最近の業績
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  • Fujitani, M., Zhang, S., Fujiki, R., Fujihara, Y. and Yamashita, T. (2017) A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling. Mol. Psychiatry 22, 364-374.
    神経発達障害群の染色体重複による発症の機序を解明しました。
    http://www.nature.com/doifinder/10.1038/mp.2016.106
    論文内容の日本語での紹介は下記サイト。
    http://resou.osaka-u.ac.jp/ja/research/2016/20160705_1
    医学系研究科の主要研究成果
    http://www.med.osaka-u.ac.jp/jpn/activities/results/2016/006
  • Kuroda, M., Muramatsu, R., Maedera, N., Koyama, Y., Hamaguchi, M., Fujimura, H., Yoshida, M., Konishi, M., Itoh, N., Mochizuki, H. and Yamashita, T. (2017) Peripherally derived FGF21 promotes remyelination in the central nervous system. J. Clin. Invest.
    脳脊髄の外部の分子が、脳脊髄の髄鞘修復を促すことを発見しました。
    https://www.jci.org/articles/view/94337
    大阪大学ホームページ
    https://resou.osaka-u.ac.jp/ja/research/2017/20170822_1               大阪大学/JSTからのプレスリリース        http://www.jst.go.jp/pr/announce/20170822-3/index.html
  • Fujita, Y., Masuda, K., Bando, M., Nakato, R., Katou, Y., Tanaka, T., Nakayama, M., Takao, K., Miyakawa, T., Tanaka, T., Ago, Y., Hashimoto, H., Shirahige, K. and Yamashita, T.(2017) Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. J. Exp. Med.214, 1431-1452.
    コヒーシンの機能低下により不安行動が高まるメカニズムを解明しました。
    医学系研究科の主要研究成果
  • Siebold, C., Yamashita, T., Monnier, P., Mueller, B.K. and Pasterkamp, R.J. (2017) RGMs: Structural Insights, Molecular Regulation and Downstream Signaling. Trends Cell Biol. 27, 365-378.
  • Ishizuka, K., Fujita, Y., Kawabata, T., Kimura, H., Iwayama, Y., Inada, T., Okahisa, Y., Egawa, J. Usami, M., Kushima, I., Uno, Y., Okada, T., Ikeda, M., Aleksic, B., Mori, D., Someya, T. Yoshikawa, T., Iwata, N., Nakamura, H., Yamashita, T. and Ozaki, N.(2017)Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders.Transl. Psychiatry7, e1184.
  • Kimura, H., Fujita, Y., Kawabata, T., Ishizuka,K., Wang, C., Iwayama, Y., Okahisa, Y., Kushima, I., Morikawa, M., Uno, Y., Okada, T., Ikeda, M., Inada,T.,Branko, A.,Mori, D.,Yoshikawa, T., Iwata, N., Nakamura, H.,Yamashita, T.and Ozaki, N. (2017) A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to Schizophrenia susceptibility.Transl. Psychiatry
  • Fujitani, M., Sato, R. and Yamashita, T. (2017) Loss of p73 in ependymal cells during the perinatal period leads to aqueductal stenosis. Sci. Rep. 7, 12007.
  • Kanemitsu, Y., Fujitani, M., Fujita, Y., Zhang, S., Su, Y.Q., Kawahara, Y. and Yamashita, T. (2017) The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain. Sci. Rep. 7, 1155.
  • Matoba, K., Muramatsu, R. and Yamashita, T. (2017) Leptin sustains spontaneous remyelination in the adult central nervous system. Sci. Rep. 7, 40397.
  • Kawai, T., Okochi, Y., Ozaki, T., Imura, Y., Koizumi, S., Yamazaki, M., Abe, M., Sakimura, K., Yamashita, T. and Okamura, Y. (2017)Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production.J. Neurochem.
  • Fujita, Y. and Yamashita, T. (2017) The roles of RGMa-neogenin signaling in inflammation and angiogenesis. Inflammation and Regeneration 37, 6.
  • Fujita, Y. and Yamashita, T.(2017) Spatial organization of genome architecture in neural development and disease.Neurochem. Int.
