{"id":632,"date":"2017-03-14T11:48:03","date_gmt":"2017-03-14T02:48:03","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2004year\/tsujimoto-yoshihide"},"modified":"2017-04-28T15:24:54","modified_gmt":"2017-04-28T06:24:54","slug":"article01","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2004year\/article01","title":{"rendered":"TSUJIMOTO Yoshihide \u226aMolecular Genetics\u226b <span>\u201cA role of Bcl-2 family of proteins in non-apoptotic programmed cell death dependent on autophagy genes.\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2004year\/article01\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1>\u8fbb\u672c \u8cc0\u82f1 \u226a\u907a\u4f1d\u5b50\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2004\/tujimoto20041121.jpeg\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2004\/tujimoto20041121.jpeg\" alt=\"\" height=\"138\" width=\"200\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2004-11-21<br \/>\n  <span class=\"lineFrame\">Publish<\/span> Nature Cell Biology 6:1221-1228 (2004)<\/p>\n<p><!-- \n\n<h3>\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u4f9d\u5b58\u7684\u306a\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u306b\u304a\u3051\u308bBcl-2\u306e\u5f79\u5272<\/h3>\n\n\n\n\n<p>\u8981\u65e8\uff1aBax\u3068Bak\u3092\u6b20\u640d\u3057\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8d77\u3053\u3055\u306a\u3044\u7d30\u80de\u682a\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u54fa\u4e73\u52d5\u7269\u7d30\u80de\u306b\u306f\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u4ee5\u5916\u306b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u4f9d\u5b58\u3057\u305f\u7d30\u80de\u6b7b\u6a5f\u69cb\u304c\u5099\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002\u3053\u306e\u7d30\u80de\u6b7b\u306b\u306f\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u6291\u5236\u56e0\u5b50\u3067\u3042\u308bBcl-2\/Bcl-xL\u304c\u30dd\u30b8\u30c6\u30a3\u30d6\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u3057\u3001\u3053\u306e\u7d30\u80de\u6b7b\u6a5f\u69cb\u304c\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u306e\u91cd\u8981\u306a\uff11\u6a5f\u69cb\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u305f\u3002<\/p>\n\n --><br \/>\n<!-- \n\n<h3>A role of Bcl-2 family of proteins in non-apoptotic programmed cell death dependent on autophagy genes.<\/h3>\n\n --><\/p>\n<p>Programmed cell death can be divided into several categories including type I (apoptosis) and type II (autophagic death). The Bcl-2 family of proteins are well-characterized regulators of apoptosis, and the multidomain pro-apoptotic members of this family, such as Bax and Bak, act as a mitochondrial gateway where a variety of apoptotic signals converge. Although embryonic fibroblasts from Bax\/Bak double knockout mice are resistant to apoptosis, we found that these cells still underwent a non-apoptotic death after death stimulation. Electron microscopic and biochemical studies revealed that double knockout cell death was associated with autophagosomes\/autolysosomes. This non-apoptotic death of double knockout cells was suppressed by inhibitors of autophagy, including 3-methyl adenine, was dependent on autophagic proteins APG5 and Beclin 1 (capable of binding to Bcl-2\/Bcl-x(L)), and was also modulated by Bcl-x(L). These results indicate that the Bcl-2 family of proteins not only regulates apoptosis, but also controls non-apoptotic programmed cell death that depends on the autophagy genes.<\/p>\n<p class=\"mt25\"><span class=\"lineFrame\">URL<\/span> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/pub\/gene\/www\/\" target=\"_blank\">http:\/\/www.med.osaka-u.ac.jp\/pub\/gene\/www\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2004-11-21 Publish Nature Cell Biology 6:1221-1228 (2004) Programmed cell de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1826,"parent":467,"menu_order":134,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/632"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=632"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/632\/revisions"}],"predecessor-version":[{"id":2354,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/632\/revisions\/2354"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1826"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}