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Tomoyuki Honda

Associate ProfessorTomoyuki Honda

Education and Employment

1999 M.D., Osaka University
1999-2000 Clinical Resident, Osaka University Hospital (First Department of Medicine)
2000-2004 Ph.D., Osaka University Graduate School of Medicine (Department of Molecular Biology and Biochemistry)
2004-2005 Project Assistant Professor, Osaka University Graduate School of Medicine
2005-2006 Assistant Professor, Mie University Graduate School of Medicine (Department of Anatomy)
2006-2007 Clinical Resident, Mie University Hospital (Department of Psychiatry)
2007-2010 Postdoctoral fellow (JSPS Researcher), Research Institute for Microbial Diseases, Osaka University (Department of Virology)
2010-2011 Assistant Professor, The Institute of Medical Science, The University of Tokyo (Laboratory Animal Research Center)
2011-2016 Assistant Professor, Institute for Virus Research, Kyoto University (Department of Viral Oncology)
2016-present Associate Professor, Osaka University Graduate School of Medicine (Division of Virology) /
Associate Professor, Center for Twin Research, Osaka University Graduate School of Medicine (Epigenetics Research Unit)


1999 Yamamura Prize (Osaka University, Faculty of Medicine)
2014 Sugiura Young Investigator Award (The Japanese Society for Virology)

Research Topics

1. Interaction between viruses and LINE-1
2. Analysis of molecular pathogenesis of psychiatric diseases using viruses
3. Arm races between viruses and host in the nucleus


(*:Equal contribution, **:Corresponding author)
Honda T. (**) , Sofuku K., Kojima S., Yamamoto Y., Ohtaki N., Tomonaga K.
Linkage between the leader sequence and leader RNA production in Borna disease virus-infected cells.
Virology 510, 104-110, 2017
Tokunaga T., Yamamoto Y., Sakai M., Tomonaga K., Honda T. (**)
Antiviral activity of Favipiravir (T-705) against mammalian and avian bornaviruses.
Antiviral Research 143, 237-245, 2017
Honda T. (**) , Sofuku K., Matsunaga H., Tachibana M., Mohri I., Taniike M., Tomonaga K.
Detection of antibodies to Borna disease virus proteins in an autistic child and her mother.
Japanese Journal of Infectious Diseases 70(2), 225-227, 2017
Honda T. (**)
Links between human LINE-1 retrotransposons and hepatitis virus-related hepatocellular carcinoma.
Frontiers in Chemistry 4, 21, 2016
Honda T. (**) , Yamamoto Y., Daito T., Matsumoto Y., Makino A., Tomonaga K.
Long-term expression of miRNA for RNA interference using a novel vector system based on a negative-strand RNA virus.
Scientific Reports 6, 26154, 2016
Honda T. (**), Tomonaga K.
Endogenous non-retroviral RNA virus elements evidence a novel type of antiviral immunity.
Mobile Genetic Elements 6(3), e1165785, 2016
Sofuku K., Parrish NF., Honda T.(**) , Tomonaga K.
Transcription profiling demonstrates epigenetic control of non-retroviral RNA virus-derived elements in the human genome.
Cell Reports 12, 1-7, 2015
Kojima S., Honda T.(**) , Matsumoto Y., Tomonaga K.
Heat stress is a potent stimulus for enhancing rescue efficiency of recombinant Borna disease virus.
Microbiology and Immunology 58(11), 636-642, 2014
Honda T.(**) , Tomonaga K.
Nucleocytoplasmic shuttling of viral proteins in Borna disease virus infection.
Viruses 5(8), 1978-1990, 2013
Honda T. (**) , Tomonaga K.
Host Molecular Chaperones: Cell Surface Receptors for Viruses.
Heat Shock Proteins 7, 293-307, 2013
Honda T., Yoneda M., Sato H., Kai C.
Pathogenesis of Encephalitis Caused by Persistent Measles Virus Infection.
Encephalitis 251-262, 2013
Honda T., Fujino K., Okuzaki D., Ohtaki N., Matsumoto Y., Horie M., Daito T., Itoh M., Tomonaga K.
Upregulation of insulin-like growth factor binding protein 3 in astrocytes of transgenic mice that express borna disease virus
Journal of Virology 85(9), 4567-4571, 2011
Horie M. (*), Honda T. (*), Suzuki Y., Kobayashi Y., Daito T., Oshida T., Ikuta K., Jern P., Gojobori T., Coffin JM., Tomonaga K.
Endogenous non-retroviral RNA virus elements in mammalian genomes.
Nature 463(7277), 84-87, 2010
Honda T.(**), Horie M., Daito T., Ikuta K., Tomonaga K.
Molecular chaperone BiP interacts with Borna disease virus glycoprotein at cell surface.
Journal of Virology 83(23), 12622-12625, 2009
Honda T., Sakisaka T., Yamada T., Kumazawa N., Hoshino T., Kajita M., Kayahara T., Ishizaki H., Tanaka-Okamoto M.,
Mizoguchi A., Manabe T., Miyoshi J., Takai Y.
Involvement of nectins in the formation of puncta adherentia junctions and the mossy fiber trajectory in the mouse hippocampus.
Molecular and Cellular Neuroscience 31(2), 315-325, 2006
Honda T., Shimizu K., Fukuhara A., Irie K., Takai Y.
Regulation by nectin of the velocity of the formation of adherens junctions and tight junctions.
Biochemical and Biophysical Research Communications 306(1), 104-109, 2003
Honda T., Shimizu K., Kawakatsu T., Fukuhara A., Irie K., Nakamura T., Matsuda M., Takai Y.
Cdc42 and Rac small G proteins activted by trans-interaction of nectins are involved in activation of c-Jun N-terminal kinase, but not
in association of nectins and E-cadherin to form adherens junctions, in fibroblasts.
Genes to Cells 8(5), 481-491, 2003
Honda T., Shimizu K., Kawakatsu T., Yasumi M., Shingai T., Fukuhara A., Ozaki-Kuroda K., Irie K., Nakanishi H., Takai Y.
Antagonistic and agonistic effeccts of an extracellular fragment of nectin on formation of E-cadherin-based cell-cell adhesion.
Genes to Cells 8(1), 51-63, 2003
English original article 27, English review article 2, Japanese review article 7, intellectual property right 2

[as of July 2017]

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