2010
- Nakamura-Utsunomiya A, Okada S, Hara K, Miyagawa S, Takeda K, Fukuhara R, Nakata Y, Hayashidani M, Tachikawa K, Michigami T, Ozono K, Kobayashi M. Clinical characteristics of perinatal lethal hypophosphatasia: A report of 6 cases. Clin Pediatr Endocrinol. 19:7-13, 2010
2009
- Ohata Y, Yamamoto T, Mori I, Kikuchi T, Michigami T, Imanishi Y, Satomura
K, Ida S, Ozono K. Severe arterial hypertension: a possible complication
of McCune-Albright syndrome. Eur J Pediatr. 168:871-876, 2009
- Matsui Y, Michigami T, Tachikawa K, Yamazaki M, Kawabata H, Nishimura G.
Czech dysplasia occurring in a Japanese family. Am J Med Genet(A). 149A:2285-2289, 2009
- Kubota T, Michigami T, Ozono K. Wnt signaling in bone metabolism. J Bone Miner Metab. 27:265-271, 2009
- Miyauchi Y, Sakaguchi N, Okada T, Makishima M, Ozono K, Michigami T. Oncogenic
nucleoporin CAN/Nup214 interacts with vitamin D receptor and modulates
its function. J Cell Biochem. 106:1090-1101, 2009
2008
- Fukumoto S, Namba N, Ozono K, Yamauchi M, Sugimoto T, Michigami T, Tanaka
H, Inoue D, Minagawa M, Endo I, Matsumoto T. Causes and differential diagnosis
of hypocalcemia-recommendation proposed by expert panel supported by ministry
of health, labour and welfare, Japan-. Endocr J. 55:787-794, 2008
- Kubota T, Michigami T, Sakaguchi N, Kokubu C, Suzuki A, Namba N, Sakai
N, Nakajima S, Imai K, Ozono K. Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice
and impairs interaction with Mesd. J Bone Miner Res. 23:1661-1671, 2008
- Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, Minagawa M, Sugimoto
T, Yamauchi M, Michigami T, Matsumoto T. Clinical usefulness of measurement
of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients. Proposal
of diagnostic criteria using FGF23 measurement. Bone. 42:1235-1239, 2008
- Suzuki A, Ozono K, Kubota T, Kondou H, Tachikawa K, Michigami T. PTH/cAMP/PKA
signaling facilitates canonical Wnt signaling via inactivation of glycogen
synthase kinase-3beta in osteoblastic Saos-2 cells. J Cell Biochem. 104:304-317, 2008
2007
- Kawai M, Mushiake
S, Bessho K, Murakami M, Kokubu C, Michigami T, Ozono K. Wnt/Lrp/β-catenin signaling suppresses adipogenesis by inhibiting
mutual activation of PPARγ and C/EBPα. Biochem
Biophys Res Commun. 363:276-282, 2007
- Uchihashi T, Kimata M, Tachikawa K, Koshimizu T, Okada T, Ihara-Watanabe
M, Sakai N, Kogo M, Ozono K, Michigami T. Involvement of nuclear factor I transcription/replication
factor in the early stage of chondrocytic differentiation. Bone.41:1025-1035, 2007
- Yamamoto T, Michigami T, Aranami F, Segawa H, Yoh K, Nakajima S, Miyamoto
KI, Ozono K. Hereditary hypophosphatemic rickets with hypercalciuria: a
study for the phosphate transporter gene IIc and osteoblastic function.
J Bone Miner Metab. 25:407-413, 2007
2006
- Ozono K, Michigami T, Namba N, Nakajima S, Yamamoto T. Molecular bases
of diseases characterized by hypophosphatemia and phosphaturia: New understanding.
