林 謙一郎准教授プロフィール

所属学会

Publication list (〜2011)

Research Articles

  1. Nakamura S, Hayashi K, Iwasaki K, Fujioka T, Egusa H, Yatani H, Sobue K. Importin a/b1 heterodimer-mediated nuclear import of myocardin family members. The Journal of Biological Chemistry, 285: 37314-33723, 2010.
  2. Kimura Y, Morita T, Hayashi K, Miki T, Sobue K. Myocardin functions as an effective inducer of growth arrest and differentiation in human uterine leiomyosarcoma cells. Cancer Research, 70: 501-511, 2010.
  3. Oikawa H, Hayashi K, Maesawa C, Masuda T, Sobue K. Expression profiles of nestin in vascular smooth muscle cells in vivo and in vitro. Experimental Cell Research, 316: 940-950, 2010.
  4. Mayanagi T, Morita T, Hayashi K, Fukumoto K, Sobue K. Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton. The Journal of Biological Chemistry, 283: 31183-3119, 2008.
  5. Iwasaki K, Hayashi K, Fujioka T, Sobue K. Rho/ROCK signal regulates myogenic differentiation via MRTF-A/Smad-dependent transcription of the Id3 gene. The Journal of Biological Chemistry, 283: 21230-21241, 2008.
  6. Hayashi K, Nakamura S, Nishida W, Sobue K. BMP-induced Msx1 and Msx2 inhibit myocardin-dependent smooth muscle gene transcription. Molecular and Cellular Biology, 26: 9456-9470, 2006.
  7. Hayashi K, Shibata K, Morita T, Iwasaki K, Watanabe M, Sobue K. Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of IGF-I signaling in vascular smooth muscle cells. The Journal of Biological Chemistry, 279: 40807-40818, 2004.
  8. Takahashi M, Hayashi K, Yoshida K, Ohkawa Y, Komurasaki T, Kitabatake A, Ogawa A, Nishida W, Yano M, Monden M, Sobue K. Epiregulin as a major autocrine/paracrine factor released from the ERK- and p38MAPK-activated vascular smooth muscle cells.
    Circulation, 108: 2524-2529 , 2003.
  9. Yoshida K, Nishida W, Hayashi K, Ohkawa Y, Ogawa A, Aoki J, Arai H, Sobue K. Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo. Circulation, 108: 1746-1752, 2003.
  10. Ohkawa Y, Hayashi K, Sobue K. Calcineurin-mediated pathway involved in the differentiated phenotype of smooth muscle cells.
    Biochemical and Biophysical Research Communications, 301: 78-83, 2003.
  11. Nishida W, Nakamura M, Mori S, Takahashi M, Ohkawa Y, Tadokoro S, Yoshida K, Hiwada K, Hayashi K, Sobue K. A triad of SRF and the GATA and NK families governs the transcription of smooth and cardiac muscle genes. The Journal of Biological Chemistry, 277: 7308-7317, 2002.
  12. Hayashi K, Takahashi, M, Nishida W, Yoshida K, Ohkawa Y, Kitabatake A, Aoki J, Arai H, Sobue K. Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids. Circulation Research, 89: 251–258, 2001.
  13. Nakamura M, Nishida W, Mori S, Hiwada K. Hayashi K, Sobue K. Transcriptional activation of beta-tropomyosin mediated by serum response factor and a novel Barx homologue, Barx1b, in smooth muscle cells. The Journal of Biological Chemistry, 276: 18313-18320, 2001.
  14. Yamanaka Y, Hayashi K, Komurasaki T, Morimoto S, Ogihara T, Sobue K. EGF family ligand-dependent phenotypic modulation of smooth muscle cells through EGF receptor. Biochemical and Biophysical Research Communications, 281: 373-377, 2001.
  15. Chimori Y, Hayashi K, Kimura K, Nishida W, Funahashi S, Miyata S, Shimane M, Matsuzawa Y, Sobue K. Phenotype-dependent expression of cadherin 6B in vascular and visceral smooth muscle cells. FEBS Letters, 469: 67-71, 2000.
  16. Hayashi K, Takahashi M, Kimura K, Nishida W, Saga H, Sobue K. Changes in a balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine the phenotype of smooth muscle cells. 
    Journal of Cell Biology, 145: 727-740, 1999.
  17. Saga H, Kimura K, Hayashi K, Gotow T, Uchiyama Y, Momiyama T, Tadokoro S, Kawashima N, Jimbou A, Sobue K. Phenotype-dependent expression of a-smooth muscle actin in visceral smooth muscle cells. Experimental Cell Research, 247: 279-292, 1999.
