村上正晃

平成元年３月 　北海道大学獣医学部卒業

平成５年３月 　大阪大学大学院医学研究科博士課程修了

平成５年４月〜平成１１年３月　北海道大学免疫科学研究所助手（平成１１年４月〜休職）

平成１１年４月〜平成１３年３月　日本学術振興会海外特別研究員（Howard Hughes Medical Institute, National Jewish Medical and Research Center）

平成１３年４月　 客員准教授（Integrated Department of Immunology, National Jewish Medical and Research Center and Colorado University Health Science Center）

平成１３年１１月１６日　大阪大学大学院医学系研究科助手

平成１４年８月１６日　大阪大学大学院医学系研究科助教授

平成１９年４月１日　大阪大学大学院生命機能研究科准教授

Publication List:

94.Arima Y., M. Harada, D. Kamimura, J-H. Park, F. Kawano, F. E. Yull, T. Kawamoto, Y. Iwakura, U.A.K. Betz, G. Ma´rquez, T. S. Blackwell, Y. Ohira, T. Hirano, and M. Murakami. Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier. Cell. 148: 447-457, 2012

93.Verjan Garcia, N., E. Umemoto, Y. Saito , M. Yamasaki, E. Hata, T. Matozaki, M. Murakami, YJ. Jung, SY. Woo, JY. Seoh , MH. Jang, K. Aozasa, M. Miyasaka. SIRPalpha/CD172a Regulates Eosinophil Homeostasis. J. Immunol. 187(5): 2268-2277, 2011

92.Murakami, M. and T. Hirano. A four step model for the IL-6 amplifier, a regulator of chromic inflammations in tissue specific MHC class II-associated autoimmune diseases. Front. Immun. 2:22. doi: 10.3389/fimmu.2011

91.Murakami, M.*, Y. Okuyama*, H. Ogura*, S. Asano, Y. Arima, M. Tsuruoka, M. Harada, M. Kanamoto, Y. Sawa, Y. Iwakura, K. Takatsu, D. Kamimura, T. Hirano. (*equal contribution) Local microbleeding facilitates IL-6− and IL-17−dependent arthritis in the absence of tissue antigen recognition by activated T cells. J. Exp. Med. 208: 103-114, 2011

90.Kitabayashi C., T. Fukada, M. Kanamoto1, W. Ohashi, S. Hojyo, T. Atsumi, N. Ueda, I. Azuma, H. Hirota, M. Murakami, and T. Hirano. Zinc suppresses Th17 development via inhibition of STAT3 activation. Int. Immunol. 22(5): 375-386, 2010

89.Nakagawa T.*, M. Tsuruoka*, H. Ogura, Y. Okuyama, Y. Arima, T. Hirano, and M. Murakami. (*equal contribution) IL-6 positively regulates Foxp3+CD8+ T cells in vivo. Int. Immunol. 22(2):129-139, 2010

88.Sawa Y., Y. Arima, H. Ogura, C. Kitabayashi, J-J Jiang, T. Fukushima, D. Kamimura, T. Hirano, and M. Murakami. Hepatic Interleukin-7 Expression Regulates T Cell Responses. Immunity 30: 447-457, 2009

87.Atsumi, T.*, M. Sato*, D. Kamimura, A. Moroi, Y. Iwakura, U. A. K. Betz, A. Yoshimura, M. Nishihara, T. Hirano, and M. Murakami. (*equal contribution) IFN-γ expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death. Int. Immunol. 21(1):73-80, 2009

86.Ogura, H, M. Murakami1, Y. Okuyama, M. Tsuruoka1, C. Kitabayashi, M. Kanamoto, M. Nishihara, Y. Iwakura and T. Hirano. Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction. Immunity , 29, 628-636, 2008.

85.Jin, G., T. Hirano, and M. Murakami. Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation. Int. Immunol. 20: 783-789, 2008.

