２０１２年 ［ 2012年｜2011年｜2010年｜2009年｜2008年｜（2007年以前→） ］

Ueno, M., Hayano, Y., Nakagawa, H. and Yamashita, T. (2012) Intraspinal rewiring of the corticospinal tract requires target-derived BDNF and compensates lost function after brain injury. Brain 135, 1253-1267. 詳しい内容はこちら Kurihara, D. and Yamashita, T. (2012) Chondroitin sulfate proteoglycans downregulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB). J. Biol. Chem. In press. Itokazu, T., Fujita, Y., Takahashi, R. and Yamashita, T. (2012) Identification of the neogenin-binding site on the repulsive guidance molecule a.  PLoS One 7, e32791. Kubo, T., Tokita, S. and Yamashita, T. (2012) Repulsive guidance molecule-a and demyelination: Implications for multiple sclerosis. J. Neuroimmune Pharmacol. In press. 山下俊英: Repulsive guidance molecule (RGM)ー自己免疫性脊髄炎・多発性硬化症の新たな治療標的、リウマチ科 糸数隆秀、高橋良輔、山下俊英: 多発性硬化症−新規薬剤とその分子標的、分子標的薬—がんから他疾患までの治癒をめざして、日本臨床、2012 村松里衣子、山下俊英: 多発性硬化症への新規治療戦略、ファルマシア、2012