  18. Nakamura J, Nishida T, Hayashi K, Kawada N, Ueshima S, Sugiyama Y, Ito T, Sobue K, Matsuda H. Kupper cell-mediated down regulation of rat hepatic CMOAT/MRP2 gene expression. Biochemical and Biophysical Research Communications, 255: 143-149, 1999.
  19. Hayashi K, Saga H, Chimori Y, Kimura K, Yamanaka Y, Sobue K. Differentiated phenotype of smooth muscle cells depends on signaling pathways through insulin-like growth factors and phosphatidylinositol 3-kinase. The Journal of Biological Chemistry, 273: 28860-28867, 1998.
  20. Kimura K, Saga H, Hayashi K, Obata H, Chimori Y, Sobue K. Identification of novel negative element in the promoter region of a-smooth muscle actin gene. Nucleic Acids Research, 26: 2420-2425, 1998.
  21. Momiyama T, Hayashi K, Chimori Y, Nishida T, Ito T, Kamiike W, Matsuda H, Sobue K. Functional involvement of serum response factor in the transcriptional regulation of caldesmon gene. Biochemical and Biophysical Research Communications, 242: 429-435, 1998.
  22. Obata H, Hayashi K, Nishida W, Momiyama T, Sobue K. Smooth muscle cell phenotype-dependent transcriptional regulation of the a1 integrin gene. The Journal of Biological Chemistry, 272: 26643-26651, 1997.
  23. Kashiwada K, Nishida W, Hayashi K, Ozawa K, Yamanaka Y, Saga H, Yamashita T, Tohyama M, Simada S, Sobue K. Coordinate expressions of a-tropomyosin and caldesmon isoforms in association with phenotypic modulation of smooth muscle cells: coordinate expression of a-tropomyosin and caldesmon isoforms. The Journal of Biological Chemistry, 272: 15396-15404, 1997.
  24. Yano H, Hayashi K, Momiyama T. Saga H. Haruna M, Sobue K. Transcriptional regulation of the chicken caldesmon gene: activation of gizzard type caldesmon promoter requires a CArG box-like motif. The Journal of Biological Chemistry, 270: 23661-23666, 1995.
  25. Yano H, Hayashi K, Haruna M, Sobue K. Identification of two distinct promoters in the chicken caldesmon gene.
    Biochemical and Biophysical Research Communications, 201: 618-626, 1994.
  26. Haruna M, Hayashi K, Yano H, Takeuchi O. Sobue K. Common structural and expressional properties of vertebrate caldesmon genes.
    Biochemical and Biophysical Research Communications, 197: 145-153, 1993.
  27. Hayashi K, Yano H, Hashida T, Takeuchi R, Takeda O. Asada K, Takahashi E-I, Kato I, Sobue K. Genomic structure of the human caldesmon gene. Proceedings of the National Academy of Sciences U. S. A., 89: 12122-12126, 1992.
  28. Hirochika H, Hayashi K. A new strategy to improve a cauliflower mosaic virus vector. Gene, 105: 239-241, 1991.
  29. Hayashi K, Fujio Y, Kato I, Sobue K. Structural and functional relationships between h- and l-caldesmons.
    The Journal of Biological Chemistry, 266: 355- 361, 1991.
  30. Hayashi K, Kanda K, Kimizuka F, Kato I, Sobue K. Primary structure and functional expression of h-caldesmon complementary DNA.
    Biochemical and Biophysical Research Communications, 164, 503-511, 1989.
  31. Hayashi K, Yamada S, Kanda K, Kimizuka F, Kato I, Sobue K. 35 kDa fragment of h-caldesmon conserves two consensus sequences of the tropomyosin-binding domain in troponin T. Biochemical and Biophysical Research Communications, 161: 38-45, 1989.
  32. Hayashi K, Nakazawa M, Ishizaki I, Hiraoka N, Obayashi A. Regulation of inter- and intramolecular ligation with T4 DNA ligase in the presence of polyethelene glycol. Nucleic Acids Research, 14: 7617-7631, 1986.
  33. Hayashi K, Nakazawa M, Ishizaki I. Hiraoka N, Obayashi A. Stimulation of intermolecular ligation with E. coli DNA ligase by high concentration of monovalent cations in polyethlene glycol solutions. Nucleic Acids Research, 13: 7979-7992, 1985.
  34. Hayashi K, Nakazawa M, Ishizaki I, Obayashi A. Influence of monovalent cations on the activity of T4 DNA ligase in the presence of polyethelene glycol. Nucleic Acids Research, 13: 3261-3271, 1985.
  35. Nishimura K, Hayashi K, Ueno A. Fujita T. Effect of pyrethroids and DTT analogs on the frequency of spontaneous discharges in crayfish central nerve cord. Journal of Pesticide Science, 8: 238-291, 1983.

