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Graduate School of Frontier Biosciences, Osaka University

2-1, Yamada-oka Suita, Osaka 565-0871, Japan


Masaaki Murakami, Ph.D., D.V.M.



無料カウンタ count
since 2013/6/12

  • Latest News
  •   [April, 2014] 2014 Japanese version of lab leaflet (PDF download)
      [March, 2014] Dr. Murakami has been appointed as Professor in Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan (IGM)
      [February, 2014]  Mori et al., Early pathological alterations of lower lumber cords detected by ultra-high field MRI in a mouse multiple sclerosis model. Int Immunol. (PubMed)
      [February, 2014]  Ogura et al., The reverse-direction method links mass experimental data to human diseases. Archivum Immunologiae et Therapiae Experimentalis (PubMed)
      [January, 2014]  Atsumi et al., Inflammation amplifier, a new paradigm in cancer biology. Cancer Research (PubMed)
      [October, 2013]  Kamimura et al., The gateway theory: bridging neural and immune interactions in the CNS. Front. Neurosci. (Front. Neurosci.)
      [August, 2013]  Arima et al., Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory. Mediators of Inflammation. (Mediators Inflamm.) (PubMed)
      [August, 2013] Singh et al., Reverse direction method: A possible tool to link animal models with corresponding human diseases and disorders. Int. J. Genomic Med. (IJGM)
      [July, 2013]  Kamimura et al., The Gate Theory Explains Regional Neural Regulation of Activated T cells Entering the Central Nervous System. Journal of Clinical & Cellular Immunology (J Clin Cell Immunol)
      [May, 2013]  Ogura et al., The Gate Theory: How Regional Neural Activation Creates a Gateway for Immune Cells via an Inflammation Amplifier.(Biomed J)
      [February, 2013]  Murakami et al., Disease-Association Analysis of an Inflammation-Related Feedback Loop. Cell Reports. (Cell Reports)
      [December, 2012]  Lee et al., IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation. Int Immunol. (Int Immunol)
      [October, 2012] Arima and Murakami, Cross talk between neural system and immune system by interleukines, Reviews of leading authors (in Japanese) 
      [October, 2012]  The Molecular Mechanisms of Chronic Inflammation Development Front. Immunol. (Front. Immunol.)
      [August, 2012]  IL-6 Amplifier, NF-κB-Triggered Positive Feedback for IL-6 Signaling, in Grafts Is Involved in Allogeneic Rejection Responses. J Immunol. (PubMed) (MDLinks)
      [March, 2012]  Leading researchers in Osaka University『The best part of the immunology research』Handai News Letter No.55 (in Japanese) (PDF download)(video)
      [February, 2012]  Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier. Cell. (PubMed)
    。47News (PDF download) 、Nature Reviews of NeurosciencePain Research Forum、Faculty of 1000 (PDF download)







Neuro-immune interaction that promotes inflammation in CNS


Major Achievements



Cell Reports 3: 946-959 (2013)

Cell. 148: 447-457 (2012)



Immunity. 2009 Mar;30(3):447-57. 2009


J. Exp. Med. 208: 103-114 (2011)


Immunity, 29, 628-636, 2008.
J. Clin. Invest. 117: 1270-1281, 2007
Nature Immunol.7:971-977, 2006
(Published online: 6 August 2006; | doi:10.1038/ni1373).
J. Exp. Med. published on line 22 May 2006.