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Graduate School of Frontier Biosciences, Osaka University

2-1, Yamada-oka Suita, Osaka 565-0871, Japan


Masaaki Murakami, Ph.D., D.V.M.




Publication list


112) Atsumi, T., R. Singh, L. Sabharwal, H. Bando, J. Meng, Y. Arima, M. Yamada, M. Harada, J-J Jiang, D. Kamimura, H. Ogura, T. Hirano, and M. Murakami. Inflammation amplifier, a new paradigm in cancer biology. Cancer Research 74(1): 8-14, 2014 (PubMed) (Review)

111) Ogura, H., T. Atsumi, H. Bando, L. Sabharwal, M. Yamada, J.-J. Jiang, A. Nakamura, Y. Arima, D. Kamimura, and M. Murakami. The reverse-direction method links mass experimental data to human diseases. Archivum Immunologiae et Therapiae Experimentalis 62(1): 41-45, 2014 (PubMed) (Review)

110) Mori, Y*, M. Murakami#,*, Y. Arima*, D. Zhu, Y. Terayama, Y. Komai, Y. Nakatsuji, D. Kamimura, and Y. Yoshioka (*, equal contribution; #, correspondence) Early pathological alterations of lower lumber cords detected by ultra-high field MRI in a mouse multiple sclerosis model. Int Immunol. 26(2): 93-101, 2014 (PubMed)


109) Kamimura, D., M Yamada, M Harada, L. Sabharwal, J Meng, H Bando, H Ogura, T Atsumi, Y Arima, M Murakami. The gateway theory: bridging neural and immune interactions in the CNS. Front. Neurosci. doi: 10.3389/fnins.2013.00204 (PubMed) (Review)

108) Singh, R., T Atsumi, H Bando, M Harada, A Nakamura, M Yamada, J-J Jiang, H Suzuki, K Katsunuma, T Nodomi, D Kamimura, H Ogura, M Murakami. Reverse direction method: A possible tool to link animal models with corresponding human diseases and disorders. Int. J. Genomic Med. 1:106. doi: 10.4172/ijgm.1000106, 2013 (Int J Genomic Med) (Review)

107) Kamimura, D., M Yamada, L Sabharwal, H Ogura, Y Okuyama, A Nakamura, T Atsumi, Y Arima, M Murakami. The Gate Theory Explains Regional Neural Regulation of Activated T cells Entering the Central Nervous System. Journal of Clinical & Cellular Immunology 4:156 doi: 10.4172/2155-9899.1000156. (J Clin Cell Immunol) (Review)

106) Murakami M*#, M Harada*, D Kamimura*, H Ogura, Y Okuyama, N Kumai, A Okuyama, R Singh, J Jiang, T Atsumi, S Shiraya, Y Nakatsuji, M Kinoshita, H Kohsaka, M Nishida, S Sakoda, N Miyasaka, K Yamauchi-Takihara, T Hirano# (*, equal contribution; #, correspondence) Disease-Association Analysis of an Inflammation-Related Feedback Loop. Cell Reports. 3: 946-959, 2013 (PubMed)

105) Sasaki M, A Tojo, Y Okochi, N Miyawaki, D Kamimura, A Yamaguchi, M Murakami, Y Okamura. Autoimmune disorder phenotype in HVCN1 gene deficient mice. Biochem. J. 450: 295-301, 2013 (PubMed)

104) Lee J*, T Nakagiri*, D Kamimura*, M Harada, T Oto, Y Susaki, Y Shintani, M Inoue, S Miyoshi, E Morii, T Hirano, M Murakami#, M Okumura. (*, equal contribution; #, correspondence) IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation. Int Immunol. 25: 319-332, 2013 (PubMed)

103) Kusu T, H Kayama, M Kinoshita, S Gyu-Jeon, Y Ueda, Y Goto, R Okumura, H Saiga, T Kurakawa, K Ikeda, Y Maeda, J Nishimura, Y Arima, K Atarashi, K Honda, M Murakami, J Kunisawa, H Kiyono, M Okumura, M Yamamoto, K Takeda. Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine. J Immunol. 190: 774-783, 2013 (PubMed)

102) Arima Y, D. Kamimura, L. Sabharwal, M. Yamada, H. Bando, H. Ogura, T. Atsumi and M Murakami. Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory. Mediators of Inflammation. vol. 2013, Article ID 898165, 8 pages, 2013. doi:10.1155/2013/898165 (Mediators Inflamm.) (Review)

