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Selected Publications
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Welcome to Molecular Regenerative Medicine, Department of
Biochemistry and Molecular Biology, Osaka University Graduate School
of Medicine Link
1. T. Nakamura, T Nishizawa, M Hagiya, T. Seki, M. Shimonishi, A.
Sugimura, K. Tashiro and S. Shimizu (1989) Molecular cloning and
expression of human hepatocyte growth factor. Nature, 342, 440-443
2. K. Tashiro, M. Hagiya, T. Nishizawa, T. Seki, M. Shimonishi, S. Shimizu and T. Nakamura (1990) Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues. Proc. Natl. Acad. Sci. USA, 87, 3200-3204
3. T. Tsuji, F. Okada, K. Yamaguchi and T. Nakamura (1990) Molecular cloning of the large subunit of TGF-β masking protein and expression of its mRNA in rat various tissues. Proc. Natl. Acad. Sci. USA, 87, 8835-8839
4. K. Matsumoto, H. Tajima, M. Hamanoue, S. Kohno, T. Kinoshita and T. Nakamura (1992) Identification and characterization of "injurin", an inducer of expression of the gene for hepatocyte growth factor. Proc. Natl. Acad. Sci.USA, 89, 3800-3804
5. K. Kawaida, K. Matsumoto, H. Shimazu and T. Nakamura (1994) Hepatocyte growth factor prevent acute renal failure and accelerate renal regeneration. Proc. Nalt. Acad. Sci. USA, 91, 4357-4361
6. H. Ohmichi, U. Koshimizu, K. Matsumoto and T. Nakamura (1998) Hepatocyte growth factor (HGF) acts as a mesenchynal-derived morphogenic factor during fetal lung develpment. Development., 125, 1315-1324.
7. S. Mizuno, T. Kurosawa, K. Matsumoto, Y. Mizuno
- Horikawa, M. Okamoto and T. Nakamura (1998) Hepatocyte growth
factor prevents renal fibrosis and dysfunction in a mouse model of
chronic renal disease. J Clin
Invest. 101(9):1827-34.
8. T. Ueki, Y. Kaneda, H. Tsutsui, K. Nakanishi, Y. Sawa, R.
Morishita, K. Matsumoto, T. Nakamura, H. Takahashi, E. Okamoto and J.
Fujimoto (1999) Hepatocyte growth factor gene therapy of liver
cirrhosis in rats. Nature
Medicine, 5, 226-230
9. M. Tahara, K. Matsumoto, T. Nukiwa and T. Nakamura (1999) Hepatocyte gowth factor l eads to recovery from alcohol-induced fatty liver in rats. J. Clin. Invest., 103, 313-320
10. K. Kosai, K. Matsumoto, H. Funakoshi and T. Nakamura (1999) Hepatocyte growth factor prevents endotoxin - induced lethal hepatic failure in mice. Hepatology, 30, 151-159
11. K. Kuba, K. Matsumoto, K. Date, H. Shimura, M. Tanaka and T. Nakamura (2000) HGF/NK4, a four-kringle fragment of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice. Cancer Res. 60, 6737-6743.
12. T. Nakamura, S. Mizuno, K. Matsumoto, Y. Sawa, H. Matsuda, and T. Nakamura (2000) Myocardial protection from infarction by endogenous and exogenous hepatocyte growth factor. J. Clin. Invest. 106, 1511-1519.
13. K. Matsumoto, T. Nakamura (2001) Hepatocyte growth factor: renotropic role and potential therapeutics for renal diseases. Kidney Int. 59 (6): 2023-38. 23092-23096.
14. D. Tomioka, N. Maehara, K. Kuba, K. Mizumoto, M. Tanaka, K. Matsumoto and T. Nakamura (2001) Inhibition of growth, invasion and metastasis of human panereatic carcinoma cells by NK4 in an orthotopic mouse model. Cancer Res., 61, 7518-7524.
15. W.Sun., H. Funskoshi and T. Nakamura (2002) Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS. J. Neurosci., 22(15), 6537-48.
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