Publications

2007 Papers 2006 Papers 2005 Papers 2004 Papers
2003 Papers

2006 Papers

  1. Neurobiological studies of dementia-biological markers and neuroprotective strategies for Alzheimer disease
    Tanaka T, Isoe-Wada K, Yamamori H, Kato K, Nessa BN, Sadik GM, Takeda M
    Acta Neurol Taiwan 15:68-71, 2006
  2. Presenilin-dependent -secretase on plasma membrane and endosomes is functionally distinct
    Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M
    Biochemistry 45(15);4907-14, 2006
  3. Altered localization of amyloid precursor protein under endoplasmic reticulum stress
    Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D,Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
    Biochem Biophys Res Commun344:525-530,2006
  4. Hyperactivation of Midbrain Dopaminergic System in Schizophrenia could be attributed to the Down-regulation of Dysbindin
    Kumamoto N, Matsuzaki S, Inoue K, Hattori T, Shimizu S, Hashimoto R, Yamatodani A, Katayama T, Tohyama M
    Biochem Biophys Res Commun 345;904-909, 2006
  5. Cognitive impairment in patients with idiopathic normal pressure hydrocephalus
    Ogino A, Kazui H, Miyoshi N, Hashimoto M, Ohkawa S, Tokunaga H, Ikejiri Y, Takeda M
    Dement Geriat Cogn Disord 21(2);113-9, 2006
  6. Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and Dementia with Lewy bodies in Japan
    Akatsu H, Yamagata HD, Kawamata J, Kamino K, Takeda M, Yamamoto T, Miki T, Tooyama I, Shimohama S, Kosaka K
    Dementia Geriat Cog Disod 22;216-222, 2006
  7. Right parietal activation during delusional state in episodic interictal psychosis of epilepsy; A report of two cases
    Ishii R, Canuet L, Iwase M, Kurimoto R, Ikezawa K, Robinson SE, Ukai S, Shinosaki K, Hirata M, Yoshimine T, Takeda M
    Epilepsy Behav 9(2);367-72 2006
  8. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology, and ERK signaling
    Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H
    Hum Mol Genet 15(20);3024-3033, 2006
  9. A possible association between the-116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder
    Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Kunugi H, Koyama T
    Int J Neuropsychopharmacol, 8;1-6, 2005
  10. Effect of linearization correction on statistical parametric mapping (SPM); A 99mTc-HMPAO brain perfusion SPECT study in mild Alzheimer's disease
    Ansar MAB, Osaki Y, Kazui H, Oku N, Takazawa M, Kimura Y, Begum NN, Ikejiri Y, Takeda M, Hatazawa
    J Annals of Nuclear Medicine 20(8) :511-517, 2006
  11. Formation of Tau Inclusions in Knock-in Mice with Familial Alzheimer Disease (FAD) Mutation of Presenilin 1 (PS1)
    K Tanemura, Du-Hua Chui, T Fukuda, M Murayama, Jung-Mi Park, T Akagi, Y Tatebayashi, T Miyasaka, T Kimura, T Hashikawa, Y Nakano, T Kudo, M Takeda, A Takashima
    J Biol Chem 281(8); 5037-5041, 2006
  12. Secretion of the Notch-1 A-like peptide during Notch signaling
    Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M
    J Biol Chem 281(12);7890-8, 2006
  13. Symptoms underlying unawareness of memory impairment in patients with mild Alzheimer's disease
    Kazui H, Hashimoto M, Nakao Y, Matsumoto K, Takatsuki Y, Mori E, Ikejiri Y, Takeda M
    J Geriatric Neurol 19(1);3-12, 2006
  14. Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus
    Chiba S, Hashimoto R, Hattori S, Yohda M, Lipska B, Weinberger DR, Kunugi H
    J Neural Transm 113;1337-1346, 2006
  15. Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population
    Kunugi H, Hashimoto R, Okada T, Hori H, Nakabayashi T, Baba A, Kudo K, Ohmori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Kosuga A, Tatsumi M, Kamijima K, Asada T, Harada S, Arima K, Saitoh O
