新着情報




業績集 (2017年4月更新)

発表論文を PubMed で検索

2016年度

1)
Kawada H, Inanobe A, Kurachi Y. (2016) Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system. Neuropharmacology. 2016 Oct;109:18-28. doi: 10.1016/j.neuropharm.2016.05.016. Epub 2016 May 26.

2) Yoshida T, Nin F, Murakami S, Ogata G, Uetsuka S, Choi S, Nakagawa T, Inohara H, Komune S, Kurachi Y, Hibino H. (2016) The unique ion permeability profile of cochlear fibrocytes and its contribution to establishing their positive resting membrane potential. Pflugers Arch. 2016 Sep;468(9):1609-19. doi: 10.1007/s00424-016-1853-2. Epub 2016 Jun 25.

3) Okamoto K, Emura N, Sato H, Fukatsu Y, Saito M, Tanaka C, Morita Y, Nishimura K, Kuramoto E, Xu Yin D, Furutani K, Okazawa M, Kurachi Y, Kaneko T, Maeda Y, Yamashiro T, Takada K, Toyoda H, Kang Y. (2016) The Possible Role of TASK Channels in Rank-Ordered Recruitment of Motoneurons in the Dorsolateral Part of the Trigeminal Motor Nucleus. eNeuro. 2016 Jul 20;3(3). pii: ENEURO.0138-16.2016. doi: 10.1523/ENEURO.0138-16.2016. eCollection 2016 May-Jun.

4) Nin F, Yoshida T, Sawamura S, Ogata G, Ota T, Higuchi T, Murakami S, Doi K, Kurachi Y, Hibino H. (2016) The unique electrical properties in an extracellular fluid of the mammalian cochlea; their functional roles, homeostatic processes, and pathological significance. Pflugers Arch. 2016 Oct;468(10):1637-49. doi: 10.1007/s00424-016-1871-0. Epub 2016 Aug 27. Review.

2015年度

1)
Inanobe A, Tsuzuki C, Kurachi Y. (2015) An Epithelial Ca2+-Sensor Protein is an Alternative to Calmodulin to Compose Functional KCNQ1 Channels. Cell Physiol Biochem. 2015;36(5):1847-61.


2)
Murakami S, Kurachi Y. (2015) Mechanisms of astrocytic K(+) clearance and swelling under high extracellular K(+) concentrations. J Physiol Sci. 2016 Mar;66(2):127-42. doi: 10.1007/s12576-015-0404-5. Epub 2015 Oct 27.


3)
Nin F, Yoshida T, Murakami S, Uetsuka S, Ogata G, Kurachi Y, Hibino H. (2015) Theoretical and experimental analysis of ototoxic mechanism in the spiral ligament fibrocytes by multi-level simulation with ion transports in the cochlea. Nihon Yakurigaku Zasshi. 2016 Feb;147(2):80-3. doi: 10.1254/fpj.147.80.

2014年度

1)
Yoshida T, Nin F, Ogata G, Uetsuka S, Kitahara T, Inohara H, Akazawa K, Komune S, Kurachi Y, Hibino H. (2014) NKCCs in the fibrocytes of the spiral ligament are silent on the unidirectional K+ transport that controls the electrochemical properties in the mammalian cochlea. Pflugers Arch.


2)
Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y. (2014) Ischemia-related subcellular redistribution of sodium channels enhances the proarrhythmic effect of class I antiarrhythmic drugs: a simulation study. PLoS One. 2014 Oct 3;9(10):e109271. doi: 10.1371/journal.pone.0109271. eCollection.


3)
Fujita A, Inanobe A, Hibino H, Nielsen S, Ottersen OP, Kurachi Y. (2014) Clustering of Kir4.1 at specialized compartments of the lateral membrane in ependymal cells of rat brain. Cell Tissue Res.


2013年度

1)
Chen IS, Furutani K, Inanobe A, Kurachi Y. (2014) RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents. J Physiol 592(Pt 6);1237-1248. doi:10.1113/jphysiol.2013.269803.


2)
Inanobe A, Kurachi Y. (2014) Membrane channels as integrators of G-protein-mediated signaling. Biochim. Biophys Acta 1838(2);521-531. doi:10.1016/j.bbamem.2013.08.018.

3) Yamazaki D, Funato Y, Miura J, Sato S, Toyosawa S, Furutani K, Kurachi Y, Omori Y, Furukawa T, Tsuda T, Kuwabata S, Mizukami S, Kikuchi K, Miki H. (2013) Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model. PLoS Genet 9(12);e1003983. doi: 10.1371/journal.pgen.1003983.

4) Inanobe A, Nakagawa A, Kurachi Y. (2013) Conformational changes underlying pore dilation in the cytoplasmic domain of mammalian inward rectifier K+ channels. PLOS ONE 8 (11);e79844. doi: 10.1371/journal.pone.0079844

5) Asai Y, Abe T, Oka H, Okita M, Okuyama T, Hagihara K, Ghosh S, Matsuoka Y, Kurachi Y, Kitano H. (2013) A versatile platform for multilevel modeling of physiological systems: Template/instance framework for large-scale modeling and simulation. Conf Proc IEEE Eng Med Biol Soc 5529-5532. doi:10.1109/EMBC.2013.6610802.

6) Murakami S, Inanobe A, Kurachi Y. (2013) Short-term desensitization of muscarinic K+ current in the heart, Biophys J 105(6);1515-1525. http://dx.doi.org/10.1016/j.bpj.2013.08.009

7) Hibino H, Nin F, Murakami S, Doi K, Suzuki T, Hisa Y, Kurachi Y. (2013) Mechanism of electrical potential dynamics of lymph fluid in inner ear. Nihon Jibiinkoka Gakkai Kaiho 116(2):60-68. http://dx.doi.org/10.3950/jibiinkoka.116.60

8) Adachi N, Yoshida T, Nin F, Ogata G, Yamaguchi S, Suzuki T, Komune S, Hisa Y, Hibino H, Kurachi Y. (2013) The mechanism underlying maintenance of the endocochlear potential by the K+ transport system in fibrocytes of the inner ear. J Physiol 591(Pt 18);4459-4472. doi: 10.1113/jphysiol.2013.258046.

9) Harada Y, Nagao Y, Shimizu S, Serikawa T, Terada R, Fujimoto M, Okuda A, Mukai T, Sasa M, Kurachi Y, Ohno Y. (2013) Expressional analysis of inwardly rectifying Kir4.1 channels in Noda epileptic rat (NER). Brain Res 1517:141-149. doi: 10.1016/j.brainres.2013.04.009.

10) Nin F, Hibino H, Kurachi Y. (2013) Computational model reproduces electrochemical properties of the mammalian cochlea. Nihon Yakurigaku Zasshi 141(4):224.