Review Articles & Books

  1. Sobue K, Hayashi K, Nishida W. Expressional regulation of smooth muscle cell-specific genes in association with phenotypic modulation. Molecular and Cellular Biochemistry, 190: 105-118, 1999.
  2. Sobue K, Hayashi K, Nishida W. Molecular mechanism of phenotypic modulation of smooth muscle cells. Hormone Research, 50 (suppl. 2): 15-24, 1998.
  3. Hayashi K, Sobue K. Expressional regulation of caldesmon isoforms in assoceation with phenotypic modulation of smooth muscle cells.
    Smooth Muscle Contraction, (Kohama K. and Saida K. ed.) Japan Sci. Soc. Press, Tokyo, 131-141, 1995.
  4. Sobue K, Hayashi K, Yano H, Haruna M. Molecular approach for smooth muscle differentiation : association of caldesmon isoformal interconversion with phenotypic modulation of smooth muscle cells. Biomedical Research, suppl. 14: 147-153, 1993.

Japanese Reviews

  1. 林謙一郎、祖父江憲治:BMPによって制御される転写因子Msx—血管壁の石灰化とのかかわりと機能 医学のあゆみ,223(13): 1108-1112, 2007.
  2. 林謙一郎、祖父江憲治:血管リモデリングにおける血管平滑筋細胞の役割 医学のあゆみ, 221(13): 1150-1155, 2007.
  3. 林謙一郎、祖父江憲治:分化型・脱分化型血管平滑筋細胞のシグナル伝達と転写制御機構 分子心血管病, 3(6): 647-657, 2002.
  4. 林謙一郎、西田亙、祖父江憲治:平滑筋細胞形質転換の分子メカニズム 細胞 The Cell, 33(9): 328-333,2001.
  5. 西田亙、林謙一郎、祖父江憲治:血管平滑筋の発生・分化 血管医学, 1(1): 86-89, 2000.
  6. 祖父江憲治、林謙一郎、 西田亙:フェノタイプ変換とシグナル伝達および遺伝子発現機構 平滑筋細胞学 動脈硬化研究のフロンティア メジカルセンス社, 12-25, 1999.
  7. 西田亙、林謙一郎、祖父江憲治:平滑筋細胞形質決定因子-その細胞内情報伝達機構と遺伝子発現制御 生体の科学, 49(2): 121-130, 1998.
  8. 林謙一郎、祖父江憲治:平滑筋細胞における形質転換機構ー細胞外マトリックスと増殖因子の役割 実験医学(増刊), 14(17): 151-159, 1996.
  9. 林謙一郎、祖父江憲治:カルデスモンの構造と機能—平滑筋・非筋組織におけるアクチン-ミオシン相互作用のCa2+制御 実験医学, 8(16): 33-41, 1990.
  10. 林謙一郎、大林晃:DNAリガーゼ反応におけるポリエチレングリコール及び一価カチオンの影響 酵素工学ニュース, 15: 16-19, 1986.