Clin Pediatr Endocrinol. 15:129-135, 2006
- Yamazaki M, Suzuki A, Ozono K, Michigami T. G-protein stimulatory alpha
subunit is involved in osteogenic activity in osteoblastic cell line SaOS-2
cells. Clin Pediatr Endocrinol. 15:65-72, 2006
- Miyoshi Y, Santo Y, Tachikawa K, Namba N, Hirai H, Mushiake S, Nakajima
S, Michigami T, Ozono K. Lack of puberty despite elevated estradiol in
a 46,XY phenotypic female with Frasier symdrome. Endocr J. 53:371-376, 2006
- Goto T, Matsui Y, Fernandes RJ, Hanson DA, KuboT, Yukata K, Michigami T,
Komori T, Fujita T, Yang L, Eyre DR, Yasui N. Sp1 family of transcription
factors regulates the human alpha2(XI) collagen gene (COL11A2) in Saos-2
osteoblastic cells. J Bone Miner Res. 21:661-673, 2006
2005
- Miyauchi Y, Michigami T*, Sakaguchi N, Sekimoto T, Yoneda Y, Pike JW, Yamagata
M, Ozono K. Importin 4 is responsible for ligand-independent nuclear translocation
of vitamin D receptor. J Biol Chem. 280:40901-40908, 2005 (*corresponding author)
- Yamagata M, Ozono K, Hashimoto Y, Miyauchi Y, Kondou H, Michigami T. Intraperitoneal
administration of recombinant receptor-associated protein causes phosphaturia
via an alteration in subcellular distribution of the renal sodium phosphate
co-transporter. J Am Soc Nephrol. 16:2338-2345, 2005
- Michigami T, Uchihashi T, Suzuki A, Tachikawa K, Nakajima S, Ozono K. Common
mutations F310L and T1559del in tissue-nonspecific alkaline phosophatase
gene are related to distinct phenotype in Japanese patients with hypophosphatasia. Eur J Pediatr. 164:277-282, 2005
- Ozono K, Nakajima S, Michigami T. Vitamin D and reproductive organs. In:
Feldman D, Pike JW, Glorieux FH (eds) Vitamin D, 2nd Edition. Elsevier Academic Press, Burlington, 851-861, 2005
2004
- Ihara-Watanabe M, Uchihashi T, Miyauchi Y, Sakai N, Yamagata M, Ozono K,
Michigami T. Involvement of phosphoinositide 3-kinase signaling pathway
in chondrocytic differentiation of ATDC5 cells: application of a gene-trap
mutagenesis. J Cell Biochem. 93:418-426, 2004
- Santo Y, Hirai H, Shima M, Yamagata M, Michigami T, Nakajima S, Ozono K.
Examination of megalin in renal tubular epithelium from patients with Dent
disease. Pediatr Nephrol. 19:612-615, 2004
2003
- Kondou H, Mushiake S, Etani Y, Miyoshi Y, Michigami T, Ozono K. A blocking
peptide for transforming growth factor-b1 activation prevents hepatic fibrosis
in vivo. J Hepatol. 39:742-748, 2003
- Myoui A, Nishimura R, Williams PJ, Hiraga T, Tamura D, Michigami T, Mundy
GR, Yoneda T. C-Src tyrosine kinase activity is associated with tumor colonization
in bone and lung in an animal model of human breast cancer metastasis.
