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Myocardial perfusion and metabolic imaging

Ammonia (13N-NH3) PET enables quantitative evaluation of myocardial blood flow. In joint research with cardiovascular surgery group, we evaluated changes in blood flow using a myocardial infarction model in treatment with a myocardial sheet or a sustained-release drug sheet. 1,2)
By using acetate (11C-acetate) PET, myocardial oxygen consumption and oxygen consumption efficiency can be evaluated. In a myocardial infarction model, iPS cell myocardial sheet was shown to improve myocardial oxygen consumption efficiency. 3)

1) S.Kainuma et al. Molecular Therapy. 2014.
2) Yajima S, et al. J Thorac Cardiovasc Surg 2018.
3) Ishida M et al. Transplantation 2019.