  • Matoba, K., Muramatsu, R. and Yamashita, T. (2017) The role of leptin in the central nervous system remyelination. Receptors & Clinical Investigation.
  • Hamaguchi, M., Muramatsu, R., Matoba, K., Maedera, N., Yamashita, T.(2017) Lysophosphatidylcholine-induced demyelination model of mouse. Protocol Exchange
  • 山下俊英: 痛みをなくすことはできるのか?-疼痛関連因子“ネトリン”の発見、academist Journal, 2017.
    https://academist-cf.com/journal/?p=3319
  • 濱口真慈、村松里衣子、山下俊英:ミエリン、脳内環境辞典、88-89, 2017
2016年 2017年|2016年|2015年 2014年2013年2012年2011年2010年(2009年以前→)
  • Hayano, Y., Takasu, K., Koyama, Y., Ogawa, K., Minami, K., Asaki, T., Kitada, K., Kuwabara, S. and Yamashita, T. (2016) Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B. J. Exp. Med.213, 2949-2966.
    神経障害性疼痛のメカニズムを解明し、分子標的治療法の開発に繋がる成果を得ました。
    http://jem.rupress.org/content/early/2016/11/16/jem.20160877
    医学系研究科の主要研究成果
    http://www.med.osaka-u.ac.jp/jpn/activities/results/2016/016.html
  • Itami, C., Huang, J.Y., Yamasaki, M., Watanabe, M., Lu, H.C. and Kimura, F. (2016) Developmental switch in spike timing-dependent plasticity and cannabinoid -dependent reorganization of the thalamocortical projection in the barrel cortex. J. Neurosci. 36, 7039-7054
  • Fujiwara, K., Fujita, Y., Kasai, A., Onaka, Y., Hashimoto, H., Okada, H. and Yamashita, T. (2016) Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior, and memory deficits in mouse. Transl. Psychiatry 6, e766.
  • Ozaki, T., Muramatsu, R., Sasai, M., Yamamoto, M., Kubota, Y., Fujinaka, T., Yoshimine, T. and Yamashita, T. (2016) The P2X4 receptor is required for neuroprotection via ischemic preconditioning. Scientific Reports 6, 25893
  • Harada, K., Fujita, Y. and Yamashita, T. (2016) Repulsive guidance molecule A suppresses angiogenesis. Biochem. Biophys. Res. Commun. 469, 993-999.
  • Hamasaki, H., Fujitani, M. and Yamashita, T. (2016) NME2 associates with PTPs to transduce signals from chondroitin sulfate proteoglycans. Biochem. Biophys. Res. Commun.471, 522-527.
  • Kuroda, M., Muramatsu, R., and Yamashita, T. (2016) Cardiomyocyte-released factors stimulate oligodendrocyte precursor cells proliferation.Biochem. Biophys. Res. Commun. 482, 1160-1164.
  • Jin, X. and Yamashita, T. Microglia in central nervous system repair after injury. J. Biochem.159, 491-496.
  • 山下俊英: 脊髄損傷後のリハビリテーション効果のメカニズム、Clinical Neuroscience、34:,242-243, 2016
  • 鈴木一博、山下俊英、熊ノ郷淳: 見えてきた!? 神経・免疫クロストーク、最新医学、最新医学社、71: 161-170, 2016
  • 山下俊英: 神経炎症と神経再生を制御するRGMの機能、最新医学、最新医学社、 71: 188-193, 2016
  • 山下俊英: 軸索再生とRhoシグナル、Clinical Neuroscience、10: 1109-1112, 2016
  • 山下俊英: 神経疾患と慢性炎症、最新医学、71:, 2309-2313,2016
2015年 2017年2016年|2015年| 2014年2013年2012年2011年2010年(2009年以前→)
  • van Erp, S., van den Heuvel, D.M.A., Fujita, Y., Robinson, R.A., Hellemons, A.J., Adolfs, Y., Van Battum, E.Y., Blokhuis, A.M., Kuijpers, M., Demmers, J., Hedman, H., Hoogenraad, C.C., Siebold, C., Yamashita, T. and Pasterkamp, R.J. (2015) Lrig2 negatively regulates ectodomain shedding of axon guidance receptors by ADAM proteases. Dev. Cell 35, 537-552.
