{"id":638,"date":"2017-03-14T11:48:56","date_gmt":"2017-03-14T02:48:56","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2005year\/takeda-junji"},"modified":"2017-04-28T15:26:02","modified_gmt":"2017-04-28T06:26:02","slug":"article02","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2005year\/article02","title":{"rendered":"TAKEDA Junji \u226aEnvironmental and Molecular Medicine\u226b <span>\u201cRegion-specific saturated germ-line mutagenesis in mice using the Sleeping Beauty transposon system.\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2005year\/article02\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1>\u7af9\u7530 \u6f64\u4e8c \u226a\u74b0\u5883\u30fb\u751f\u4f53\u6a5f\u80fd\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2005\/takeda20051002.jpeg\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2005\/takeda20051002.jpeg\" alt=\"\" height=\"158\" width=\"200\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2005-10-2<br \/>\n  <span class=\"lineFrame\">Publish<\/span> Nat. Methods.2; 763-769, 2005<\/p>\n<p><!-- \n\n<h3>Sleeping Beauty\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u30b7\u30b9\u30c6\u30e0\u306b\u3088\u308b\u9818\u57df\u306b\u9650\u5b9a\u3057\u305f\u5168\u907a\u4f1d\u5b50\u306e\u5909\u7570\u5c0e\u5165\u6cd5<\/h3>\n\n\n\n\n<p> \u6211\u3005\u306fSleeping Beauty\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u304c\u9818\u57df\u306b\u9650\u5b9a\u3057\u305f\u5834\u6240\u306b\u8ee2\u79fb\u3057\u3084\u3059\u3044\u6027\u8cea\u3092\u5229\u7528\u3057\u3001\u9818\u57df\u306b\u9650\u5b9a\u3057\u305f\u5168\u907a\u4f1d\u5b50\u7834\u58ca\u30b7\u30b9\u30c6\u30e0\u3092\u69cb\u7bc9\u3057\u3088\u3046\u3068\u8003\u3048\u305f\u3002\u5b9f\u969b\u306b\u306f4- MB\u306e\u30b2\u30ce\u30e0\u9818\u57df\u306b\u304a\u3044\u3066\u3059\u3079\u3066\u306e\u907a\u4f1d\u5b50\u304c\u7834\u58ca\u3055\u308c\u3066\u3044\u305f\u306e\u3067\u3001\u4eca\u5f8c\u3053\u306e\u30b7\u30b9\u30c6\u30e0\u304c\u9650\u5b9a\u3055\u308c\u305f\u9818\u57df\u306e\u30b2\u30ce\u30e0\u6a5f\u80fd\u89e3\u6790\u3092\u3059\u308b\u969b\u3001\u975e\u5e38\u306b\u6709\u7528\u306a\u30c4\u30fc\u30eb\u306b\u306a\u308b\u4e8b\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/p>\n\n --><\/p>\n<p> We use the &#8216;local hopping&#8217; phenomenon of a DNA-type transposon, Sleeping Beauty (SB), for region-specific saturation mutagenesis. All genes within a 4-Mb region of the original donor site were mutated by SB, indicating the potential of this system for functional genomic studies within a specific chromosomal region.<\/p>\n<p class=\"mt25\"><span class=\"lineFrame\">URL<\/span> <a href=\"http:\/\/www.casi.osaka-u.ac.jp\/25\/\" target=\"_blank\">http:\/\/www.casi.osaka-u.ac.jp\/25\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2005-10-2 Publish Nat. Methods.2; 763-769, 2005 We use the &#8216;local hopp [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1823,"parent":466,"menu_order":166,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/638"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=638"}],"version-history":[{"count":7,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/638\/revisions"}],"predecessor-version":[{"id":2359,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/638\/revisions\/2359"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/466"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1823"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=638"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}