2012年度

1) Nin F, Hibino H T, Murakami S, Suzuki T, Hisa Y, Kurachi Y. (2012) Computational model of a circulation current that controls electrochemical properties in the mammalian cochlea. Proc Natl Acad Sci U S A 109(23)
:9191-9196.



2011年度

1) Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y. (2011) Roles of subcellular Na+ channel distributions in the mechanism of cardiac conduction. Biophys J 100(3):554-563.

2) Inanobe A, Matsuura T, Nakagawa A, Kurachi Y. (2011) Inverse agonist-like action of cadmium on G-protein-gated inward-rectifier K(+) channels. Biochem Biophys Res Commun 407(2):366-371.

3) Furutani K, Yamakawa Y, Inanobe A, Iwata M, Ohno Y, Kurachi Y. (2011) A mechanism underlying compound-induced voltage shift in the current activation of hERG channel by anti arrhythmic agents. Biochem Biophys Res Commun 415(1):141-146.

4) Inanobe A, Nakagawa A, Kurachi Y. (2011) Interactions of cations with the cytoplasmic pores of inward rectifier K+ channel in the closed state. J Biol Chem 286(48):41801-41811.

5) Yamakawa Y, Furutani K, Inanobe A, Ohno Y, Kurachi Y. (2012) Pharmacophore modeling for hERG channel facilitation. Biochem Biophys Res Commun
418(1):161-166.

6) Noble D, Kurachi Y, Hunter P, Wang X, Gordon M, Boron W. (2012) Physiology without borders 2. Physiology (Bethesda). 27(1), 2.

2010年度

1) Murakami S, Suzuki S, Ishii M, Inanobe A, Kurachi Y. (2010) Cellular modeling: experiments and simulation to develop the physiological model for G-protein control of Cardiac muscarinic K+ channels in mammalian atrial cells.
Philos Transact A Math Phys Eng Sci 368(1921):2983-3000.

2) Ait-Haddou R, Kurachi Y, Nomura T. (2010) On calcium-buffer dynamics within the excess buffer regime. J Theor Biol 264(1):55-65.

3) Ikushima M, Ishii M, Ohishi M, Yamamoto K, Ogihara T, Rakugi H, Kurachi Y. (2010) ANG II inhibits insulin-mediated production of PI 3,4,5-triphosphates via a Ca2+-dependent but PKC-independent pathway in the cardiomyocytes. Am J Physiol Heart Circ Physiol 299(3):H680-689.

4) Mitsuma T, Tani K, Hiroaki Y, Kamegawa A, Suzuki H, Hibino H, Kurachi Y, Fujiyoshi Y. (2010) Influence of the cytoplasmic domains of aquaporin-4 on water conduction and array formation. J Mol Biol 402(4):669-681.

5) Inanobe A, Nakagawa A, Matsuura T, Kurachi Y. (2010) A structural determinant for the control of PIP2-sensitivity in G protein-gated inward rectifier K+ channels. J Biol Chem 285(49):38517-38523.

6) Haraguchi R, Ashihara T, Namba K, Tsumoto K, Murakami S, Kurachi Y, Ikeda T, Nakazawa K. (2010) Transmural dispersion of repolarization determines scroll wave behavior during ventricular tachyarrhythmias: A simulation study.
Circ J 75(1):80-88.

2009年度


1) Furutani K*, Ohno Y*, Inanobe A, Hibino H, Kurachi Y. (2009) Mutational and In silico analyses for antidepressants block of astroglial inward-rectifier Kir4.1 channel. Mol Pharmacol 75 (6), 1287-1295 [*: equal contributors]

2) Yokoe M, Okuno R, Hamasaki T, Kurachi Y, Akazawa K, Sakoda S.
(2009) Opening velocity, a novel parameter, for finger tapping test in patients with Parkinson's disease. Parkinsonism Relat Disord 15 (6):440-444.

3) Ogawa S, Yamashita T, Yamazaki T, Aizawa Y, Atarashi H, Inoue H, Ohe T, Ohtsu H, Okumura K, Katoh T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K, Tabuchi T, Nakaya H, Nakayama T, Hirai M, Fukatani M, Mitamura H; J-RHYTHM Investigators. (2009)
Circ J 73(2), 242-248.

4) Furutani K, Hibino H, Inanobe A, Kurachi Y. (2009) Compound-induced block of ion channel pore functon: inward-rectifier potassium channels as a model. Mol Cell Pharmacol 1(5), 234-244.

5) Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, Kurachi Y. (2010) Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol Rev 90, 291-366.

6) Hibino H, Nin F, Tsuzuki C, Kurachi Y. (2010) How is the highly positive endocochlear potential formed? The specific architecture of the stria vascularis and the roles of the ion-transport apparatus. Pflugers Arch-Eur J Physiol. 459(4), 521-533.


2008年度

1) Tsujimae K, Murakami S, Kurachi Y. (2008) In silico study on the effects of IKur block kinetics on prolongation of human action potential after atrial fibrillation-induced electrical-remodeling. Am J Physiol Heart Circ Physiol. 294 (2), H793-800

2) Nin F*, Hibino H*, Doi K, Suzuki T, Hisa Y, Kurachi Y. (2008) The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear. Proc Natl Acad Sci USA 105(5), 1751-1756. [*: equal contributors]

3) Findlay I, Suzuki S, Murakami S, Kurachi Y. (2008) Physiological modulation of voltage-dependent inactivation in the cardiac muscle L-type calcium channel: a modelling study. Prog Biophys Mol Bio 96, 482-498

4) Lachheb S, Cluzeaud F, Bens M, Genete M, Hibino H, Lourdel S, Kurachi Y, Vandewalle A, Teulon J, Paulais M. (2008) Kir4.1/Kir5.1 channel forms the major K+ channel in the basolateral membrane of mouse renal collecting duct principal cells. Am J Physiol Renal Physiol 294, F1398-F1407

5) Hasegawa Y, Kanai Y, Hasegawa S, Okamoto T, Matsui T, Shimosegawa E, Kurachi Y, Hatazawa J. (2008).Evaluation of brain and whole-body pharmacokinetics of 11C-labeled diphenylhydantoin in rats by means o planar position imaging system. Ann Nucl Med 22, 301-307

6) Suzuki S, Murakami S, Tsujimae K, Findlay I, Kurachi Y. (2008) In silico assessment for drug-induction of cardiac arrhythmia. Prog Biophys Mol Bio 98, 52-60

7) Hunter P, Kurachi Y, Noble D, Viceconti M. (2008) Meeting report on the 2nd MEI International Symposium - The worldwide Challenge to Physiome and systems biology and Osaka Accord-. J Physiol Sci 58, 425-431