101) Ogura H, Y. Arima, D. Kamimura, and M Murakami# (#, correspondence) The Gate Theory: How Regional Neural Activation Creates a Gateway for Immune Cells via an Inflammation Amplifier. Biomedical J. 36(6): 269-273, 2013 (PubMed) (Review)



100) Lee J, T Nakagiri, T Oto, M Harada, E Morii, Y Shintani, M Inoue, Y Iwakura, S Miyoshi, M Okumura, T Hirano, M Murakami#. IL-6 Amplifier, NF-κB-Triggered Positive Feedback for IL-6 Signaling, in Grafts Is Involved in Allogeneic Rejection Responses. (#, correspondence) J Immunol. 189: 1928-1936, 2012 (PubMed) (MDLinks)

99) Kayama H, Y Ueda, Y Sawa, SG Jeon, JS Ma, R Okumura, A Kubo, M Ishii, T Okazaki, M Murakami, M Yamamoto, H Yagita, K Takeda. Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis. Proc. Natl. Acad. Sci. USA. 109: 5010-5015, 2012 (PubMed)

98) Arima Y, M Harada, D Kamimura, J Park, F Kawano, FE Yull, T Kawamoto, Y Iwakura, UAK Betz, G Márquez, T S Blackwell, Y Ohira, T Hirano, M Murakami#. Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier. (#, correspondence) Cell. 148: 447-457, 2012 (PubMed) (Cell Previews) (Research Highlight in Nature Reviews of Neuroscience) (Pain Research Forum) (Global Medical Discovery)

97) Murakami M#, T Hirano. (#, correspondence) The Molecular Mechanisms of Chronic Inflammation Development Front. Immunol. 07 October 2012 | doi: 10.3389/fimmu.2012.00323 (Front. Immunol.) (Review)

96) Murakami M#, T Hirano. The pathological and physiological roles of IL-6 amplifier activation. (#, correspondence) Int. J. Biol. Sci. 8: 1267-1280. 2012 (PubMed) (Review)


95) Verjan Garcia N, E Umemoto, Y Saito , M Yamasaki, E Hata, T Matozaki, M Murakami, YJ Jung, SY Woo, JY Seoh, MH Jang, K Aozasa, M Miyasaka. SIRPalpha/CD172a Regulates Eosinophil Homeostasis. J. Immunol. 187: 2268-2277, 2011 (PubMed) 

94) Murakami M*, Y Okuyama*, H Ogura*, S Asano, Y Arima, M Tsuruoka, M Harada, M Kanamoto, Y Sawa, Y Iwakura, K Takatsu, D Kamimura, T Hirano. (*equal contribution) Local microbleeding facilitates IL-6– and IL-17–dependent arthritis in the absence of tissue antigen recognition by activated T cells. J. Exp. Med. 208: 103-114, 2011 (PubMed) (Research Highlight in Nature Review Immunology)

93) Nishida K., T Fukada, S Yamasaki, M Murakami, T Hirano. Zinc in Allergy, Autoimmune, and Hard and Connective Tissue Diseases. in Zinc in Human Health edited by L. Rink., IOS Press, 268-282, 2011. (Review)

92) Fukada, T, K Nishida, S Yamazaki, M Murakami, T Hirano. Zinc homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem.16:1123-1134, 2011 (PubMed) (Review)

91) Murakami M, T Hirano. A four step model for the IL-6 amplifier, a regulator of chromic inflammations in tissue specific MHC class II-associated autoimmune diseases. Front. Immun. 2:22. doi: 10.3389/fimmu.2011.00022 (Front. Immun,) (Review)


90) Kitabayashi C, T. Fukada M Kanamoto, W Ohashi, S Hojyo, T Atsumi, N Ueda, I Azuma, H Hirota, M Murakami, T Hirano. Zinc suppresses Th17 development via inhibition of STAT3 activation. Int. Immunol. 22: 375-386, 2010 (PubMed) (Editor's choice: featured articles)

89) Nakagawa T*, M Tsuruoka*, H Ogura, Y Okuyama, Y Arima, T Hirano, M Murakami#. (*equal contribution; #, correspondence) IL-6 positively regulates Foxp3+CD8+ T cells in vivo. Int. Immunol. 22(2):129-139, 2010 (PubMed) (Editor's choice: featured articles)


