Integrative Physiology
Graduate School of Medicine & Frontier Biosciences, Osaka University 生命を支える電気信号:分子からシステムへ
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Outcome - Old System Physiology group


三好智満 (2012) 網膜の情報処理. Clinical Neuroscience 30(8), 887-889. (Japanese)

Nishitani Y, Hosokawa C, Mizuno-Matsumoto Y, Miyoshi T, Sawai H, Tamura S.(2012) Detection of m-sequences from spike sequence in neuronal networks. Comput Intell Neurosci. Article ID 2012:862579.

Tamura S, Miyoshi T, Sawai H, Yuko Mizuno-Matsumoto.(2012) Random Bin for Analyzing Neuron Spike Trains. Comput Intell Neurosci. Article ID 2012:153496.

Fujikado T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Ikuno Y, Nishida K, Kishima H, Maruo T, Sawai H, Miyoshi T, Osawa K, Ozawa M. (2012) Clinical trial of chronic implantation of suprachoroidal-transretinal stimulation system for retinal prosthesis. Sensors and Materials. 24(4) 181-187.

Aoki, R., Okamura, S., Sakimoto, T., Yoshida, K. and Sasaki, H. (2012) Event-related potential investigation of different neural pathways for face and pattern perceptions in the human brain. J. Biomedical Science and Engineering, 5, 174-179.


Mihashi T, Okawa Y, Miyoshi T, Kitaguchi Y, Hirohara Y and Fujikado T (2011) Comparing Retinal Reflectance Changes Elicited by Transcorneal Electrical Retinal Stimulation with Those of Optic Chiasma Stimulation in Cats. Jpn J Ophthalmol 55:49-56.

Sasaki, H., Nagata, T, and Inoue, T. (2011) Functional role of the extrageniculostriate system in visual perception. In James L. McGreeley (Ed.) Encyclopedia of Eye Research. Nova Science Publishers, New York, pp. 1737-1777.


Okazaki Y., Sawai H., and Yagi T. (2010) In vivo optical measurements of cortical response evoked by electrical stimulation in the mouse visual cortex. ME and bio cybernetics 109(460), 119-122.

Morimoto, T., Miyoshi, T., Sawai, H., Fujikado, T. (2010) Optimal parameters of transcorneal electrical stimulation (TES) to be neuroprotective of axotomized RGCs in adult rats. Experimental Eye Research 90 (2): 285-291.

Sasaki, H. (2010) Frontal midline theta rhythm: Comment on Chan and Hsu. Perceptual and Motor Skills, 110, 1010-1012.

Sasaki, H. (2010) Dual processing model of visual information: Cortical and subcortical processing. Nova Science Publishers, New York.


Oono S, Kurimoto T, Nakazawa T, Miyoshi T, Okamoto N, Kashimoto R, Tagami Y, Ito Y, Mimura O. (2009) Pyroglutamic acid promotes survival of retinal ganglion cells after optic nerve injury. Curr Eye Res. 34(7):598-605.

Tagami, Y., Kurimoto, T., Miyoshi, T., Morimoto, T., Sawai, H., Mimura, O. (2009) Axonal regeneration induced by repetitive electrical stimulation of crushed optic nerve in adult rats. Japanese Journal of Ophthalmology 53 (3): 257-266.

Sasaki, H. (2009)Cortical and the subcortical processing of color: A dual processing model of visual inputs. In: Skusevich, D. and Matikas, P. (Eds.), Color perception: physiology, processes and analysis. Nova Science Publishers, New York, pp. 1-50.

Aoki, R., Wake, H., Sasaki, H. and Agata, K. (2009) Recording and spectrum analysis of the planarian electroencephalogram. Neuroscience, 159: 908-914.


Okazaki Y, Morimoto T, Sawai H. (2008) Parameters of optic nerve electrical stimulation affecting neuroprotection of axotomized retinal ganglion cells in adult rats. Neurosci Res. 61(2):129-35.

Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T. (2008) Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. Nat Neurosci. 11(8):923-931.

Kashimoto, R., Kurimoto, T., Miyoshi, T., Okamoto, N., Tagami, Y., Oono, S., Ito, Y., Mimura, O. (2008) Cilostazol promotes survival of axotomized retinal ganglion cells in adult rats. Neurosci. Lett., 436, 116-119.

Sasaki, H., Sakane, S., Ishida, T., Todorokihara, M., Kitamura, T. and Aoki, R. (2008) Suprathreshold stochastic resonance in visual signal detection. Behav. Brain Res, 193: 152-155.

Sasaki, H., Nagata, T, and Inoue, T. (2008) Functional role of the extrageniculostriate system in visual perception, In: Nilsson, I. L. and Lindberg, W. V. (Eds.), Visual perception: New research. Nova Science Publishers, New York, pp. 49-89.

Sasaki, H., Sakane, S., Ishida, T., Todorokihara, M., Kitamura, T., and Aoki, R. (2008) Subthreshold noise facilitates the detection and discrimination of visual signals. Neurosci Lett., 436: 255-258.

澤井元、三好智満、不二門尚、田野保雄(2008) 「人工感覚器―最近の進歩」人工臓器 37 (3):163-167. (査読無し)


Tanida M, Shen J, Horii Y, Matsuda M, Kihara S, Funahashi T, Shimomura I, Sawai H, Fukuda Y, Matsuzawa Y, Nagai K. Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats. Exp Biol Med (Maywood). 232(3):390-397.

Okawa Y, Fujikado T, Miyoshi T, Sawai H, Kusaka S, Mihashi T, Hirohara Y, Tano Y. Optical imaging to evaluate retinal activation by electrical currents using suprachoroidal-transretinal stimulation. Invest Ophthalmol Vis. Sci. 48(10): 4777-4784.

Fujikado T, Sawai H, Tano Y. Artificial vision: vision of a newcomer Artificial Sight: Basic Research, Biomedical Engineering, and Clinical Advances by Mark S. Humayun (Editor), James D. Weiland (Editor), Gerald Chader (Editor), Elias Greenbaum (Editor) Springer; 1 edition (November 19, 2007)pp31-45.

Morimoto, T., Fujikado, T., Choi, J.-S., Kanda, H., Miyoshi, T., Fukuda, Y., Tano, Y. (2007) Transcorneal electrical stimulation promotes the survival of photoreceptors and preserves retinal function in royal college of surgeons rats. Inv. Ophthalmol. Vis. Sci., 48, 4725-4732.

Sasaki, H. and Hanamoto, A. (2007) Shock sensitization and fear potentiation of auditory startle response in hamsters. Perceptual and Motor Skills 105: 862-871.

Sasaki, H., Morimoto, A., Nishio, A. and Matsuura, S. (2007) Right hemisphere specialization for color detection. Brain and Cognition 64, 282-289.

小山内実, 榮原晴子, 澤井元, 宋文杰, 八木哲也.(2007)「網膜電気刺激に対する網膜および視覚野応答の光学計測」 電気学会論文誌C 127: 1595-1602.

澤井元 (2007)「人工網膜とは」(若倉雅登、三村治編「視覚と眼球運動のすべて」pp110-113、メジカルビュー社、東京)

澤井元 (2007)「新しい刺激法を用いた人工網膜の開発」メディカルバイオ 4(5):36-41. (査読無し)

澤井元、三好智満、不二門尚、田野保雄 (2008) 人工視覚. 人工臓器, 37, 163-67.

三好智満 (2007) 網膜神経節細胞とその役割はなにか? 若倉雅登、三村治編「視覚と眼球運動のすべて」pp38-45, メジカルビュー社、東京(査読無し)


Tanida, M, Niijima, A, Shen, J, Yamada, S, Sawai, H, Fukuda, Y, Nagai, K.(2006) Dose-different effects of orexin-A on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats. Exp Biol Med 231:1616-1625

Kurimoto, T., Ishii, M., Tagami, Y., Nishimura, M., Miyoshi, T., Tsukamoto, Y., Mimura, O. (2006) Xylazine promotes axonal regeneration in crushed optic nerve of adult rats. Neuroreport, 17, 1525-1529.

