{"id":311,"date":"2017-03-13T16:52:09","date_gmt":"2017-03-13T07:52:09","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/research\/acute\/anesthesiology-and-intensive-care-medicine"},"modified":"2024-12-25T12:21:42","modified_gmt":"2024-12-25T03:21:42","slug":"anesthesiology","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/introduction\/research\/acute\/anesthesiology","title":{"rendered":"Anesthesiology and Intensive Care Medicine"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li><a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/anes\/\" target=\"_blank\" rel=\"noopener\">Website<\/a><\/li>\n<li><a href=\"http:\/\/www.med.osaka-u.ac.jp\/introduction\/research\/acute\/anesthesiology\">Text in Japanese<\/a><\/li>\n<p><!-- \n\n<li><a href=\"#\" target=\"_blank\" class=\"pdf\" rel=\"noopener\">\u5927\u5b66\u9662\u751f\u5411\u3051\u7814\u7a76\u6982\u8981<\/a><\/li>\n\n --><\/ul>\n<div class=\"title\">Deliver \u201conly one\u201d to the world with an exploratory mindset to elucidate clinical questions as the driving force behind research<\/div>\n<ul>\n<li>Always respect clinical practice as the starting point of anesthesiologists and keep an exploratory mindset to solve questions arising from clinical practice<\/li>\n<li>Engage in the following three research areas with the goal of delivering \u201ctreatment\u201d and \u201ctechnology\u201d developed in Osaka University to the world:<br \/>1. Ultimate respiratory physiology research to eliminate lung injury <br \/>2. Neuroscience research aiming to prevent perioperative neurocognitive disorders <br \/>3. Pioneering research leading to elucidation of the mechanism of chronic pain<\/li>\n<\/ul>\n<p><!-- \/ .index --><\/p>\n<div class=\"profile\">\n<div class=\"clearfix\">\n<div class=\"fl photo\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-8586\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/yoshidatakeshi-299x400.jpg\" alt=\"\" width=\"299\" height=\"400\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/yoshidatakeshi-299x400.jpg 299w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/yoshidatakeshi-765x1024.jpg 765w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/yoshidatakeshi-768x1028.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/yoshidatakeshi-1148x1536.jpg 1148w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/yoshidatakeshi-1530x2048.jpg 1530w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/yoshidatakeshi-scaled.jpg 1913w\" sizes=\"(max-width: 299px) 100vw, 299px\" \/><\/div>\n<p><!-- \/ .photo --><\/p>\n<div class=\"name\"><span class=\"position\">Professor <\/span>YOSHIDA Takeshi<\/div>\n<p><!-- \/ .name --><\/p>\n<div class=\"member\">Anesthesiology and Intensive Care Medicine<\/div>\n<p><!-- \/ .member --><\/p>\n<div class=\"description\">The Department of Anesthesiology and Intensive Care Medicine has a long history of consistently pursuing comprehensive approach to anesthesiology, covering the entire areas including operating room anesthesia, intensive care, and pain treatment. Producing many anesthesiologists with high expertise and academic skills, we have continuously led basic and clinical research in anesthesiology and intensive care. We will continue to deliver innovative technology and treatment developed in Osaka University to the world.<\/div>\n<p><!-- \/ .description --><\/div>\n<p><!-- \/ .clearfix --><\/div>\n<p><!-- \/ .profile --><\/p>\n<h3>The Department of Anesthesiology and Intensive Care Medicine will lead the world with unique research that can only be achieved by us<\/h3>\n<h4>1. Pulmonary Physiology Research Group<\/h4>\n<p><strong>\u30fbProactive initiative for establishment and clinical application of lung stress mapping to visualize the risk of lung injury<\/strong><\/p>\n<p>With an innovative approach combining pulmonary physiology and imaging analysis, we are striving to establish lung stress mapping, a technology to visualize an infinite amount of information on lung stress in the entire lung area. This will enable evaluation and visualization of the \u201camount\u201d and \u201csite and pattern\u201d of the areas at risk of lung injury (see figure below). In addition, by estimating patient prognosis from the evaluation of the areas at risk of lung injury using artificial intelligence, a patient group with higher risks can be extracted and \u201cpreemptive\u201d personalized medicine provided. Our ultimate goal is to develop a next-generation ventilator incorporating lung stress mapping with automatic risk area reduction system to optimize the ventilating condition for patients automatically for 24 hours a day, 365 days a year, enabling provision of personalized medicine \u201canytime,\u201d \u201canywhere,\u201d and to \u201canyone.\u201d This is expected to help destroy the preconceived notion that \u201cventilator management is a skilled technique based on experience\u201d and become an innovative breakthrough for improvement of acute respiratory distress syndrome (ARDS) treatment outcome.