大阪大学大学院医学系研究科免疫制御学

2017
256. Matsuno H, Kayama H, Nishimura J, Sekido Y, Osawa H, Barman S, Ogino T, Takahashi H, Haraguchi N, Hata T, Matsuda C, Yamamoto H, Uchino M, Ikeuchi H, Doki Y, Mori M, Takeda K, Mizushima T. CD103+ Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative Colitis. Inflamm Bowel Dis. In press (2017)

 

255. Kitada S, Kayama H, Okuzaki D, Koga R, Kobayashi M, Arima Y, Kumanogoh A, Murakami M, Ikawa M and Takeda K: BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection. J. Exp. Med 214, 1313-1331 (2017).

 

254. Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H and Takeda K: E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLOS ONE 12, e0172509 (2017).

 

253. Motooka D, Fujimoto K, Tanaka R, Yaguchi T, Gotoh K, Maeda Y, Furuta Y, Kurakawa T, Goto N, Yasunaga T, Narazaki M, Kumanogoh A, Horii T, Iida T, Takeda K, and Nakamura S.: Fungal ITS1 deep-sequencing strategies to reconstruct the composition of a 26-species community and evaluation of the gut mycobiota of healthy Japanese individuals. Front. Microbiol. in press

 

252. Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori H, Suto A, Suzuki K, Hirose K, Takeda K, and Nakajima H: IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models. Allergy in press

 

2016
251. Barman S, Kayama H, Okuzaki D, Ogino T, Osawa H, Matsuno H, Mizushima T, Mori M, Nishimura J and Takeda K: Identification of a human intestinal myeloid cell subset that regulates the gut homeostasis. Int. Immunol. 28, 533-545 (2016)

 

250. Fujimoto K, Kinoshita M, Tamura A, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, and Takeda K: Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.Mucosal Immunol 10, 446-445 (2017).

 

249. Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, and Takeda K: Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheum68, 2646-2661 (2016).

 

248. Kawano H, Kayama H, Nakama T, Hashimoto T, Umemoto E, and Takeda K: IL-10-producing lung interstitial macrophages prevent neutrophilic asthma. Int. Immunol. 28, 489-501 (2016).

 

247. Bag S, Saha B, Mehta O, Anbumani D, Kumar N, Dayal M, Pant A, Kumar P, Saxena S, Allin KH, Hansen T, Arumugam M, Vestergaard H, Pedersen O, Pereira V, Abraham P, Tripathi R, Wadhwa N, Bhatnagar S, Prakash VG, Radha V, Anjana RM, Mohan V, Takeda K, Kurakawa T, Nair GB, Das B.: An improved method for high quality metagenomics DNA extraction from human and environmental samples. Sci. Rep. 6, 26775 (2016).

 

246. Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motoka D, Gotoh K, Kimura T, Kamiyama N, Kusu T, Ueda Y, Wu H, Iijima H, Barman S, Osawwa H, Matsuno H, Nishimura J, Ohba Y, Nakamura S, Iida T, Yamamoto M, Umemoto E, Sano K, and Takeda K: Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature 532, 117-121 (2016).

 

245. Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi M, Tohya K, Inoue A, Hata E, Akahoshi , Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, and Umemoto E: Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. eLife 5, e10561 (2016).

 

2015
244. Ohshima, J., Sasai, M., Liu, J., Yamashita, K., Ma, J.S., Lee, Y., Bando, H., Howard, J.C., Ebisu, S., Hayashi, M., Takeda, K., Standley, D.M., Frickel, E.M., and Yamamoto, M.: RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii. Proc Natl Acad Sci USA 112, 4581-4590 (2015).

 

243. Chinen I, Nakahama T, Kimura A, Nguyen NT, Takemori H, Kumagai A, Kayama H, Takeda K, Lee S, Hanieh H, Ripley B, Millrine D, Dubey PK, Nyati KK, Fujii-Kuriyama Y, Chowdhury K, Kishimoto T.: The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis. Int. Immunol. 27, 405-415 (2015).

 

242. Kashiwagi, I., Morita, R., Shichita, T., Komai, K., Saeki, K., Matsumoto, M., Takeda, K., Nomura, M., Hayashi, A., Kanai, T. and Yoshimura, A.: Smad2 and Smad3 inversely regulate TGF-β autoinduction in Clostridium butyricum-activated dendritic cells. Immunity 43, 65-79 (2015).