88) Sawa Y, Y Arima, H Ogura, C Kitabayashi, J Jiang, T Fukushima, D Kamimura, T Hirano, M Murakami#. (#, correspondence) Hepatic Interleukin-7 Expression Regulates T Cell Responses. Immunity 30: 447-457, 2009 (PubMed) (Immunity Preview) (Comment in Science-Buisiness eXchange)

87) Atsumi T*, M Sato*, D Kamimura, A Moroi, Y Iwakura, UAK Betz, A Yoshimura, M Nishihara, T Hirano, M Murakami#. (*equal contribution; #, correspondence) IFN-γ expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death. Int. Immunol. 21: 73-80, 2009 (PubMed)


86) Ogura H*, M Murakami*, Y Okuyama, M Tsuruoka, C Kitabayashi, M Kanamoto, M Nishihara, Y Iwakura T Hirano. (*equal contribution) Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction. Immunity, 29: 628-636, 2008. (PubMed)

85) Jin G, T Hirano, M Murakami#. Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation. (#, correspondence) Int. Immunol. 20: 783-789, 2008. (PubMed)

84) Tanaka Y, N Tanaka, Y Saeki, K Tanaka, M Murakami, T Hirano, N Ishii, K Sugamura. c-Cbl-dependent Monoubiquitination and Lysosomal Degradation of gp130. Mol. Cell. Biol.  28: 4805-4818, 2008.(PubMed)

83) Murakami M, Hirano T. Intracellular Zinc homeostasis and Zinc signaling. Cancer Science 99: 1515-22, 2008.(PubMed) (Review)

82) Hirano T, M Murakami, T Fukada, K Nishida, S Yamasaki, T Suzuki. Roles of Zinc and Zinc signaling in immunity: Zinc is an intracellular signaling molecule. Advances in Immunology. 97: 149-176, 2008. (PubMed)(Review)


81) *Nishihara M, *H Ogura, N Ueda, M Tsuruoka, C Kitabayashi, F Tuji, H Aono, K Ishihara, E Huseby, UAK Betz, M Murakami, T Hirano. (*equal contribution) IL-6-gp130-STAT3 in T cells directs the development of IL-17+T helper cells with a minimum effect on that of Treg in the steady state. Int. Immunol. 19: 695-702,2007. (PubMed)

80)*Khiong K, *M Murakami#, C Kitabayashi, N Ueda, S Sawa, A Sakamoto, BL Kotzin, SJ. Rozzo, K Ishihara, M Verella-Garcia, J Kappler, P Marrack, T Hirano. (*equal contribution; #, correspondence). Homeostatic proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J. Clin. Invest. 117: 1270-1281, 2007(PubMed) (Full text of JCI) (Commentary in JCI) (Research Highlights in Nature Immunology) (Research Highlight in Nature Reviews Immunology)


79) Kamon H, T Kawabe, H Kitamura, D Kamimura, G Jin, T Kaisyo, S Akira, A Iwamatsu, H Koga, K Ishihara, M Murakami, T Hirano. TRIF-GEFH1-RhoB cascade regulates surface expression of MHC class II in dendritic cells that is critical for CD4+ T cell activation. EMBO J. 25: 4108-4119, 2006. Epub 2006 Aug 17 (PubMed)

78) Ueda N, H Kuki, D Kamimura, S Sawa, K Seino, M Taniguchi, T Hirano, M Murakami#.  (#, correspondence) CD1d-restricted natural killer T cell activation enhanced homeostatic proliferation of CD8+T cells in a manner dependent on IL-4. Int. Immunol.18: 1397-1404, 2006. Epub 2006 Aug 16 (PubMed)

77) Kitamura H, H Morikawa, H Kamon, M Iguchi, S Hojyo, T Fukada, S Yamashita, T Kaisho, S Akira, M Murakami T Hirano. Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nat. Immunol.7: 971-977, 2006 (PubMed) (Research Highlights in Nature) (RIKEN RESEARCH) (Spotlight of ACS Chemical Biology)

76) Kamimura D, Y Sawa, M Sato, E Agung, T Hirano, M Murakami#.  (#, correspondence) IL-2 in vivo activities and anti-tumor efficacy enhanced by an anti-IL-2 mAb. J. Immunol. 177: 306-314, 2006 (PubMed)