    J Neural Transm 113;1569-1573, 2006
  16. Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzhiemer's disease
    K. Nakamura, W. Ohya, H Funakoshi, G Sakaguchi, A Kato, M Takeda, Tkudo, T Nakamura
    J Neurocie Res 84,874-890,2006
  17. Actions anchored by concepts; defective action comprehension in semantic dementia
    Nishio Y, Kazui H, Hashimoto M, Shimizu K, Onouchi K, Mochio S, Suzuki K, Mori E
    J Neurol Neurosurg Psychiatry77(12):1313-1317,2006
  18. Polymorphism of the regulatory region of the presenilin-2 gene in sporadic
    Alzheimer's disease; a case-control study
    Quan W, Yasuda M, Hashimoto M, Yamamoto Y, Ishii K, Kazui H, Mori E, Kakigi T,Maeda K
    J Neurol Sci 240;71-75, 2006
  19. Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice
    Tanaka K, Shintani N, Hashimoto H,
    Kawagishi N, Ago Y, Matsuda T, Hashimoto R, Kunugi H, Yamamoto A, Kawaguchi C, Shimada T, Baba A
    J Neurosci 26(19);5091-5097,2006
  20. Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain
    Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, Takeda M
    J Neurosci Res 84(4);918-25,2006
  21. The protease active site domain of secretase contributes to substrate identification
    Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H
    J Neurosci 26(14);3821-8,2006
  22. A novel alternative splice variant of nicastrin and its implication in Alzheimer disease
    Mitsuda N, Yamagata HD, Zhong W, Aoto M, Akatsu H, Uekawa N, Kamino K, Taguchi K, Yamamoto T, Maruyama M, Kosaka K, Takeda M, Kondo I, Miki T
    Life Sci 78 (21);2444-8, 2006
  23. A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity
    Okada T, Hashimoto R, Numakawa T, Iijima Y, Kosuga A, Tatsumi M, Kamijima K, Kato T, Kunugi H
    Mol Psychiatry 11;1-9, 2006
  24. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease
    Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM
    Nat Neurosci 9(2);234-42,2006
  25. Development of new screening system for Alzheimer disease, in vitro A sink assay,
    to identify the dissociation of soluble Afrom
    fibrils
    Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T,Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
    Neurobiol Dis 22(3);487-95.,2006
  26. Spatially filtered magnetoencephalographic analysis of cortical oscillatory changes in basic brain rhythms during the Japanese "shiritori" word generation task
    Yamamoto M, Ukai S, Shinosaki K, Ishii R, Kawaguchi S, Ogawa A, Mizuno-Matsumoto Y, Fujita N, Yoshimine T, Takeda M
    Neuropsychobiology 53;215-222 2006
  27. The Val66Met polymorphism of the BDNF gene affects age-related brain morphology
    Nemoto K, Ohnishi T, Mori T, Moriguchi Y, Hashimoto R, Asada T, Kunugi H
    Neurosci Lett 397;25-29, 2006
  28. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease
    Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR
    Proc Natl Acad Sci USA, 103(17);6747-6752, 2006
  29. Susceptibility genes for schizophrenia
    Hashimoto R, Hattori S, Chiba S, Yagasaki Y, Okada T, Kumamaru E, Mori T, Nemoto K, Tanii H, Hori H, Noguchi H, Numakawa T, Ohnishi T, Kunugi H
    Psychiatry Clin Neurosci 60;S4-S10, 2006
  30. Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells
    Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M
    Psyichiat Clin Neurosci 60; S27-S33, 2006
  31. Albumin gene encoding free fatty acid and -amyloid transporter is genetically associated with Alzheimer disease
    Kimura R, Kamino K, Yamamoto M, Akatsu H, Uema T, Kobayashi T, Hattori H, Nuripa A, Nessa B, Kudo T, Yamagata H, Miki T, Takeda M
    Psyichiat Clin Neurosci 60; S34-S39, 2006