84.Tanaka, Y., N. Tanaka, Y. Saeki, K. Tanaka, M. Murakami, T. Hirano, N. Ishii, and K. Sugamura. c-Cbl-dependent Monoubiquitination and Lysosomal Degradation of gp130. Mol. Cell. Biol.  28: 4805-4818, 2008.

83.Masaaki Murakami and Toshio Hirano. Intracellular Zinc homeostasis and Zinc signaling. Cancer Science 99:1515-22, 2008.

81.*Nishihara, M., *H. Ogura, N. Ueda, M. Tsuruoka, C. Kitabayashi, F. Tuji, H. Aono, K. Ishihara, E. Huseby, U. A.K.Betz, M. Murakami and T. Hirano. (*equal contribution) IL-6-gp130-STAT3 in T cells directs the development of IL-17+T helper cells with a minimum effect on that of Treg in the steady state. Int. Immunol. 19: 695-702, 2007.

80.*Khiong, K., *M. Murakami, C. Kitabayashi, N. Ueda, S. Sawa, A. Sakamoto, B. L. Kotzin, S. J. Rozzo, K. Ishihara, M. Verella-Garcia, J. Kappler, P. Marrack, and T. Hirano. (*equal contribution). Homeostatic proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J. Clin. Invest. 117: 1270-1281, 2007

79.Kamon, H., T. Kawabe, H. Kitamura, D. Kamimura, G.-H. Jin, T. Kaisyo, S. Akira, A. Iwamatsu, H. Koga, K. Ishihara, M. Murakami and T. Hirano. TRIF-GEFH1-RhoB cascade regulates surface expression of MHC class II in dendritic cells that is critical for CD4+ T cell activation. EMBO J. 25:4108-4119, 2006. Epub 2006 Aug 17

78.Ueda, N., H. Kuki, D. Kamimura, S. Sawa, K. Seino, M. Taniguchi, T. Hirano and M. Murakami. CD1d-restricted natural killer T cell activation enhanced homeostatic proliferation of CD8+T cells in a manner dependent on IL-4. Int. Immunol.18:1397-1404, 2006. Epub 2006 Aug 16

77.Kitamura, H., H. Morikawa, H. Kamon, M. Iguchi, S. Hojyo, T. Fukada, S. Yamashita, T. Kaisho, S. Akira, M. Murakami and T. Hirano. Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nature Immunol.7:971-977, 2006

76.Kamimura, D., Y. Sawa, M. Sato, E. Agung, T. Hirano, and M. Murakami. IL-2 in vivo activities and anti-tumor efficacy enhanced by an anti-IL-2 mAb. J. Immunol. 177:306-314, 2006

75.Sawa, S., D. Kamimura, G.-H. Jin, H. Morikawa, H. Kamon, M. Nishihara, K. Ishihara, M. Murakami, and T. Hirano. Autoimmune arthritis associated with mutated IL-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T. J. Exp. Med. 203:1459-1470, 2006. published on line 22 May 2006,

74.Hirano, T. and M. Murakami. Grasp a pTyr-peptide by its SOCS. Dev. Cell 10:542-544, 2006

73.Kitamura, H., H. Kamon, S. Sawa, S-J. Park, N. Katsunuma, K. Ishihara, M. Murakami and T. Hirano. IL-6-STAT3 controls intracellular MHC classII ab-dimer level through Cathepsin S activity in dendritic cells. Immunity, 23: 491-502, 2005.

72.Murakami, M., Kamimura, D., and Hirano, T. New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27. Growth Facotrs 22:75-77, 2004.

71.Kamimura, D., Ueda N, Hachida S, Atsumi T, Nakagawa T, Sawa S, Suzuki H, Ishihara K, Murakami M, Hirano T. Evidence of a novel IL-2/15Rbeta-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells. J. Immunol. 173:6041-6049, 2004.

70.Park, S-J., Nakagawa T, Kitamura H, Atsumi T, Kamon H, Sawa S, Kamimura D, Ueda N, Iwakura Y, Ishihara K, Murakami M, and Hirano T. IL-6 Regulates in vivo Dendritic Cell Differentiation through STAT3 Activation. J. Immunol. 173：3844-3854, 2004.

