Achievements

Major Achievements
J. Exp. Med. 208: 103-114 (2011) A 4 step model for MHC class II associated autoimmune diseases	Cell. 148: 447-457 (2012) Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier
Immunity. 2009 Mar;30(3):447-57. 2009 Hepatic IL-7 regulates T cell responses in vivo.	J. Exp. Med. 206:1351-1364 (2009) Zinc Transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction.
Immunity, 29, 628-636, 2008. Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction	PLoS ONE 3 (11): e3642, 2008 The Zinc Transporter SLC39A13/ZIP13 is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways.
J. Cell Biol. Published online 14 May 2007 Zinc is a novel intracellular second messenger.	J. Clin. Invest. 117: 1270-1281, 2007 Omenn Syndrome ; a murine model is established.
Nature Immunol.7:971-977, 2006 Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function.	J. Exp. Med. published on line 22 May 2006. Autoimmune arthritis associated with mutated IL-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T.
J. Cell Biol. 170:115-126, 2005. FceRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane.	Nature 429: 298-302, 2004, Zinc transporter LIVI controls epithelial-mesenchymal transition　in zebrafish gastrula organizer
J. Exp Med. 196: 979-990, 2002 / A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis.	Dev. Cell. 2: 363-375, 2002. Stat3 controls cell movements during zebrafish gastrulation.

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Achievements