8) Asai Y, Suzuki Y, Kido Y, Oka H, Heien E, Nakanishi M,Urai T, Hagihara K, Kurachi Y, Nomura T. (2008) Specification of insilicoML 1.0: A Multilevel Biophysical Model Description Language. J Physiol Sci 58, 447-458

9) Inanobe A, Kamiya N, Murakami S, Fukunishi Y, Nakamura H, Kurachi Y. (2008) In Silico Prediction of the Chemical Block of Human Ether-a-Go-Go-Related Gene (hERG) K+ Current. J Physiol Sci 58, 459-470

10) Kawazu T, Murakami S, Adachi-Akahane S, Findlay I, Ait-Haddou R, Kurachi Y, Nomura T. (2008) Microstructure-based monte carlo simulation of Ca2+ dynamis evoking cardiac culcium channel inactivation. J Physiol Sci 58, 571-480

11) Ogawa S, Yamashita T, Yamazaki T, Aizawa Y, Atarashi H, Inoue H, Ohe T, Ohtsu H, Okumura K, Katoh T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K Tabuchi T, Nakaya H, Nakayama T, Hirai M, Fukatani M, Mitamura H; for the J-RHYTHM investigators. (2008) Optimal Treatment Strategy for Patients With Paroxysmal Atrial Fibrillation. Circ J (in press)

12) Yokoe M, Okuno R, Hamasaki T, Kurachi Y, Akazawa K, Sakoda S. (2008) Opening velocity, a novel parameter, for finger tapping test in patients with Parkinson's disease. Parkinsonism Relat Disord (in press)

13) Suzuki Y, Asai Y, Kawazu T, Nakanishi M, Taniguchi Y, Heien E, Hagiharai K, Kurachi Y, Nomura T. (2008) A platform for in silico modeling of physiological systems II. CellML compatibility and other extended capabiliyies. Conf Proc IEEE Eng Med Biol Soc 2008, 573-576


2007年度

1) Shieh C-C, Brune ME, Buckner SA, Whiteaker KL, Molinari E, Milicic IA, Fabiyi AC, Daza A, Brioni JD, Carroll WA, Matsushita K, Yamada M, Kurachi Y, Gopalakrishnan M (2007) Characterization of a Novel ATP-sensitive K+ Channel Opener, 4-methyl-N-(2,2,2-trichloro-1-(3-pyridin-3-ylthioureido)ethyl)benzamide (A-251179) on Urinary Bladder Relaxation and Cystometric Parameters. Brit J Pharmacol. 51, 467-475.

2) Inanobe A, Matsuura T, Nakagawa A, Kurachi Y (2007) Structural diversity in the cytoplasmic region of G protein-gated inward rectifier K+ channel. Channels. 1, 39-45.

3) Tsujimae K. Suzuki S. Murakami S. Kurachi Y. (2007) Frequency dependent effects of various IKr blockers on cardiac action potential duration in a human atrial model. Am J Physiol Heart Circ Physiol. 293, H660-H669.

4) Su S, Ohno Y, Lossin C, Hibino H, Inanobe A, Kurachi Y. (2007) Inhibition of astroglial inwardly rectifying Kir4.1 channels by a tricyclic antidepressant, nortriptyline. J Pharmacol Exp Ther. 320, 573-580.

5) Huang C, Sindic A, Hill CE, Hujer KM, Chan KW, Sassen M, Wu Z, Kurachi Y, Nielsen S, Romero MF, Miller RT. (2007) Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function. Am J Physiol Renal Physiol. 292, F1073-1081.

6) Hosaka Y, Iwata M, Kamiya N, Yamada M, Kinoshita K, Fukunishi Y, Tsujimae K, Hibino H, Aizawa Y, Inanobe A, Nakamura H, Kurachi Y. (2007) Mutational analysis of block and facilitation of HERG current by a class III anti-arrhythmic agent, nifekalant. Channels. 1, 198-208.

7) Hibino H, Kurachi Y (2007) Distinct detergent-resistant membrane micro-domains (lipid-rafts) respectively harvest K+ and water transport systems in brain astroglia. Eur J Neurosci. 26, 2539-2555.

8) Ohno Y, Hibino H, Lossin C, Inanobe A, Kurachi Y (2007) Inhibition of astroglial Kir4.1 channels by selective serotonin reuptake inhibitors. Brain Research. 1178C, 44-51.

9) Nakamura K, Katayama Y, Kusano KF, Haraoka K, Tani Y, Nagase S, Morita H, Miura D, Fujimoto Y, Furukawa T, Ueda K, Aizawa Y, Kimura A, Kurachi Y, Ohe T (2007) Anti-KCNH2 antibody: induced long QT syndrome - novel acquired form of long QT syndrome. J Am Coll Cardiol. 50, 1808-1809.

10) Murakami S, Kurachi Y (2007) Mechanisms of action of antiarrhythmic drugs. In "Electrical diseases of the heart: Genetics, mechanisms, treatment, prevention" (Gussak I, Antzelevitch C, eds.) Springer-Verlag, London, pp.133-144.


2006年度

1) Iwashita M, Watanabe M, Ishii M, Chen T, Johnson SL, Kurachi Y, Okada N, Kondo S. (2006) Pigment pattern in jaguar/obelix zebrafish is caused by a Kir7.1 mutation: implications for the regulation of melanosome movement. PLoS Genet. 2, e197, 1861-1870.

2) Kikuta J, Ishii M, Kishimoto K, Kurachi Y. (2006) Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the bundle-crossing regions. Eur J Pharmacol. 529, 47-54.

3) Hibino H, Kurachi Y. (2006) A new insight into the pathogenesis of coronary vasospasm. Circ Res. 98, 579-581.

4) Shibata T, Hibino H, Doi K, Suzuki T, Hisa Y, Kurachi Y. (2006) Gastric type H+,K+-ATPase in the cochlear lateral wall is critically involved in formation of the endocochlear potential. Am J Physiol Cell Physiol. 291, C1038-48.

5) Watanabe M, Iwashita M, Ishii M, Kurachi Y, Kawakami A, Kondo S, Okada N. (2006) Spot pattern of leopard Danio is caused by mutation in the zebrafish connexin41.8 gene. EMBO Rep. 7, 893-897.

6) Hibino H, Kurachi Y. (2006) Molecular and physiological bases of the K+ circulation in the mammalian inner ear. Physiology (Bethesda). 21, 336-345.