75) Sawa S, D Kamimura, G Jin, H Morikawa, H Kamon, M Nishihara, K Ishihara, M Murakami, T Hirano. Autoimmune arthritis associated with mutated IL-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J. Exp. Med. 203: 1459-1470, 2006. published on line 22 May 2006, 10.1084/jem.20052187.(PubMed) (J Exp Med) (In This Issue of JEM) (Research Highlights in Nature Reviews Immunology )

74) Hirano T, M. Murakami. Grasp a pTyr-peptide by its SOCS. Dev. Cell 10: 542-544, 2006 (PubMed) (Review)


73) Kitamura, H., H. Kamon, S. Sawa, S-J. Park, N. Katsunuma, K. Ishihara, M. Murakami and T. Hirano. IL-6-STAT3 controls intracellular MHC classII ab-dimer level through Cathepsin S activity in dendritic cells. Immunity, 23: 491-502, 2005. (PubMed). (Immunity) (Science's STKE) (Research Highlights in Nature Immunology)


72) Kamimura D, Ueda N, Hachida S, Atsumi T, Nakagawa T, Sawa S, Suzuki H, Ishihara K, Murakami M, Hirano T. Evidence of a novel IL-2/15Rbeta-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells. J. Immunol. 173: 6041-6049, 2004. (PubMed).

71) Park S, Nakagawa T, Kitamura H, Atsumi T, Kamon H, Sawa S, Kamimura D, Ueda N, Iwakura Y, Ishihara K, Murakami M, Hirano T. IL-6 Regulates in vivo Dendritic Cell Differentiation through STAT3 Activation. J. Immunol. 173:3844-3854, 2004. (PubMed)

70) Ishihara K, Sawa S, Ikushima H, Hirota S, Astumi T, Kamimura D, Park S, Murakami M, Kitamura Y, Iwakura Y, Hirano T. The point mutation of Y759 of the IL-6 family receptor gp130 synergizes with HTLV-1 pX in promoting RA-like arthritis. Int. Immunol. 16: 455-465, 2004. (PubMed) (Int. Immunol)

69) Murakami M, Kamimura D, Hirano T. New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27. Growth Facotrs 22: 75-77, 2004. (Review)


68)Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, Yoshimura A. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nature Immunology, 4: 551-556, 2003. (PubMed).

Before 2003

67. Yamashita K, Masunaga T, Yanagida N, Takehara M, Hashimoto T, Kobayashi T, Echizenya H, Hua N, Fujita M, Murakami M, Furukawa H, Uede T, Todo S. Long-term acceptance of rat cardiac allografts on the basis of adenovirus mediated CD40Ig plus CTLA4Ig gene therapies. Transplantation 15;76:1089-96. 2003.

66. Tosa N, Murakami M, Jia WY, Yokoyama M, Masunaga T, Iwabuchi C, Inobe M, Iwabuchi K, Miyazaki T, Onoe K, Iwata M, Uede T. Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis. Int Immunol. 15, 741-749, 2003.

65. Kanaya K, Tsuchida Y, Inobe M, Murakami M, Hirose T, Kon S, Kawaguchi S, Wada T, Yamashita T, Ishii S, Uede T. Combined gene therapy with adenovirus vectors containing CTLA4Ig and CD40Ig prolongs survival of composite tissue allografts in rat model. Transplantation 75, 275-81, 2003.

64. Nagamori M, Kawaguchi S, Murakami M, Wada T, Nagoya S, Yamashita T, Inobe M, Uede T. Intrinsic and extrinsic manipulation of B7/CTLA-4 interaction for induction of anti-tumor immunity against osteosarcoma cells. Anticancer Res. 22, 3223-3227, 2002.

63. Nagamori M, Kawaguchi S, Murakami M, Wada T, Inobe M, Ishii S, Uede T. In vivo immunogenicity of osteosarcoma cells that express B7-1a, an alternatively spliced form of B7-1. Anticancer Res. 22, 2009-13, 2002.

62. Swanson BJ, Murakami M, Mitchell1 TC, Kappler J, Marrack P. RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR dependent process. Immunity 17, 5, 605-615. 2002.

61. Murakmi M, Sakamoto A, Bender J, Kappler J, Marrack P. CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc. Natl. Acad. Sci. U.S.A. 99, 8832-8837, 2002.