Cancer Res. 63:5028-5033, 2003
2002
- Michigami T, Kageyama T, Satomura K, Shima M, Yamaoka K, Nakayama M, Ozono K. Novel mutations in the a3 subunit of vacuolar H+-adenosine triphosphatase in a Japanese patient with infantile malignant
osteopetrosis. Bone. 30:436-439, 2002
- Michigami T, Hiraga T, Williams PJ, Niewolna M, Nishimura R, Mundy GR, Yoneda T. The effect of the bisphosphonate ibandronate on breast cancer metastasis to visceral organs. Breast Cancer Res Treat. 75:249-258, 2002
2001
- Yamamoto T, Miyamoto K,
Ozono K, Taketani Y, Katai K, Miyauchi A, Shima M, Yoshikawa H, Yoh K, Takeda E,
Okada S. Hypophosphatemic rickets accompanying McCune-Albright syndrome:
evidence that a humoral factor causes hypophosphatemia. J Bone Miner Metab.19:287-295, 2001
- Michigami T, Yamato H, Suzuki H, Nagai-Itagaki Y, Sato K, Ozono K. Conflicting
actions of parathyroid hormone-related protein and serum calcium as regulators
of 25-hydroxyvitamin D3-1a-hydroxylase expression in a nude rat model of humoral hypercalcemia of
malignancy. J Endocrinol.171:249-251, 2001
- Yanagihara I, Inui K, Yanagihara K, Boku E, Tanaka J, Ozono K, Okada S,
Kurahashi H. FISH analysis of peripheral blood cells in Pearson marrow-pancreas
syndrome. J Pediatr. 139:452-455,2001
- Matsui Y, Kawabata H, Ozono K, Yasui N. Skeletal development of achondroplasia:
analysis of genotyped patients. Pediatr Int. 43:361-363, 2001
- Matsui Y, Nakata K, Araki N, Ozono K, Fujita Y, Tsumaki N, Kawabata H,
Yasui N, Sekiguchi K and Yoshikawa H. Alternative splicing of fibronectin
transcripts in osteochondrogenic tumors. Anticancer Res. 21:1103-1106, 2001
- Yamagata M, Kimoto A, Michigami T, Nakayama M, Ozono K. Hydroxylases involved in vitamin D metabolism are differentially expressed in murine embryonic kidney: Application of whole mount in situ hybridization. Endocrinology. 142:3223-3230, 2001
- Hatakeyama S, Okano T, Maeyama J, Esumi T, Hiyamizu H, Iwabuchi Y, Nakagawa
K, Ozono K, Kawase A, Kubodera N. Synthesis and evaluation of A-ring diastereomers
of 1alpha,25-dihydroxy-22-oxavitamin D3 (OCT). Bioorg Med Chem. 9:403-415, 2001
- Matsui Y, Yasui N, Ozono K, Yamagata M, Kawabata H, Yoshikawa H. Loss of
the SEDL gene product (Sedlin) causes X-linked spondyloepiphyseal dysplasia
tarda: Identification of a molecular defect in a Japanese family. Am J Med Genet. 99:328-330, 2001
- Nakagawa K, Sowa Y, Kurobe M, Ozono K, Siu-Caldera M, Reddy GS, Uskokovic
MR, Okano T. Differential activities of 1alpha,25-dihydroxy-16-ene-vitamin
D3 analogs and their 3-epimers on human promyelocytic leukemia (HL-60) cell
differentiation and apoptosis. Steroids. 66:327-337, 2001
- Ishizuka S, Miura D, Ozono K, Saito M, Eguchi H, Chokki M, Norman AW. (23S)- and (23R)-25-dehydro-1a-hydroxyvitamin D3-26,23-lactone function as antagonists of vitamin D receptor-mediated genomic
actions of 1a,25-dihydroxyvitamin D3. Steroids. 66:227-237, 2001
- Michigami T, Ihara-Watanabe M, Yamazaki M, Ozono K. Receptor activator of NF-kB ligand (RANKL) is a key molecule of osteoclast formation for bone metastasis in a newly- developed model of human neuroblastoma. Cancer Res. 61:1637-1644, 2001
- Ishizuka S, Miura D, Ozono K, Chokki M, Mimura H, Norman AW. Antagonistic actions in vivo of (23S)-25-dehydro-1a-hydroxyvitamin D3-26,23-lactone on calcium metabolism induced by 1a,25-dihydroxyvitamin D3. Endocrinology. 142:59-67, 2001
- Hirai H, Nakajima S, Miyauchi A, Nishimura K, Shimizu N, Shima M, Michigami
T, Ozono K, Okada S. A novel activating mutation in calcium-sensing receptor
gene (C129S) in a Japanese family with autosomal dominant hypocalcemia.
