Research interest:
The role of zinc transporters in vivo

Toshiyuki Fukada, PhD

Senior Research Scientist:
RIKEN Research Center for Allergy and Immunology
Immune System Regulation Group, Laboratory for Cytokine Signaling
1-7-22, Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan
Tel: 81-45-503-7056 (ex6522), Fax: 81-45-503-7054
(Adjunct Associate Professor:　Osaka University Medical School)

深田俊幸

上級研究員:
理化学研究所　横浜研究所　免疫アレルギー科学総合研究センター　サイトカイン制御研究グループ
〒230-0045 神奈川県横浜市鶴見区末広1-7-22
Tel: 045-503-7056 (6522), Fax: 045-503-7054
（招聘准教授:　大阪大学大学院医学系研究科免疫アレルギー医学）

Research and Professional Experience

1986-1990. B.A. in Dept. of Applied Biological Science, Hiroshima University, Hiroshima, Japan (Supervisor: Assoc. Prof. Yasunori Nagamatsu)

1990-1992. M.A. in Dept. of Applied Biological Science, Hiroshima University, Hiroshima, Japan (Supervisor: Prof. Susumu Ikegami)

1992-1994. Mochida Pharmaceutical Co. Ltd.

1994-1998. Ph.D. Program in Dept. of Molecular Oncology, Biomedical Research Center, Osaka University Medical School, Osaka, Japan (Supervisor: Prof. Toshio Hirano)

1998-1999. Postdoctoral Research Fellow in Dept. of Molecular Oncology, Biomedical Research Center, Osaka University Medical School, Osaka, Japan (Supervisor: Prof. Toshio Hirano) as a Research Fellowship of the Japan Society for the Promotion of Science (JSPS Research Fellow).

1999-2003. Postdoctoral Fellow, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (Supervisor: Prof. Nicholas K. Tonks) as a JSPS Postdoctoral Fellowships for Research Abroad (4/2000-3/2002).

2003-Present. Research Scientist, RIKEN Research Center for Allergy and Immunology, Laboratory for Cytokine Signaling

2004-Present. Deputy Team Leader, Senior Research Scientist, RIKEN Research Center for Allergy and Immunology, Laboratory for Cytokine Signaling

2005-Present. Adjunct Associate Professor, Osaka University Medical School
　

Publication (Times cited: by ISI as of 2009)

-Original Research Articles-

21) A Rac GTPase-Activating Protein, MgcRacGAP, Is a Nuclear Localizing Signal-Containing Nuclear Chaperone in the Activation of STAT Transcription Factors. Kawashima T. *, * Y-C. Bao*, Y. Minoshima, Y. Nomura, T. Hatori, T. Hori, T. Fukagawa, T. Fukada, N. Takahashi, T. Nosaka, M. Inoue, T. Sato, M. Kukimoto-Niino, M. Shirouzu, S. Yokoyama, and T. Kitamura. (* equal contribution) Mol. Cell. Biol. 29  (7): 1796-1813, 2009. (Times Cited: 4)  

20) The Zinc Transporter SLC39A13/ZIP13 is Required for Connective Tissue Development; Its Involvement in BMP/TGF-b Signaling Pathways. Fukada, T.*, N. Civic*, T. Furuichi*, S. Shimoda, K. Mishima, H. Higashiyama, Y. Idaira, Y. Asada, H. Kitamura, S. Yamasaki, S. Hojyo, M. Nakayama, O. Ohara, H. Koseki, H. G. dos Santos, L. Bonafe, R. Ha-Vinh, A. Zankl, S. Unger, M. E. Kraenzlin, J. S. Beckmann, I. Saito, C. Rivolta, S. Ikegawa, A. Superti-Furga and T. Hirano. (* equal contribution) PLoS ONE 3(11): e3642, 2008. (Times Cited : 3 by Scopus) 　F1000 Factor: 9.0. This paper was selected by ”Faculty of 1000 Biology” .

19) Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Kitamura, H., H. Morikawa, H. Kamon, M. Iguchi, S. Hojyo, T. Fukada, S. Yamashita, T. Kaisho, S. Akira, M. Murakami and T. Hirano. Nature Immunol. 7: 971-977, 2006. (Times Cited: 44) 　F1000 Factor: 6.4. This paper was selected by ”Faculty of 1000 Biology” .

18) Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer. Yamashita S., C. Miyag, T. Fukada, N. Kagara, Y-S. Che1 and T. Hirano. Nature 429: 298-302, 2004. (Times Cited: 98) 　 F1000 Factor: 5.0. This paper was selected by ”Faculty of 1000 Biology” .

17) Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signalling. Fukada. T., and N. K. Tonks. EMBO J. 22: 479-493 2003. (Times Cited: 20)

16) Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Meng. T. C., T. Fukada, and N. K. Tonks. Molecular Cell 9: 387-399, 2002. (Times Cited: 378) 　F1000 Factor: 4.8. This paper was selected by ”Faculty of 1000 Biology” .