69.Ishihara, K. , Sawa S, Ikushima H, Hirota S, Astumi T, Kamimura D, Park S-J, Murakami M, Kitamura Y, Iwakura Y, and Hirano T. The point mutation of Y759 of the IL-6 family receptor gp130 synergizes with HTLV-1 pX in promoting RA-like arthritis. Int. Immunol. 16: 455-465, 2004.

68. Yamashita K, Masunaga T, Yanagida N, Takehara M, Hashimoto T, Kobayashi T, Echizenya H, Hua N, Fujita M, Murakami M, Furukawa H, Uede T, Todo S. Long-term acceptance of rat cardiac allografts on the basis of adenovirus mediated CD40Ig plus CTLA4Ig gene therapies. Transplantation. 15;76:1089-96. 2003.

67. Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, Yoshimura A. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol. 4: 551-556, 2003.

66. Tosa N, Murakami M, Jia WY, Yokoyama M, Masunaga T, Iwabuchi C, Inobe M, Iwabuchi K, Miyazaki T, Onoe K, Iwata M, Uede T. Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis. Int Immunol. 15, 741-749, 2003.

65. Kanaya K, Tsuchida Y, Inobe M, Murakami M, Hirose T, Kon S, Kawaguchi S, Wada T, Yamashita T, Ishii S, Uede T. Combined gene therapy with adenovirus vectors containing CTLA4Ig and CD40Ig prolongs survival of composite tissue allografts in rat model. Transplantation. 75, 275-81, 2003.

64. Nagamori M, Kawaguchi S, Murakami M, Wada T, Nagoya S, Yamashita T, Inobe M, Uede T.　Intrinsic and extrinsic manipulation of B7/CTLA-4 interaction for induction of anti-tumor immunity against osteosarcoma cells.　Anticancer Res. 22, 3223-3227, 2002.

63. Nagamori M, Kawaguchi S, Murakami M, Wada T, Inobe M, Ishii S, Uede T. In vivo immunogenicity of osteosarcoma cells that express B7-1a, an alternatively spliced form of B7-1.Anticancer Res. 22, 2009-13, 2002.

62. Bradley J. Swanson, Masaaki Murakami, Thomas C. Mitchell1, John Kappler, and Philippa Marrack RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR dependent process. Immunity 17, 5, 605-615. 2002.

61.Masaaki Murakmi, Akemi Sakamoto, Jeremy Bender, John Kappler, and Phillipa Marrack. CD25+CD4+ T cells contribute to the control of memory CD8+ T cells Proc. Natl. Acad. Sci. U.S.A. 99, 8832-8837, 2002.

60. M. Nomura, K. Yamashita, M. Murakami, M. Takehara, H. Echizenya, M. Sunahara, N. Kitagawa, M. Fujita, H. Furukawa, T. Uede and S. Todo : Induction of donor-specific tolerance by adenovirus mediated CD40Ig gene therapy in rat liver transplantation. Transplantation. I1403-1410, 2002.

59. K. Konishi, M. Inobe, A. Yamada, M. Murakami, S. Todo and T. Uede : Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative desease in a murine airway model. J Heart Lung Transplant.21, 692-700, 2002.

58. N. Iwasaki, T. Gohda, C. Yoshioka, M. Murakami, M. Inobe, A. Minami and T. Uede : Feasibility of immunosuppression in composite tissue allografts. Transplantation.73, 334-40, 2002.

57. S. Chiba, H. Okamoto, S. Kon, C. Kimura, M. Murakami, M. Inobe, Y. Matsui, T. Sugawara, T. Shimizu, T. Uede and A. Kitabatake : Development of atherosclerosis in osteopontin transgenic mice. Heart and vesseles. 16,111-117, 2002.

56. Ijima, K., Murakami, M., Okamoto, H., Inobe, M., Chikuma, S., Saito, I., Kanegae, Y., Kawaguchi, Y., Kitabatake, A., Uede, T. Successful gene therapy via intraarticular injection of adenovirus vector containing CTLA4IgG in a murine model of type II collagen-induced arthritis. Human Gene Therapy 12, 1063-77, 2001.

