新着情報




1999年度

1) Inanobe A, Yoshimoto Y, Horio Y, Morishige K, Hibino H, Matsumoto S, Tokunaga Y, Maeda T, Hata Y, Takai Y, Kurachi Y. Characterization of G-protein-gated K+ channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra (1999). Journal of Neuroscience, 19 (3): 1006-1017.

2) Yoshimoto Y, Fukuyama Y, Horio Y, Inanobe A, Gotoh M, Kurachi Y. (1999) Somatostatin induces hyperpolarization in pancreatic islet a cells by activating a G protein-gated K+ channel. FEBS Letters 444: 265-269.

3) Morishige K, Inanobe A, Yoshimoto Y, Kurachi H, Murata Y, Tokunaga Y, Maeda T, Maruyama Y, Kurachi Y. (1999) Secretagogue-induced exocytosis recruits G protein-gated K+ channels to plasma membrane in endocrine cells. Journal of Biological Chemistry, 274 (12): 7969-7974.

4) Hibino H, A. Terzic, Inanobe A, Horio Y, Kurachi Y. (1999) Regulation of ion channels by membrane proteins. Potassium Ion Channels " Molecular structure, function, and disease" (Y. Kurachi, L. Y. Jan and M. Lazdunski, eds.). Current Topics in Membranes 46, pp243-272.

5) Hosoya Y, Kurachi Y. (1999) Functional analyses of G-protein activation of cardiac KG channel. Potassium Ion Channels " Molecular structure, function, and disease" (Y. Kurachi, L. Y. Jan and M. Lazdunski, eds.). Current Topics in Membranes 46, pp355-369.

6) Yamada M, Satoh E, Kondo C, V.P.Repunte, Kurachi Y. (1999) Molecular structure and function of cardiovascular ATP-sensitive potassium channels. Potassium Ion Channels " Molecular structure, function, and disease" (Y. Kurachi, L. Y. Jan and M. Lazdunski, eds.). Current Topics in Membranes 46, pp387-415.

7) Horio Y, Kurach Y. (1999) Glial inwardly rectifying potassium channels. Potassium Ion Channels " Molecular structure, function, and disease" (Y. Kurachi, L. Y. Jan and M. Lazdunski, eds.). Current Topics in Membranes 46, pp471-484.

8) Stephen J. Pieper, Alexis M. Fenton, Y. Kurachi, Win-Kuang Shen (1999) Bradykinin modulates arginine vasopressin-induced calcium influx in vascular myocytes. International Journal of Cardiology 69, 191-200.

9) Vez P.Repunte, Nakamura H, Fujita A, Horio Y, Ian Findlay, Lutz Pott, Kurachi Y. (1999) Extracellular links in Kir subunits control the unitary conductance of SUR/Kir6.0 ion channels. EMBO Journal 18 (12), 3317-3324.

10) Chachin M, Katayama Y, Yamada M, Horio Y, Ohmura T, Kitagawa H, Uchida S, Kurachi Y. (1999) Epinastine, a nonsedating histamine H1 receptor antagonist, has a negligible effect on HERG channel. European Journal of Pharmacology 374, 457-460.

11) Hibino H. Horio Y. Fujita A. Inanobe A. Doi K. Kubo T. Kurachi Y. (1999) Expression of an inwardly rectifying K+ channel, Kir4.1, in satellite cells of rat cochlear ganglia. American Journal Physiology 277 (Cell Physiol. 46): C638-C644.

12) Fujita A , Horio Y, Soren Nielsen, Erlend A. Nagelhus, Hata F, Ole Petter Ottersen, Kurachi Y. (1999) High-resolution immunogold cytochemistry indicates that AQP4 is concentrated along the basal membarne of parietal cell in rat stomach. FEBS Letters 459: 305-309.