  • Arima, Y., Kamimura, D., Atsumi, T., Harada, M., Kawamoto, T., Nishikawa, N., Stofkova, A., Ohki, T., Higuchi, K., Morimoto, Y., Wieghofer, P., Okada, Y., Mori, Y., Sakoda, S., Saika, S., Yoshioka, Y., Komuro, I., Yamashita, T., Hirano, T., Prinz, M., Murakami, M. (2015) Pain-mediated sympathetic activation induces relapse via microglia accumulation in a multiple sclerosis model. eLIFE 4, e08733.
  • Miyake, S., Muramatsu, R., Hamaguchi, M. and Yamashita, T. (2015) Prolyl hydroxylase regulates axonal rewiring and motor recovery after traumatic brain injury. Cell Death Dis. 6, e1638
  • Muramatsu, R., Kuroda, M., Matoba, K., Hsiaoyun, L., Takahashi, C., Koyama, Y., Yamashita, T. (2015) Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system. J. Biol. Chem. 290, 11515-25..
  • Nakagawa, H., Ninomiya, T., Yamashita, T. and Takada, M. (2015) Reorganization of corticospinal tract fibers after spinal cord injury in adult macaques. Sci. Rep. 5, 11986.
  • Fujita, Y., Fujiwara, K., Zenitani, S. and Yamashita, T. (2015) Acetylation of NDPK-D regulates its subcellular localization and cell survival. PLoS ONE 10, e0139616.
  • Toda, T., Ishida, K., Kiyama, H. Yamashita, T. and Lee, S. (2015) Down-regulation of KCC2 expression and phosphorylation in motoneurons, and increases the number of in primary afferent projections to motoneurons in mice with post-stroke spasticity. PLoS ONE 9, e114328.
  • Hirano, M., Satake, W., Ihara, K., Tsuge, I., Kondo, S., Betsui, H., Okubo, K., Sakamoto, H., Ueno, S., Ikuno, Y., Ishihara, R., Iwahashi, H., Ohishi, M., Mano, T., Yamashita, T., Suzuki, Y., Nakamura, Y., Kusunoki, S. and Toda, T. (2015) The first nationwide survey and genetic analyses of Bardet-Biedl syndrome. PLoS ONE 10, e0136317.
  • Yamashita, T. (2014) Significance of corticospinal tract sprouting after cortical injury in rodents. J. Neurosci. Neuroeng. In press.
  • Sumimoto, S., Muramatsu, R., Yamashita, T. (2015) Thromboxane A2 stimulates neurite outgrowth in cerebral cortical neurons via mitogen activated protein kinase signaling. Brain Res. 1594, 46-51.
  • Fujita, Y. and Yamashita, T. (2014) Microglia, Neuroprotection and Regeneration for Retinal Diseases, Neuroprotection and Neuroregeneration for retinal diseases, Springer, p175-187.
  • 山下俊英: 神経炎症と神経・免疫クロストーク—神経炎症と神経再生をつなぐ分子—、感染・炎症・免疫、羊土社、44: , 2015
  • 山下俊英: ROCKと神経再生、Medical View Point、興和創薬株式会社、36 (2), 2015
  • 山下俊英: 軸索再生阻害因子を標的とした中枢神経回路の再生と細胞保護、神経眼科、日本神経眼科学会、32: 255-262, 2015
  • 山下俊英: 網膜の炎症とミクログリア、Clinical Neuroscience、33:, 2015
2014年 2017年2016年2015年| 2014年|2013年2012年2011年2010年(2009年以前→)
  • Tanabe, S. and Yamashita, T. (2014) Repulsive guidance molecule-a is involved in Th17-cell-induced neurodegeneration in autoimmune encephalomyelitis. Cell Rep. 9, 1459-1470.
    多発性硬化症の病態下で、ヘルパーT細胞がニューロンを傷つけるメカニズムを明らかにしました。
    http://www.cell.com/cell-reports/abstract/S2211-1247(14)00907-3
    JSTからのプレスリリース
    http://www.jst.go.jp/pr/announce/20141114/index.html
  • Ueno, M., Fujiki, R. and Yamashita, T. (2014) A selector orchestrates cortical function. Nat. Neurosci. 17, 1016-1017.