7) Yamashita T, Ogawa S, Aizawa Y, Atarashi H, Inoue H, Ohe T, Okumura K, Ohtsu H, Kato T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K, Nakaya H, Hirai M, Hirayama A, Fukatani M, Mitamura H, Yamazaki T, Watanabe E; J-RHYTHM II Investigators. (2006) Randomized study of angiotensin II type 1 receptor blocker vs dihydropiridine calcium antagonist for the treatment of paroxysmal atrial fibrillation in patients with hypertension. Circ J. 70, 1318-1321.

8) Ishii M, Kurachi Y.(2006) Muscarinic acetylcholine receptors. Curr Pharm Des. 12, 3573-3581.


2005年度

1) Ishii M, Fujita S, Yamada M, Hosaka Y, Kurachi Y. (2005) Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action. Biochem J. 385, 65-73.

2) Yamada, M., and Kurachi, Y. (2005). A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K+ channels. Journal of Molecular and Cellular Cardiology 39, 1-6.

3) Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA. (2005) International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev. 57, 509-26.

4) Koyrakh L, Lujan R, Colon J, Karschin C, Kurachi Y, Karschin A, Wickman K. (2005) Molecular and cellular diversity of neuronal G-protein-gated potassium channels. J Neurosci. 25, 11468-11478.

5) Ishii M, Ikushima M, Kurachi Y. (2005) In vivo interaction between RGS4 and calmodulin visualized with FRET techniques: possible involvement of lipid raft. Biochem Biophys Res Commun. 338, 839-46.

6) Sawada K, Morishige K, Hashimoto K, Tasaka K, Kurachi H, Murata Y, Kurachi Y. (2005) Gestational change of K+ channel opener effect is correlated with the expression of uterine KATP channel subunits. Eur J Obstet Gynecol Reprod Biol. 122, 49-56.


2004年度

1) Ishii M, Kurachi Y. (2004) Assays of RGS protein modulation by phosphatidylinositides and calmodulin. Methods Enzymol. 389, 105-118.

2) Hibino H, Fujita A, Iwai K, Yamada M, Kurachi Y. (2004) Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes. J Biol Chem. 279, 44065-44073.

3) Yamada M, Ishii M, Hibino H, Kurachi Y. (2004) Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: implication for dimerization of nucleotide-binding domains to induce channel opening. Mol Pharmacol. 66, 807-816.

4) Tsujimae K, Suzuki S, Yamada M, Kurachi Y. (2004) Comparison of kinetic properties of quinidine and dofetilide block of HERG channels. Eur J Pharmacol. 493, 29-40.

5) Yamada M, Kurachi Y. (2004) The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Mol Pharmacol. 65, 1198-1207.

6) Makino Y,Matsushita K,Yamada M,Yamashita S,Matsuzawa Y,Kurachi Y. (2004) Effect of Tertiapin on Different Types of Recombinant Inwardly Rectifying Potassium Channels. Med J Osaka Univ. 47, 1-11.

7) Hibino H, Higashi-Shingai K, Fujita A, Iwai K, Ishii M, Kurachi Y. (2004) Expression of an inwardly rectifying K+ channel, Kir5.1, in specific types of fibrocytes in the cochlear lateral wall suggests its functional importance in the establishment of endocochlear potential. European Journal of Neuroscience 19: 76-84.

8) Kurachi Y, Ishii M. (2004) Cell signal control of the G protein-gated potassium channel and its subcellular localization. The Journal of Physiology 554, 285-294.

9)Kurachi Y, North RA. (2004) Ion channels: their structure, function and control - an overview. The Journal of Physiology 554, 245-247.


2003年度

1) Chachin M, Yamada M, Fujita A, Matsuoka T, Matsushita K, Kurachi Y. (2003) Nateglinide,a D-Phenylalanine Derivative Lacking Either a Sulfonylurea or Benzamido Moiety,Specifically Inhibits Pancreatic β-Cell-Type K ATP Channel. The Journal of Pharmacology and Experimental Therapeutics 304: 1025-1032.

2) Ishii M, Fujita A, Iwai K, Kusaka S, Higashi K, Inanobe A, Hibino H, Kurachi Y. (2003) Differential expression and distribution of Kir5.1and Kir4.1 Inwardly rectifying K+ channels in retina. America Journal of Physiology: Cell Physiology 285: C260-C267.

3) Yamashita T, Ogawa S, Aizawa Y, Atarashi H, Inoue H, Ohe T, Okumura K, Kato T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K, Nakaya H, Nakayama T, Hirai M, Fukatani M, Mitamura H, Yamazaki T; J-RHYTHM Investigators (2003) Investigation of the optimal treatment strategy for atrial fibrillation in Japan. Circulation Journal 67: 738-741.

4) Ishii M, Kurachi Y. (2003) Physiological actions of regulators of G-protein signaling (RGS) proteins. Life Sciences 74: 163-171.

5) Jay PY, Berul CI, Tanaka M, Ishii M, Kurachi Y, Izumo S. (2003) Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans. Novartis Foundation Symposium 250: 227-238.

6) Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS (2003) International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacological Review 55: 583-586.


2002年度

1) Kondo H, Shimomura I, Kishida K, Kuriyama H, Makino Y, Nishizawa H, Matsuda M, Maeda N, Nagaretani H, Kihara S, Kurachi Y, Nakamura T, Funahashi T, Matsuzawa Y (2002) Human aquaporin adipose (AQPap)gene: gennomic structure, promoter analysis and functionalmutation. European Journal of Biochemistry 269:1814-1826.

2) Saito H, Kimura M, Inanobe A, Ohe T, Kurachi Y. (2002) An N-terminal sequnece specific for a novel Homer1 isoform controls trafficking of group I metabltropic glutamate receptor in mamma;ian cells. Biochemical and Biophysical Research Communications 296: 523-529.

3) Inanobe A, Ito M, Fujita A, Tomoike H, Kurachi Y. (2002) Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses. American Journal of Physiology 282: C1396-1403.

4) Tanemoto M, Fujita A, Higashi K, Kurachi Y. (2002) PSD-95 mediates formation of a functional homomeric Kir5.1 channel in the brain. Neuron 34: 387-397.

5) Matsushita K, Kinoshita K, Matsuoka T, Fujita A, Fujikado T, Tano Y, Nakamura H, Kurachi Y (2002) Intramolecular interaction of SUR2 subtypes for intracellular ADP-induced differential control of KATP channels. Circulation Research 90: 554-561.

6) Ishii M, Inanobe A, Kurachi Y (2002) PIP3-inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel. Proceedings of National Academy of Sciences, USA 99(7); 4325-4330.

7) Fujita A, Horio Y, Higashi K, Mouri T, Hata F, Takeguchi N, Kurachi Y. (2002) Specific localization of an inwardly rectifying K+ channel, Kir4.1, at the apical membrane of gastric parietal cells; its possible involvement in K+ recycling for activation of H+/K+ pump. The Journal of Physiology 540.1; 85-92.

