{"id":319,"date":"2017-03-13T16:54:39","date_gmt":"2017-03-13T07:54:39","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/research\/neural\/neurosurgery"},"modified":"2025-09-03T10:28:18","modified_gmt":"2025-09-03T01:28:18","slug":"neurosurgery","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/introduction\/research\/neural\/neurosurgery","title":{"rendered":"Neurosurgery"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li><a href=\"https:\/\/www.med.osaka-u.ac.jp\/pub\/nsurg\/\" target=\"_blank\" rel=\"noopener\">Website<\/a><\/li>\n<li><a href=\"http:\/\/www.med.osaka-u.ac.jp\/introduction\/research\/neural\/neurosurgery\">Text in Japanese<\/a><\/li>\n<p><!-- <!-- \n\n<li><a href=\"#\" target=\"_blank\" class=\"pdf\" rel=\"noopener\">\u5927\u5b66\u9662\u751f\u5411\u3051\u7814\u7a76\u6982\u8981<\/a><\/li>\n\n --><\/ul>\n<div class=\"index\">\n<div class=\"title\">Doing one&#8217;s best<\/div>\n<ul>\n<li>Reconstruction of brain function by an implantable brain machine interface<\/li>\n<li>Epilepsy Research<\/li>\n<li>Regeneration of injured spinal cord function by autologous olfactory mucosal transplantation<\/li>\n<li>Immunotherapy of malignant brain tumor by Wilms Tumor peptide vaccination<\/li>\n<li>Laser speckle flowmetry (LSF) to study cerebral ischemia<\/li>\n<\/ul>\n<\/div>\n<p><!-- \/ .index --><\/p>\n<div class=\"profile\">\n<div class=\"clearfix\">\n<div class=\"fl photo\"><img decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/introduction\/research\/neural\/neurosurgery_profile.png\" alt=\"\" \/><\/div>\n<div class=\"name\"><span class=\"position\">Professor <\/span>Haruhiko Kishima<\/div>\n<div class=\"member\">Department of Neurosurgery<\/div>\n<div class=\"description\">The neurosurgery unit was opened in 1972, and Professor Kishima will be the fourth professor to run the lab. The laboratory conducts both basic and clinical research to advance medical care through neurosurgery. Part of this effort includes the training of future neurosurgeons and related scientists.<\/div>\n<\/div>\n<\/div>\n<p><!-- \/ .profile --><\/p>\n<h3>Neurosurgery research<\/h3>\n<h4>1) Reconstruction of brain function by an implantable brain machine interface<\/h4>\n<p>The lab aims to introduce a high performance brain-machine interface by implanting an electrode in the cranium. This brain machine interface is capable of moving a prosthetic arm using the brain signals of patients with severe paralysis.<\/p>\n<p class=\"figure\"><img decoding=\"async\" class=\"imgC\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/introduction\/research\/neural\/neurosurgery_01.png\" alt=\"\" \/> <span class=\"caption\">Figure 1<\/span><\/p>\n<h4>2)Epilepsy research<\/h4>\n<p>The lab is conducting research aimed at predicting epileptic seizures and clarifying pathological conditions in the brain using electrodes and cerebral magnetometers to map brain activity.<\/p>\n<h4>3) Regeneration of injured spinal cord function by autologous olfactory mucosal transplantation<\/h4>\n<p>Spinal cord injury (SCI) can cause irreversible damage to the nervous system, resulting in sensory paralysis and bladder and bowel dysfunction. In 2001, the Hospital de Egas Moniz in Lisbon, Portugal developed a novel and reproducible autologous olfactory mucosal transplantation approach for treating SCI. The olfactory mucosa is a tissue capable of nerve regeneration even in adulthood, and there are expectations that its transplantation may improve SCI symptoms.<\/p>\n<h4>4) Immunotherapy of malignant brain tumor by Wilms Tumor peptide vaccination<\/h4>\n<p>In a phase II clinical trial conducted in 2004, the lab demonstrated the efficacy of immunotherapy targeting the Wilms\u2019 Tumor 1 protein for recurrent glioblastoma multiforme.<\/p>\n<h4>5) Laser speckle flowmetry (LSF) to study cerebral ischemia<\/h4>\n<p>LSF is a noninvasive tool to measure and visualize dynamic changes in blood flow in the brain that are undetectable by MRI and PET. With this technology, the lab aims to elucidate the mechanism of secondary brain damage after cerebral infarction. Moreover, the lab is planning to apply similar research methods toward epilepsy and trauma models in order to elucidate new mechanisms.<\/p>\n<p class=\"figure\"><img decoding=\"async\" class=\"imgC\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/introduction\/research\/neural\/neurosurgery_02.png\" alt=\"\" \/> <span class=\"caption\">Figure 2<br \/>Real-time monitoring of cerebral blood flow using laser speckle flowmetry (LSF)<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Website Text in Japanese Doing one&#8217;s best Reconstruction of brain function by an implantable brain machi [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":84,"menu_order":172,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/319"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=319"}],"version-history":[{"count":10,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/319\/revisions"}],"predecessor-version":[{"id":9268,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/319\/revisions\/9268"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/84"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=319"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}