  • Hayano, Y., Sasaki, K., Ohmura, N., Takemoto, M., Maeda, Y., Yamashita, T., Hata, Y., Kitada, K and Yamamoto, N. (2014) Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion.Proc. Natl. Acad. Sci. USA 111, 15226-15231.
  • Ueno, M. and Yamashita, T. (2014) Bidirectional tuning of microglia in the developing brain: From neurogenesis to neural circuit formation. Curr. Opin. Neurobiol 27C, 8-15.
  • Lee, S., Toda, T., Kiyama, H. and Yamashita, T. (2014) Weakened rate-dependent depression of Hoffmann’s reflex and increased motoneuron hyperactivity after motor cortical infarction in mice. Cell Death Dis. 5, e1007.
  • Zhang, S., Kanemitsu, Y., Fujitani, M. and Yamashita, T. (2014) The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex. Sci. Rep 4, 5984.
  • Suehiro, K., Nakamura, Y., Xu, S., Uda, Y., Matsumura, T., Yamaguchi, Y., Okamura, H.Yamashita, T. and Takei, Y. (2014) Ecto-domain phosphorylation promotes functional recovery from spinal cord injury. Sci. Rep. 4, 4972.
  • Itokazu, T., Hayano, Y., Takahashi, R. and Yamashita, T. (2014) Involvement of Wnt/β-catenin signaling in the development of neuropathic pain. Neurosci. Res 79, 34-40.
  • Sumimoto, S., Muramatsu, R., Fujii, S., Yamashita, T. (2014) Vascular endothelial cells promote cortical neurite outgrowth via an integrin beta3-dependent mechanism. Biochem. Biophys. Res. Commun 450, 593-597.
  • Fujita, Y. and Yamashita, T. (2014) Role of DAPK in neuronal cell death. Apoptosis 19, 339-345.
  • Fujita, Y. and Yamashita, T. (2014) Microglia, Neuroprotection and Regeneration for Retinal Diseases, Springer.
  • Ueno, M. and Yamashita, T. (2014) The brain-immune network in spinal cord injury, Springer.
  • Fujita, Y and Yamashita, T. (2014) Axon growth inhibition by Rho/ROCK. Front. Neurosci.
  • Muramatsu, R. and Yamashita, T. (2014) Concept and molecular basis of axonal regeneration after central nervous system injury. Neurosci Res. 78, 45-49.
  • Muramatsu, R. and Yamashita, T. (2014) Pericyte function in the physiological central nervous system. Neurosci Res. 81-82, 38-41.
  • Kimura, Y., Fujita, Y. and Yamashita, T. (2014) Effect of the Sigma-1 receptor on neurite outgrowth. Receptors & Clinical Investigation 1, 8-12.
  • Fujita, Y and Yamashita, T. (2014) The functions and signaling pathways induced by the interactions of APP–related molecules with p75NTR. Receptors & Clinical Investigation 1, 299-303.
  • 村松里衣子、山下俊英: 中枢神経炎症からの再生メカニズム、Annual Review神経 2014、中外医学社、221-225, 2014
  • 山下俊英: 中枢神経回路の修復現象とそのメカニズム、脳神経系の発生・再生の融合的新展開、診断と治療社、2014
  • 山下俊英: 網膜における慢性炎症、脳21、金芳堂、17: 2014
2013年 2017年2016年2015年 2014年|2013年|2012年2011年2010年(2009年以前→)
  • Ueno, M., Fujita, Y., Tanaka, T., Nakamura, Y., Kikuta, J., Ishii, M. and Yamashita, T. (2013) Layer V cortical neurons require microglial support for survival during postnatal development. Nat. Neurosci. 16, 543-551.
    脳の免疫細胞が運動の神経細胞を保護することを発見しました。ALSなど運動機能障害性の脳神経疾患への新たな治療法の開発に繋がる成果です。
    大阪大学ホームページ
    http://www.med.osaka-u.ac.jp/jpn/activities/results/2013/002.html
    JST/大阪大学からのプレスリリース
    http://www.jst.go.jp/pr/announce/20130325/index.html
    ライフサイエンス新着論文レビュー
    http://first.lifesciencedb.jp/archives/6794
  • Fujiki, R., Sato, A., Fujitani, M. and Yamashita, T. (2013) A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons. Cell Death Dis. 4, e677.
