先端移植グループ

新しいMUC1のフレームシフト変異家を有する家族性尿細管間質腎炎患者家系の解析により明らかになった、変異MUC1蛋白の性質 (解説)

Nephrology Dialysis Transplantation. 2017. 32(12) 2010-2017 PMID 29156055

Analysis of an ADTKD family with a novel frameshift mutation in MUC1 reveals characteristic features of mutant MUC1 protein.

Yamamoto S, Kaimori JY, Yoshimura T, Namba T, Imai A, Kobayashi K, Imamura R, Ichimaru N, Kato K, Nakaya A, Takahara S, Isaka Y.

スピンエコーシークエンスと長時間DTI MRIによる糖尿病腎症における腎繊維化の可視化 (解説)

Sci Rep. 2017 Jul 18;7(1):5731. doi: 10.1038/s41598-017-06111-4. PMID 28720778

Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence.

Kaimori JY, Isaka Y, Hatanaka M, Yamamoto S, Ichimaru N, Fujikawa A, Shibata H, Fujimori A, Miyoshi S, Yokawa T, Kuroda K, Moriyama T, Rakugi H, Takahara S.

ARPKD異常によるNEDD4-family E3 ligaseの機能不全がARPKDの臨床像を説明できる可能性 (解説)

Scientific Reports, 7(7733) PMID 28798345

NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.

Kaimori JY, Lin CC, Outeda P, Garcia-Gonzalez MA, Menezes LF, Hartung EA , Li A, Wu G, Fujita H, Sato Y, Nakanuma Y, Yamamoto S, Ichimaru N, Takahara S, Isaka Y, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG.

ヒトの細胞において、ヒストンH4 lysine20 のアセチル化は遺伝子抑制と相関する (解説)

Scientific Reports. 2016 Apr 11;6:24318 PMID 27064113

Histone H4 lysine 20 acetylation is associated with gene repression in human cells.

Kaimori JY, Maehara K, Hayashi-Takanaka Y, Harada A, Fukuda M, Yamamoto S, Ichimaru N, Umehara T, Yokoyama S, Matsuda R, Ikura T, Nagao K, Obuse C, Nozaki N, Takahara S, Takao T, Ohkawa Y, Kimura H, Isaka Y.

アジルサルタンは近位尿細管のNa+-H+ Exchanger-3を調節してマウスの食塩感受性を改善する (解説)

PLoS One. 2016 Jan 25;11(1):e0147786. PMID 26807585

Azilsartan Improves Salt Sensitivity by Modulating the Proximal Tubular Na+-H+ Exchanger-3 in Mice.

Hatanaka M, Kaimori JY, Yamamoto S, Matsui I, Hamano T, Takabatake Y, Ecelbarger CM, Takahara S, Isaka Y, Rakugi H.