アクセス情報

大阪大学 心臓血管外科
〒565-0871
大阪府吹田市山田丘2-15
TEL  :  06-6879-3154
FAX  :  06-6879-3163

メールでのお問合せはこちら

最寄駅
大阪モノレール阪大病院前
駐車場  あり
受付時間 8:30~11:30
予約がある場合は午後も受付
面会時間(一般病棟)
12:00~19:00

研究実績

研究内容と実績

実績各論

研究
  1. Imanishi Y, Miyagawa S, Fukushima S, Ishimaru K, Sougawa N, Saito A, Sakai Y, Sawa Y.Sustained-release delivery of prostacyclin analogue enhances bone marrow-cell recruitment and yields functional benefits for acute myocardial infarction in mice. PLoS One. 2013 Jul 19;8(7):e69302. doi: 10.1371/journal.pone.0069302. Print 2013 Jul 22.
  2. Kamata S, Miyagawa S, Fukushima S, Nakatani S, Kawamoto A, Saito A, Harada A, Shimizu T, Daimon T, Okano T, Asahara T, Sawa Y. Improvement of Cardiac Stem Cell-Sheet Therapy for Chronic Ischemic Injury by Adding Endothelial Progenitor Cell Transplantation: Analysis of Layer-Specific Regional Cardiac Function. Cell Transplant. 2013 Apr 3. [Epub ahead of print]
  3. Shirasaka T, Miyagawa S, Fukushima S, Saito A, Shiozaki M, Kawaguchi N, Matsuura N, Nakatani S, Sakai Y, Daimon T, Okita Y, Sawa Y. A slow-releasing form of prostacyclin agonist (ONO1301SR) enhances endogenous secretion of multiple cardiotherapeutic cytokines and improves cardiac function in a rapid-pacing-induced model of canine heart failure. J Thorac Cardiovasc Surg. 2013 Aug;146(2):413-21. doi: 10.1016/j.jtcvs.2012.10.003. Epub 2013 Mar 28.
  4. Alshammary S, Fukushima S, Miyagawa S, Matsuda T, Nishi H, Saito A, Kamata S, Asahara T, Sawa Y. Impact of cardiac stem cell sheet transplantation on myocardial infarction. Surg Today. 2013 Sep;43(9):970-6. doi: 10.1007/s00595-013-0528-2. Epub 2013 Mar 5.
  5. Sawa Y, Miyagawa S. Cell sheet technology for heart failure. Curr Pharm Biotechnol. 2013 Jan;14(1):61-6. Review.
  6. Kin K, Miyagawa S, Fukushima S, Shirakawa Y, Torikai K, Shimamura K, Daimon T, Kawahara Y, Kuratani T, Sawa Y. Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm. J Am Heart Assoc. 2012 Oct;1(5):e000745. doi: 10.1161/JAHA.112.000745. Epub 2012 Oct 25.
  7. Shudo Y, Miyagawa S, Nakatani S, Fukushima S, Sakaguchi T, Saito A, Asanuma T, Kawaguchi N, Matsuura N, Shimizu T, Okano T, Sawa Y. Myocardial layer-specific effect of myoblast cell-sheet implantation evaluated by tissue strain imaging. Circ J. 2013;77(4):1063-72. Epub 2012 Dec 29.
  8. Miki K, Uenaka H, Saito A, Miyagawa S, Sakaguchi T, Higuchi T, Shimizu T, Okano T, Yamanaka S, Sawa Y. Bioengineered myocardium derived from induced pluripotent stem cells improves cardiac function and attenuates cardiac remodeling following chronic myocardial infarction in rats. Stem Cells Transl Med. 2012 May;1(5):430-7. doi: 10.5966/sctm.2011-0038. Epub 2012 May 14.
  9. Sawa Y. Current status of myocardial regeneration therapy. Gen Thorac Cardiovasc Surg. 2013 Jan;61(1):17-23. doi: 10.1007/s11748-012-0153-9. Epub 2012 Nov 7.
  10. Kawamura M, Miyagawa S, Miki K, Saito A, Fukushima S, Higuchi T, Kawamura T, Kuratani T, Daimon T, Shimizu T, Okano T, Sawa Y. Feasibility, safety, and therapeutic efficacy of human induced pluripotent stem cell-derived cardiomyocyte sheets in a porcine ischemic cardiomyopathy model. Circulation. 2012 Sep 11;126(11 Suppl 1):S29-37.