  • Nakagawa, H., Ueno, M., Itokazu, T. and Yamashita, T. (2013) Bilateral movement training promotes axonal remodeling of the corticospinal tract and recovery of motor function following traumatic brain injury in mice. Cell Death Dis. 4, e534.
  • Uesugi, N., Kimura, Y. and Yamashita, T. (2013) Suppression of the p75 receptor signal attenuates the effect of ephrin-B3 and promotes axonal regeneration of the injured optic nerve. Cell Death Dis. 4, e557.
  • Tanaka, T., Fujita, Y., Ueno, M., Shultz, L.D. and Yamashita, T. (2013) Suppression of SHP-1 promotes functional corticospinal tract rewiring after brain injury. Cell Death Dis. 4. e567.
  • Onishi, M., Fujita, Y., Yoshikawa, H. and Yamashita, T. (2013) Inhibition of Rac1 promotes BMP-2–induced osteoblastic differentiation. Cell Death Dis. 4, e698.
  • Ishii, H., Tanabe, S., Ueno, M., Kubo, T., Kayama, H., Serada, S., Fujimoto, M., Takeda, K., Naka, T. and Yamashita, T. (2013) ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. Cell Death Dis. 4, e710.
  • Fujita, Y., Sato, A. and Yamashita, T. (2013) Brimonidine promotes axon growth after optic nerve injury through Erk phosphorylation. Cell Death Dis. 4. E763.
  • Takahashi, C., Muramatsu, R., Fujimura, H., Mochizuki, H. and Yamashita, T. (2013) Prostacyclin promotes oligodendrocyte precursor recruitment and remyelination after spinal cord demyelination. Cell Death Dis. 4, e795.
  • Kimura, Y., Fujita, Y., Shibata, K., Mori, M. and Yamashita, T. (2013) Sigma-1 receptor enhances neurite elongation of cerebellar granule neurons via TrkB signaling. PLoS ONE 8, e75760.
  • Hasebe, N., Fujita, Y., Ueno, M., Yoshimura, K., Fujino, Y. and Yamashita, T. (2013) Soluble β-amyloid precursor protein alpha binds to p75 neurotrophin receptor to promote neurite outgrowth. PLoS ONE
  • Fujiki, R., Sato, A., Hata, K., Tashiro, F., Yasuhara, Y., Miyazaki, J., Yoneda, Y., Fujitani, M. and Yamashita, T. (2013) Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis. Biochem. Biophys. Res. Commun. 430, 604-609.
  • Shibata, K., Nakahara, S., Shimizu, E., Yamashita, T., Matsuki, N. and Koyama, R. (2013) Repulsive guidance molecule a (RGMa) regulates axonal morphogenesis in the hypocampus. NeuroReport 24, 609-615.
  • 糸数隆秀、高橋良輔、山下俊英: 錐体路の機能回復メカニズム、Annual Review神経 2013、中外医学社、22-28, 2013
  • 村松里衣子、山下俊英:中枢神経傷害後の皮質脊髄路の再編成と機能回復のメカニズ ム、脳21、16: 42-45, 2013
  • 山下俊英: 脳脊髄損傷後の運動機能回復のメカニズム解明に向けて、脳21、金芳堂、16: 7-11, 2013
  • 上野将紀、藤田幸、山下俊英: 脳発達期においてミクログリアは大脳皮質第5層神経細胞の生存に寄与する、ライフサイエンス 新着論文レビュー、2013
  • 村松里衣子、山下俊英: 病態モデルと神経−血管相互作用、血管医学、メディカルレ ビュー社、2013
  • 村松里衣子: 新生血管による神経回路修復機構の解明、神経化学、52: 45-47, 2013
  • 山下俊英: 網膜における慢性炎症、脳21、金芳堂、17: 2014
2012年 2017年2016年2015年 2014年2013年|2012年|2011年2010年(2009年以前→)
  • Muramatsu, R., Takahashi, C., Miyake, S., Fujimura, H., Mochizuki, H. and Yamashita, T. (2012) Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin. Nature Medicine 18, 1658-1664.