２０１１年 ［ 2012年｜2011年｜2010年｜2009年｜2008年｜（2007年以前→） ］

Muramatsu, R., Kubo, T., Mori, M., Nakamura, Y., Fujita, Y., Akutsu, T., Okuno, T., Taniguchi, J., Kumanogoh, A., Yoshida, M., Mochizuki, H., Kuwabara, S. and Yamashita, T. (2011) RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis. Nature Medicine 17, 488-494. RGMaがT細胞の活性化を制御すること、またRGMa中和抗体が自己免疫性脳脊髄炎の発症および再発を抑制することを報告しました。多発性硬化症の治療開発に繋がる成果です。 大阪大学よりプレスリリース 詳しい内容はこちら 久保武一氏のこと Sanuki, R., Onishi, A., Koike, C., Muramatsu, R., Watanabe, S., Muranishi, Y, Irie, S., Ueno, S., Koyasu, T., Matsui, R., Cherasse, Y., Urade, Y., Watanabe, D., Kondo, M., Yamashita, T. and Furukawa, T. (2011)miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nature Neurosci. Fujita, Y., Endo, S., Takai, T. and Yamashita, T. (2011) Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. EMBO J. 30, 1389-1401. 傷ついた視神経の再生を抑制するメカニズムを明らかにするとともに、マウスを用いた実験で視神経を再生させることに成功しました。 JST／大阪大学よりプレスリリース http://www.jst.go.jp/pr/announce/20110302/index.html Yamagishi, S., Hampe1, F., Hata, K., del Toro, D., Schwark, M., Kvachnina, E., Bastmeyer, M., Yamashita, T., Tarabykin, V., Klein, R. and Egea. J. (2011) FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. EMBO J. 30, 2920-2933. Lee, S., Ueno, M. and Yamashita, T. (2011) Axonal remodeling for motor recovery after traumatic brain injury requires downregulation of γ-aminobutyric acid signaling. Cell Death Dis. 2, e133. Ohara, R., Fujita, Y., Hata, K., Nakagawa, M. and Yamashita, T. Axotomy induces axonogenesis in hippocampal neurons through STAT3. Cell Death Dis. 2, e175. Fujita, Y., Takashima, R. Endo, S., Takai, T. and Yamashita, T. The p75 receptor mediates axon growth inhibition through an association with PIR-B. Cell Death Dis. 2, e198. Imagama, S., Sakamoto, K., Tauchi, R., Shinjo, R., Ohgomori, T., Ito, Z., Zhang, H., Nishida, Y., Asami, N., Takeshita, S., Sugiura, N., Watanabe, H., Yamashita, T., Ishiguro, N., Matsuyama, Y. and Kadomatsu K. (2011) Keratan sulfate restricts neural plasticity after spinal cord injury. J. Neurosci. 31, 17091-17102. Nakamura, Y., Fujita, Y., Ueno, M., Takai, T. and Yamashita, T. (2011) Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury. J. Biol. Chem. 286, 1876-1883. Nogoの受容体であるPirBおよびNogo受容体を抑制しても脊髄損傷後の機能的再生が認められないことを報告しました。 Hagihara, M., Endo, M., Hata, K., Higuchi, C., Takaoka, K., Yoshikawa, H. and Yamashita, T. (2011) Neogenin: A receptor for bone morphogenetic proteins. J. Biol. Chem. 286, 5157-5165. NeogeninがBMPのシグナルを伝えることを報告しました。 Science SignalingのEditors’ Choiceで紹介されました。 Neogenin, a "Neo" Receptor for BMP http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/161/ec54 Ueno, M. and Yamashita, T. (2011) Kinematic analyses reveal impaired locomotion following injury of the motor cortex in mice. Exp. Neurol. 230, 280-290. Kitayama, M., Ueno, M., Itakura, T. and Yamashita, T. (2011) Activated microglia inhibit axonal growth through RGMa. PLoS One 6, e25234. Ohara, R., Hata, K., Yasuhara, N., Mehmood, R., Yoneda, Y., Nakagawa, M. and Yamashita, T. (2011) Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on Importin β. Biochem. Biophys. Res. Commun. 405, 697-702. Omoto, S., Ueno, M., Mochio, S. and Yamashita, T. (2011) Corticospinal tract fibers cross the ephrin-B3–negative part of the midline of the spinal cord after brain injury. Neurosci. Res. 69, 187-195. Okamura, Y., Kohmura, E. and Yamashita, T. (2011) TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule. Neurosci. Res. 71, 63-70. Yoshimura, K., Ueno, M., Lee, S., Nakamura, Y., Sato, A., Yoshimura, K., Kishima, H., Yoshimine, T. and Yamashita, T. (2011) C-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice. Neurosci. Res. 71, 266-277. Ryu, M., Nakazawa, T., Akagi, T., Tanaka, T., Watanabe, R., Yasuda, M., Himori, N, Maruyama, K., Yamashita, T., Abe, T., Akaishi, M. and Nishida, K. (2011) Suppression of phagocytic cells in retinal disorders using amphiphilic poly (γ-glutamic acid) nanoparticles containing dexamethasone. J. Control. Release 151, 65-73. Hirano, M., Ohishi, M., Yamashita, T., Ikuno, Y., Iwahashi, H., Mano, T., Ishihara, R., Tanaka, I., Yanagihara, K., Isono, C, Sakamoto, H, Nakamura, Y, Kusunoki, S. (2011) Abnormal cystatin C levels in two patients with Bardet-Biedl syndrome. Clin. Med. Insights Case Rep. 4, 17-20. Fang, X., Ueno, M., Yamashita, T. and Ikuno, Y. (2011) RhoA activation and effect of Rho-kinase inhibitor in the development of retinal neovascularization in a mouse model of oxygen-induced retinopathy. Curr. Eye Res. 36, 1028-1036. Kubo, T., Tokita, S. and Yamashita, T. (2011) Crosstalk between the immune and central nervous systems with special reference to drug development. Drug Development - A Case Study Based Insight into Modern Strategies, Intec Publishers, p365-380. 山下俊英: 中枢神経の軸索再生を制御する分子機構、脳２１、2011 村松里衣子、山下俊英: RGMはT細胞活性化を制御し、自己免疫性脳脊髄炎に関与する、ライフサイエンス 新着論文レビュー、2011 山下俊英: 失われた神経回路を取り戻すために、共創・協奏（独立行政法人　科学技術振興機構　JSTイノベーションプラザ大阪　編）、55-68, 2011 山下俊英: 中枢神経障害による神経症状を改善する治療薬の開発の現状と今後、医薬品医療機器レギュラトリーサイエンス、２０１１ 佐藤真、山下俊英: 神経系におけるiPS細胞：iPS細胞の活用も含めた神経機能修復の現状と将来、脳２１、2011 村松里衣子、山下俊英: 多発性硬化症とRepulsive guidance molecule、脳２１、4: 401-404, 2011