55. Ueno, H., Murakami, M., Okumura, M., Kadosawa, T., Uede, T., and Fujinaga, T. Chitosan accelerates the production of osteopontin from polymorphonuclear leukocytes. Biomaterials 22, 1667-73, 2001.

54.　Takehara, M., Murakami, M., Nakagawa, I., Saito, I., Kanegae, Y.,　Nomura, M., Ohmura, T., Todo, S., and Uede, T. Long-term acceptance of　allografts by in vivo gene transfer of regulatable adenovirus vector　containing CTLA4Ig. Human Gene Therapy 12, 415-426, 2001.

53.　Nomura, M., Yamashita, K., Murakami, M., Takehara, M., Konishi,　M., Echizenya, H., Yanagida, N., Sunahara, M., Kitagawa, N., Furukawa, H.,　Uede, T., and Todo, S. Novel CD40-IgG adenovirus-mediated gene therapy as a　potent immunosuppressive treatment for liver transplantation in rats.　Transplant. Proc. 33, 189, 2001.

52.　Yanagida, N., Nomura, M., Yamashita, K., Takehara, M., Murakami,　M., Echizenya, H., Konishi, K., Kitagawa, N., Furukawa, H., Uede, T., and　Todo, S.　Tolerance induction by a single donor pretreatment with the　adenovirus vector encoding CTLA4Ig gene in rat orthotopic liver　transplantation. Transplant. Proc. 33, 573-574, 2001.

51. 　Ku, C. C., Murakami, M., Sakamoto, A., Kappler, J., and Marrack,　P. Control of homeostasis of CD8+ memory T cells by opposing cytokines.　Science 288, 675-678, 2000. (First two authors are equally contributed.)

50.　Marrack, P., Bender, J., Hildeman, D., Jordan, M., Mitchell,　T., Murakami, M., Sakamoto, A., Schaefer, B. C., Swanson, B., and Kappler,　J. Homeostasis of alpha and beta TCR+ T cells. Nature Immunol. 2, 107-111,　2000.

49.　Chikuma, S., Murakami, M., Tanaka, K., and Uede, T. Janus Kinase 2　is associated with box 1-like motif and phosphrylates a critical tyrosine　residue in the cytoplasmic region of CTLA-4. J. Cell. Biochem. 78, 241-250,　2000.

48.　Chiba, S., Rashid, M. M., Okamoto, H., Shiraiwa, H., Kon, S., Maeda,　M., Murakami, M., Inobe, M., Kitabatake, A, Chambers, A. F., and Uede, T.　The role of osteopontin in the development of granulomatous lesions in lung.　Microbiol. Immunol. 44, 319-332, 2000.

47.　Takiguchi, M., Murakami, M., Nakagawa, I., Rashid, M. M., Tosa,　N., Chikuma, S., Hashimoto, A., and Uede, T. Involvement CD28/CTLA4-B7　costimulatory pathway in the development of lymphadenopathy and splenomegary　in MRL/lpr mice. J. Vet. Med. Sci. 62, 29-36, 2000.

46.　Yamada, A., Konishi, K., Crus, G. L., Takehara, M., Morikawa, M.,　Nakagawa, I., Murakami, M., Abe, T., Todo, S., and Uede, T.　Blocking the CD28-B7 T-cell costimulatory pathway abrogates the　development of obliterative bronchiolitis in a murine heterotopic　airway model. Transplantation 69, 743-749, 2000.

45.　Harada, H., Ishikura, H., Nakagawa, I., Shindou, J., Murakami, M.,　Uede, T., Koyanagi, I., and Yoshiki, T. Donor-specific prolongation of　survival of rat renal allografts by preoperative inoculation of CTLA4Ig plus　allogeneic dendritic cells. Urol. Res. 28, 69-74, 2000.