<\/p>\n<p><strong>\u30fbElucidation of the mechanism of spontaneous respiration-associated lung injury and establishment of comprehensive treatment<\/strong><\/p>\n<p>As diaphragmatic breathing is a physiological function, it has been recommended to preserve spontaneous breathing during mechanical ventilation. However, we found a phenomenon that lung injury worsens due to dependence on respiratory effort, which led to the development of the new concept of \u201cspontaneous respiration-associated lung injury\u201d in our department. After more than 10 years of consistent research, we revolutionized conventional ventilator management for ARDS. We reversed the existing perception that \u201cspontaneous breathing should always be preserved,\u201d and now cessation or suppression of respiratory effort using muscle relaxants, high positive end-expiratory pressure (PEEP), and prone position has become the standard of care for ARDS with high respiratory effort. We will further promote our research to elucidate the mechanism of spontaneous respiration-associated lung injury, aiming to develop an innovative treatment.<\/p>\n<p class=\"figure\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-8657 size-full\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/anesthesiology_efig1.jpg?_t=1735094382\" alt=\"\" width=\"900\" height=\"674\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/anesthesiology_efig1.jpg 900w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/anesthesiology_efig1-400x300.jpg 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/anesthesiology_efig1-768x575.jpg 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><\/p>\n<h4>2. Neuroscience Research Group<\/h4>\n<p><strong>\u30fbElucidation of the mechanism of onset of perioperative neurocognitive disorders<\/strong><\/p>\n<p>Postoperative delirium is one of the perioperative neurocognitive disorders caused by surgery\/anesthesia, and the most frequent postoperative complication in elderly patients. In addition, the onset of postoperative delirium is associated with poor long-term prognosis such as increased mortality, warranting early establishment of the prediction, prevention, and treatment methods. We found \u201cdecreased synaptic transmission\u201d in prefrontal cortex (see left figure below) and \u201cdysfunction of brain microvascular endothelial cells\u201d in hippocampus (see right figure below) after surgery\/anesthesia. Based on these findings we are promoting basic research and clinical research to further elucidate the mechanism of onset of postoperative delirium and discover a biomarker to predict the onset of postoperative delirium.<\/p>\n<p class=\"figure\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-8658 size-full\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/anesthesiology_efig2.jpg?_t=1735094415\" alt=\"\" width=\"900\" height=\"452\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/anesthesiology_efig2.jpg 900w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/anesthesiology_efig2-400x201.jpg 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2024\/12\/anesthesiology_efig2-768x386.jpg 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><\/p>\n<h4>3. Pain Science Research Group<\/h4>\n<p><strong>\u30fbElucidation of the mechanism of analgesic action of peripheral nerve pulsed radiofrequency<\/strong><\/p>\n<p>Peripheral nerve pulsed radiofrequency has been attracting worldwide attention as a minimally invasive treatment to provide long-term pain relief to patients with refractory neuropathic pain and joint pain without causing neuropathy. However, the mechanism of analgesic action of this treatment remains largely unexplored. We are exploring to clarify the mechanism through animal experiments, aiming to further improve and optimize the quality of this promising treatment. We have conducted a study on the mechanism of action at peripheral and spinal level using an inflammatory pain mouse model and obtained a new finding that the treatment does not just act on the pain nervous system but also improves inflammation of peripheral tissues. We will continue our efforts for further breakthroughs in the treatment of chronic pain through animal experiments and clinical research.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Website Text in Japanese Deliver \u201conly one\u201d to the world with an exploratory mindset to elucidate clinical que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":82,"menu_order":168,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/311"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=311"}],"version-history":[{"count":9,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/311\/revisions"}],"predecessor-version":[{"id":2327,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/311\/revisions\/2327"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/82"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}