveolar epithelial cell death induced by hydrogen peroxide Am J Physiol Lung Cell Mol Physiol 288(2)L342-9,2004
  2. Tsuboi, A., Oka, Y., Osaki, T., Kumagai, T., Tachibana, I., Hayashi, S., Murakami,M., Nakajima, H., Elisseeva, O. A., Fei, W., Masuda, T., Yasukawa, M., Oji, Y., Kawakami,M., Hosen, N., Ikegame, K., Yoshihara, S., Udaka, K., Nakatsuka, S., Aozasa,K., Kawase, I., Sugiyama, H. WT1 Peptide-Based Immunotherapy for Patients with Lung Cancer: Report of Two Cases Microbiol Immunol48(3)175-84 2004
  3. Mori, M., Morishita, H., Nakamura, H., Matsuoka, H., Yoshida, K., Kishima,Y., Zhou, Z., Kida, H., Funakoshi, T., Goya, S., Yoshida, M., Kumagai, T., Tachibana,I., Yamamoto, Y., Kawase, I., Hayashi,S. Hepatoma-derived growth factor is involved in lung remodeling by stimulating epithelial growth Am J Respir Cell Mol Biol30(4)459-69 2004
  4. Hayashi, S., Abe, K., Matsuoka, H., Goya, S., Morishita, H., Mori, M., Arai,T., Kida, H., Nishino, K., Takeda, Y., Osaki, T., Tachibana, I., Kimura, K., Yokota, S., Inoue, Y., Sakatani, M. Increased level of soluble E-selectin in the serum from patients with idiopathic pulmonary fibrosis. Inflammation 28(1)1-5 2004
 <2003年>
  1. Takeda, Y. Tachibana, I. Miyado, K. Kobayashi, M. Miyazaki, T. Funakoshi,T. Kimura, H. Yamane, H. Saito, Y. Goto, H. Yoneda, T. Yoshida, M. Kumagai, T. Osaki,T. Hayashi, S. Kawase, I. Mekada, E. Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.J Cell Biol 161(5)945-56 2003.
  2. Goya, S. Matsuoka, H. Mori, M. Morishita, H. Kida, H. Kobashi, Y. Kato, T. Taguchi, Y. Osaki,T. Tachibana, I. Nishimoto, N. Yoshizaki, K. Kawase, I. Hayashi, S. Sustained interleukin-6 signalling leads to the development of lymphoid organ-like structures in the lung . J Pathol 200(1)82-7 2003.
  3. Kumagai, T. Katsumata, M. Hasegawa, A. Furuuchi, K. Funakoshi, T. Kawase,I. Greene, M. I. Role of extracellular subdomains of p185c-neu and the epidermal growth factor receptor in ligand-independent association and transactivation Proc Natl Acad Sci U S A 100(16)9220-5 2003.
  4. Funakoshi T, Tachibana I, Takeda Y, Kijima T, Nishino K, Goto H, Yoneda T, Kumagai T, Osaki T, Hayashi S, Aozasa K, Kawase I. Expression of tetraspanins in human lung cancer cells: frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer. Oncogene. 2003 Feb 6;22(5):674-87.
 <2002年>
  1. Goto, H., Osaki, T., Nishino, K., Tachibana, I., Takeda, Y., Yoneda,T., Funakoshi, T., Kimura, H., Hayashi, S., and Tahara, H. Constructionand analysis of new vector systems with improved interleukin-18 secretionin a xenogeneic human tumor model, J Immunother. 25 Suppl 1: S35-41., 2002
  2. Matsuoka, H., Arai, T., Mori, M., Goya, S., Kida, H., Morishita, H., Fujiwara, H., Tachibana, I., Osaki, T., and Hayashi, S. A p38 MAPK inhibitor,FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis, Am J Physiol Lung Cell Mol Physiol. 283: L103-12., 2002.
 <2001年>
  1. Suzuki, M.,Kimura, H.Tachibana, I.Fujimura, H.Nakatsuji, Y.Sugai, F.Naba, I.Nakamori, M.Morishita, H.Arai, T.Osaki, T.Hayashi, S. Improvement of anti-Hu-associated paraneoplastic sensory neuropathy after chemoradiotherapy in a small cell lung cancer patient. Intern Med.40(11):1140-3 2001
  2. Goto, H., Osaki, T., Kijima, T., Nishino, K., Kumagai, T., Funakoshi,T., Kimura, H., Takeda, Y., Yoneda, T., Tachibana, I., and Hayashi, S. Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells, Int J Cancer. 94: 414-9., 2001
  3. Nishino, K., Osaki T., Kumagai T., Kijima T., Tachibana, I., Goto H., Arai, T., Kimura, H., Funakoshi, T., Takeda, Y., Tanio, Y., and Hayashi,S. Adenovirus-mediated gene therapy specific for small cell lung cancer cells using a Myc-Max binding motif, Int J Cancer. 91: 851-6., 2001.
  4. Mori, M., Kida, H., Morishita, H., Goya, S., Matsuoka, H., Arai, T., Osaki, T., Tachibana, I., Yamamoto, S., Sakatani, M., Ito, M., Ogura, T., and Hayashi, S. Microsatellite instability in transforming growth factor-beta 1 type II receptor gene in alveolar lining epithelial cells of idiopathic pulmonary fibrosis, Am J Respir Cell Mol Biol. 24: 398-404., 2001
研修医募集
大学院生募集
ご寄附のお願い
このページの先頭へ
大阪大学大学院医学系研究科 呼吸器・免疫アレルギー内科学 呼吸器内科(8研) / 大阪大学医学部附属病院 呼吸器内科
Copyright (c) Respiratory Medicine, Allergy and Rheumatic Disease, Graduate School of Medicine, Osaka University. All Rights Reserved.