44.　Yamashita, K., Nomura, M., Omura, T., Takehara, M., Suzuki,　T., Shimamura, T., Kishida, A., Furukawa, H., Murakami, M., Uede, T., and　Todo, S. Effect of a novel immunosuppressant, FTY720, on heart and liver　transplantations in rats. Transplant. Proc. 31, 1178-1179, 1999.

43.　Takiguchi, M., Murakami, M., Nakagawa, I., Yamada, A., Chikuma,　S., Kawaguchi, Y., Hashimoto, A., and Uede, T.Blockade of CD28/CTLA4-B7　costimulatory pathway prevented autoantibody-related diseases but not lung　diseases in MRL/lpr mice. Life Science 79, 317-326, 1999.

42.　Sato, J., Asakura, K., Murakami, M., Uede, T., and Kataura, A.　Topical CTLA4Ig suppresses ongoing mucosal immune response in presensitized　murine model of allergic rhinitis. Int. Aarch. Allergy Immunol. 119,　197-200, 1999.

41.　Takiguchi, M., Murakami, M., Nakagawa, I., Yamada, A., Chikuma,　S., Hashimoto, A., and Uede, T. Blockade of CD28/CTLA4-B7 pathway prevented　lymphadenopacy in MRL/lpr mice. Laboratory Investigation 79, 317-326, 1999.

40.Tarumi, K., Murakami, M., Yagihashi, A., Nakagawa, I., Hirata, K., and Uede, T. CTLA4IgG treatment induces long-term acceptance of rat small　bowel allografts. Transplantation 67, 520-525, 1999.

39. Katagiri, Y., Sleeman, T., Fujii, H., Herlich, P., Hotta, H., Tanaka, K., Chikuma, S., Yagita, H., Okumura, K., Murakami, M., Saiki, I., Chambers, A., and Uede, T. CD44 variants but not CD44s cooperate with　b1-containing integrins to permit cells to bind to osteopontin independently　of RGD, there by stimulating cell motility and chemotaxis. Cancer Res. 59,　219-226, 1999.

38. Aoki, N., Inobe, M., Murakami, M., Abe, R., and Iizuka, H.　The functional role of B7 molecules on the induction of thymocyte activation　and apoptosis. Microbiol. Immunol. 42, 5555-5565, 1998.

37. Isashi, Y., Yamashita, T., Nagasawa, S., Tanaka, K., Murakami, M., and Uede, T. The mechanism by which proteolysis enhances the ligand-binding　activity of guinea pig type II Fc receptor for IgG (FcgRII). J. Biochem.　123, 959-967, 1998.

36. Fujii, H., Inobe, M., Hayakawa, Y., Kimura, F., Murakami, M., Ohnishi, Y., Azuma, I., Uede, T., and Saiki, I. Vaccination with B7-1+ tumor and antiadhesion therapy with RGD pseudo-peptide (FC-336) efficiently induce　anti-metastatic effect. Clin. Exp. Metastasis 16, 141-148, 1998.

35. Tarumi, K., Yagihashi, A., Murakami, M., Uede, T and Hirata, K.,. Prolongation of rat small bowel allograft survival by CTLA4Ig. Transplant. Proc. 30, 2596-2599, 1998.

34. Iizuka, J., Katagiri, Y., Tada, N., Murakami, M., Ikeda, T., Sato,　M., Hirokawa, K., Okada, S., Hatano, M., Tokuhisa, T., and Uede, T. Introduction of an osteopontin gene confers the increase in B1 cell　population and the production of anti-DNA autoantibodies. Laboratory　Investigation 78, 1523-1533.

33. Nakagawa, I., Murakami, M., Ijima, K., Chikuma, S., Saito, I., Kanegae, Y., Ishikura, H., Yoshiki, T., Okamoto, H., Kitabatake, A., and Uede, T. Persistent and secondary adenovirus-mediated hepatic gene　expression using adenovirus vector containing CTLA4IgG. Human Gene Therapy　9, 1739-1745, 1998.

32. Hakamida-Taguchi, R., Kato, T., Ushijima, H., Murakami, M., Uede, T., and Nariuchi, H. Expression and co-stimulatory function of B7-2 on murine CD4+ T cells. Eur. J. Immunol. 28, 865-873, 1998.