15) Reciprocal role of Egr-1 and Sp family proteins to regulation of the PTP1B promoter in response to the p210 Bcr-Abl oncoprotein-tyrosine kinase. Fukada. T., and N. K. Tonks. J. Bio. Chem. 276: 25512-25519, 2001. (Times Cited: 29)

14) Dissection of signaling cascades through gp130 in vivo: Reciprocalroles for STAT3- and SHP2 mediated signals in immune responses. Ohtani, T., K. Ishihara, T. Atsumi, K. Nishida, Y. Kaneko, T. Miyata , S. Itoh, M. Narimatsu, H. Maeda, T. Fukada､, M. Itoh, H. Okano, M. Hibi and T. Hirano. Immunity 12: 95-105, 2000. (Times Cited: 113)

13) Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and anti-apoptosis. Shirogane, T., T. Fukada, J. M. M. Muller, D. T. Shima, M. Hibi, and T. Hirano, Immunity 11: 709-719, 1999. (Times Cited: 202)

12) Gab-family adapter proteins act downstream of cytokine and growth factor receptors, and T and B cell antigen receptors. Nishida, K., Y. Yoshida, M. Itoh, T. Fukada, T. Ohtani, T. Shirogane, T. Atsumi, M. Takahashi-Tezuka, K. Ishihara, M. Hibi, and T. Hirano. Blood 93: 1809-1816, 1999. (Times Cited: 180)

11) STAT3 is required for the gp130-mediated full activation of the c-myc gene. Kiuchi, N., K. Nakajima, M. Ichiba, T. Fukada, M. Narimatsu, K. Mizuno, M. Hibi, and T. Hirano. J. Exp. Med. 189: 63-73, 1999. (Times Cited: 163)

10) STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell cycle transition. Fukada, T., T. Ohtani, Y. Yoshida, T. Shirogane, K. Nishida, K. Nakajima, M. Hibi, and T. Hirano. EMBO J. 17: 6670-6677,1998. (Times Cited: 133)

9) Gab1 acts as an adaptor molecule linking a cytokine receptor gp130 to ERK MAP kinase. Takahashi-Tezuka, M., Y. Yoshida, T. Fukada, T. Yamaguchi, Y. Yamanaka, K. Nakajima, M. Hibi, and T. Hirano (equal contribution of the first two authors). Mol. Cell. Biol. 18: 4109-4117, 1998. (Times Cited: 168)

8) Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6. Ihara, S., K. Nakajima, T. Fukada, M. Hibi, S. Nagata, T. Hirano, and Y. Fukui. EMBO J. 17: 5345-5352, 1997. (Times Cited: 104)

7) Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK. Takahashi-Tezuka, M., M. Hibi, Y. Fujitani, T. Fukada, T. Yamaguchi, and T. Hirano. Oncogene 14: 2273-2282, 1997. (Times Cited: 56)

6) An alternative pathway for STAT activation that is mediated by direct interaction of JAK and STAT. Fujitani, Y., M. Hibi, T. Fukada, M. Takahashi-Tezuka, H. Yoshida, T. Yamaguchi, K. Sugiyama, Y. Yamanaka, K. Nakajima, and T. Hirano. Oncogene 14: 751-761,1997. (Times Cited: 110)

5) Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Fukada, T., M. Hibi, Y. Yamanaka, M. Takahashi-Tezuka, Y. Fujitani, T. Yamaguchi, K. Nakajima, and T. Hirano. Immunity 5: 449-490, 1996. (Times Cited: 411)

4) A central role for STAT3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J. 15: 3651-3658, 1996. Nakajima, K., Y. Yamanaka, H. Nakae, H. Kojima, N. Kiuchi, M. Ichiba, T. Kitaoka, T. Fukada, M. Hibi, and T. Hirano. (Times Cited: 415)

3) Differentiation and growth arrest signals generate through the cytoplasmic region of gp130 that is essential for STAT3 activation. Yamanaka, Y., K. Nakajima, T. Fukada, M. Hibi, and T. Hirano. EMBO J. 15: 1557- 1565, 1996. (Times Cited: 153)

2) Activation of Fes tyrosine kinase by gp130, an Interleukine-6 family cytokine signal transducer and their association. Matsuda, T., T. Fukada., M. Takahashi-Tezuka, Y. Okuyama, Y. Fujitani, Y. Hanazono, H. Hirai and T. Hirano. J. Bio. Chem. 270: 11037-11039, 1995. (Times Cited: 76)

1) Association and activation of Btk and Tec tyrosine kinases by gp130, an Il-6 family of cytokine. Matsuda, T., M. Takahashi-Tezuka, T. Fukada., Y. Okuyama, Y. Fujitani, S. Tsukada, H. Mano, H. Hirai, O.N. Witte, and T. Hirano. Blood 85: 627-633, 1995. (Times Cited: 119)

　
-Review Articles-

4) Roles of Zinc and Zinc signaling in immunity: Zinc is an intracellular signaling molecule. Hirano, T., M. Murakami, T. Fukada, K. Nishida, S. Yamasaki, and T. Suzuki. Advances in Immunology 97: 149-176, 2008. (Times Cited: 6)

3) A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. Anderson, J. N., P. G. Jansen, S. M. Echwald, O. H. Mortensen, T. Fukada, R. Del Vecchio, N. K. Tonks, and N. P. H. Moller.　FASEB J. 18: 8-30, 2004. (Times Cited: 129)

2) IL-6 Ligand and Receptor Family. Hirano, T., T. Fukada. Cytokine Reference 2000 Academic Press, 524-535, 2000.

1) Signaling through gp130: Toward a general scenario of cytokine action. Fukada, T., Y. Yoshida, K. Nishida, T. Ohtani, T. Shirogane, M. Hibi, and T. Hirano. Growth Factors 17: 81-91, 1999. (Times Cited: 24)

第８回口腔医科学フロンティア学術集会 (PHOTO)