{"id":639,"date":"2017-03-14T11:48:56","date_gmt":"2017-03-14T02:48:56","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2005year\/tsujimoto-yoshihide-takeda-junji"},"modified":"2017-04-28T15:25:57","modified_gmt":"2017-04-28T06:25:57","slug":"article03","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2005year\/article03","title":{"rendered":"TSUJIMOTO Yoshihide \u226aMolecular Genetics\u226b TAKEDA Junji \u226aEnvironmental and Molecular Medicine\u226b <span>\u201cCyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic death\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2005year\/article03\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1>\u8fbb\u672c \u8cc0\u82f1 \u226a\u907a\u4f1d\u5b50\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2005\/tujimoto20050331.jpeg\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2005\/tujimoto20050331.jpeg\" alt=\"\" height=\"151\" width=\"200\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2005-3-31<br \/>\n  <span class=\"lineFrame\">Publish<\/span> Nature&#12288;434: 652-658 (2005)<\/p>\n<p><!-- \n\n<h3>\u30b7\u30af\u30ed\u30d5\u30a3\u30ea\u30f3D\u4f9d\u5b58\u7684\u30df\u30c8\u30b3\u30c9\u30ea\u30a2\u819c\u900f\u904e\u6027\u9077\u79fb\u73fe\u8c61\u306f\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3067\u306f\u306a\u304f\u3001\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u306b\u95a2\u4e0e\u3059\u308b<\/h3>\n\n\n\n\n<p>\u8981\u65e8\uff1a\u7d30\u80de\u6b7b\u306b\u304a\u3044\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u6f14\u3058\u3066\u3044\u308b\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u819c\u900f\u904e\u6027\u9077\u79fb\u73fe\u8c61\uff08MPT\uff09\u306e\u7d30\u80de\u6b7b\u306b\u304a\u3051\u308b\u5f79\u5272\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u30b7\u30af\u30ed\u30d5\u30a3\u30ea\u30f3D\uff08CypD\uff09\u3092\u6b20\u640d\u3057\u305f\u30de\u30a6\u30b9\u3092\u4f5c\u51fa\u3057\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001CypD\u306fMPT\u306b\u5fc5\u9808\u3067\u3042\u308b\u3053\u3068\u3001MPT\u306f\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u306f\u95a2\u4e0e\u305b\u305a\u3001\u6d3b\u6027\u9178\u7d20\u306a\u3069\u306b\u3088\u308b\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\u3002\u307e\u305fCypD\u6b20\u640d\u30de\u30a6\u30b9\u306f\u3001\u5fc3\u81d3\u306e\u865a\u8840\u518d\u6f45\u6d41\u50b7\u5bb3\u306b\u5f37\u3044\u8010\u6027\u3092\u793a\u3059\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n\n --><\/p>\n<p>Mitochondria play   an important role in energy production, Ca<sup>2+<\/sup> homeostasis, and   cell death. In recent years, the role of the mitochondria in apoptotic   and necrotic cell death has attracted much attention. In apoptotic and   necrotic death, the mitochondrial permeability transition (mPT), which   leads to disruption of the outer mitochondrial membrane and   mitochondrial dysfunction, is considered to be one of the key events,   although its exact role in cell death remains elusive. Therefore, we   created mice lacking cyclophilin D (Cyp D), which is considered to be   involved in the mPT to analyze its role in cell death. Cyp D-deficient   mice were developmentally normal and showed no apparent anomalies, but   Cyp D-deficient mitochondria did not undergo the Cyclosporin A   (CsA)-sensitive mPT. Cyp D-deficient cells died normally in response to   various apoptotic stimuli, but showed resistance to necrotic cell death   induced by oxygen radicals and Ca<sup>2+<\/sup> overload. In addition,   Cyp D-deficient mice showed a high level of resistance to ischemia\/   reperfusion-induced cardiac injury. Our results indicate that the Cyp   D-dependent mPT regulates some forms of necrotic death, but not   apoptotic death.<\/p>\n<p class=\"mt25\"><span class=\"lineFrame\">URL<\/span> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/pub\/gene\/www\/\" target=\"_blank\">http:\/\/www.med.osaka-u.ac.jp\/pub\/gene\/www\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2005-3-31 Publish Nature&#12288;434: 652-658 (2005) Mitochondria play an imp [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1824,"parent":466,"menu_order":169,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/639"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=639"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/639\/revisions"}],"predecessor-version":[{"id":2358,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/639\/revisions\/2358"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/466"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1824"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=639"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}