31. Fukumoto, T., Torigoe, N., Kawabata, S., Murakami, M., Uede, T.,　Nishi, T., Ito, Y., and Sugimura, K. Peptide mimics of the CTLA4-binding domain stimulate T-cell proliferation. Nature Biothechnology 16, 267-270,　1998.

30. Kaneda, R., Iwabuchi, K., Kasai, M., Murakami, M., Uede, T., and　Onoe, K. Selective antigen presenting activity of cortical thymic epithelial cells against CD4+ T cells associated with both lack of　costimulatory molceules and in efficient presentation of MHC-peptide　ligands. Cell.Immunol. 181, 163-171, 1997.

29. Uede, T., Katagiri, Y., Iizuka, J., and Murakami, M. Osteopontin,　a cordinator of host defense system: a cytokine or an extracellular adhesive protein? Microbiol. Immunol. 41, 641-648, 1997.

28. Tsuchida, T., Usui, M., Murakami, M., and Uede, T. Vascularized　bone marrow allotransplantation in rats prolong the survival of simultaneously grafted alloskin, Transplantation Proc. 29, 1732-1733, 1997.

27. Tsuchida, T., Naitoh, T., Takahashi, T., Usui, M., Murakami, M., and Uede, T. Limb allografts in rats treated with anti-ICAM1 and anti-LFA1 monoclonal antibodies. J. of Recconst. Microsurg. 13, 107-110, 1997.

26. Hara, T., Murakami, M., Maeda, H., Hibi, M., and Uede, T.　Involvement of common 10 amino acid segment in the cytoplasmic region of CD40 but different MAP kinases in different CD40-mediated respnses.　Biochem. Biophys. Res. Commun. 233, 187-192, 1997.

25. Hayakawa, M., Kwaguchi, S., Ishii, S., Murakami, M., and Uede, T.　B7-1-transfected tumor vaccine counteracts chemoterapy-induced immunosuppression and prolongs the survival of rats bearing highly　metastatic osteosarcoma cells. Int. J. Cancer 72, 1-12, 1997.

24. Murakami, M., Takahashi, Y., Isashi, Y., Kon, S., Inobe, M., Abe,　R. and Uede, T. Identification and characterization of an alternative CTLA4　binding molecule (ACBM) on B cells. Proc. Natl. Acad. Sci., U.S.A. 93,　7838-7842, 1996.

23. Yamada, A., Murakami, M., Ijima, K., Yagita, H., Okumura, K.,　Komatsu, S., and Uede, T. Long-term acceptance of major histocompatibility　complex-mismached cardiac allograft induced by a low dose of CTLA4IgM plus　FK506. Microbiol. Immunol. 40, 513-518, 1996.

22.Isashi, Y., Yamashita, T., Nagasawa, S., Murakami, M., and Uede, T. Molecular cloning and characterization of gunia-pig FcgRIII: expression but not function is independent of the g chain of FceRI. Int. Immunol. 8, 1335-1346, 1996.

21. Katagiri, Y., Murakami, M., Mori, K., Iizuka, J., Hara, T., Tanaka, K., Jia, W.-Y., Chambers, A. F., and Uede, T. Non-RGD domains of osteopontin promote cell adhesion without involving aV integrins. J. Cell Biochem. 62, 123-131, 1996.

20. Inobe, M., Aoki, N., P. S. Linsley, J. A. Ledbetter, Murakami, M., and Uede, T. The role of B7-1a molecule, an alternatively spliced form of murine B7-1, on T cell activation. J. Immunol. 157, 582-588, 1996.

19. Fujii, H., Inobe, M., Kimura, F., Murata, J., Murakami, M., Onishi, Y., Azuma, I., Uede, T. and Saiki, I. Vaccination of tumor cells transfected with B7-1 (CD80) gene induces the anti-metastatic effect and tumor immunity in mice. Int. J. Cancer 66, 219-224, 1996.

