{"id":637,"date":"2017-03-14T11:48:56","date_gmt":"2017-03-14T02:48:56","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2005year\/hirano-toshio"},"modified":"2017-04-28T15:29:04","modified_gmt":"2017-04-28T06:29:04","slug":"article01","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2005year\/article01","title":{"rendered":"HIRANO Toshio \u226aDevelopmental Immunology\u226b <span>\u201cIL-6-STAT3 controls intracellular MHC class II \u03b1\u03b2-dimer level through Cathepsin S activity in dendritic cells.\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2005year\/article01\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1>\u5e73\u91ce \u4fca\u592b \u226a\u514d\u75ab\u767a\u751f\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2005\/hirano200511.jpeg\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2005\/hirano200511.jpeg\" alt=\"\" height=\"200\" width=\"145\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2005-11<br \/>\n  <span class=\"lineFrame\">Publish<\/span> Immunity, 23: 491-502, 2005.<\/p>\n<p><!-- \n\n<h3>IL-6- STAT3\u7d4c\u8def\u306f\u30ab\u30c6\u30d7\u30b7\u30f3S\u6d3b\u6027\u3092\u4ecb\u3057\u3066\u6a39\u72b6\u7d30\u80de\u306e\u7d30\u80de\u5185MHC\u30af\u30e9\u30b9II \u03b1\u03b2\u4e8c\u91cf\u4f53\u30ec\u30d9\u30eb\u3092\u5236\u5fa1\u3059\u308b<\/h3>\n\n\n\n\n<p> \u8981\u65e8\uff1a\u6211\u3005\u306f\u4ee5\u524d\u306bIL-6\u304c\u6a39\u72b6\u7d30\u80de\u306e MHC\u30af\u30e9\u30b9II\u30ec\u30d9\u30eb\u3092\u8ca0\u306b\u5236\u5fa1\u3059\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u3066\u3044\u308b\u3002\u4eca\u56de\u6211\u3005\u306f\u3001\u305d\u306e\u5206\u5b50\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002IL-6-STAT3\u7d4c\u8def\u306f\u5185\u5728\u6027\u306e\u30ab\u30c6\u30d7\u30b7\u30f3\u963b\u5bb3\u56e0\u5b50\u3067\u3042\u308b\u30b7\u30b9\u30bf\u30c1\u30f3C\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u6a39\u72b6\u7d30\u80de\u5185\u306eMHC\u30af\u30e9\u30b9II \u03b1\u03b2\u4e8c\u91cf\u4f53\u3001Ii\u304a\u3088\u3073h3-DM\u30ec\u30d9\u30eb\u3092\u4e0b\u3052\u305f\u3002\u91cd\u8981\u306a\u3053\u3068\u306b\u3001\u30ab\u30c6\u30d7\u30b7\u30f3S\u963b\u5bb3\u5264\u3082\u3057\u304f\u306f\u30b7\u30b9\u30bf\u30c1\u30f3C\u306e\u5f37\u5236\u767a\u73fe\u306b\u3088\u308a\u3001IL-6\u306e\u52b9\u679c\u306f\u6253\u3061\u6d88\u3055\u308c\u308b\u3002\u53cd\u5bfe\u306b\u3001\u30ab\u30c6\u30d7\u30b7\u30f3S\u306e\u5f37\u5236\u767a\u73fe\u306fIL-6\u3068\u540c\u69d8\u306e\u52b9\u679c\u3092\u767a\u63ee\u3057\u3001LPS\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\u6a39\u72b6\u7d30\u80de\u306eMHCII\u306e\u767a\u73fe\u5897\u5f37\u304a\u3088\u3073CD4+ T \u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3057\u305f\u3002IL-6-STAT3\u7d4c\u8def\u306b\u3088\u308b\u6a39\u72b6\u7d30\u80de\u306e\u30b7\u30b9\u30bf\u30c1\u30f3C\u3068MHC\u30af\u30e9\u30b9II \u03b1\u03b2\u4e8c\u91cf\u4f53\u306e\u6e1b\u5c11\u306f\u3001\u30de\u30a6\u30b9\u500b\u4f53\u3092\u7528\u3044\u305f\u5b9f\u9a13\u3067\u3082\u78ba\u8a8d\u3055\u308c\u305f\u3002\u5f93\u3063\u3066\u3001IL-6-STAT3\u30b7\u30b0\u30ca\u30eb\u306f\u6a39\u72b6\u7d30\u80de\u306b\u304a\u3044\u3066MHCII\u6297\u539f\u63d0\u793a\u6a5f\u69cb\u3092\u5236\u5fa1\u3057\u3001 CD4+ T\u7d30\u80de\u514d\u75ab\u5fdc\u7b54\u3092\u6291\u5236\u3059\u308b\u3002<\/p>\n\n --><\/p>\n<p>We previously demonstrated that IL-6 signaling negatively regulates MHC class II (MHCII) levels in dendritic cells (DCs). Here we showed the molecular mechanism behind the IL-6 effect. The IL-6-STAT3 signaling reduced intracellular MHCII \u03b1\u03b2 dimer, Ii, and h3-DM levels by decreasing an endogenous inhibitor of cathepsins, cystatin C. Importantly, cathepsin S inhibitors or overexpression of cystatin C reversed the effect of IL-6. Conversely, cathepsin S overexpression mimicked the IL-6 effect, which led to suppress LPS-induced surface expression of MHCII in DC and CD4+ T cell activation. IL-6-STAT3 signaling in vivo also decreased cystatin C expression and MHCII \u03b1\u03b2 dimer levels in DCs. Thus, IL-6-STAT3 signals in DCs regulates MHCII antigen presentation machinery and suppresses CD4(+) T cell-mediated immune responses.<\/p>\n<p class=\"mt25\"><span class=\"lineFrame\">URL<\/span> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/pub\/molonc\/www\/\" target=\"_blank\">http:\/\/www.med.osaka-u.ac.jp\/pub\/molonc\/www\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2005-11 Publish Immunity, 23: 491-502, 2005. We previously demonstrated that [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1822,"parent":466,"menu_order":134,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/637"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=637"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/637\/revisions"}],"predecessor-version":[{"id":2360,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/637\/revisions\/2360"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/466"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1822"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=637"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}