 

241. Sato, A., Kayama, H., Shojima, K., Matsumoto, S., Koyama, H., Minami, Y., Nojima, S., Morii, E., Honda, H., Takeda, K. and Kikuchi, A.: The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis. Sci. Rep.. 5, 10536 (2015).

 

240. Tsai, S. H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada, Y., Takeda, A., Yoshikawa, S., Kurashima, Y., Sato, S., Umemoto, E., Kiyono, H., Karasuyama, H. and Takeda, K.: Ectoenzyme E-NPP3 (CD203c) negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity 42, 279-293 (2015).

 

2014
239. Mastumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nut, S. L., Sakaguchi, S., Takeda, K., Kurosaki, T., and Baba, Y.: Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation. Immunity 41,1040-1051 (2014).

 

238. Kobayashi, S., Hara, A., Isagawa, T., Manabe, I., Takeda, K. and Maruyama, T.: The nuclear IkB family protein IkBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model. PLoS One 9, e110838 (2014).

 

237. Ma, J. S., Sasai, M., Ohshima, J., Lee, Y., Bando, H., Takeda, K. and Yamamoto, M.: Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6. J. Exp. Med. 211, 2013-2032 (2014).

 

236. Masahata, K., Umemoto, E., Kayama, H., Kotani, M., Nakamura, S., Kurakawa, T., Kikuta, J., Gotoh, K., Motooka, D., Sato, S., Higuchi, T., Baba, Y., Kurosaki, T., Kinoshita, M., Shimada, Y., Kimura, T., Okumura, R., Takeda, A., Tajima, M. Yoshie, O., Fukuzawa, M., Kiyono, H., Fagarasan, S., Iida, T., Ishii, M. and Takeda,K.: Generation of colonic IgA-secreting cells in the cecal patch. Nat. Commun. 5, 3704 (2014).

 

235. Meunier, E., Dick, M., Dreier, R., Broz, D. K., Yamamoto, M., Takeda, K., Schurmann, N., Bumann, D., Warming, S., Roose-Girma, M., Kayagaki, N., Broz, P.: Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature 509, 366-370 (2014).

 

234. Ohshima, J., Lee, Y., Sasai, M., Saitoh, T., Ma, J.S., Kamiyama, N., Matsuura, Y., Pann-Ghill, S., Hayashi, M., Ebisu, S., Takeda, K., Akira, S., and Yamamoto, M.: Role of the mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii. J. Immunol. 192, 3328-3335 (2014).

 

233. Hyde, J. L., Gardner, C. L., Kimura, T., White, J. P., Trobauh D. W., Huang, C., Szretter, K. J., Paessler, S., Takeda, K., Amarasinghe, G., Klimstra, W. B. and Diamond, M. S.: A viral RNA structural element alters host recognition of non-self RNA. Science 343, 783-787 (2014).

 

232. Yokota, K., Sato, K., Miyazaki, T., Kitaura, H., Kayama, H., Miyoshi, F., Akiyama, Y., Takeda, K., and Mimura, T.: Combination of tumor necrosis factor ? and interleukin 6 induces both in vitro and in vivo osteoclast-like cells with bone-resorption activity. Arthritis Rheum. 66, 121-129 (2014).

 

2013
231. Shimada, Y., Kinoshita, M., Harada, K., Mizutani, M., Masahata, K., Kayama, H. and Takeda, K.: Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon. PLoS One 8(11): e80604 (2013).

 

230. Ogino, T., Nishimura, J., Barman, S., Kayama, H., Uematsu, S., Haraguchi, N., Uemura, M., Hata, T., Takemasa, I., Mizushima, T., Yamamoto, H., Takeda, K., Doki, Y., and Mori, M.: Increased Th17-inducing activity of CD14(+) CD163(low) myeloid cells in intestinal lamina propria of patients with Crohn's disease. Gastroenterol. 145, 1380-1391 (2013).

 

229. Kimura, T., Katoh, H., Kayama, H., Saiga, H., Okuyama, M., Okamoto, T., Umemoto, E., Matsuura, Y., Yamamoto, M. and Takeda, K.: Ifit1 inhibits JEV replication through binding to 5' capped 2'-O unmethylated RNA. J. Virol. 87, 9997-10003 (2013).

 

228. Ishii, H., Tanabe, S., Ueno, M., Kubo, T., Kayama, H., Serada, S., Fujimoto, M., Takeda, K., Naka, T., and Yamashita, T.: Ifn-g-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. Cell Death Dis. 4, e710 (2013).