8) Lourdel S, Paulais M, Cluzeaud F, Bens M, Tanemoto M, Kurachi Y, Vandewalle A, Tuelon J. (2002) A K+ inward rectifier at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4-Kir5.1 heteromeric channels. The Journal of Physiology 538.2: 391-404.

9) Tanaka M, Berul CI, Ishii M, Jay PY, Wakimoto H, Douglas P, Yamasaki N,Kawamoto T, Gehrmann J, Maguire CT, Schnke M, Seidman CE, Seidman JG, Kurachi Y, Izumo S (2002) A Mouse Model of Congenital Heart Disease: Cardiac Arrhythmias and Atrial Septal Defect Caused by Haploinsufficiency of the Cardiac Transcription factor Csx/Nkx2.5. Cold Spring Harbor Symposia on Quantitative Biology,Volume LXVII.


2001年度

1) Tanemoto A, Fujita A, Kurachi Y. (2001) Inwardly-rectifying K+ channels in heart. Heart Physiology and Pathophysiology, p281-308

2) Kusaka S, Inanobe A, Fujita A, Makino Y, Tanemoto M, Matsushita K, Tano Y, Kurachi Y. (2001) Functional Kir7.1 channels localized at the root of apical processes in rat retinal pigment epithelium. Journal of Physiology 531(1) 27-36

3) Fujita A, Kurachi Y. (2001) Inward rectifiying and ATP-sensitive K+ channels in the ventricular myocardium. Potassiu Channels in Cardiovascular Biology p363-386 (edited by Archer & Rusch. ) by Kluwer Academic.

4) Inanobe A, Kurachi Y. (2001) Direct regulation of ion channels by G proteins. Cell Physiology Source Book: A Molecular Approach, Third Ediion p573-583 by Academic Press

5) Fujita A, Hibino H, Kurachi Y. (2001) Regulation of ion channels by membrane proteins and cytoskeleton. Cell Physiology Source Book: A Molecular Approach, Third Ediion p601-622 by Academic Press

6) Adachi-Akahane S, Kurachi Y. (2001) New era for translational research in cardiac arrhythmias. Circulation Research 88, 1095-1096

7) Inanobe A, Fujita S, Makino Y, Matsushita K, Ishii M, Chachin M, Kurachi Y. (2001) Interaction between the RGS4 with G protein alpha subunits mediates the voltage-dependent relaxation of the G protein-gated potassium channel. The Journal of Physiology 535(1) 133-143.

8) Higashi K, Fujita A, Inanobe A, Tanemoto M, Doi K, Kubo T, Kurachi Y. (2001) An inwardly rectifying K+ channel, Kir4.1, expressed in astrocytes surrounds synapses and blood vessels in brain. Am J Physiol Cell Physiol 281: C922-C931.

9) Bender K, Wellner-Kienitz M-C, Inanobe A, Meyer T, Kurachi Y, Pott L. (2001) Overexpression of monomeric and multimeric GIRK4 subunits in rat atrial myocytes removes fast desensitization and reduced inward rectification of muscarinic K+ current (IK(ACh)). The Journal of Biological Chemistry 276 (31): 28873-28880.

10) Kishida K, Shimomura I, Kondo H, Kuriyama H, Makino Y, Nishikawa H, Maeda N, Matsuda M, Ouchi N, Kihara S, Kurachi Y, Funahashi T, Matsuzawa Y. (2001) Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose specific glycerol channel. The Journal of Biological Chemistry 276: 36251-36260.

11) Ishii M, Inanobe A, Fujita S, Makino Y, Hosoya Y, Kurachi Y. (2001) Ca2+-elevation evoked by membrane depolarization regulates G protein cycle via RGS proteins in the heart. Circulation Research 89: 1045-1050.

12) Matsumoto S, Isomoto S, Saito H, Inanobe A, Hibino H, Cachin M, Yamada M,Horio Y,KurachiY. (1999) The strong inwardly rectifying background potassium channel(IK1) in cardiac myocytes is composed of Kir2.2(IRK2):RT-PCR analysis of single cardiac myocyte mRNA Medical. Journal of Osaka University vol.44 No.1-4 March 2001


2000年度

1) Fujita A, Kurachi Y. (2000) Molecular aspects of ATP-sensitive K+ channels in the cardiovascular system and K+ channel openers. Pharmacology & Therapeuties 85, 39-53

2) Shinndo T, Katayama Y, Horio Y, Kurachi Y. (2000) MCC-134, a novel vascular relaxing agent, is an inverse agonist for the pancreatic-type ATP-sensitive K+ channel. The Journal of Pharmacology and Expreimental Therapeutics 292(1), 131-135

3) Hibino H, Inanobe A, Tanemoto M, Fujita A, Doi K, Kubo T, Hata Y, Takai Y, Kurachi Y. (2000) Anchoring proteins confer G protein sensitivity to an inward-rectifier K+ channel through the GK domain. The EMBO Journal 19(1), 78-83

4) Fujita Akikazu and Yoshihisa Kurachi. (2000) Breakthroughs and views SAP family proteins. Biochemical and Biophysical Research Communications 269, 1-6

5) Katayama T, Fujita A, Ohe T, Findlay I, Kurachi Y. (2000) Inhibitory effects of vesnarinone on cloned cardiac delayed rectifier K+ channels expressed in a mammalian cell line. The Journal of Pharmacology and Expreimental Therapeutics, 294(1), 339-346

6) Fujita S, Inanobe A, Chachin M, Aizawa Y, Kurachi Y. (2000) A regulator of G protein signalling (RGS) protein confers agonist-dependent relaxation gating to a G protein-gated K+ channel. The Journal of Physiology, 526(2) 341-347

7) Tanemoto M, Kittaka N, Inanobe A, Kurachi Y. (2000) In vivo formation of a proton-sensitive K+ channel by heteromeric subunit assembly of Kir5.l with Kir4.1. The Journal of Physiology, 525(3) 587-592

8) Kitamura H, Yokoyama M, Akita H, Matsushita K, Kurachi Y, Yamada M. (2000) Tertiapin potently and selectively blocks muscarinic K+ channels in rabbit cardiac myocytes. The Journal of Pharmacological and Experimental Therapiutics 293(1) 339-346

9) Matsuoka T, Masushita K, Katayaman Y, Fujita A, Inageda K, Tanemoto M, Inanobe A, Yamashita S, Matsuzawa Y, Kurachi Y. (2000) C-terminal tails of sulfonylurea-receptors control ADP-induced activation and diazoxide modulation of ATP-sensitive K+ channels. Circulation Research 87, 873-880