２０１０年 ［ 2012年｜2011年｜2010年｜2009年｜2008年｜（2007年以前→） ］

Omoto, S., Ueno, M., Mochio, S., Takai, T. and Yamashita, T. (2010) Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury. J. Neurosci. 30, 13045-13052. Ito, Z., Sakamoto, K., Imagama, S., Matsuyama, Y., Zhang, H, Hirano, K.,Ando, K., Yamashita, T., Ishiguro, N. and Kadomatsu, K. (2010)　N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury. J. Neurosci. 30, 5937-5947. Shinohara, M., Sato, N., Kurinami, H., Takeuchi, D., Takeda, S., Shimamura, M., Yamashita, T., Uchiyama, Y., Rakugi, H. and Morishita, R. (2010) Reduction of brain Ab by Fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and Ab clearance. J. Biol. Chem. 285, 22091-22102. Ishii, H., Kubo, T., Kumanogoh, A. and Yamashita, T. (2010) Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins. Biochem. Biophys. Res. Commun.Biochem. Biophys. Res. Commun. 402, 168-172. Aoki, M., Kishima, H., Yoshimura, Y., Ishihara, M., Ueno, M., Hata, K.,Yamashita, T., Iwatsuki, K. and Yoshimine, T. (2010) Transplantation of whole-layer olfactory mucosa promotes restricted functional recovery in rats with complete spinal cord injury. Journal of Neurosurgery: Spine 12,122-130. Kurihara, D., Ueno, M., Tanaka, T. and Yamashita, T. (2010) Expression of galectin-1 in immune cells and glial cells after spinal cord injury. Neurosci. Res. 66, 265-270. Nakayama, J., Takao, T., Kiuchi, H., Yamamoto, K., Fukuhara, S., Miyagawa,Y., Aoki, M., Iwatsuki, K., Yoshimine, T., Ueno, M., Yamashita, T., Nonomura, N., Tsujimura, A. and Okuyama, A. (2010) Olfactory mucosa transplantation following spinal cord injury improves voiding efficiency by suppressing detrusor sphincter dyssynergia in rats. J. Urol. 184, 775-782. 山下俊英: 中枢神経回路の修復と再生、自律神経、印刷中 山下俊英: 脊髄損傷後の神経回路のダイナミックな変化、実験医学、印刷中