13) Kusaka S, Horio Y, Fujita A, Matsushita K, Inanobe A, Gotow T, Uchiyama Y, Tano Y, Kurachi Y. (1999) Expression and polarized distribution of an inwardly rectifying K+ channel, Kir4.1, in rat retinal pigment epithelium. Journal of Physiology 520 (2): 373-381.

14) Inanobe A, Horio Y, Fujita A, Tanemoto M, Hibino H, Inageda K, Kurachi Y. (1999) Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis. Journal of Physiology 521 (1): 19-30.




1998年度

1) Kim D, Fujita A, Horio Y, Kurachi Y. (1998) Cloning and functional expression of a novel cardiac two-pore background K+ channel (cTBAK-1). Circ Res, 82; 513-518.

2) Tada Y, Horio Y, Kurachi Y. (1998) Inwardly Rectifying K+ channel in retinal Muller cells: Comparison with the KAB-2/kir4.1 channel expressed in HEK293T Cells. Japanese Journal of Physiology, 48, 71-80.

3) Okuyama Y, Yamada M, Kondo C, Sato E, Isomoto S, Shindo T, Horio Y, Kitakase M, Hori M, Kurachi Y. (1998) The effects of nucleotides and potassium channel openers on the SUR2A/Kir6.2 complex K+ channel expressed in a mammalian cell line, HEK293T cells. Pflügers Arch- Eur J. Physiol , 435: 595-603.

4) Shindo T, Yamada M, Isomoto S, Horio Y, Kurachi Y. (1998) SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. British Journal of Pharmacology 124, 985-991.

5) Hambrock A, Loffler-Walz C, Kurachi Y, Quas U. (1998) Mg2+ and ATP dependence of KATP channel modulator binding to the recombinant sulphonylurea receptor, SUR2B. British Journal of Pharmacology 125, 577-583.

6) Mouri T, Kittaka N, Horio Y, Copeland N.G., Gilbert D.J., Jenkins N.A., Kurachi Y. (1998) Assignment of mouse inwardly rectifying potassium channel Kcnj16 to the distal region of mouse chromosome 11. Genomics 54, 181-182.

7) Fujita A, Horio Y, Copeland N.G., Gilbert D.J., Jenkins N.A. and Kurachi Y. (1998) Assignment of mouse cardiac two-pore background K+ channel Gene (Kcnk4) to the proximal region of mouse chromosome 5. Genomics 54, 183-184.

8) Satoh E, Yamada M, Kondo C, Vez P.Repunte, Horio Y, Iijima T, Kurachi Y. (1998) Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil. Journal of Physiology 511.3 663-674.

9) Kondo C, Vez P. Repunte, Sato E, Yamada M, Horio Y, Masuzawa Y, Lutz P, Kurachi Y. (1998) Chimeras of Kir6.1 and Kir6.2 reveal structural elements involved in spontaneous opening and unitary conductance of the ATP-sensitive K+ channels. Receptors and Channels, 6, 129-140.

10) Yamada M, Inanobe A, and Kurachi Y. (1998) G Protein regulation of potassium ion channels. Pharmacological, Reviews 50(4), 723-757.

11) Yakushigawa H, Tokunaga Y, Inanobe A, Kani K, Kurachi Y and Maeda T. (1998) A novel junction-like membrane complex in the optic nerve astrocyte of the Japanese Macaque with a possible relation to a potassium channel. Anat. Rec. 250:465-474.

12) Ohta Y, Tanizawa Y, Inoue H, Hosaka T, Ueda K, Matsutani A, Repunte VP, Yamada M, Kurachi Y, Bryan J, Aguilar-Bryan L,Permutt MA and Oka Y. (1998) Identification and functional analysis of sulfonylurea receptor I variants in Japanese patients with NIDDM. Diabetes 47: 476-781.




1997年度

1) Ito H, Tsuchimochi H, Tada Y, Kurachi Y (1997) Phosphorylation-independent inhibition by intracellular cyclic nucleotides of brain inwardly rectifying K+ current expressed in Xenopus oocytes. FEBS Letters 402; 12-16.