    傷害された中枢神経回路が自然に修復するメカニズムを発見しました。
    JST/大阪大学よりプレスリリース
    http://www.jst.go.jp/pr/announce/20121008/index.html
  • Ueno, M., Hayano, Y., Nakagawa, H. and Yamashita, T. (2012) Intraspinal rewiring of the corticospinal tract requires target-derived BDNF and compensates lost function after brain injury. Brain 135, 1253-1267.
    詳しい内容はこちら
  • Tanokashira, D., Morita,T., Hayashi, K., Mayanagi, T., Fukumoto, K., Kubota, Y., Yamashita, T. and Sobue, K. (2012) Glucocorticoid suppresses dendritic spine development mediated by down-regulation of caldesmon expression. J. Neurosci. 32, 14583-14560.
  • Ishii, H., Jin, X., Ueno, M., Tanabe, S., Kubo, T., Serada, S., Naka, T. and Yamashita, T. (2012) Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury. Cell Death Dis. 3, e363.
  • Kurihara, D. and Yamashita, T. (2012) Chondroitin sulfate proteoglycans downregulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB). J. Biol. Chem. 287, 13822-13828.
  • Itokazu, T., Fujita, Y., Takahashi, R. and Yamashita, T. (2012) Identification of the neogenin-binding site on the repulsive guidance molecule a.  PLoS One 7, e32791.
  • Jin, X., Ishii, H., Bai, Z., Itokazu, T. and Yamashita, T. (2012) Temporal changes in cell marker expression and cellular infiltration in a controlled cortical impact model in adult male C57BL/6 mice. PLoS ONE 7, e41892.
  • Kubo, T., Tokita, S. and Yamashita, T. (2012) Repulsive guidance molecule-a and demyelination: Implications for multiple sclerosis. J. Neuroimmune Pharmacol. 7, 524-528.
  • 山下俊英: Repulsive guidance molecule (RGM)ー自己免疫性脊髄炎・多発性硬化症の新たな治療標的、リウマチ科、科学評論社、47: 389-395, 2012
  • 糸数隆秀、高橋良輔、山下俊英: 多発性硬化症−新規薬剤とその分子標的、分子標的薬—がんから他疾患までの治癒をめざして、日本臨床、日本臨床社、609-612、2012
  • 村松里衣子、山下俊英: 多発性硬化症への新規治療戦略、ファルマシア、48: 935-939, 2012
  • 山下俊英、藤田幸: 視覚が戻る−傷ついた視神経が再生する、未来材料、株式会社エヌ・ティー・エス、12 (8): 38-41, 2012
  • 村松里衣子、山下俊英:中枢神経回路の障害と修復を制御する生体システム、脳21
  • 村松里衣子、山下俊英:新生した血管から放出されるプロスタサイクリンは神経回路の再生を促進する、ライフサイエンス 新着論文レビュー、2012
2011年 2017年2016年2015年 2014年2013年2012年|2011年|2010年(2009年以前→)
  • Muramatsu, R., Kubo, T., Mori, M., Nakamura, Y., Fujita, Y., Akutsu, T., Okuno, T., Taniguchi, J., Kumanogoh, A., Yoshida, M., Mochizuki, H., Kuwabara, S. and Yamashita, T. (2011) RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis. Nature Medicine 17, 488-494.
    RGMaがT細胞の活性化を制御すること、またRGMa中和抗体が自己免疫性脳脊髄炎の発症および再発を抑制することを報告しました。多発性硬化症の治療開発に繋がる成果です。
    大阪大学よりプレスリリース
    詳しい内容はこちら
    久保武一氏のこと
  • Sanuki, R., Onishi, A., Koike, C., Muramatsu, R., Watanabe, S., Muranishi, Y, Irie, S., Ueno, S., Koyasu, T., Matsui, R., Cherasse, Y., Urade, Y., Watanabe, D., Kondo, M., Yamashita, T. and Furukawa, T. (2011)miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nature Neurosci.
  • Fujita, Y., Endo, S., Takai, T. and Yamashita, T. (2011) Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. EMBO J. 30, 1389-1401.