J Hum Genet. 46:41-44, 2001
2000
- Michigami T, Shimizu N, Williams PJ, Niewolna M, Dallas SL, Mundy GR, Yoneda T. Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha4beta1-integrin enhances production of osteoclast-stimulating activity. Blood. 96:1953-1960, 2000
- Ishizuka S, Miura D, Eguchi H, Ozono K, Chokki M, Kamimura T, Norman AW.
Antagonistic action of novel 1a,25-dihydroxyvitamin D3-26,23-lactone analogs on 25-dihydroxyvitamin D3-24-hydroxylase gene expression induced by 1a,25-dihydroxy vitamin D3 in human promyelocytic leukemia (HL-60) cells. Arch Biochem Biophys. 380:92-102, 2000
- Kubodera N, Okano T, Nakagawa K, Ozono K, Mikami K. Biological activities
of 19-Nor-1alpha,25-dihydroxyvitamin D3 analogs singly dehydroxylated at the C-1 or C-3 position of the A-ring.
Curr Pharm Des. 6:791-801, 2000
- Nakagawa K, Kurobe M, Ozono K, Konno K, Fujishima T, Takayama H, Okano
T. Novel ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D3 and 2-methyl-20-epi-1alpha,25-dihydroxyvitamin D3: transactivation of target genes and modulation of ifferentiation in human
promyelocytic leukemia (HL-60) cells. Biochem Pharmacol. 59:691-702, 2000
- Tsugawa N, Nakagawa K, Kurobe M, Ono Y, Kubodera N, Ozono K, Okano T. In
vitro biological activities of a series of 2b-substituted analogues of
1a,25-dihydroxyvitamin D3. Biol Pharm Bull. 23:66-71, 2000
- Mochizuki H, Saito M, Michigami T, Ohashi H, Koda N, Yamaguchi S, Ozono
K. Severe hypercalcemia and respiratory insufficiency associated with infantile
hypophosphatasia caused by two novel mutations of the TNSALP gene. Eur J Pediatr. 159:375-379, 2000
- Muller HL, Yamazaki M, Michigami T, Kageyama T, Schonau E, Schneider P,
Ozono K. Asp361Val mutant of alkaline phosphatase found in patients with
dominantly inherited hypophosphatasia inhibits the activity of the wild-type
enzyme. J Clin Endocrinol Metab. 85:743-747, 2000
- Okano T, Nakagawa K, Kubodera N, Isaka A, Osawa A, Terada M, Ozono K, Mikami
K. Catalytic asymmetric syntheses and biological activities of a series
of singly dehydroxylated19-nor-1a,25-dihydroxyvitamin D3 A-ring analogs in cancer cell differentiation and apoptosis. Chem Biol. 7:173-184, 2000
- Matsui Y, Yasui N, Kawabata H, Ozono K, Nakata, K, Mizushima T, Tsumaki,
N, Kataoka E, Fujita Y, Ochi T. A novel type X collagen gene mutation (G595R)
associated with Schmid-type metaphyseal chondrodysplasia. J Hum Genet. 45:105-108, 2000
- Matsumoto S, Ozono K, Yamamoto T, Yamaoka K, Okamura T, Hara J, Shima M, Okada S. Treatment with recombinant IL-2 for recurrent respiratory infection in a case of cartilage- hair hypoplasia with autoimmune hemolytic anemia. J Bone Miner Metab. 18:36-40, 2000
- Yanagihara I, Yamagata M, Sakai N, Shukunami C, Kurahashi H, Yamazaki M,
Michigami T, Hiraki Y, Ozono K. Genomic organization of the human chondromodulin-1
gene containing a promoter region which confers the expression of reporter
gene in chondrogenic ATDC5 cells. J Bone Miner Res. 15:421-429, 2000
- Nakajima S, Yamagata M, Sakai N, Ozono K. Effect of cyclic adenosine 3', 5'- monophosphate and protein kinase A on ligand-dependent transactivation via the vitamin D receptor. Mol Cell Endocrinol. 159:45-51, 2000
