2) Diagnostic PET/SPECT【Neurology PET/SPECT】
O-15 PET clinical research
The default mode network (DMN) was revealed by O-15 gas PET as a brain network activated at rest. 1)
Resting-state functional MRI (rs-fMRI) is used to evaluate the network in the brain, but in principle, evaluation by BOLD (blood oxygenation level-dependent) signals cannot separate the effects of cerebral oxygen metabolism and cerebral blood flow. 2)
We evaluated the functional correlation in DMN by O-15 gas PET, and the correlation (Intersubject correlation coefficients) between cerebral blood flow (CBF) and cerebral oxygen consumption (CMRO2) was evaluated. 3)
As a result, it was found that CBF showed more functional correlation than CMRO2, and that changes in blood flow could capture the functional correlation in DMN more accurately compared to oxygen metabolism. 3)
1) Raichle ME, et al. Proc Natl Acad Sci U S A. 2001.
2) Watabe T, et al. Front Neurosci. 2019.
3) Aoe J, et al. Ann Nucl Med. 2018.