  11. Maehata Y, Miyagawa S, Sawa Y. Activated protein C has a protective effect against myocardial I/R injury by improvement of endothelial function and activation of AKT1. PLoS One. 2012;7(8):e38738. doi: 10.1371/journal.pone.0038738. Epub 2012 Aug 20.
  12. Saito S, Miyagawa S, Sakaguchi T, Imanishi Y, Iseoka H, Nishi H, Yoshikawa Y, Fukushima S, Saito A, Shimizu T, Okano T, Sawa Y.Myoblast sheet can prevent the impairment of cardiac diastolic function and late remodeling after left ventricular restoration in ischemic cardiomyopathy. Transplantation. 2012 Jun 15;93(11):1108-15. doi: 10.1097/TP.0b013e31824fd803.
  13. Shudo Y, Miyagawa S, Fukushima S, Saito A, Shimizu T, Okano T, Sawa Y. Novel regenerative therapy using cell-sheet covered with omentum flap delivers a huge number of cells in a porcine myocardial infarction model. J Thorac Cardiovasc Surg. 2011 Nov;142(5):1188-96. doi: 10.1016/j.jtcvs.2011.07.002. Epub 2011 Sep 14.
  14. Shudo Y, Miyagawa S, Fukushima S, Saito A, Kawaguchi N, Matsuura N, Sawa Y. Establishing new porcine ischemic cardiomyopathy model by transcatheter ischemia-reperfusion of the entire left coronary artery system for preclinical experimental studies. Transplantation. 2011 Oct 15;92(7):e34-5.
  15. Imanishi Y, Miyagawa S, Maeda N, Fukushima S, Kitagawa-Sakakida S, Daimon T, Hirata A, Shimizu T, Okano T, Shimomura I, Sawa Y. Induced adipocyte cell-sheet ameliorates cardiac dysfunction in a mouse myocardial infarction model: a novel drug delivery system for heart failure. Circulation. 2011 Sep 13;124(11 Suppl):S10-7.
  16. Imanishi Y, Miyagawa S, Saito A, Kitagawa-Sakakida S, Sawa Y. Allogenic skeletal myoblast transplantation in acute myocardial infarction model rats. Transplantation. 2011 Feb 27;91(4):425-31.
  17. Miyagawa S, Saito A, Sakaguchi T, Yoshikawa Y, Yamauchi T, Imanishi Y, Kawaguchi N, Teramoto N, Matsuura N, Iida H, Shimizu T, Okano T, Sawa Y. Impaired Myocardium Regeneration With Skeletal Cell Sheets-A Preclinical Trial for Tissue-Engineered Regeneration Therapy.  Transplantation. 2010 Aug 27;90(4):364-72.
  18. Hata H, Bär A, Dorfman S, Vukadinovic Z, Sawa Y, Haverich A, Hilfiker A. Engineering a novel three-dimensional contractile myocardial patch with cell sheets and decellularised matrix. Eur J Cardiothorac Surg. 2010 Oct;38(4):450-5. Epub 2010 Mar 23.
  19. Kitabayashi K, Siltanen A, Pätilä T, Mahar MA, Tikkanen I, Koponen J, Ono M, Sawa Y, Kankuri E, Harjula A. Bcl-2 Expression Enhances Myoblast Sheet Transplantation Therapy for Acute Myocardial Infarction. Cell Transplant. 2010;19(5):573-88. Epub 2010 Jan 20.
  20. Sekiya N, Matsumiya G, Miyagawa S, Saito A, Shimizu T, Okano T, Kawaguchi N, Matsuura N, Sawa Y. Layered implantation of myoblast sheets attenuates adverse cardiac remodeling of the infarcted heart. J Thorac Cardiovasc Surg. 2009 Oct;138(4):985-93.
  21. Imanishi Y. Miyagawa S. Kitagawa-Sakakida S. Taketani S. Sekiya N. Sawa Y. Impact of synovial membrane-derived stem cell transplantation in a rat model of myocardial infarction. J Artif Organs 2009;12:187-193.
  22. Hoashi T, Matsumiya G, Miyagawa S, Ichikawa H, Ueno T, Ono M, Saito A, Shimizu T, Okano T, Kawaguchi N, Matsuura N, Sawa Y. Skeletal myoblast sheet transplantation improves the diastolic function of a pressure-overloaded right heart.  J Thorac Cardiovasc Surg. 2009 Aug;138(2):460-7.

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