2) Yamada M, Isomoto S, Matsumoto S, Kondo C, Shindo T, Horio Y, Kurachi Y. (1997) Sulfonylurea receptor 2B and Kir6.1 form a sulfonilurea-sensitive but ATP-insensitive K+ channel. Journal of Physiology 499.3; 715-720.

3) Horio Y, Hibino H, Inanobe A, Yamada M, Ishii M, Tada Y, Sato E, Hata Y, Takai Y, Kurachi Y. (1997) Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1. by an anchoring protein, PSD-95/SAP 90 family. The Journal of Biological Chemistry,272 (20); 12885-12888.

4) Hibino H, Horio, Inanobe A, Doi K, Yamada M, Gotow T, Uchiyama ・ Kubo T, Kurach Y. (1997) An ATP-dependent inwardly rectifying potassium channel, KAB-2 (Kir4.1), in cochlear stria vascularis of inner ear: its specific subcellular localization and correlation with the formation of endocochlear potential. The Journal of Neuroscience, 17(12): 4711-4721

5) Morishige K, Takumi T, Takahashi N, Koyama H, Kurachi H, Miyake A, Murata Y, Neal G.Copeland, Debra J. Gilbert, Nancy A. Jenkins, Kurachi Y. (1997) Assignment of the murine inwardly rectifying potassium channel IRK3 gene (Kcnj4)to the mouse Chromosome 15. Mammalian Genome 8: 699-700.

6) Takumi T, Fujiwake H, Kurachi Y. (1997) A dye terminator method for automated DNA sequencing using four fluorescent dideoxynucleosides and thermal cycling. Analytical Sciences, 13: 735-739.

7) Isomoto S. Horio Y. Matsumoto S. Kondo C. Yamada M. Gilbert D.J. Copeland N.G. Jenkins N.A. Kurachi Y. (1997) Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse chromosome. Mammalian Genome 8: 790-791.

8) Ishii M, Horio Y, Tada Y, Hibino H, Inanobe A, Ito M, Yamada M, Gotow T, Uchiyama Y, Kurachi Y. (1997) Expression and clustered distribution of an inwardly rectifying potassium channel, KAB-2/Kir4.1, on mammalian retinal Muller cell membrane: Their Regulation by insulin and laminin signals. The Journal of Neuroscience, 17(20):7725-7735.

9) Tada Y, Horio Y, Takumi T, Terayama M, Tsuji L, Copeland N.G., Jenkins N.A, Kurachi Y. (1997) Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1(Kcnj10) gene to the distal region of mouse chromosome 1. Genomics 45: 629-630.

10) Ohta Y, Tanizawa Y, Inoue H, Hosaka T, Ueda K, Matsutani A, V.P. Repunte, Yamada M, Kurachi Y, J. Bryan, L.A. Bryan, M.A. Permutt, Oka Y. (1998) Identification and functional analysis of sulfonylurea receptor 1 variants in japanese patients with NIDDM. Diabetes 47: 476-481.

11) Isomoto S, Kondo C, Kurachi Y (1997) Inwardly rectifying potassium channels: their molecular heterogeneity and function. Japanese Journal of Physiology 47:11-39.

12) Isomoto S, Kurachi Y (1997) Function, regulation, pharmacology and molecular structure of ATP-sensitive K+ channels in the cardiovascular system. Journal of Cardiovascular Electrophysiology. 8:1431-1446.




1996年度

1) Isomoto S, Kondo C, Takahashi N, Matsumoto S, Yamada M, Takumi T, Horio Y, Kurachi Y (1996) A novel ubiquitously-distributed isoform of GIRK2 (GIRK2B) enhances GIRK1-expression of the G-protein-gated K+ current in Xenopus oocytes. Biochemical and Biophysical Research Communications 218; 286-291.

