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教授:金井 好克

金井教授金井教授の研究風景

■ Selected papers

1. Kanai Y, Hediger MA (1992)
Primary structure and functional characterization of a high-affinity glutamate transporter.
Nature 360: 467-471
2. You G, Smith CP, Kanai Y, Lee WS, Stelzner M, Hediger MA (1993)
Cloning and characterization of the vasopressin-regulated urea transporter.
Nature 365: 844-847
3. Fei YJ, Kanai Y, Nussberger S, Ganapathy V, Leibach FH, Romero MF, Singh SK, Boron WF, Hediger MA (1994)
Expression cloning of a mammalian proton-coupled oligopeptide transporter.
Nature 368: 563-566
4. Kanai Y, Lee WS, You G, Brown D, Hediger MA (1994)
The human kidney low affinity Na+/glucose cotransporter SGLT2.
Delineation of the major renal reabsorptive mechanism for D-glucose.
J Clin Invest 93: 397-404
5. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H (1997)
Expression cloning and characterization of a novel multispecific organic anion transporter.
J Biol Chem 272: 18526-18529
6. Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E, Endou H (1998)
Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98).
J Biol Chem 273: 23629-23632
7. Okuda T, Haga T, Kanai Y, Endou H, Ishihara T, Katsura I (2000)
Identification and characterization of the high-affinity choline transporter.
Nat Neurosci 3: 120-125
8. Igarashi T, Inatomi J, Sekine T, Cha SH, Kanai Y, Kunimi M, Tsukamoto K, Satoh H, Shimadzu M, Tozawa F, Mori T, Shiobara M, Seki G, Endou H (1999)
Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities.
Nat Genet 23: 264-266
9. Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H (2002)
Molecular identification of a renal urate anion exchanger that regulates blood urate levels.
Nature 417: 447-452
10. Kleta R, Romeo E, Ristic Z, Ohura T, Stuart C, Arcos-Burgos M, Dave MH, Wagner CA, Camargo SR, Inoue S, Matsuura N, Helip-Wooley A, Bockenhauer D, Warth R, Bernardini I, Visser G, Eggermann T, Lee P, Chairoungdua A, Jutabha P, Babu E, Nilwarangkoon S, Anzai N, Kanai Y, Verrey F, Gahl WA, Koizumi A (2004)
Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder.
Nature Genet 36: 999-1002
11. Miyazaki, H, Anzai, N, Ekaratanawong, S, Sakata, T, Shin, H. J, Jutabha, P, Hirata, T, He, X, Nonoguchi, H, Tomita, K, Kanai, Y, and Endou, H. (2005)
Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins,
J Am Soc Nephrol 16: 3498-3506.
12. Shigeta, Y, Kanai, Y, Chairoungdua, A, Ahmed, N, Sakamoto, S, Matsuo, H, Kim, D. K,  Fujimura, M, Anzai, N, Mizoguchi, K, Ueda, T, Akakura, K, Ichikawa, T, Ito, H. Endou, H. (2006)
A novel missense mutation of SLC7A9 frequent in Japanese cystinuria cases affecting the C-terminus of the transporter,
Kidney Int 69: 1198-1206.
13. Kaira, K, Oriuchi, N, Otani, Y, Shimizu, K, Tanaka, S, Imai, H, Yanagitani, N, Sunaga, N, Hisada, T, Ishizuka, T, Dobashi, K, Kanai, Y, Endou, H, Nakajima, T, Endo, K, and Mori, M. (2007)
Fluorine-18-alpha-methyltyrosine positron emission tomography for diagnosis and staging of lung cancer: a clinicopathologic study,
Clin Cancer Res 13: 6369-6378.
14. Matsuo H, Chiba T, Nagamori S, Nakayama A, Domoto H, Phetdee K, Wiriyasermkul P, Kikuchi Y, Oda T, Nishiyama J, Nakamura T, Morimoto Y, Kamakura K, Sakurai Y, Nonoyama S, Kanai Y, Shinomiya N (2008)
Mutations in Glucose Transporter 9 Gene SLC2A9 Cause Renal Hypouricemia.
Am J Hum Genet 83: 744-751
15. Sakamoto, S, Chairoungdua, A, Nagamori, S, Wiriyasermkul, P, Promchan, K, Tanaka, H, Kimura, T, Ueda, T, Fujimura, M, Shigeta, Y, Naya, Y, Akakura, K, Ito, H, Endou, H, Ichikawa, T, Kanai, Y. (2008)
A novel role of C-terminus of b0,+AT in the ER-Golgi trafficking of rBAT-b0,+AT heterodimeric amino acid transporter,
Biochem J 417: 441-448.
16. Matsuo, H, Takada, T, Ichida, K, Nakamura, T, Nakayama, A, Ikebuchi, Y, Ito, K, Kusanagi, Y, Chiba, T, Tadokoro, S, Takada, Y, Oikawa, Y, Inoue, H, Suzuki, K, Okada, R, Nishiyama, J, Domoto, H, Watanabe, S, Fujita, M, Morimoto, Y, Naito, M, Nishio, K, Hishida, A, Wakai, K, Asai, Y, Niwa, K, Kamakura, K,  Nonoyama, S, Sakurai, Y, Hosoya, T, Kanai, Y, Suzuki, H, Hamajima, N, and Shinomiya, N. (2009)
Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population,
Science Translational Medicine 1: 5ra11
17. Shiraya K., Hirata T., Hatano R., Nagamori S., Wiriyasermkul P., Jutabha P., Matsubara M., Muto S., Tanaka H., Asano S., Anzai N., Endou H., Yamada A., Sakurai H., Kanai Y.
A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules.
J Biol Chem. 2010; 285:22141-51
18. Wiriyasermkul, P. Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, Kitashoji T, Ohgaki R. Tanaka H, Endou H, Endo K, Sakurai H and Kanai Y. 
Transport of 3-fluoro-L-α-methyl tyrosine by tumor-upregulated amino acid transporter LAT1: a cause of the tumor uptake in PET.
J Nucl Med  2012; 53: 1253-61

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