新着情報


新学術領域研究「多階層生体機能学 HD Physiology」
第二回国際シンポジウム
プログラム

開催日時:平成25年(2013年)6月28日(金曜日)・29日(土曜日)
開催場所:〒100-0005 東京都千代田区丸の内2-1-1 明治安田生命ビル
丸の内 My Plaza Hall
アクセス

プログラム(確定)(2013年6月12日更新)
---
Day 1st: Friday June 28, 2013
9:15-10:00 Registration
10:00-10:10 Opening Remark:
Yoshihisa Kurachi (HDP Project Director, Osaka University)
10:10-10:20 Welcome Address:
Himeno Ryutaro (RIKEN)

I. HD-Physiology Overview
10:25-11:00
Hiroaki Kitano (HDP, The Systems Biology Institute, OIST) “HD-Physiology Project -A Japanese Flagship Physiological Modeling Project-

II. The Interdisciplinary Researches in Pushing the Integrative Life Science Field
1.Systems Biology Platform, Software & Tools

Chairs: Yoshiyuki Asai & Akira Funahashi
11:00-11:20
Samik Ghosh (The Systems Biology Institute) “Garuda: An Open, Community Platform for Biomedical Research
11:20-11:40
Akira Funahashi (HDP, Keio University) “CellDesigner 4.3: A Modeling Tool for Biochemical Networks
11:40-12:00
Yoshiyuki Asai (HDP, OIST) “PhysioDesigner and Flint: Modeling and Simulation Tools for Multilevel Physiological Systems

12:00-13:10 Lunch Break

2. Quantitative Biology
Chairs: Kazuhiro Aoki & Noriko Hiroi
13:10-13:30
Kazuhiro Aoki (HDP, Kyoto University) “Quantitative Measurement of In Vivo Dissociation Constant with Fluorescence Cross-Correlation Spectroscopy
13:30-13:50
Taichiro Tomida (University of Tokyo) “How Does MAPK Signal Code Environment? : Imaging of Kinase Activity in C.elegans
13:50-14:10
Philip Bittihn (Max Planck Institute) “The Role of Cardiac Structural Heterogeneity during Electric-Field Stimulation
14:10-14:30
Urs Frey (RIKEN QBiC) “CMOS-Based Microelectrode Arrays for High-Resolution Electrophysiology of the Retina

Special Lecture
Chair: Hiroyuki Kagechika
14:30-15:05
Michiyuki Matsuda (Kyoto University) “FRET Biosensors as the Tools to Understand the Heterogeneity of Glioma Cells in a Quantitative Manner

15:05-15:20 Break

3.Challenge of Genome- and Protein-Informatics
Chairs: Kengo Kinoshita & Akira Amano
15:20-15:45
Masao Nagasaki (Tohoku University) “Genome Explosion and its Data Management and Bioinformatics on Supercomputer: the Prospective Genome Chort Study in Japan
15:45-16:10
Haruki Nakamura (Osaka University) “Prediction of Protein-Protein Interactions
Special Lecture
16:10-16:45
Ryutaro Himeno (RIKEN) “Development of a High Performance Software Package in Life Science for K Computer and its Applied Results as a Grand Challenge

16:45-16:55 Break

Plenary Lecture
Chair: Ryuji Inoue
16:55-17:30
Toshio Yanagida (Osaka University, RIKEN QBiC, NICT CiNet) “Design of New Measurement and Analysis Techniques to Study Complex Biological Systems

4.Systems Pharmacology
Chairs: Hiroshi Suzuki & Shigehiro Ohdo
17:30-17:55
Donald Mager (University at Buffalo SUNY) “Translational Systems Pharmacology Modeling of Anti-CD20-Based Combinatorial Chemotherapeutic Regimens
17:55-18:20
Hiroshi Suzuki (HDP, University of Tokyo Hospital) “Systems Pharmacological Approaches to Analyze TKI Toxicity
Special Lecture
18:20-18:45
Darrell Abernethy (US Food and Drug Administration) “A Systems Approach to Characterize and Predict Tyrosine Kinase Inhibitor-Induced Cardiotoxicity

19:30-21:30 Reception at the Hotel Grand Arc Hanzomon


Day 2nd: Saturday June 29, 2013
9:00-9:30 Registration
9:30-9:50: Speech:
Kiyoshi Kurokawa (National Graduate Institute for Policy Studies)

III. HD Physiology I. Logics for Integration of Molecular and Cellular Function
1.Transportsome

Chairs: Yoshikatsu Kanai & Hiroyuki Kusuhara
9:55-10:15
Yoshikatsu Kanai (Osaka University) “ “Transportsome”, the Multi-Molecular Assemblies for Transport-Transport and Transport-Metabolism Couplings
10:15-10:35
Yasuo Mori (Kyoto University) “Receptor Signaling Integration by TRP Channelsomes
Special Lecture
10:35-11:10
Ernest Wright (University of California Los Angeles) “Human Biology of Active Glucose Transport

11:10-11:25 Break

2.Spatio-temporal integration of intracellular signal transduction
Chairs: Ryuji Inoue & Satomi Adachi-Akahane
Special Lecture
11:25-11:50
Dermot Cooper (University of Cambridge) “Calcium-Sensitive Adenylyl Cyclases – Key Integrators of cAMP- and Ca2+-Signaling
11:50-12:10
Yoshihiro Ishikawa (HDP, Yokohama City University) “Regulation of Cardiac Function by cAMP Signal
12:10-12:30
Ayako Takeuchi (HDP, Kyoto University) “Contribution of Mitochondrial Na+-Ca2+ Exchanger, NCLX, in Making the Cardiac Rhythmicity. A Combination Study of Experiments and Simulations
12:30-12:50
Asuka Hatano (University of Tokyo) “A 3D Integrated Model of Cardiomyocytes Revealed the Importance of Intracellular Structure for the Maintenance of Contractile Function

12:50-13:00 Group Photo
13:05-13:50 Lunch Break
13:50-14:35 Poster Session

IV. HD Physiology II. Logics for Integration of Cellular Function and Tissue Organ Function
1.High Definition Physiology in the Heart, from Ion Channel to Organ

Chairs: Mark R Boyett & Haruo Honjo
Special Lecture
14:40-15:10
Mark R Boyett (University of Manchester) “High Definition Mapping of the Cardiac Conduction System
15:10-15:30
Shin Inada (HDP, National Cerebral and Cardiovascular Center) “Multi-Scale Simulation Studies of Excitation Conduction from the Sinoatrial Node to the Ventricles in the Heart
15:30-15:50
Takeshi Aiba (HDP, National Cerebral and Cardiovascular Center) “Biophysical Properties of Na Channel in the S5-S6 High Risk LQT3 Mutations of the Long QT Syndrome
15:50-16:10
Yukiomi Tsuji (Nagasaki University) “Ventricular Fibrillation Storm and Ca2+/Calmodulin-Dependent Protein Kinase II

16:10-16:25 Break

Special Lecture
Chair: Hiroshi Suzuki
16:25-16:55
Hiroshi Tanaka (Tokyo Medical and Dental University) “Systems Molecular Medicine for Cancer Metastasis and Drug Discovery

Plenary Lecture
Chair: Hiroaki Kitano
16:55-17:30
Adriano M. Henney (The Virtual Liver Network, University of Heidelberg) “The Virtual Liver: A Multidisciplinary, Multilevel Challenge for Systems Biology

17:30-17:40 Closing Remarks:
Hiroaki Kitano (HDP Project Co-Director, The Systems Biology Institute, OIST)