10) Kusaka S, Inanobe A, Matsushita K, Tano Y, Kurachi Y (2001) Functional Kir7.1 channels localized at the root of apical processes in rat retinal pigment epithelium. The Journal of Physiology 531(1), 27-36

11) Inanobe A, Kurachi Y. (2000) G protein-gated K+ channels. in Handbook of Experimental Pharmacology, Vol.147, "Pharmacology of Ionic Channel Function: Activators and Inhibitors". (M. Endo, Y. Kurachi, and M. Mishina, eds.) Springer-Verlasg, Heidelbeg, p297-p331

12) Tanemoto M, Fjita A, Kurachi Y. (2000) Inwardly rectifying K+ channels. In "Heart Physiology and Pathophysiology, 4th edition" (Sperelakis N, Kurachi Y, Terzic A, Cohen MV, eds.) Academic Press, pp. 281-pp. 308


1999年度

1) Inanobe A, Yoshimoto Y, Horio Y, Morishige K, Hibino H, Matsumoto S, Tokunaga Y, Maeda T, Hata Y, Takai Y, Kurachi Y. Characterization of G-protein-gated K+ channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra (1999). Journal of Neuroscience, 19 (3): 1006-1017.

2) Yoshimoto Y, Fukuyama Y, Horio Y, Inanobe A, Gotoh M, Kurachi Y. (1999) Somatostatin induces hyperpolarization in pancreatic islet a cells by activating a G protein-gated K+ channel. FEBS Letters 444: 265-269.

3) Morishige K, Inanobe A, Yoshimoto Y, Kurachi H, Murata Y, Tokunaga Y, Maeda T, Maruyama Y, Kurachi Y. (1999) Secretagogue-induced exocytosis recruits G protein-gated K+ channels to plasma membrane in endocrine cells. Journal of Biological Chemistry, 274 (12): 7969-7974.

4) Hibino H, A. Terzic, Inanobe A, Horio Y, Kurachi Y. (1999) Regulation of ion channels by membrane proteins. Potassium Ion Channels " Molecular structure, function, and disease" (Y. Kurachi, L. Y. Jan and M. Lazdunski, eds.). Current Topics in Membranes 46, pp243-272.

5) Hosoya Y, Kurachi Y. (1999) Functional analyses of G-protein activation of cardiac KG channel. Potassium Ion Channels " Molecular structure, function, and disease" (Y. Kurachi, L. Y. Jan and M. Lazdunski, eds.). Current Topics in Membranes 46, pp355-369.

6) Yamada M, Satoh E, Kondo C, V.P.Repunte, Kurachi Y. (1999) Molecular structure and function of cardiovascular ATP-sensitive potassium channels. Potassium Ion Channels " Molecular structure, function, and disease" (Y. Kurachi, L. Y. Jan and M. Lazdunski, eds.). Current Topics in Membranes 46, pp387-415.

7) Horio Y, Kurach Y. (1999) Glial inwardly rectifying potassium channels. Potassium Ion Channels " Molecular structure, function, and disease" (Y. Kurachi, L. Y. Jan and M. Lazdunski, eds.). Current Topics in Membranes 46, pp471-484.

8) Stephen J. Pieper, Alexis M. Fenton, Y. Kurachi, Win-Kuang Shen (1999) Bradykinin modulates arginine vasopressin-induced calcium influx in vascular myocytes. International Journal of Cardiology 69, 191-200.

9) Vez P.Repunte, Nakamura H, Fujita A, Horio Y, Ian Findlay, Lutz Pott, Kurachi Y. (1999) Extracellular links in Kir subunits control the unitary conductance of SUR/Kir6.0 ion channels. EMBO Journal 18 (12), 3317-3324.

10) Chachin M, Katayama Y, Yamada M, Horio Y, Ohmura T, Kitagawa H, Uchida S, Kurachi Y. (1999) Epinastine, a nonsedating histamine H1 receptor antagonist, has a negligible effect on HERG channel. European Journal of Pharmacology 374, 457-460.

11) Hibino H. Horio Y. Fujita A. Inanobe A. Doi K. Kubo T. Kurachi Y. (1999) Expression of an inwardly rectifying K+ channel, Kir4.1, in satellite cells of rat cochlear ganglia. American Journal Physiology 277 (Cell Physiol. 46): C638-C644.

12) Fujita A , Horio Y, Soren Nielsen, Erlend A. Nagelhus, Hata F, Ole Petter Ottersen, Kurachi Y. (1999) High-resolution immunogold cytochemistry indicates that AQP4 is concentrated along the basal membarne of parietal cell in rat stomach. FEBS Letters 459: 305-309.

13) Kusaka S, Horio Y, Fujita A, Matsushita K, Inanobe A, Gotow T, Uchiyama Y, Tano Y, Kurachi Y. (1999) Expression and polarized distribution of an inwardly rectifying K+ channel, Kir4.1, in rat retinal pigment epithelium. Journal of Physiology 520 (2): 373-381.

14) Inanobe A, Horio Y, Fujita A, Tanemoto M, Hibino H, Inageda K, Kurachi Y. (1999) Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis. Journal of Physiology 521 (1): 19-30.


1998年度

1) Kim D, Fujita A, Horio Y, Kurachi Y. (1998) Cloning and functional expression of a novel cardiac two-pore background K+ channel (cTBAK-1). Circ Res, 82; 513-518.

2) Tada Y, Horio Y, Kurachi Y. (1998) Inwardly Rectifying K+ channel in retinal Muller cells: Comparison with the KAB-2/kir4.1 channel expressed in HEK293T Cells. Japanese Journal of Physiology, 48, 71-80.

3) Okuyama Y, Yamada M, Kondo C, Sato E, Isomoto S, Shindo T, Horio Y, Kitakase M, Hori M, Kurachi Y. (1998) The effects of nucleotides and potassium channel openers on the SUR2A/Kir6.2 complex K+ channel expressed in a mammalian cell line, HEK293T cells. Pflügers Arch- Eur J. Physiol , 435: 595-603.

4) Shindo T, Yamada M, Isomoto S, Horio Y, Kurachi Y. (1998) SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. British Journal of Pharmacology 124, 985-991.

5) Hambrock A, Loffler-Walz C, Kurachi Y, Quas U. (1998) Mg2+ and ATP dependence of KATP channel modulator binding to the recombinant sulphonylurea receptor, SUR2B. British Journal of Pharmacology 125, 577-583.

6) Mouri T, Kittaka N, Horio Y, Copeland N.G., Gilbert D.J., Jenkins N.A., Kurachi Y. (1998) Assignment of mouse inwardly rectifying potassium channel Kcnj16 to the distal region of mouse chromosome 11. Genomics 54, 181-182.