1999
- Michigami T, Suga A, Yamazaki M, Shimizu C, Cai G, Okada S, Ozono K. Identification
of amino acid sequence in the hinge region of human vitamin D receptor
which transfers a cytosolic protein to the nucleus. J Biol Chem. 274: 33531-33538, 1999
- Ozono K, Saito M, Miura D, Michigami T, Nakajima S, Ishizuka S. Analysis
of the molecular mechanism for the antagonistic action of a novel 1a,25-dihydroxyvitamin
D3 analogue toward vitamin D receptor function. J Biol Chem. 274:32376-32381, 1999
- Nishimura G, Hong HS, Kawame H, Sato S, Cai G, Ozono K. A mild variant
of Desbuquois dysplasia. Eur J Pediatr. 158:479-483, 1999
- Tsugawa N, Nakagawa K, Kawamoto Y, Tachibana Y, Hayashi T, Ozono K, Okano
T. Biological activity profiles of 1alpha,25-dihydroxyvitamin D2, D3, D4, D7, and 24-epi-1alpha,25-dihydroxyvitamin D2. Biol Pharm Bull. 22:371-377, 1999
- Miura D, Manabe K, Ozono K, Saito M, Gao Q, Norman AW, Ishizuka S. Antagonistic
action of novel 1a,25-dihydroxyvitamin D3-26,23-lactone analogs on differentiation of human leukemia cells (HL-60)
induced by 1a,25-dihydroxyvitamin D3. J Biol Chem. 274:16392-16399, 1999
- Yamagata M, Nakajima S, Tokita A, Sakai N, Yanagihara I, Yabuta K, Ozono
K. Analysis of the stable levels of messenger RNA derived from different
polymorphic alleles in the vitamin D receptor gene. J Bone Miner Metab. 17:164-170, 1999
1998
- Okano T, Nakagawa K, Tsugawa N, Ozono K, Kubodera N, Osawa A, Terada M
and Mikami K.Singly dehydroxylated A-ring analogues of 19-nor-1a,25-dihydroxyvitamin
D3 and19-nor-22-oxa-1a,25-dihydroxyvitamin D3: novel vitamin D3 analogues with potent transcriptional activity but extremely low affinity for vitamin D receptor. Biol Pharm Bull. 21:1300-1305, 1998
- Etani Y, Mushiake S, Tajiri H, Miki K, Kozaiwa K, Sawada A, Tada K, Ozono
K, Okada S. Novel mutation of the down-regulated in adenoma gene in a Japanese
case with congenital chloride diarrhea. Hum Mut in Brief Online. 1998
- Cai G, Michigami T, Yamamoto T, Yasui N, Satomura K, Yamagata M, Shima
M, Nakajima S, Mushiake S, Okada S, Ozono K. Analysis of localization of
mutated tissue-nonspecific alkaline phosphatase proteins associated with
neonatal hypophosphatasia using green fluorescent protein chimeras. J Clin Endocrinol Metab. 83:3936-3942, 1998
- Yamamoto T, Ozono K, Shima M, Yamaoka K, Okada S. 24R,25-Dihydroxyvitamin
D3 increases cyclic GMP contents, leading to an enhancement of osteocalcin synthesis by 1,25-dihydroxyvitamin D3 in cultured human osteoblastic cells. Exp Cell Res. 244:71-76, 1998
- Ozono K, Yamagata M, Ohyama Y and Nakajima S. Direct repeat 3-type element
lacking the ability to bind to the vitamin D receptor enhances the function
of a vitamin D-responsive element. J Steroid Biochem Mol Biol. 66:263-269, 1998
- Nakajima S, Yamagata M, Sakai N, Ozono K. Characterization of the activation function-2 domain of the human 1,25-dihydroxyvitamin D3 receptor. Mol Cell Endocrinol. 139:15-24, 1998
- Cai G, Nakayama M, Hiraki Y, Ozono K. Mutational analysis of the DTDST
gene in a fetus with achondrogenesis type 1B. Am J Med Genet, 78:58-60, 1998