60. Nomura M, Yamashita K, Murakami M, Takehara M, Echizenya H, Sunahara M, Kitagawa N, Fujita M, Furukawa H, Uede T, Todo S. Induction of donor-specific tolerance by adenovirus mediated CD40Ig gene therapy in rat liver transplantation. Transplantation 74, 1403-1410, 2002.

59. Konishi K, Inobe M, Yamada A, Murakami M, Todo S, Uede T. Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative desease in a murine airway model. J Heart Lung Transplant. 21, 692-700, 2002.

58. Iwasaki N, Gohda T, Yoshioka C, Murakami M, Inobe M, Minami A, Uede T. Feasibility of immunosuppression in composite tissue allografts. Transplantation 73, 334-40, 2002.

57. Chiba S, Okamoto H, Kon S, Kimura C, Murakami M, Inobe M, Matsui Y, Sugawara T, Shimizu T, Uede T, Kitabatake A. Development of atherosclerosis in osteopontin transgenic mice. Heart and vesseles. 16,111-117, 2002.

56. Ijima K, Murakami M, Okamoto H, Inobe M, Chikuma S, Saito I, Kanegae Y, Kawaguchi Y, Kitabatake A, Uede T. Successful gene therapy via intraarticular injection of adenovirus vector containing CTLA4IgG in a murine model of type II collagen-induced arthritis. Human Gene Therapy 12, 1063-77, 2001.

55. Ueno H, Murakami M, Okumura M, Kadosawa T, Uede T, and Fujinaga T. Chitosan accelerates the production of osteopontin from polymorphonuclear leukocytes. Biomaterials 22, 1667-73, 2001.

54. Takehara M, Murakami M, Nakagawa I, Saito I, Kanegae Y, Nomura M, Ohmura T, Todo S, Uede T. Long-term acceptance of allografts by in vivo gene transfer of regulatable adenovirus vector containing CTLA4Ig. Human Gene Therapy 12, 415-426, 2001.

53. Nomura M, Yamashita K, Murakami M, Takehara M, Konishi M, Echizenya H, Yanagida N, Sunahara M, Kitagawa N, Furukawa H, Uede T, Todo S. Novel CD40-IgG adenovirus-mediated gene therapy as a potent immunosuppressive treatment for liver transplantation in rats. Transplant. Proc. 33, 189, 2001.

52. Yanagida N, Nomura M, Yamashita K, Takehara M, Murakami M, Echizenya H, Konishi K, Kitagawa N, Furukawa H, Uede T, Todo S. Tolerance induction by a single donor pretreatment with the adenovirus vector encoding CTLA4Ig gene in rat orthotopic liver transplantation. Transplant. Proc. 33, 573-574, 2001.

51. *Ku CC, *Murakami M, Sakamoto A, Kappler J, Marrack P. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 288, 675-678, 2000. (*equal contribution)

50. Marrack P, Bender J, Hildeman D, Jordan M, Mitchell T, Murakami M, Sakamoto A, Schaefer BC, Swanson B, Kappler J. Homeostasis of alpha and beta TCR+ T cells. Nature Immunol. 2, 107-111, 2000. (Review)

49. Chikuma S, Murakami M, Tanaka K, Uede T. Janus Kinase 2 is associated with box 1-like motif and phosphrylates a critical tyrosine residue in the cytoplasmic region of CTLA-4. J. Cell. Biochem. 78, 241-250, 2000.

48. Chiba S, Rashid MM, Okamoto H, Shiraiwa H, Kon S, Maeda M, Murakami M, Inobe M, Kitabatake A, Chambers AF, Uede T. The role of osteopontin in the development of granulomatous lesions in lung. Microbiol. Immunol. 44, 319-332, 2000.

47. Takiguchi M, Murakami M, Nakagawa I, Rashid MM, Tosa N, Chikuma S, Hashimoto A, Uede T. Involvement CD28/CTLA4-B7 costimulatory pathway in the development of lymphadenopathy and splenomegary in MRL/lpr mice. J. Vet. Med. Sci. 62, 29-36, 2000.

46. Yamada A, Konishi K, Crus GL, Takehara M, Morikawa M, Nakagawa I, Murakami M, Abe T, Todo S, Uede T. Blocking the CD28-B7 T-cell costimulatory pathway abrogates the development of obliterative bronchiolitis in a murine heterotopic airway model. Transplantation 69, 743-749, 2000.