Miyoshi, T., Kurimoto, T., Fukuda, Y. (2006) Attempts to restore visual function after optic nerve damage in adult mammals. Adv. Exp. Med. Biol. 557, 133-147. (Review、査読なし)

Sasaki, H., Todorokihara, M., Ishida, T., Miyachi, J., Kitamura, T., Aoki, R. (2006) Effect of noise on the contrast detection threshold in visual perception. Neurosci Lett., 408:94-97.


Nakauchi K, Fujikado T, Kanda H, Morimoto T, Choi J-S, Ikuno Y, Sakaguchi H, Kamei Motohiro, Ohji Masahito, Yagi Tohru, Nishimura S, Sawai H, Fukuda Yutaka , Tano Y. (2005) Transretinal Electrical Stimulation by an Intrascleral Multichannel Electrode Array in Rabbit Eyes. Graefe's Archive for Clinical and Experimental Ophthalmology, 243(2):169-174.

Tanida M, Niijima A, Fukuda Y, Sawai H, Tsuruoka N, Shen J, Yamada S, Kiso Y, Nagai K. (2005) Dose-dependent effects of L-carnosine on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats. Am J Physiol Regul Integr Comp Physiol. 288(2):R447-55.

Morimoto, T., Miyoshi, T., Matsuda, S., Fujikado, T., Tano, Y., Fukuda, Y. (2005) Transcorneal electrical stimulation rescues axotomized retinal ganglion cells by activating endogenous retinal IGF-1 system. Inv. Ophthalmol. Vis Sci. 46, 2147-2155.

岡崎祐香、森本壮、三好智満、澤井元 (2005)「サイトカインの神経生存活性」Clinical Neuroscience 23(8) :904-907. (査読無し)

平田雅之、加藤天美、三好智満、澤井元、貴島晴彦、谷直樹、吉峰俊樹 (2005) 大脳皮質刺激型電極. 臨床眼科. 59, 142-146.(査読無し)

三好智満 (2005) 視神経機能再生からみた中枢神経機能回復. 分子脳血管病学, 4, 32-37.(査読無し)


Kanda H, Morimoto T, Fujikado T, Tano Y, Fukuda Y, and Sawai H. (2004) Electrophysiological Studies on the Feasibility of Suprachoroidal-Transretinal Stimulation for Artificial Vision in Normal and RCS Rats. Invest Ophthalmol Vis Sci., 45(2): 560-566.

三好智満 (2004) 中枢神経系における軸索再生阻害因子研究の最近の動向. 神経眼科 21, 37-40.(査読無し)


Kurimoto, T., Miyoshi, T., Suzuki, A., Yakura, T., Watanabe, M., Mimura, O. and Fukuda, Y. (2003) Apoptotic death of beta cells after optic nerve transection in adult cats. J. Neurosci., 23, 4023-4028.

Kurimoto, T., Miyoshi, T., Yakura, T., Watanabe, M., Mimura, O. and Fukuda, Y. (2003) Difference in survival and axonal regeneration between alpha and beta types of cat retinal ganglion cells. In The neural basis of early vision, 151-155, 2003. (Conference Proceedings、査読無し)

Miyoshi, T., Morimoto, T., Yakura, T., Okazaki, Y., Kurimoto, T., Inoue, T., Sawai, H., Fujikado, T., Tano, Y. and Fukuda, Y. (2003) Survival promoting effect of electrical stimulation on axotomized retinal ganglion cells. In The neural basis of early vision, 156-159. (Conference Proceedings、査読無し)

Sasaki, H., Matsuura, S., Morimoto, A. and Fukuda, Y.(2003)Behavioral and Physiological study of color processing in human brain, In A. Kaneko (Ed.) The neural basis of early vision, Keio Univ. Int. Sympo. For Life Sci. and Med. II, Springer-Verlag, Tokyo, pp.240-244.