  32. Neural substrates of emotional habituation; A PET study using film stimuli
    Hatta N, Nishikawa T, Ikejiri Y, Tokunaga H, Masaki Y, Uema T, Kazui H, Doronbekov TK, Ogino A, Miyoshi N, Tanii H, Tanaka T, Oku N, Takeda M
    Psychiatry Clin Neurosci. 60 Suppl 1;S40-45,2006
  33. Neural substrates of emotionally valenced episodic memory; A PET study using film stimuli
    Masaki Y, Nishikawa T, Ikejiri Y, Tokunaga H, Hatta N, Uema T, Kazui H, Doronbekov TK, Ogino A, Miyoshi N, Tanii H, Tanaka T, Oku N, Takeda M
    Psychiatry Clin Neurosci 60 Suppl 1;S46-51, 2006
  34. Discrepancy of perforamance among working memory-related tasks in autism spectrum disorders was caused by task charactereistics, apart from working memory, which could interfere with task execution
    T Nakahachi, M Iwase, H Takahashi, E Honaga, W Ishigami, O Kajimoto, K Yamashita, R Hashimoto, H Tanii, A Shimizu, M Takeda
    Psychiat Clin Neurosci 60, 312-318, 2006
  35. Lithium response and Val66Met polymorphism of the BDNF gene in Japanese patients with bipolar disorder
    Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Kunugi H, Koyama T
    Psychiatr Genet 16(2);49-50, 2006
  36. Multiple anti-Alzheimer disease activities of non-steroidal anti-inflammatory drugs
    Morihara T, Cole GM, Tanii H, Tanaka T, Kudo T, Takeda M
    Psychogeriatrics 6(1);1-3,2006
  37. Ainduces endoplasmic reticulum stress causing possible proteasome impairment via the encoplasmic reticulum-associated degradation pathway
    Kanayama D, Kudo T, Kimura R, Tabuchi N, Fukumori A, Morihara T, Tagami S, Tanii H, Okochi M, Kamino K, Tanaka T, Imaizumi K, Tabira T, Takeda M
    Psychogeriatrics 6;100-106, 2006
  38. Inhibition of endocytosis activates alternative degradation pathway of APP in cultured cells
    Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Ito N, Tagami S, Okochi M, Takeda M
    Psychogeriatrics 6;107-113, 2006
  39. Neuropsychological test for the detection in elderly individuals;the Nishimura Dementia Test
    T Fukunaga,S Ukai,T Kobayashi,T Nishimura,M Takeda
    Psychogeriatrics.6;159-167,2006
  40. Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease
    Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M , Takeda M
    Psychogeriatrics 6(Suppl 2); S57-S63,2006
  41. Antipsychotic medication and cognitive function in schizophrenia
    Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Omori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Harada S, Saitoh O, Iwase M, Kajimoto O, Takeda M, Okabe S, Kunugi H
    Schizophr Res 86;138-146,2006
  42. Change of cleavage precision by Presenilin-dependent gamma-secretase
    Okochi M. Tagami S, Takeda M
    Alzheimer's and Dementia;The Journal of the Alzheimer's association 2(3)Suppl 1 S11,2006
  43. Presenilin-dependent gamma-secretases on plasma membrane and endosomes are functionally distinct
    Fukumori A, Okochi M,Jingwei J, Ikuta A, Yanagida K, Nakayama T, Katsura Y, Mori K, Hong Tao, Morihara T,,Kamino K, Tanaka T, Kudo T, Steiner H, Haass C, Tagami S,Takeda M
    Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S446,2006
  44. Effects of nitration of PS/gamma-secretase
    Mori K, Okochi M, Fukumori A, Jingwei J, Ikuta A, Yanagida K, Nakayama T, Katsura Y, Hong Tao, Morihara T, Kamino K, Tanaka T, Kudo T, Tagami S, Takeda M
    Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S447,2006
  45. Amyloid-beta generation and degradation by BACE1
    Ikuta A, Tagami S, Jingwei J, Yanagida K, Nakayama T, Katsura Y, Mori K, Hong Tao, Morihara T, Kamino K, Tanaka T, Kudo T, Steiner H, Haass, C, Okochi, M, Takeda, M.
