{"id":634,"date":"2017-03-14T11:48:03","date_gmt":"2017-03-14T02:48:03","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2004year\/takeda-junji"},"modified":"2017-04-28T15:22:12","modified_gmt":"2017-04-28T06:22:12","slug":"article03","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2004year\/article03","title":{"rendered":"TAKEDA Junji \u226aEnvironmental and Molecular Medicine\u226b <span>\u201cGenome-wide phenotype analysis in ES cells by regulated disruption of the Bloom&#8217;s syndrome gene.\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2004year\/article03\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1>\u7af9\u7530 \u6f64\u4e8c \u226a\u74b0\u5883\u30fb\u751f\u4f53\u6a5f\u80fd\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2004\/takeda20040624.jpeg\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2004\/takeda20040624.jpeg\" alt=\"\" height=\"151\" width=\"200\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2004-6-24<br \/>\n  <span class=\"lineFrame\">Publish<\/span> Nature&#12288;429, 896-899, 2004<\/p>\n<p><!-- \n\n<h3>\u80da\u6027\u5e79\u7d30\u80de\u306b\u304a\u3051\u308b\u30d6\u30eb\u30fc\u30e0\u75c7\u5019\u7fa4\u306e\u907a\u4f1d\u5b50\u7834\u58ca\u3092\u5229\u7528\u3057\u305f\u7db2\u7f85\u7684\u8868\u73fe\u578b\u89e3\u6790<\/h3>\n\n\n\n\n<p> \u54fa\u4e73\u52d5\u7269\u306b\u304a\u3044\u3066\u8868\u73fe\u578b\u3092\u6307\u6a19\u306b\u907a\u4f1d\u5b66\u7684\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u3059\u308b\u969b\u3001\uff12\u500d\u4f53\u3067\u3042\u308b\u3053\u3068\u304c\u554f\u984c\u306b\u306a\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u30d6\u30eb\u30fc\u30e0\u75c7\u5019\u7fa4\u306e\u907a\u4f1d\u5b50\u3092\u30c6\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u3067\u5236\u5fa1\u3057\u3001\u7db2\u7f85\u7684\u306b\u4e21\u30a2\u30ec\u30eb\u5909\u7570\u304c\u5c0e\u5165\u51fa\u6765\u305f\u306e\u3067\u5831\u544a\u3059\u308b\u3002<\/p>\n\n --><\/p>\n<p>The limitation of phenotype-based genetic screening in mammalian systems is the diploid nature of the genome. We used a tetracycline-regulated Bloom\u2019s syndrome gene to introduce bi-allelic mutations across the genome in mouse ES cells.<\/p>\n<p class=\"mt25\"><span class=\"lineFrame\">URL<\/span> <a href=\"http:\/\/www.casi.osaka-u.ac.jp\/25\/\" target=\"_blank\">http:\/\/www.casi.osaka-u.ac.jp\/25\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2004-6-24 Publish Nature&#12288;429, 896-899, 2004 The limitation of phenoty [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1828,"parent":467,"menu_order":169,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/634"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=634"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/634\/revisions"}],"predecessor-version":[{"id":2352,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/634\/revisions\/2352"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1828"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}