 

227. Kunisawa, J., Gohda, M., Hashimoto, E., Ishikawa, I., Higuchi, M., Suzuki, Y., Goto, Y., Panea, C., Ivanov, I. I., Sumiya, R., Aayam, L., Wake, T., Tajiri, S., Kurashima, Y., Shikata, S., Akira, S., Takeda, K., and Kiyono, H.: Microbe-dependent CD11b+ IgA+ plasma cells in early-phase robust intestinal IgA responses in mice. Nat. Commun. 23, 1772 (2013).

 

226. Kamiyama, N., Yamamoto, M., Saiga, H., Ma, J.S., Ohshima, J., Machimura, S., Sasai, M., Kimura, T., Ueda, Y., Kayama, H., and Takeda, K.: CREBH determines the severity of sulpyrine-induced fatal shock. PLoS One. 8, e55800 (2013).

 

225. Kusu, T., Kayama, H., Kinoshita, M., Jeon, S.G., Ueda, Y., Goto, Y., Okumura, R., Saiga, H., Kurakawa, T., Ikeda, K., Maeda, Y., Nishimura, J., Arima, Y., Atarashi, K., Honda, K., Murakami, M., Kunisawa, J., Kiyono, H., Okumura, M., Yamamoto, M., and Takeda, K.: ENTPDase7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J. Immunol. 190, 774-783 (2013).

 

2012
224. Shigekawa, M., Hikita, H., Kodama, T., Shimizu, S., Li, W., Uemura, A., Miyagi, T., Hosui, A., Kanto, T., Hiramatsu, N., Tatsumi, T., Takeda, K., Akira, S., and Takehara, T.: Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction. Am. J. Pathol. 181, 2105-2113 (2012).

 

223. Saiga, H., Kitada, S., Shimada, Y., Kamiyama, N., Okuyama, M., Makino, M., Yamamoto, M. and Takeda, K.: Critical role of AIM2 in Mycobacterium tuberculosis infection. Int. Immunol. 24, 637-644 (2012).

 

222. Kinoshita, M., Kayama, H., Kusu, T., Yamaguchi, T., Kunisawa, J., Kiyono, H., Sakaguchi, S. and Takeda, K.: Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J. Immunol. 189, 2869-2878 (2012).

 

221. Yamamoto, M., Okuyama, M., Ma, J. S., Kimura, T., Kamiyama, N., Saiga, H., Ohshima, J., Kayama, H., Okamoto, T., Huang, D. C. S., Soldati-Farve, D., Horie, K., Takeda, J. and Takeda, K.: A cluster of IFN-g-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii. Immunity 37, 302-313 (2012).

 

220. Jeon, S. G., Kayama, H., Ueda, Y., Takahashi, T., Asahara, T., Tsuji, H., Tsuji, N. M., Kiyono, H., Ma, J. S., Kusu, T., Okumura, R., Hara, H., Yoshida, H., Yamamoto, M., Nomoto, K. and Takeda, K.: Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathogens 8, e1002714 (2012).

 

219. Kayama, H., Ueda, Y., Sawa, Y., Jeon, S. G., Ma, J. S., Okumura, R., Kubo, A., Ishii, M., Okazaki, T., Murakami, M., Yamamoto, M., Yagita, H. and Takeda, K.: Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T cell-dependent colitis. Proc. Natl. Acad. Sci. USA. 109, 5010-5015 (2012).

 

218. Niida, T., Isoda, K., Kitagaki, M., Ishigami, N., Adachi, T., Matsubara, O., Takeda, K., Kishimoto, T. and Ohsuzu, F.: IkBNS regulates interleukin-6 production and inhibits neointimal formation after vascular injury in mice. Cardiovas. Res. 93, 371-379 (2012).

 

2011
217. Takata, K., Kinoshita, M., Okuno, T., Moriya, M., Kohda, T. Honorat. J.A., Sugimoto, T., Kumanogoh, A., Kayama, H., Takeda, K., Sakoda, S. and Nakatsuji, Y.: The lactic acid bacterium Pediococcus acidilactici suppresses autoimmune encephalomyelitis by inducing IL-10-producing regulatory T Cells. PLoS One 6, e27644, (2011).

 

216. Matsuda, A., Ogawa, M., Yanai, H., Naka, D., Goto, A., Ao, T., Tanno, Y., Takeda, K., Watanabe, Y., Honda, K., and Taniguchi, T.: Generation of mice deficient in RNA-binding motif protein 3 and characterization of its role in innate immune responses and cell growth. Biochem. Biophys. Res. Commun. 411, 7-13 (2011).