    傷ついた視神経の再生を抑制するメカニズムを明らかにするとともに、マウスを用いた実験で視神経を再生させることに成功しました。
    JST/大阪大学よりプレスリリース
    http://www.jst.go.jp/pr/announce/20110302/index.html
  • Yamagishi, S., Hampe1, F., Hata, K., del Toro, D., Schwark, M., Kvachnina, E., Bastmeyer, M., Yamashita, T., Tarabykin, V., Klein, R. and Egea. J. (2011) FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. EMBO J. 30, 2920-2933.
  • Lee, S., Ueno, M. and Yamashita, T. (2011) Axonal remodeling for motor recovery after traumatic brain injury requires downregulation of γ-aminobutyric acid signaling. Cell Death Dis. 2, e133.
  • Ohara, R., Fujita, Y., Hata, K., Nakagawa, M. and Yamashita, T. Axotomy induces axonogenesis in hippocampal neurons through STAT3. Cell Death Dis. 2, e175.
  • Fujita, Y., Takashima, R. Endo, S., Takai, T. and Yamashita, T. The p75 receptor mediates axon growth inhibition through an association with PIR-B. Cell Death Dis. 2, e198.
  • Imagama, S., Sakamoto, K., Tauchi, R., Shinjo, R., Ohgomori, T., Ito, Z., Zhang, H., Nishida, Y., Asami, N., Takeshita, S., Sugiura, N., Watanabe, H., Yamashita, T., Ishiguro, N., Matsuyama, Y. and Kadomatsu K. (2011) Keratan sulfate restricts neural plasticity after spinal cord injury. J. Neurosci. 31, 17091-17102.
  • Nakamura, Y., Fujita, Y., Ueno, M., Takai, T. and Yamashita, T. (2011) Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury. J. Biol. Chem. 286, 1876-1883.
    Nogoの受容体であるPirBおよびNogo受容体を抑制しても脊髄損傷後の機能的再生が認められないことを報告しました。
  • Hagihara, M., Endo, M., Hata, K., Higuchi, C., Takaoka, K., Yoshikawa, H. and Yamashita, T. (2011) Neogenin: A receptor for bone morphogenetic proteins. J. Biol. Chem. 286, 5157-5165.
    NeogeninがBMPのシグナルを伝えることを報告しました。
    Science SignalingのEditors’ Choiceで紹介されました。
    Neogenin, a "Neo" Receptor for BMP
    http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/161/ec54
  • Ueno, M. and Yamashita, T. (2011) Kinematic analyses reveal impaired locomotion following injury of the motor cortex in mice. Exp. Neurol. 230, 280-290.
  • Kitayama, M., Ueno, M., Itakura, T. and Yamashita, T. (2011) Activated microglia inhibit axonal growth through RGMa. PLoS One 6, e25234.
  • Ohara, R., Hata, K., Yasuhara, N., Mehmood, R., Yoneda, Y., Nakagawa, M. and Yamashita, T. (2011) Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on Importin β. Biochem. Biophys. Res. Commun. 405, 697-702.
  • Omoto, S., Ueno, M., Mochio, S. and Yamashita, T. (2011) Corticospinal tract fibers cross the ephrin-B3–negative part of the midline of the spinal cord after brain injury. Neurosci. Res. 69, 187-195.
  • Okamura, Y., Kohmura, E. and Yamashita, T. (2011) TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule. Neurosci. Res. 71, 63-70.
  • Yoshimura, K., Ueno, M., Lee, S., Nakamura, Y., Sato, A., Yoshimura, K., Kishima, H., Yoshimine, T. and Yamashita, T. (2011) C-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice. Neurosci. Res. 71, 266-277.
  • Ryu, M., Nakazawa, T., Akagi, T., Tanaka, T., Watanabe, R., Yasuda, M., Himori, N, Maruyama, K., Yamashita, T., Abe, T., Akaishi, M. and Nishida, K. (2011) Suppression of phagocytic cells in retinal disorders using amphiphilic poly (γ-glutamic acid) nanoparticles containing dexamethasone. J. Control. Release 151, 65-73.