- Nishimura G, Satoh M, Aihara T, Aida N, Yamamoto T, Ozono K. A distinct
subtype of "metatropic dysplasia variant" characterized by advanced
carpal skeletal age and subluxation of the appendicular joint. Pediatr Radiol. 28:120-125, 1998
- Sakai N, Fukushima H, Inui K, Fu L, Nishigaki T, Yanagihara I, Tatsumi
N, Ozono K, Okada S. Human galactocerebrosidase gene: promoter analysis
of the 5'-flanking region and structural organization. Biochim Biophys Acta. 1395:62-67, 1998
1997
- Nakajima S, Yanagihara I, Ozono K. A 65 kilodalton nuclear protein binds
to the human vitamin D receptor: A bacterial expressed histidine tagged
receptor study. Biochem Biophys Res Commun. 232:806-809, 1997
- Ozono K, Abumi R, Kitabatake K, Akazawa K, Nakayama M. Delayed bone age observed in fetuses with symmetrical intrauterine growth retardation assessed by the ossification of selected bones. Clin Pediatr Endocrinol. 6:1-6, 1997
- Uchida M, Ozono K, Pike JW. In vitro binding of vitamin D receptor occupied
by 24R, 25-dihydroxyvitamin D3 to vitamin D responsive element of human osteocalcin gene. J Steroid Biochem Mol Biol. 60:181-187, 1997
- Ozono K, Mushiake S, Takeshima T, Nakayama M. Diagnosis of congential cytomegalovirus
infection by examination of placenta: Application of polymerase chain reaction
and in situ hybridization. Pediatr Pathol Lab Med. 17:249-258, 1997
1996
- Ozono K, Yamagata M,
Michigami T, Nakajima S, Sakai N, Cai G, Satomura K, Yasui N, Okada S, Nakayama
M. Identification of novel mutations (Phe310Leu and Gly439Arg) in a neonatal
case of hypophosphatasia. J Clin Endocrinol Metab. 81:4458-4461, 1996
- Yamamoto T, Yamamoka K, Yamamoto K, Ozono K, Michigami T, Matsumoto S,
Hiroshima K, Nakahara H, Okada S. The role of insulin like growth factor
I for the impaired growth of the patients with hypophosphatemic vitamin
D resistant rickets. J Bone Miner
Metab. 14:222-228, 1996
- Akamatsu H, Ichihara-Tanaka
K, Ozono K, Kamiike W, Matsuda H, Sekiguchi K. Suppression of transformed
phenotype of human fibrosarcoma cells by overexpression of recombinant
fibronectin. Cancer Res. 56:4541-4546, 1996
- Michigami T, Yamato H,
Mushiake S, Nakayama M, Yoneda A, Satomura K, Imura K, Ozono K. Hypercalcemia
associated with infantile fibrosarcoma producing parathyroid hormone-related
protein. J Clin Endocrinol Metab.
81:1090-1095, 1996
- Sakai N, Inui K, Tatsumi N,
Fukushima H, Nishigaki T, Taniike M, Nishimoto J, Tsukamoto H, Yanagihara I,
Ozono K, Okada S. Molecular cloning and expression of cDNA for murine
galactocerebrosidase and mutation analysis of the twitcher mouse, a model of
Krabbe's disease. J Neurochem. 66:1118-1124, 1996
- Yamamoto T, Ozono K,
Kasayama S, Yoh K, Hiroshima K, Takagi M, Matsumoto S, Michigami T, Yamamoto K,
Kishimoto T, Okada S. Increased IL-6 production by cells isolated from the
fibrous bone dysplasia tissues in patients with McCune-Albright syndrome.
J Clin
Invest. 98:30-35, 1996
- Ohyama Y, Ozono K, Uchida M, Yoshimura M, Shinki T, Suda T, Yamamoto O.
Function of two vitamin D-responsive elements in the rat 25-hydroxyvitamin
D3 24-hydroxylase gene. J BiolChem. 271:30381-30385, 1996