2) Horio Y, Morishige K, Takahashi N, Kurachi Y (1996) Differential distribution of classical inwardly rectifying potassium channel mRNAs in the brain; comparison of IRK2 with IRK1 and IRK3. FEBS Letters 379; 239-243.

3) Morishige K, Inanobe A, Takahashi N, Yoshimoto Y, Kurachi H, Miyake A, Tokunaga Y, Maeda T, Kurachi Y (1996) G Protein-gated K+ channel (GIRK1) protein is expressed presynaptically in the paraventricular nucleus of the hypothalamus. Biochemical and Biophysical Research Communications 220; 300-305

4) Terzic A, Kurachi Y (1996) Actin microfilament-distrupters enhance KATP channel opening in patches from guinea-pig cardiomyocytes. Journal of Physiology 492.2; 395-404

5) Ito M, Inanobe A, Horio Y, Hibino H, Isomoto S, Ito H, Mori K, Tonosaki A, Tomoike H, Kurachi Y (1996) Immunolocalization of an inwardly rectifying K+ channel, KAB-2 (Kir4.1), in the basolateral membrane of renal distal tubular epithelia. FEBS Letters 388; 11-15

6) Yamashita T, Horio Y, Yamada M, Takahashi N, Kondo C, Kurachi Y (1996) Competition between Mg2+ and spermine for a cloned IRK2 channel expressed in a human cell line. Journal of Physiology 493; 143-156

7) Isomoto S, Kondo C, Yamada M, Matsumoto S, Higashiguchi O, Horio Y, Matsuzawa Y, Kurachi Y (1996) A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel. The Journal of Biological Chemistry 271; 24321-24324

8) Kurachi Y, Takahashi N (1996) Molecular and functional heterogeneity of inward rectifier potassium channels in brain and heart. Journal of Cardiac Failure 2(4S);S59-S62

9) Takumi T, Tsuji L, Kondo C, Takahashi N, Morishige K, Copeland NG, Gilbert DJ, Jenkins NA, Kurachi Y. (1996) Assignment of the murine inward rectifier potassium channel Irk2 (Kir2.2) gene to the central region of mouse chromosome 11. Genomics 37; 270-272

10) Kondo C, Isomoto S, Matsumoto S, Yamada M, Horio Y, Yamashita S, Takemura-Kameda K, Matsuzawa Y, Kurachi Y. (1996) Cloning and functional expression of a novel isoform of ROMK inwardly rectifying ATP-dependent K+ channel, ROMK6 (Kirl.lf). FEBS Letters 399; 122-126

11) Hosoya Y, Yamada M, Ito H, Kurachi Y (1996) A functional model for G protein activation of the muscarinic K+ channel in guinea pig atrial myocytes. Journal of General Physiology108; 485-495

12) Hazama H, Nakajima T, Hamada E, Omata M, Kurachi Y. (1996) Neurokinin a and Ca2+ current induce Ca2+ -activated Cl- currents in guinea-pig tracheal myocytes. Journal of Physiology 492(2); 377-393

13) Nakajima T, Hazama H, Hamada E, Shen-Nan Wu, Igarashi K, Yamashita T, Seyama Y, Omata M, Kurachi Y (1996) Endothelin-1 and vasopressin activate Ca2+-permeable non-selective cation channels in aortic smooth muscle cells: mechanism of receptor-mediated Ca2+ influx. Journal of Molecular and Cellular Cardiology 28; 707-722

14) Takahashi N, Morishige K, Yamada M, Kondo C, Kurachi Y. (1996) Molecular and functional heterogeneity of inward rectifier potassium channels in the brain and heart. "Molecular and Cellular Mechanisms of Cardiovascular Regulation" (Eds, M.Endoh, M.Morada, H.Scholz, T.Iijima), p59-67, Springer-Verlag Tokyo. 