  • Hirano, M., Ohishi, M., Yamashita, T., Ikuno, Y., Iwahashi, H., Mano, T., Ishihara, R., Tanaka, I., Yanagihara, K., Isono, C, Sakamoto, H, Nakamura, Y, Kusunoki, S. (2011) Abnormal cystatin C levels in two patients with Bardet-Biedl syndrome. Clin. Med. Insights Case Rep. 4, 17-20.
  • Fang, X., Ueno, M., Yamashita, T. and Ikuno, Y. (2011) RhoA activation and effect of Rho-kinase inhibitor in the development of retinal neovascularization in a mouse model of oxygen-induced retinopathy. Curr. Eye Res. 36, 1028-1036.
  • Kubo, T., Tokita, S. and Yamashita, T. (2011) Crosstalk between the immune and central nervous systems with special reference to drug development. Drug Development - A Case Study Based Insight into Modern Strategies, Intec Publishers, p365-380.
  • 山下俊英: 中枢神経の軸索再生を制御する分子機構、脳21、2011
  • 村松里衣子、山下俊英: RGMはT細胞活性化を制御し、自己免疫性脳脊髄炎に関与する、ライフサイエンス 新着論文レビュー、2011
  • 山下俊英: 失われた神経回路を取り戻すために、共創・協奏(独立行政法人 科学技術振興機構 JSTイノベーションプラザ大阪 編)、55-68, 2011
  • 山下俊英: 中枢神経障害による神経症状を改善する治療薬の開発の現状と今後、医薬品医療機器レギュラトリーサイエンス、2011
  • 佐藤真、山下俊英: 神経系におけるiPS細胞:iPS細胞の活用も含めた神経機能修復の現状と将来、脳21、2011
  • 村松里衣子、山下俊英: 多発性硬化症とRepulsive guidance molecule、脳21、4: 401-404, 2011
2010年 2017年2016年2015年 2014年2013年2012年2011年|2010年|(2009年以前→)
  • Omoto, S., Ueno, M., Mochio, S., Takai, T. and Yamashita, T. (2010) Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury. J. Neurosci. 30, 13045-13052.
  • Ito, Z., Sakamoto, K., Imagama, S., Matsuyama, Y., Zhang, H, Hirano, K.,Ando, K., Yamashita, T., Ishiguro, N. and Kadomatsu, K. (2010) N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury. J. Neurosci. 30, 5937-5947.
  • Shinohara, M., Sato, N., Kurinami, H., Takeuchi, D., Takeda, S., Shimamura, M., Yamashita, T., Uchiyama, Y., Rakugi, H. and Morishita, R. (2010) Reduction of brain Ab by Fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and Ab clearance. J. Biol. Chem. 285, 22091-22102.
  • Ishii, H., Kubo, T., Kumanogoh, A. and Yamashita, T. (2010) Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins. Biochem. Biophys. Res. Commun.Biochem. Biophys. Res. Commun. 402, 168-172.
  • Aoki, M., Kishima, H., Yoshimura, Y., Ishihara, M., Ueno, M., Hata, K.,Yamashita, T., Iwatsuki, K. and Yoshimine, T. (2010) Transplantation of whole-layer olfactory mucosa promotes restricted functional recovery in rats with complete spinal cord injury. Journal of Neurosurgery: Spine 12,122-130.
  • Kurihara, D., Ueno, M., Tanaka, T. and Yamashita, T. (2010) Expression of galectin-1 in immune cells and glial cells after spinal cord injury. Neurosci. Res. 66, 265-270.
  • Nakayama, J., Takao, T., Kiuchi, H., Yamamoto, K., Fukuhara, S., Miyagawa,Y., Aoki, M., Iwatsuki, K., Yoshimine, T., Ueno, M., Yamashita, T., Nonomura, N., Tsujimura, A. and Okuyama, A. (2010) Olfactory mucosa transplantation following spinal cord injury improves voiding efficiency by suppressing detrusor sphincter dyssynergia in rats. J. Urol. 184, 775-782.
  • 山下俊英: 中枢神経回路の修復と再生、自律神経、印刷中
  • 山下俊英: 脊髄損傷後の神経回路のダイナミックな変化、実験医学、印刷中
2007年以前の業績はこちら
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