45. Harada H, Ishikura H, Nakagawa I, Shindou J, Murakami M, Uede T, Koyanagi I, Yoshiki T. Donor-specific prolongation of survival of rat renal allografts by preoperative inoculation of CTLA4Ig plus allogeneic dendritic cells. Urol. Res. 28, 69-74, 2000.

44. Yamashita K, Nomura M, Omura T, Takehara M, Suzuki T, Shimamura T, Kishida A, Furukawa H, Murakami M, Uede T, Todo S. Effect of a novel immunosuppressant, FTY720, on heart and liver transplantations in rats. Transplant. Proc. 31, 1178-1179, 1999.

43. Takiguchi M, Murakami M, Nakagawa I, Yamada A, Chikuma S, Kawaguchi Y, Hashimoto A, Uede T. Blockade of CD28/CTLA4-B7 costimulatory pathway prevented autoantibody-related diseases but not lung diseases in MRL/lpr mice. Life Science 79, 317-326, 1999.

42. Sato J, Asakura K, Murakami M, Uede T, Kataura A. Topical CTLA4Ig suppresses ongoing mucosal immune response in presensitized murine model of allergic rhinitis. Int. Aarch. Allergy Immunol. 119, 197-200, 1999.

41. Takiguchi M, Murakami M, Nakagawa I, Yamada A, Chikuma S, Hashimoto A, Uede T. Blockade of CD28/CTLA4-B7 pathway prevented lymphadenopacy in MRL/lpr mice. Laboratory Investigation 79, 317-326, 1999.

40. Tarumi K, Murakami M, Yagihashi A, Nakagawa I, Hirata K, Uede T. CTLA4IgG treatment induces long-term acceptance of rat small bowel allografts. Transplantation 67, 520-525, 1999.

39. Katagiri Y, Sleeman, T, Fujii H, Herlich P, Hotta H, Tanaka K, Chikuma S, Yagita H, Okumura K, Murakami M, Saiki I, Chambers A, Uede T. CD44 variants but not CD44s cooperate with b1-containing integrins to permit cells to bind to osteopontin independently of RGD, there by stimulating cell motility and chemotaxis. Cancer Res. 59, 219-226, 1999.

38. Aoki N, Inobe M, Murakami M, Abe R, Iizuka H. The functional role of B7 molecules on the induction of thymocyte activation and apoptosis. Microbiol. Immunol. 42, 5555-5565, 1998.

37. Isashi Y, Yamashita T, Nagasawa S, Tanaka K, Murakami M, Uede T. The mechanism by which proteolysis enhances the ligand-binding activity of guinea pig type II Fc receptor for IgG (FcgRII). J. Biochem. 123, 959-967, 1998.

36. Fujii H, Inobe M, Hayakawa Y, Kimura F, Murakami M, Ohnishi Y, Azuma I, Uede T, Saiki I. Vaccination with B7-1+ tumor and antiadhesion therapy with RGD pseudo-peptide (FC-336) efficiently induce anti-metastatic effect. Clin. Exp. Metastasis 16, 141-148, 1998.

35. Tarumi K, Yagihashi A, Murakami M, Uede T. Hirata K. Prolongation of rat small bowel allograft survival by CTLA4Ig. Transplant. Proc. 30, 2596-2599, 1998.

34. Iizuka J, Katagiri Y, Tada N, Murakami M, Ikeda T, Sato M, Hirokawa K, Okada S, Hatano M, Tokuhisa T, Uede T. Introduction of an osteopontin gene confers the increase in B1 cell population and the production of anti-DNA autoantibodies. Laboratory Investigation 78, 1523-1533.

33. Nakagawa I, Murakami M, Ijima K, Chikuma S, Saito I, Kanegae Y, Ishikura H Yoshiki T, Okamoto H, Kitabatake A, Uede T. Persistent and secondary adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4IgG. Human Gene Therapy 9, 1739-1745, 1998.

32. Hakamida-Taguchi R, Kato T, Ushijima H, Murakami M, Uede T, Nariuchi H. Expression and co-stimulatory function of B7-2 on murine CD4+ T cells. Eur. J. Immunol. 28, 865-873, 1998.

31. Fukumoto T, Torigoe N, Kawabata S, Murakami M, Uede T, Nishi T, Ito Y, Sugimura K. Peptide mimics of the CTLA4-binding domain stimulate T-cell proliferation. Nature Biothechnology 16, 267-270, 1998.