 

215. Yamamoto, M., Ma, J. S., Mueller, C., Kamiyama, N., Saiga, H., Kubo, E., Kimura, T., Okamoto, T., Okuyama, M., Kayama, H., Nagamune, K., Takashima, S., Soldati-Favre, D., Matsuura, Y., Takeda, K.: ATF6? is a host cellular target of the Toxoplasma gondii virulence factor ROP18. J. Exp. Med. 208, 1533-1546 (2011).

 

214. Iwata-Kajihara, T., Sumimoto, H., Kawamura, N., Ueda, R., Takahashi, T., Mizuguchi, H., Miyagishi, M., Takeda, K. and Kawakami, Y.: Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors. J. Immunol. 187, 27-36 (2011).

 

213. Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., Taniguchi, T., Takeda, K., Hori, S., Ivanov, I.I., Umesaki, Y., Itoh, K., and Honda, K.: Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331, 337-341 (2011).

 

2010
212. Ueda, Y., Kayama, H., Jeon, S.-G., Kusu, T., Isaka, Y., Rakugi, H., Yamamoto, M. and Takeda, K.: Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10. Int. Immunol. 22, 953-962 (2010).

 

211. Xiao, G., Miyazato, A., Abe, Y., Zhang, T., Nakamura, K., Inden, K., Tanaka, M., Tanno, D., Miyasaka, T., Ishii, K., Takeda, K., Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Yamamoto, N., Kunishima, H., Hirakata, Y., Kaku, M., and Kawakami, K.: Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensis via a Toll-like receptor 9-dependent pathway. Cell Immunol. 263, 241-250 (2010).

 

210. Okuyama, M., Kayama, H., Atarashi, K., Saiga, H., Kimura, T., Waisman, A., Yamamoto, M., and Takeda, K.: A novel inducible dendritic cell ablation model in mice. Biochem. Biophys. Res. Commun. 397, 559-563 (2010).

 

209. Obana, M., Maeda, M., Takeda, K., Hayama, A., Mohri, T., Yamashita, T., Nakaoka, Y., Komuro, I., Takeda, K., Matsumiya, G., Azuma, J. and Fujio, Y.: Therapeutic activation of STAT3 by Interleukin-11 ameliorates cardiac fibrosis after myocardial infarction. Circulation 121, 684-691 (2010).

 

2009
208. Yamamoto, M., Standley, D.M., Takashima, S., Saiga, H., Okuyama, M., Kayama, H., Kubo, E., Ito, H., Takaura, M., Matsuda, T., Soldati-Farve, D., and Takeda, K.: A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3. J. Exp.Med. 206, 2747-2760 (2009).

 

207. Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., Tanoue, T., Imaoka, A., Itoh, K., Takeda, K., Umesaki, Y., Honda, K., Littman, D. R.:Induction of Intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485-498 (2009).

 

206. Pejnovic, N., Vratimos, A., Lee, S. H., Popadic, D., Takeda, K., Akira, S., and Chan, W. L.: Increased atherosclerotic lesions and Th17 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet. Mol Immunol. 47, 37-45 (2009).

 

205. Miyazato, A., Nakamura, K., Yamamoto, N., Mora-Montes, H. N., Tanaka, M., Abe, Y., Tannno, D., Inden, K., Gang, X., Ishii, K., Takeda, K., Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Mitsutake, K., Gowm N. A. R., Kaku, M., and Kawakami, K.: Toll-like receptor 9-dependent activation of myeloid dendritic cells by deoxynucleic acids from Candida albicans. Infect. Immun. 77, 3056-3064 (2009).

 

204. Kayama, H., Koga, R., Atarashi, K., Mak, T. W., Takayanagi, H., Honda, K., Yamamoto, M. and Takeda, K.: NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection. PLoS Pathogens 5, e1000514 (2009).

 

203. Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Takeno, H., Uno, J., Hirabayashi, J., Mikami, Y., Takeda, K., Akira, S., and Saito, T.: C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc. Natl. Acad. Sci. USA. 106, 1897-902 (2009).

 

202. Morishita, H., Saito, F., Kayama, H., Atarashi, K., Kuwata, H., Yamamoto, M., and Takeda, K.: Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses. Int. Immunol. 21, 457-465 (2009).

 

201. Haga, S., Ozaki, M., Inoue, H., Okamoto, Y., Ogawa, W., Takeda, K., Akira, S., and Todo, S.: The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. Hepatology 49, 204-214 (2009).