18. Toyooka, K., Maruo, S., Iwahori, T., Yamamoto, N., Tai, X. G., Abe, R., Takahama, Y., Murakami, M., Uede, T., Hamaoka, T. and Fujiwara, H. CD28 costimulatory signals induce IL-2 receptor expression on antigen stimulated virgin T cells by an IL-2-independent mechanisms. Int. Immunol. 8, 159-169, 1995.

17. Isashi, Y., Tamakoshi, M., Nagai, Y., Sudo, T., Murakami, M., and Uede, T. The rat neutrophil low affinity Fc receptor for IgG: Moleculare cloning and functional characterization. Immunology letters 46, 157-163, 1995.

16. Yoneya, K., Okamoto, H., Machida, M., Onozuka, H., Noguchi, M., Mikami, T., Kawaguchi, H., Murakami, M., Uede, T., and Kitabatake, A. Angiotensin-converting enzyme gene polymorphism in japanese patients with hypertrophic cardiomypathy. American Heart J. 130, 1089-1093, 1995.

15. Kamikubo, Y., Murakami, M., Imamura, M., Murashita, T., Yasuda, K., and Uede, T. Neutrophil-independent myocardial dysfunction during an early stage of global ischemia and repurfusion of isolated hearts. Immunopharmacology 29, 261-271, 1995.

14. Katagiri, Y., Mori, K., Hara, T., Tanaka, K., Murakami, M., and Uede, T. Functional analysis of osteopontin molecule. Ann. N. Y. Acad. Sci. 760, 371-374, 1995.

13. Murakami, M., Hibi, M., Nakagawa, T., Yasukawa, K., Yamanishi, K., Taga, T. and Kishimoto, T. IL-6 induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 160, 1808-1810, 1993.

12. Yawata, H., Yasukawa, K., Nastuka, S., Murakami, M., Yamasaki, H., Hibi, M., Taga, T. and Kishimoto, T. Structure-function analysis of human IL-6 receptor: disscciation of amino acid residues required for IL-6 binding and for IL-6 siganl transduction through gp130. EMBO J. 12, 1705-1712, 1993.

11. Kishimoto, T., Hibi, M., Murakami, M., Narazaki, M., Saito, M. and Taga, T. The molecular bioloby of interleukin 6 and its receptor. In Polyfunctional cytokines: IL-6 an LIF, edt. by Gregory R. Bock, Joan Marsh (Organizers) and Kate Widdows, John Wiley & Sons, Chichester. p.5-23, 1992.

10. Falus, A., Hibi, M., Murakami, M., Taga, T. and Kishimoto, T. Regulation of IL-6 receptor and gp130 expression on human cell lines of lymphoid myeloid origin. Cytokine 4, 495-499, 1992.

9. Taga, T., Hibi, M., Murakami, M., Saito, M., Yawata, H., Narazaki, M., Hirata, Y., Sugita, T., Yasukawa, K., Hirano, T. and Kishimoto, T. Interleukin 6 receptor and signals. Chem. Immunol. 51:181-204, 1992.

8. Liu, J., Modrell, B., Aruffo, A., Marken, J. S., Taga, T., Yasukawa, K., Murakami, M., Kishimoto, T. and Shoyab, M. Interleukin-6 signal transducer gp130 mediates Oncostatin M signaling. J. Biol. Chem. 267, 16763-16766, 1992.

7. Kishimoto, T., Hibi, M., Murakami, M., Narazaki, M., Saito, M., and Taga, T. The molecular biology of interleukin 6 and its receptor. Chiba-Found-Symp. 167, 5-23, 1992.

6. Taga, T., Hibi, M., Murakami, M., Saito, M., Yawata, H., Narazaki, M., Hirata, Y., Sugita, T., Yasukawa, K., Hirano, T., and Kishimoto, T. IL-6 receptor and signals. In Chemical Immunology: Interleukins: MolecularBiology and Immunology, ed. by Kishimoto, T., and S. Karger AG, Basel Switzerland. vol. 51, p181-204, 1992.

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