30. Kaneda R, Iwabuchi K, Kasai M, Murakami, M, Uede T, Onoe K. Selective antigen presenting activity of cortical thymic epithelial cells against CD4+ T cells associated with both lack of costimulatory molceules and in efficient presentation of MHC-peptide ligands. Cell.Immunol. 181, 163-171, 1997.

29. Uede T, Katagiri Y, Iizuka J, Murakami M. Osteopontin, a cordinator of host defense system: a cytokine or an extracellular adhesive protein? Microbiol. Immunol. 41, 641-648, 1997. (Review)

28. Tsuchida T, Usui M, Murakami M, Uede T. Vascularized bone marrow allotransplantation in rats prolong the survival of simultaneously grafted alloskin, Transplantation Proc. 29, 1732-1733, 1997.

27. Tsuchida T, Naitoh T, Takahashi T, Usui M, Murakami M, Uede T. Limb allografts in rats treated with anti-ICAM1 and anti-LFA1 monoclonal antibodies. J. Recconst. Microsurg. 13, 107-110, 1997.

26. Hara T, Murakami M, Maeda H, Hibi M, Uede T. Involvement of common 10 amino acid segment in the cytoplasmic region of CD40 but different MAP kinases in different CD40-mediated responses. Biochem. Biophys. Res. Commun. 233, 187-192, 1997.

25. Hayakawa M, Kwaguchi S, Ishii S, Murakami M, Uede T. B7-1-transfected tumor vaccine counteracts chemoterapy-induced immunosuppression and prolongs the survival of rats bearing highly metastatic osteosarcoma cells. Int. J. Cancer 72, 1-12, 1997.

24. Murakami M, Takahashi Y, Isashi Y, Kon S, Inobe M, Abe R. Uede T. Identification and characterization of an alternative CTLA4 binding molecule on B cells. Proc. Natl. Acad. Sci., U.S.A. 93, 7838-7842, 1996.

23. Yamada A, Murakami M, Ijima K, Yagita H, Okumura K, Komatsu S, Uede T. Long-term acceptance of major histocompatibility complex-mismached cardiac allograft induced by a low dose of CTLA4IgM plus FK506. Microbiol. Immunol. 40, 513-518, 1996.

22. Isashi Y, Yamashita T, Nagasawa S, Murakami M, Uede T. Molecular cloning and characterization of gunia-pig FcgRIII: expression but not function is independent of the g chain of FceRI. Int. Immunol. 8, 1335-1346, 1996.

21. Katagiri Y, Murakami M, Mori K, Iizuka J, Hara T, Tanaka K, Jia WY, Chambers AF, Uede T. Non-RGD domains of osteopontin promote cell adhesion without involving aV integrins. J. Cell Biochem. 62, 123-131, 1996.

20. Inobe M, Aoki N, Linsley PS, Ledbetter JA, Murakami M, Uede, T. The role of B7-1a molecule, an alternatively spliced form of murine B7-1, on T cell activation. J. Immunol. 157, 582-588, 1996.

19. Fujii H, Inobe M, Kimura F, Murata J, Murakami M, Onishi Y, Azuma I, Uede T, Saiki I. Vaccination of tumor cells transfected with B7-1 (CD80) gene induces the anti-metastatic effect and tumor immunity in mice. Int. J. Cancer 66, 219-224, 1996.

18. Toyooka K, Maruo S, Iwahori T, Yamamoto N, Tai XG, Abe R, Takahama Y, Murakami M, Uede T, Hamaoka T Fujiwara H. CD28 costimulatory signals induce IL-2 receptor expression on antigen stimulated virgin T cells by an IL-2-independent mechanisms. Int. Immunol. 8, 159-169, 1995.

17. Isashi Y, Tamakoshi M, Nagai Y, Sudo T, Murakami M, Uede T. The rat neutrophil low affinity Fc receptor for IgG: Moleculare cloning and functional characterization. Immunology letters 46, 157-163, 1995.

16. Yoneya K, Okamoto H, Machida M, Onozuka H, Noguchi M, Mikami T, Kawaguchi H, Murakami M, Uede T, Kitabatake A. Angiotensin-converting enzyme gene polymorphism in japanese patients with hypertrophic cardiomypathy. American Heart J. 130, 1089-1093, 1995.