15) Morad M, Ebashi S, Trautwein W, Kurachi Y. eds. (1996) Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters. Kluwer Academic Publishers, Dordrecht/Boston/London   

16) Kurachi Y. (1996) Muscarinic and purinergic regulation of cardiac K+ channels. In "Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters" (Eds M. Morad, S.Ebashi, W.Trautwein and Y.Kurachi), p177-186, Kluwer Academic Publishers Dordrecht/Boston/London

17) Kurachi Y, Terzic A, Findlay I. (1996) Pharmacological regulation of the cardiac ATP-sensitive K+ channel . In "Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters" (Eds M. Morad, S.Ebashi, W.Trautwein and Y.Kurachi), p305-312, Kluwer Academic Publishers.

18) Terzic A, Kurachi Y. (1996) Regulation of intracellular protons: Role of Na/H exchange in cardiac myocytes. In "Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters" (Eds M. Morad, S.Ebashi, W.Trautwein and Y.Kurachi), p555-561, Kluwer Academic Publishers.

19) Iain M. Robinson, Yamada M, Mariano Carrion-Vazquez, Vanda A. Lennon, Julio M. Fernandez(1996) Specialized release zones in chromaffin cells examined with pulsed-laser imaging. Cell Calcium 20(2) 181-201.




1995年度

1) Yamada M, Kurachi Y (1995) Spermine gates inward-rectifying muscarinic but not ATP-sensitive K+ channels in rabbit atrial myocytes: intracellular substance-mediated mechanism of inward rectification. The Journal of Biological Chemistry 270; 9289-9294

2) Yamashita T, Nakajima T, Hamada E, Hazama H, Omata Y, Kurachi Y (1995) Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. The Journal of Pharmacology and Experimental Therapeutics 274; 315-321

3) Hazama H, Nakajima T, Hisada T, Hamada E, Omata M, Kurachi Y (1995) Effects of azelastine on membrane currents in tracheal smooth muscle cells isolated from the guinea-pig. European Journal of Pharmacology 259; 143-150

4) Takumi T, Ishii T, Horio Y, Morishige K, Takahasi N, Yamada M, Yamashita T, Kiyama H, Sohmiya K, Nakanishi S. Kurachi Y (1995) A novel ATP-dependent inward rectifier potassium channel is expressing predominantly in glial cells. The Journal of Biological Chemistry 270; 16339-16346

5) Nakajima T, Hazama H, Hamada E, Omata M, Kurachi Y (1995) Ionic basis of neurokinin-A-induced depolarization in single smooth muscle cells isolated from guinea-pig trachea. Pflügers Archiv European Journal of Physiology 430; 552-562

6) Inanobe A, Morishige K, Takahashi N, Ito H, Yamada M, Takumi T, Nishina H, Takahashi K, Kanaho Y, Katada T, Kurachi Y (1995) Gbg directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GlRK1. Biochemical and Biophysical Research Communications 212; 1022-1028

7) Inanobe A, Ito H, Ito M, Hosoya Y, Kurachi Y (1995) Immunological and physical characterization of the brain G protein-gated muscarinic potassium channel. Biochemical and Biophysical Research Communications 217; 1238-1244

8)Nakajima T, Kitazawa T, Hamada E, Hazama H, Omata M, Kurachi Y (1995) 17b-Estradiol inhibits the voltage-dependent L-type Ca2+ currents in aortic smooth muscle cells. European Journal of Pharmacology 294; 625-635

9) Shen WK, Kurachi Y. (1995) Mechanisms of adenosine-mediated actions of cellular and clinical cardiac electrophysiology. Mayo Clin Proc 70; 274-291

10) Terzic A, Jahangir A, Kurachi Y (1995) Cardiac ATP-sensitive K+ channels: regulation by intracellular nucleotides and K+ channel-opening drugs. American Journal of Physiology 269; C525-C545

11) Kurachi Y (1995) G protein regulation of cardiac muscarinic potassium channel. American Journal of Physiology 269; C821-C830

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