    Alzheimer's and Dementia;The Journal of the Alzheimer's association 2(3)Suppl 1 S449,2006
  46. Inhibition of amyloid-beta production is possible without directly affecting secretases and Notch signaling
    Yanagida, K, Okochi M, Ito N, Nishitomi K, Sakaguchi G, Kato A, Fukumori A, Jingwei J, Ikuta A, Nakayama T, Morihara T, Kamino, K, Tanaka T, Kudo T, Katsura Y, Hong Tao, Mori K, Tagami S, Takeda M
    Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S449,2006
  47. Characterization of The Notch-1 amyloid- like peptides
    Katsura Y, Okochi M, Fukumori A, Ito N, Jingwei J, Ikuta A, Yanagida K, Nakayama T, Morihara T, Kamino K, Tanaka T, Kudo, T, Hong Tao, Mori K, Tagami S, Takeda M
    Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S449,2006
  48. Comparison of S3 cleavage of Notch-1 with -cleavage of APP by presenilin/-secretase
    Tagami S, Okochi M, Fukumori A, Takeda M
    Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S494,2006
  49. Inhibition of endocytosis activates alternative degradation pathway of bAPP in cultured cells
    Hong Tao, Oguri T, Okochi M, Fukumori A, Jingwei J, Ikuta A., Yanagida K, Nakayama T, Katsura Y, Mori K, Morihara T, Kamino K, Tanaka T, Kudo T, Tagami S, Takeda M
    Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S528,2006
  50. Effects of 3,5-bis(4-nitrophenoxy)-benzoic acid on PS/-secretase cleavage
    Nakayama T, Okochi M, Ito N, Nishitomi K, Baba T, Sakaguchi G, Kato A, Fukumori A, Jingwei J, Ikuta A, Yanagida K, Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Hong Tao, Mori K, Tagami S, Takeda M
    Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S600,2006
  51. Brain functional reaction under emotional stimulation related with mental stability
    Mizuno-Matsumoto Y, Nakao M, Ishii R, Ukai S, Kaishima T, Shinosaki K
    NeuroImage 31 Suppl 1 101 T-AM 2006
  52. SAM(G2) Analysis; A New Approach for MEG Source Localization of Epilepsy
    Ishii R, Robinson SE, Iwase M, Canuet L, Kurimoto R, Ikezawa K, Azechi M, Ukai S, Yoshimine T, Shinosaki K, Takeda M
    Neuropsychobiology 54;29-30 2006
  53. Working memory in pervasive developmental disorders-Comparison of advanced trail making test, digit symbol and digit span
    Nakahachi T, Iwase M, Takahashi H, Honaga E, Sekiyama R, Ukai A, Ishii R, Ishigami W, Kajimoto O, Hashimoto R, Yamashita K, Shimizu A, Takeda M
    Psychiatry and Clinical Neurosciences 60, A2, 2006
  54. MEG study of an epileptic patient with colored visual auras
    Ukai S, Ishii R, Kawaguchi S, Yamamoto M, Ogawa A, Mizuno Y, Fujita N, Yoshimine T, Shinosaki K, Takeda M
    Psychiat and Clin Neurosci 60, A4, 2006
  55. MEG neuroimaging of delusions in epileptic psychosis
    Ishii R, Ukai S, Iwase M, Shinosaki K, Takeda M
    Psychiat and Clin Neurosci 60, A7, 2006
  56. The psychoneuroimmunological effect of laughter on patients with chronic fatigue syndrome
    Iwase M, Takahashi K, Yamashita K, Tatsumoto Y, Ue H, Kuratsune H, Shimizu A, Takeda M
    Psychiatry and Clinical Psychiat 60, A12, 2006
  57. The different patterns of cognitive impairment between autism spectrum disorders and schizophrenia
    Iwase M, Takahashi H, Nakahachi T, Kajimoto O, Sekiyama R, Takahashi K, Ishii R, Ukai S, Shimizu A, Takeda M
    Psychiat and Clin Neurosci 60, A18, 2006
  58. Spatial working memory relates to social function in schizophrenia
    Takahashi H, Iwase M, Nakahachi T, Sekiyama R, Ishii R, Ukai S, Tabushi K, Kajimoto O, Shimizu A, Takeda M
    Psychiat and Clin Neurosci 60, A48, 2006
  59. The effect of rTMS on neurogenesis in the dentate gyrus of rat hippocampus
    Ueyama E, Ogawa A, Yamamoto M, Kawaguchi S, Masumoto N, Shouyama M, Kose A, Tsuji T, Kitabata Y, Ishii R, Ukai S, Kudo T, Shinosaki K
    Psychiat and Clin Neurosci 60, A49, 2006
  60. Biological markers for diagnosis of MCI and neurodegenerative dementia
    M. Takeda, T Kudo, T Tanaka, K Kamino, M Okochi, S Tagami
    Functional and Moleculart Imaging of Strokeka dn Dementia (Nishimura T & Sorensen GA eds), 101-107, Elsevier, 2006
  61. Neural correlates of symptom improvement in posttraumatic stress disorder; Psitron emission tomography study.
    Tokunaga H, Ikejiri Y, Kazui H, Masaki Y, Hatta N, Doronbekov T, Honda M, Oku N, Hatazawa J, Nishikawa N, Takeda M;
    In; PTSD; Brain mechanisms and clinical implications. N Kato, R Kawata, K Pitman (Eds.),247-254, Springer-Verlag Tokyo, 2006
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