15. Kamikubo Y, Murakami M, Imamura M, Murashita T, Yasuda K, Uede T. Neutrophil-independent myocardial dysfunction during an early stage of global ischemia and repurfusion of isolated hearts. Immunopharmacology 29, 261-271, 1995.

14. Katagiri Y, Mori K, Hara T, Tanaka K, Murakami M, Uede T. Functional analysis of osteopontin molecule. Ann. N. Y. Acad. Sci. 760, 371-374, 1995.

13. Murakami M, Hibi M, Nakagawa T, Yasukawa K, Yamanishi K, Taga T, Kishimoto T. IL-6 induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 160, 1808-1810, 1993.

12. Yawata H, Yasukawa K, Nastuka S, Murakami M, Yamasaki H, Hibi M, Taga T Kishimoto T. Structure-function analysis of human IL-6 receptor: disscciation of amino acid residues required for IL-6 binding and for IL-6 siganl transduction through gp130. EMBO J. 12, 1705-1712, 1993.

11. Kishimoto T, Hibi M, Murakami M, Narazaki M, Saito M Taga T. The molecular bioloby of interleukin 6 and its receptor. In Polyfunctional cytokines: IL-6 an LIF, edt. by Gregory R. Bock, Joan Marsh (Organizers) and Kate Widdows, John Wiley & Sons, Chichester. p.5-23, 1992. (Review)

10. Falus A, Hibi M, Murakami M, Taga T Kishimoto T. Regulation of IL-6 receptor and gp130 expression on human cell lines of lymphoid myeloid origin. Cytokine 4, 495-499, 1992.

9. Taga T, Hibi M, Murakami M, Saito M, Yawata H, Narazaki M, Hirata Y, Sugita T, Yasukawa K, Hirano T, Kishimoto T. Interleukin 6 receptor and signals. Chem. Immunol. 51:181-204, 1992. (Review)

8. Liu J, Modrell B, Aruffo A, Marken JS, Taga T, Yasukawa K, Murakami M, Kishimoto T. Shoyab M. Interleukin-6 signal transducer gp130 mediates Oncostatin M signaling. J. Biol. Chem. 267, 16763-16766, 1992.

7. Kishimoto T, Hibi M, Murakami M, Narazaki M, Saito M, Taga T. The molecular biology of interleukin 6 and its receptor. Chiba-Found-Symp. 167, 5-23, 1992. (Review)

6. Taga T, Hibi M, Murakami M, Saito M, Yawata H, Narazaki M, Hirata Y, Sugita T, Yasukawa K, Hirano T, Kishimoto T. IL-6 receptor and signals. In Chemical Immunology: Interleukins: MolecularBiology and Immunology, ed. by Kishimoto, T., and S. Karger AG, Basel Switzerland. vol. 51, p181-204, 1992. (Review)

5. Murakami M, Narazaki M, Hibi M, Yawata H, Yasukawa K, Hamaguchi M, Taga T. Kishimoto T. Critical cytoplasmic region of the IL-6 signal transducer, gp130, is conserved in the cytokine receptor family. Proc. Natl. Acad. Sci. U.S.A. 88, 11349-11353, 1991

4. Taga T, Hibi M, Murakami M, Saito M, Hirano T Kishimoto, T. A new cytokine receptor family ans a novel signaling mechanism by receptor-associate IL-6 signal transducer, gp130. In Origins Human Cancer: A comprehensive Review. Cold Spring Harver Lab. Press, NY, USA. 277-284, 1991. (Review)

3. Hibi M, Murakami M, Saito M, Hirano T, Taga T Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63, 1149-1157, 1990.

2. Hirano T, Taga T, Matsuda T, Hibi M, Suematsu S, Tang B, Murakami M, Kishimoto T. Interleukin 6 and its receptor in the immune response and hematopoiesis. Int. J. Cell Cloning 8:155-167, 1990. (Review)

1. Suematsu S, Hibi M, Sugita T, Saito M, Murakami M, Matsusaka T, Matsuda T, Hirano T, Taga T, Kishimoto T. Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma. In Current topics in microbiology and immunology Vol. 166, edt. by M. Potter and F. Melchers, Springer-Verlag Berlin Heidelberg. p.13-22, 1990. (Review)



RIKEN Research Center for Allergy and Immunology Graduate School of Medicine Graduate School of Frontier Biosciences Osaka University