 

2008
200. Saiga, H., Nishimura, J., Kuwata, H., Okuyama, M., Matsumoto, S., Sato, S., Matsumoto, M., Akira, S., Yoshikai, Y., Honda, K., Yamamoto, M. and Takeda, K.: Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium. J. Immunol. 181, 8521-8527 (2008).

 

199. Nakamura, K., Miyazato, A., Koguchi, Y., Adachi, Y., Ohno, N., Saijo, S., Iwakura, Y., Takeda, K., Akira, S., Fujita, J., Ishii, K., Kaku, M., and Kawakami, K.: Toll-like receptor (TLR) 2 and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei. Microbes Infect. 10, 1223-1227 (2008).

 

198. Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., and Takeda, K.: ATP drives lamina propria TH17 cell differentiation. Nature 455, 808-812 (2008).

 

197. Nakamura, J., Fujimoto, M., Yasuda, K., Takeda, K., Akira, S., Hatayama, T., Takagi, Y., Nozaki, K., Hosokawa, N., and Nagata, K.: Targeted disruption of Hsp110/105 gene protects against ischemic stress. Stroke 9, 2853-2859 (2008).

 

196. Saito, F., Kuwata, H., Oike, E., Koike, M., Uchiyama, Y., Honda, K., and Takeda, K.: Inefficient phagosome maturation in infant macrophages. Biochem. Biophys. Res. Commun. 375, 113-118 (2008).

 

195. Herrmann, J., Imura, T., Song, B., Ao, Y., Qi, J., Nguyen, T., Korsak, R., Takeda, K., Akira, S., and Sofroniew, M.: STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J. Neurosci. 28, 7231-7243 (2008).

 

194. Gong, L., Yao, F., Hockman, K., Heng, H. H., Morton, G. J., Takeda, K., Akira, S., Low, M. J., Rubinstein, M., and Mackenzie, R. G.: Stat3 is required in hypothalamic Agrp/Npy neurons for normal energy homeostasis. Endocrinology 149, 3346-3354 (2008).

 

193. Ueta, M., Hamuro, J., Ueda, E., Katoh, N., Yamamoto, M., Takeda, K., Akira, S., and Kinoshita, S.: Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of I?B?-/- mice. Invest. Ophthalmol. Vis. Sci. 49, 3387-3394 (2008).

 

192. Kayama, H., Ramirez-Carrozzi, V. R., Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S. T., and Takeda, K.: Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkB?. J. Biol. Chem. 283, 12468-12477 (2008).

 

191. Nakamura, K., Miyazato, A., Gang, X., Hatta, M., Inden, K., Aoyagi, T., Takeda, K., Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Suzuki, K., Fujita, J., Kaku, M., and Kawakami, K: Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway. J. Immunol. 180, 4067-4074 (2008).

 

190. Nishimura, J., Saiga, H., Sato, S., Okuyama, M., Kayama, H., Kuwata, H., Matsumoto, S., Nishida, T., Sawa, Y., Akira, S., Yoshikai, Y., Yamamoto, M., and Takeda, K.: Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor. J. Immunol. 180, 4032-4039 (2008).

 

189. Hisaeda, H., Tetsutani, K., Imai, T., Moriya, C., Tu, L., Hamano, S., Duan, X., Chou, B., Ishida, H., Aramaki, A., Shen, J., Ishii, K., J., Coban, C., Akira, S. Takeda, K., Yasutomo, K., Torii, M., and Himeno, K.: Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells. J. Immunol. 180, 2496-2503 (2008).

 

188. Owaki, T., Asakawa, M., Morishima, N., Mizoguchi, I., Fukai, F., Takeda, K., Mizuguchi, J. and Yoshimoto, T.: STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production. J. Immunol. 180, 2903-2911 (2008).

 

2007
187. Yamamoto, M., Uematsu, S., Okamoto, T., Matsuura, Y., Sato, S., Kumar, H., Satoh, T., Saitoh, T., Takeda, K., Ishii, K. J., Takeuchi, O., Kawai, T., and Akira, S.: Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. J. Exp. Med. 204, 2233-2239 (2007).

 

186. Sakamori, R., Takehara, T., Ohnishi, C., Tatsumi, T., Ohkawa, K., Takeda, K., Akira, S., Hayashi, N.: STAT3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice. Hepatology 46, 1564-1573 (2007).

 

185. Nemoto,Y., Kanai, T., Makita, S., Okamoto, R., Totsuka, T., Takeda, K., and Watanabe, M.: Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastoroenterology 132, 176-189 (2007).


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