２００９年 ［ 2012年｜2011年｜2010年｜2009年｜2008年｜（2007年以前→） ］

Hata, K., Kaibuchi, K., Inagaki, S. and Yamashita, T. (2009) Unc5B associates with LARG to mediate the action of repulsive guidance molecule. J. Cell Biol. 184, 737-750. Taniguchi, J., Sawai, S., Mori, M., Kubo, T., Kanai, K., Misawa, S., Isose, S., Yamashita, T. and Kuwabara, S. (2009) CIDP sera inhibit axonal growth of mouse DRG neurons by activation of Rho-kinase. Ann. Neurol. 66, 694-697. Endo, M. and Yamashita, T. (2009) Inactivation of Ras by p120GAP via FAK dephosphorylation mediates RGMa-induced growth cone collapse. J. Neurosci. 29, 6649-6662. Tanaka, T., Ueno, M. and Yamashita, T. (2009) Engulfment of axon debris by microglia requires p38 MAPK activity. J. Biol. Chem. 284, 21626-21636. Miyashita, T., Koda, M., Kitajo, K., Yamazaki, M., Takahashi, K., Kikuchi,A. and Yamashita, T. (2009) Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury. J.Neurotrauma. 26, 955-964. Fujita, Y., Yamaguchi, A. Hata, K., Endo, M., Yamaguchi, N. and Yamashita, T. (2009) Zyxin is a novel interacting partner for SIRT1. BMC Cell Biol. 10, 6. Liu, X., Hashimoto, M., Horii, H., Yamaguchi, A., Naito, K. and Yamashita, T. (2009) Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury. Biochem. Biophys. Res. Commun. 382, 795-800. Uesugi, N., Muramatsu, R. and Yamashita, T. (2009) Endothelin promotes neurite elongation by a mechanism dependent on c-Jun N-terminal kinase. Biochem. Biophys. Res. Commun. 383, 509-512. Kohta, M., Kohmura, E. and Yamashita, T. (2009) Inhibition of TGF-ß1 promotes functional recovery after spinal cord injury. Neurosci. Res. 65,393-401. Yamashita, M., Yamauchi, K., Suzuki, M., Eguchi, Y., Orita, S., Endo, M.,Yamashita, T., Takahashi, K. and Ohtori, S. (2009) Transfection of rat cells with proopiomeranocortin gene, precursor of endogenous endorphin, using radial shock waves suppresses inflammatory pain. Spine 34, 2270-2277. Yamauchi, K., Inoue, G., Koshi, T., Yamashita, M., Ito, T., Suzuki, M.,Eguchi, Y., Orita, S., Takaso, M., Nakagawa, K., Aoki, Y., Ochiai, N., Kishida, S., Endo, M., Yamashita, T., Takahashi, K. and Ohtori, S. (2009) Nerve growth factor of cultured medium extracted from human degenerative nucleus pulposus promotes sensory nerve growth and induces substance P in vitro. Spine 34, 2263-2269. Oshima, T., Lee, S., Sato, A., Oda, S., Hirasawa, H. and Yamashita, T. (2009) TNF-α contributes to axonal sprouting and functional recovery following traumatic brain injury. Brain Res. 1290, 102-110. Furuya, T.,Hashimoto, M., Koda, M., Okawa, A., Murata, A., Takahashi, K., Yamashita, T. and Yamazaki, M. (2009) Treatment of spinal cord injury with a rho-kinase inhibitor and bone marrow stromal cell transplantation. Brain Res. 1295, 192-202. Muramatsu R, Ueno M, and Yamashita T. Intrinsic regenerative mechanisms of central nervous system neurons. BioscienceTrend. 2009; 3(5):179-183. 山下俊英: 軸索伸展阻害因子と中枢神経の再生、分子脳血管病、8: 45-50, 2009 山下俊英: 脊髄の軸索再生を制御する分子群、臨床整形外科、 44: 378-380, 2009 村松里衣子、山下俊英: 中枢神経回路の再編、日本薬理学雑誌、134:46-47, 2009 山下俊英: 中枢神経回路の修復機構、脳２１、12: 306-311,2009 山下俊英: 軸索の神経化学―構造と機能、再生―、Clinical Neuroscience、27: , 1218-1220, 2009