澤井元. (2003)「再生視神経の上位中枢への投射様式」眼科診療プラクティス, 6 (2): 90-93 (査読無し)

澤井元、神田寛行、森本壮、三好智満、不二門尚、福田淳 (2003)「人工視覚システムによる視覚機能の再生:網膜・皮質埋植装置の現状と課題」脳21 6(4):420-426 (査読無し)

三好智満、栗本拓治、森本壮 (2003) 網膜神経節細胞の変性過程と電気刺激の神経保護効果. 神経眼科, 20, 290-297.


Yakura T, Fukuda Y, and Sawai H. (2002) Effect of Bcl-2 overexpression on establishment of ipsilateral retinocollicular projection in mice. Neuroscience 110 (4)): 667-673.

Takao, M., Miyoshi, T., Watanabe, M. and Fukuda, Y. (2002) Changes in visual response properties of cat retinal ganglion cells within two weeks after axotomy. Exp. Neurol., 177, 171-182.

Morimoto, T., Miyoshi, T., Fujikado, T., Tano, Y. and Fukuda, Y. (2002) Electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo. Neuroreport, 13, 227-230.

澤井元、矢倉徹、岡崎祐香.(2002)「軸索切断による逆行性変性過程にグルタミン酸毒性は関与しているか」Molecular Medicine, 36: 80-86. (査読無し)

矢倉徹、澤井元.(2002)「生後発達過程における同側性網膜-上丘投射のrefinementのメカニズム」Molecular Medicine, 36: 175-184. (査読無し)

澤井元. (2002)「再生視神経の上丘支配様式-レチノトピーの再建について」Molecular Medicine, 36: 192-198. (査読無し)

矢倉徹、澤井元、福田淳.(2002)「哺乳類の視交叉-同側性視神経投射形成のメカニズムを中心に」 脳21, 5 (1): 14-18. (査読無し)

三好智満 (2002) 実験動物の視覚 -視神経の再生と視覚伝導路の再構築-. 比較眼科研究, 21, 115-121.(査読無し)

三好智満、森本壮 (2002) 網膜神経節細胞の変性・再生と細胞の電気活動. Molecular Medicine 39巻別冊「網膜・視神経の発生と再生(福田淳編)」pp.113-119, 中山書店.(査読無し)

佐々木仁(2002)再生視神経投射の行動学的視覚機能解析、Molecular Medicine 39巻別冊「網膜・視神経の発生と再生(福田淳編)」pp.199-208, 中山書店.(査読無し)


佐々木仁(2002)再生視神経投射の行動学的視覚機能解析、Molecular Medicine 39巻別冊「網膜・視神経の発生と再生(福田淳編)」pp.199-208, 中山書店.(査読無し)

- 2000

Takao, M., Morigiwa, K., Sasaki, H., Miyoshi, T., Shima, T., Nakanishi, S., Nagai, K. and Fukuda, Y. (2000) Impaired Behavioral Suppression by Light in Metabotropic Glutamate Receptor Subtype 6-deficient Mice. Neuroscience, 97, 779-787.

Takao, M., Wang, Y., Miyoshi, T., Fujita, I. and Fukuda Y. (2000) A New Intraretinal Recording System with Multiple-barreled Electrodes for Pharmacological Studies on Cat Retinal Ganglion cells. J. Neurosci. Methods, 97, 87-92.

三好智満, 福田淳 (2000) 視神経の再生. Clinical Neuroscience, 18, 1313-1316.(査読無し)

Inoue, T., Sasaki, H., Hosakawa, M. and Fukuda, Y. (2000) Axonal regeneration of mouse retinal ganglion cells by peripheral nerve transplantation; a quantitative stidy. Restor. Neurol. Neuroscience, 17: 23-29.