7) Fujita A, Horio Y, Copeland N.G., Gilbert D.J., Jenkins N.A. and Kurachi Y. (1998) Assignment of mouse cardiac two-pore background K+ channel Gene (Kcnk4) to the proximal region of mouse chromosome 5. Genomics 54, 183-184.

8) Satoh E, Yamada M, Kondo C, Vez P.Repunte, Horio Y, Iijima T, Kurachi Y. (1998) Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil. Journal of Physiology 511.3 663-674.

9) Kondo C, Vez P. Repunte, Sato E, Yamada M, Horio Y, Masuzawa Y, Lutz P, Kurachi Y. (1998) Chimeras of Kir6.1 and Kir6.2 reveal structural elements involved in spontaneous opening and unitary conductance of the ATP-sensitive K+ channels. Receptors and Channels, 6, 129-140.

10) Yamada M, Inanobe A, and Kurachi Y. (1998) G Protein regulation of potassium ion channels. Pharmacological, Reviews 50(4), 723-757.

11) Yakushigawa H, Tokunaga Y, Inanobe A, Kani K, Kurachi Y and Maeda T. (1998) A novel junction-like membrane complex in the optic nerve astrocyte of the Japanese Macaque with a possible relation to a potassium channel. Anat. Rec. 250:465-474.

12) Ohta Y, Tanizawa Y, Inoue H, Hosaka T, Ueda K, Matsutani A, Repunte VP, Yamada M, Kurachi Y, Bryan J, Aguilar-Bryan L,Permutt MA and Oka Y. (1998) Identification and functional analysis of sulfonylurea receptor I variants in Japanese patients with NIDDM. Diabetes 47: 476-781.


1997年度

1) Ito H, Tsuchimochi H, Tada Y, Kurachi Y (1997) Phosphorylation-independent inhibition by intracellular cyclic nucleotides of brain inwardly rectifying K+ current expressed in Xenopus oocytes. FEBS Letters 402; 12-16.

2) Yamada M, Isomoto S, Matsumoto S, Kondo C, Shindo T, Horio Y, Kurachi Y. (1997) Sulfonylurea receptor 2B and Kir6.1 form a sulfonilurea-sensitive but ATP-insensitive K+ channel. Journal of Physiology 499.3; 715-720.

3) Horio Y, Hibino H, Inanobe A, Yamada M, Ishii M, Tada Y, Sato E, Hata Y, Takai Y, Kurachi Y. (1997) Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1. by an anchoring protein, PSD-95/SAP 90 family. The Journal of Biological Chemistry,272 (20); 12885-12888.

4) Hibino H, Horio, Inanobe A, Doi K, Yamada M, Gotow T, Uchiyama ・ Kubo T, Kurach Y. (1997) An ATP-dependent inwardly rectifying potassium channel, KAB-2 (Kir4.1), in cochlear stria vascularis of inner ear: its specific subcellular localization and correlation with the formation of endocochlear potential. The Journal of Neuroscience, 17(12): 4711-4721

5) Morishige K, Takumi T, Takahashi N, Koyama H, Kurachi H, Miyake A, Murata Y, Neal G.Copeland, Debra J. Gilbert, Nancy A. Jenkins, Kurachi Y. (1997) Assignment of the murine inwardly rectifying potassium channel IRK3 gene (Kcnj4)to the mouse Chromosome 15. Mammalian Genome 8: 699-700.

6) Takumi T, Fujiwake H, Kurachi Y. (1997) A dye terminator method for automated DNA sequencing using four fluorescent dideoxynucleosides and thermal cycling. Analytical Sciences, 13: 735-739.

7) Isomoto S. Horio Y. Matsumoto S. Kondo C. Yamada M. Gilbert D.J. Copeland N.G. Jenkins N.A. Kurachi Y. (1997) Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse chromosome. Mammalian Genome 8: 790-791.

8) Ishii M, Horio Y, Tada Y, Hibino H, Inanobe A, Ito M, Yamada M, Gotow T, Uchiyama Y, Kurachi Y. (1997) Expression and clustered distribution of an inwardly rectifying potassium channel, KAB-2/Kir4.1, on mammalian retinal Muller cell membrane: Their Regulation by insulin and laminin signals. The Journal of Neuroscience, 17(20):7725-7735.

9) Tada Y, Horio Y, Takumi T, Terayama M, Tsuji L, Copeland N.G., Jenkins N.A, Kurachi Y. (1997) Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1(Kcnj10) gene to the distal region of mouse chromosome 1. Genomics 45: 629-630.

10) Ohta Y, Tanizawa Y, Inoue H, Hosaka T, Ueda K, Matsutani A, V.P. Repunte, Yamada M, Kurachi Y, J. Bryan, L.A. Bryan, M.A. Permutt, Oka Y. (1998) Identification and functional analysis of sulfonylurea receptor 1 variants in japanese patients with NIDDM. Diabetes 47: 476-481.

11) Isomoto S, Kondo C, Kurachi Y (1997) Inwardly rectifying potassium channels: their molecular heterogeneity and function. Japanese Journal of Physiology 47:11-39.

12) Isomoto S, Kurachi Y (1997) Function, regulation, pharmacology and molecular structure of ATP-sensitive K+ channels in the cardiovascular system. Journal of Cardiovascular Electrophysiology. 8:1431-1446.


1996年度

1) Isomoto S, Kondo C, Takahashi N, Matsumoto S, Yamada M, Takumi T, Horio Y, Kurachi Y (1996) A novel ubiquitously-distributed isoform of GIRK2 (GIRK2B) enhances GIRK1-expression of the G-protein-gated K+ current in Xenopus oocytes. Biochemical and Biophysical Research Communications 218; 286-291.

2) Horio Y, Morishige K, Takahashi N, Kurachi Y (1996) Differential distribution of classical inwardly rectifying potassium channel mRNAs in the brain; comparison of IRK2 with IRK1 and IRK3. FEBS Letters 379; 239-243.