２００８年 ［ 2012年｜2011年｜2010年｜2009年｜2008年｜（2007年以前→） ］

Fujita, Y., Taniguchi, J., Uchikawa, M., Endo, M., Hata, K., Kubo, T., Mueller, B.K. and Yamashita, T. (2008) Neogenin regulates neuronal survival through DAP-kinase. Cell Death Differ.15, 1593-1608. Taniguchi, J., Fujitani, M., Endo, M., Kubo, T., Fujitani, M., Miller, F.D., Kaplan, D.R. and Yamashita, T. (2008) Rap1 is involved in the signal transduction of myelin-associated glycoprotein. Cell Death Differ.15, 408-419. Ohshima, Y., Kubo, T., Koyama, R., Ueno, M., Nakagawa, M. and Yamashita, T. (2008) Regulation of axonal elongation and pathfinding from the entorhinal cortex to the dentate gyrus in the hippocampus by the chemokine stromal cell-derived factor 1a. J. Neurosci.28, 8344-8353. Ohnami, S., Endo, M., Hirai, S., Uesaka, N., Hatanaka, Y., Yamashita, T. and Yamamoto, N. (2008) Role of RhoA in Activity-Dependent Cortical Axon Branching. J. Neurosci. 28, 9117-9121. Tohyama, D., Yamaguchi, A., and Yamashita, T. (2008) Inhibition of eIF2B∂/F11A3.2 during adulthood extends lifespan in Caenorhabditis elegans. FASEB J.22, 4327-4337. Matsuura, I., Taniguchi, J., Hata, K., Saeki, N. and Yamashita, T.(2008) BMP inhibition enhances axonal growth and functional recovery after spinal cord injury. J. Neurochem. 105, 1471-1479. Kubo, T., Endo, M., Hata, K., Taniguchi, J., Kitajo, K., Tomura, S.,Yamaguchi, A., Mueller, B.K. and Yamashita, T. (2008) Myosin IIA is required forneurite outgrowth inhibition produced by RGMa. J. Neurochem.105, 113-126. Schaffer, G., Taniguchi, J., Brodbeck, T., Meyer, A.H., Schmidt, M., Yamashita, T. and Mueller, B.K. (2008) LIM-Only-Protein 4 (LMO4) interacts directly with the RGM A Receptor Neogenin. J. Neurochem. 107, 418-431. Watanabe, T., Ito, T., Inoue, G., Ohtori, S., Kitajo, K., Doya, H., Takahashi, K. and Yamashita, T. The p75 receptor is associated with inflammatory thermal hypersensitivity. J. Neurosci. Res. 86, 3566-3574. Yoshida, J., Kubo, T. and Yamashita, T. Inhibition of branching and spine maturation by repulsive guidance molecule in cultured cortical neurons. Biochem. Biophys. Res. Commun.372, 725-729. Kawaguchi, K., Ishiwata, S. and Yamashita, T. (2008) Temperature dependence of the flexural rigidity of single microtubules. Biochem Biophys Res Commun.366, 637-642. Suda, M., Hata, K., Sawada, A., Nakamura, Y., Kubo., Yamaguchi, A. and Yamashita, T.(2008) Peptides derived from repulsive guidance molecule act as antagonists. Biochem Biophys Res Commun.371, 501-504. Ueno, M. and Yamashita, T. (2008) Strategies for regenerating injured axons after spinal cord injury-insights from brain development. Biologics: Targets & Therapy.2, 253-264. Kubo, T., Yamaguchi, A., Iwata, N. and Yamashita, T. (2008) The therapeutic effects of Rho-ROCK inhibitors on CNS disorders. Therapeutics and Clinical Risk Management. 4, 605-615. 山下俊英: 軸索再生阻害機構とその制御による中枢神経再生治療、蛋白質・核酸・酵素　増刊号「神経の分化、回路形成、機能発現」、53: 406-410, 2008 山下俊英: 中枢神経の再生、脳２１、11: 125-129, 2008 山下俊英: 中枢神経損傷後の機能回復と神経回路の再生、日本整形外科学会雑誌、82: 895-900, 2008 山下俊英: 中枢神経と末梢神経の再生、第１７回国際痒みシンポジウム記録集、2008 山下俊英: 神経回路修復の分子機構とリハビリテーションへの期待、脳科学とリハビリテーション、8: 2008 田中達英、山下俊英: 脳・脊髄はなぜ再生しないのか、脳死・脳蘇生、2008 村松里衣子、山下俊英: 中枢神経損傷後の機能回復と神経回路の修復機構、再生医療、7: 371-374, 2008