3) Morishige K, Inanobe A, Takahashi N, Yoshimoto Y, Kurachi H, Miyake A, Tokunaga Y, Maeda T, Kurachi Y (1996) G Protein-gated K+ channel (GIRK1) protein is expressed presynaptically in the paraventricular nucleus of the hypothalamus. Biochemical and Biophysical Research Communications 220; 300-305

4) Terzic A, Kurachi Y (1996) Actin microfilament-distrupters enhance KATP channel opening in patches from guinea-pig cardiomyocytes. Journal of Physiology 492.2; 395-404

5) Ito M, Inanobe A, Horio Y, Hibino H, Isomoto S, Ito H, Mori K, Tonosaki A, Tomoike H, Kurachi Y (1996) Immunolocalization of an inwardly rectifying K+ channel, KAB-2 (Kir4.1), in the basolateral membrane of renal distal tubular epithelia. FEBS Letters 388; 11-15

6) Yamashita T, Horio Y, Yamada M, Takahashi N, Kondo C, Kurachi Y (1996) Competition between Mg2+ and spermine for a cloned IRK2 channel expressed in a human cell line. Journal of Physiology 493; 143-156

7) Isomoto S, Kondo C, Yamada M, Matsumoto S, Higashiguchi O, Horio Y, Matsuzawa Y, Kurachi Y (1996) A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel. The Journal of Biological Chemistry 271; 24321-24324

8) Kurachi Y, Takahashi N (1996) Molecular and functional heterogeneity of inward rectifier potassium channels in brain and heart. Journal of Cardiac Failure 2(4S);S59-S62

9) Takumi T, Tsuji L, Kondo C, Takahashi N, Morishige K, Copeland NG, Gilbert DJ, Jenkins NA, Kurachi Y. (1996) Assignment of the murine inward rectifier potassium channel Irk2 (Kir2.2) gene to the central region of mouse chromosome 11. Genomics 37; 270-272

10) Kondo C, Isomoto S, Matsumoto S, Yamada M, Horio Y, Yamashita S, Takemura-Kameda K, Matsuzawa Y, Kurachi Y. (1996) Cloning and functional expression of a novel isoform of ROMK inwardly rectifying ATP-dependent K+ channel, ROMK6 (Kirl.lf). FEBS Letters 399; 122-126

11) Hosoya Y, Yamada M, Ito H, Kurachi Y (1996) A functional model for G protein activation of the muscarinic K+ channel in guinea pig atrial myocytes. Journal of General Physiology108; 485-495

12) Hazama H, Nakajima T, Hamada E, Omata M, Kurachi Y. (1996) Neurokinin a and Ca2+ current induce Ca2+ -activated Cl- currents in guinea-pig tracheal myocytes. Journal of Physiology 492(2); 377-393

13) Nakajima T, Hazama H, Hamada E, Shen-Nan Wu, Igarashi K, Yamashita T, Seyama Y, Omata M, Kurachi Y (1996) Endothelin-1 and vasopressin activate Ca2+-permeable non-selective cation channels in aortic smooth muscle cells: mechanism of receptor-mediated Ca2+ influx. Journal of Molecular and Cellular Cardiology 28; 707-722

14) Takahashi N, Morishige K, Yamada M, Kondo C, Kurachi Y. (1996) Molecular and functional heterogeneity of inward rectifier potassium channels in the brain and heart. "Molecular and Cellular Mechanisms of Cardiovascular Regulation" (Eds, M.Endoh, M.Morada, H.Scholz, T.Iijima), p59-67, Springer-Verlag Tokyo. 


15) Morad M, Ebashi S, Trautwein W, Kurachi Y. eds. (1996) Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters. Kluwer Academic Publishers, Dordrecht/Boston/London   

16) Kurachi Y. (1996) Muscarinic and purinergic regulation of cardiac K+ channels. In "Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters" (Eds M. Morad, S.Ebashi, W.Trautwein and Y.Kurachi), p177-186, Kluwer Academic Publishers Dordrecht/Boston/London

17) Kurachi Y, Terzic A, Findlay I. (1996) Pharmacological regulation of the cardiac ATP-sensitive K+ channel . In "Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters" (Eds M. Morad, S.Ebashi, W.Trautwein and Y.Kurachi), p305-312, Kluwer Academic Publishers.

18) Terzic A, Kurachi Y. (1996) Regulation of intracellular protons: Role of Na/H exchange in cardiac myocytes. In "Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters" (Eds M. Morad, S.Ebashi, W.Trautwein and Y.Kurachi), p555-561, Kluwer Academic Publishers.

19) Iain M. Robinson, Yamada M, Mariano Carrion-Vazquez, Vanda A. Lennon, Julio M. Fernandez(1996) Specialized release zones in chromaffin cells examined with pulsed-laser imaging. Cell Calcium 20(2) 181-201.


1995年度

1) Yamada M, Kurachi Y (1995) Spermine gates inward-rectifying muscarinic but not ATP-sensitive K+ channels in rabbit atrial myocytes: intracellular substance-mediated mechanism of inward rectification. The Journal of Biological Chemistry 270; 9289-9294

2) Yamashita T, Nakajima T, Hamada E, Hazama H, Omata Y, Kurachi Y (1995) Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. The Journal of Pharmacology and Experimental Therapeutics 274; 315-321

3) Hazama H, Nakajima T, Hisada T, Hamada E, Omata M, Kurachi Y (1995) Effects of azelastine on membrane currents in tracheal smooth muscle cells isolated from the guinea-pig. European Journal of Pharmacology 259; 143-150

4) Takumi T, Ishii T, Horio Y, Morishige K, Takahasi N, Yamada M, Yamashita T, Kiyama H, Sohmiya K, Nakanishi S. Kurachi Y (1995) A novel ATP-dependent inward rectifier potassium channel is expressing predominantly in glial cells. The Journal of Biological Chemistry 270; 16339-16346

5) Nakajima T, Hazama H, Hamada E, Omata M, Kurachi Y (1995) Ionic basis of neurokinin-A-induced depolarization in single smooth muscle cells isolated from guinea-pig trachea. Pflügers Archiv European Journal of Physiology 430; 552-562

6) Inanobe A, Morishige K, Takahashi N, Ito H, Yamada M, Takumi T, Nishina H, Takahashi K, Kanaho Y, Katada T, Kurachi Y (1995) Gbg directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GlRK1. Biochemical and Biophysical Research Communications 212; 1022-1028

7) Inanobe A, Ito H, Ito M, Hosoya Y, Kurachi Y (1995) Immunological and physical characterization of the brain G protein-gated muscarinic potassium channel. Biochemical and Biophysical Research Communications 217; 1238-1244

8)Nakajima T, Kitazawa T, Hamada E, Hazama H, Omata M, Kurachi Y (1995) 17b-Estradiol inhibits the voltage-dependent L-type Ca2+ currents in aortic smooth muscle cells. European Journal of Pharmacology 294; 625-635

9) Shen WK, Kurachi Y. (1995) Mechanisms of adenosine-mediated actions of cellular and clinical cardiac electrophysiology. Mayo Clin Proc 70; 274-291

10) Terzic A, Jahangir A, Kurachi Y (1995) Cardiac ATP-sensitive K+ channels: regulation by intracellular nucleotides and K+ channel-opening drugs. American Journal of Physiology 269; C525-C545

11) Kurachi Y (1995) G protein regulation of cardiac muscarinic potassium channel. American Journal of Physiology 269; C821-C830

このページのトップに戻る