{"id":645,"date":"2017-03-14T11:50:30","date_gmt":"2017-03-14T02:50:30","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2007year\/nakaoka-yoshikazu"},"modified":"2017-04-28T15:30:04","modified_gmt":"2017-04-28T06:30:04","slug":"article01","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2007year\/article01","title":{"rendered":"NAKAOKA Yoshikazu \u226aCardiovascular Medicine\u226b <span>\u201cGab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1\/ErbB signaling.\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2007year\/article01\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1>\u4e2d\u5ca1 \u826f\u548c \u226a\u5faa\u74b0\u5668\u5185\u79d1\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2007\/nakaoka20070702.jpeg\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2007\/nakaoka20070702.jpeg\" alt=\"\" height=\"124\" width=\"200\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2007-7-2<br \/>\n  <span class=\"lineFrame\">Publish<\/span> Journal of Clinical Investigation; 117, 1771-1781, 2007<\/p>\n<p><!-- \n\n<h3>Gab\u30d5\u30a1\u30df\u30ea\u30fc\u86cb\u767d\u8cea\u306f\u30cb\u30e5\u30fc\u30ec\u30ae\u30e5\u30ea\u30f3-1\uff0fErbB\u30b7\u30b0\u30ca\u30eb\u3092\u4ecb\u3057\u305f\u751f\u5f8c\u306e\u5fc3\u6a5f\u80fd\u7dad\u6301\u306b\u5fc5\u9808\u3067\u3042\u308b<\/h3>\n\n\n\n\n<p>\u8981\u65e8\uff1a\u6210\u4f53\u3067\u306eGab\u30d5\u30a1\u30df\u30ea\u30fc\u86cb\u767d\u8cea\u306e\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u76ee\u7684\u3067\u5fc3\u7b4b\u7279\u7570\u7684Gab1\/Gab2\u4e8c\u91cd\u6b20\u640d  \uff08\uff24\uff2b\uff2f\uff09\u30de\u30a6\u30b9\u3092\u4f5c\u6210\u3057\u305f\u3002\uff24\uff2b\uff2f\u30de\u30a6\u30b9\u306f\u5fc3\u4e0d\u5168\u3092\u81ea\u7136\u767a\u75c7\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u300c\u5fc3\u5185\u819c\u5f3e\u6027\u7dda\u7dad\u75c7\u300d\u306b\u985e\u4f3c\u3057\u305f\u75c5\u7406\u50cf\u3092\u5448\u3057\u305f\u3002\u5fc3\u7b4b\u3067\u306eGab1\/2\u306e\u6b20  \u640d\u306b\u3088\u3063\u3066\u3001\u2460Neuregulin-1\/ErbB\u30b7\u30b0\u30ca\u30eb\u306b\u3088\u308bERK1\/2\u3068AKT\u306e\u6d3b\u6027\u5316\u304c\u969c\u5bb3\u3055\u308c\u3066\u304a\u308a\u3001\u2461\u5fc3\u7b4b\u3067\u306eNeuregulin-1\u523a  \u6fc0\u4f9d\u5b58\u6027\u306e\u5185\u76ae\u4fdd\u8b77\u56e0\u5b50Angiopoietin-1\u306e\u767a\u73fe\u5fdc\u7b54\u3082\u969c\u5bb3\u3055\u308c\u3001\u5fc3\u5185\u819c\u7dda\u7dad\u5f3e\u6027\u5316\u3068\u5fc3\u81d3\u7d44\u7e54\u5185\u306e\u7570\u5e38\u306b\u62e1\u5927\u3057\u305f\u5909\u6027\u6bdb\u7d30\u8840\u7ba1\u50cf\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3002  \u4ee5\u4e0a\u3088\u308a\u5fc3\u81d3\u7d44\u7e54\u5185\u3067\u306e\u5fc3\u7b4b\uff0d\u5185\u76ae\u9593\u3067Neuregulin-1\u3068Angiopoietin-1\u306b\u3088\u308b\u53cc\u65b9\u5411\u6027\u30b7\u30b0\u30ca\u30eb\u306b\u3088\u308b\u751f\u5f8c\u306e\u5fc3\u6a5f\u80fd\u7dad\u6301\u3068\u5fc3\u5185\u819c\u7dda  \u7dad\u5f3e\u6027\u5316\u4e88\u9632\u306bGab\u30d5\u30a1\u30df\u30ea\u30fc\u86cb\u767d\u8cea\u304c\u5fc5\u9808\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u3002<\/p>\n\n --><\/p>\n<p> I examined   the role of Gab family proteins in the heart by creating   cardiomyocyte-specific Gab1\/Gab2-double knockout (DKO) mice. DKO mice   were viable, but exhibited marked ventricular dilatation and reduced   contractility with aging. NRG-1\u03b2 induced activation of both ERK and AKT   in the hearts of control mice, but not in those of DKO mice. In   addition, endocardial fibroelatsosis and abnormally dilated vessels were   observed in the ventricles of DKO mice. NRG-1\u03b2 upregulated expression   of an endothelium-stabilizing factor, angiopoeitin-1, in the hearts of   control mice, but not in those of DKO mice, possibly accounting for the   pathological abnormalities in the DKO hearts. Collectively, Gab1 and   Gab2 are essential for both maintenance of myocardial function and   stabilization of cardiac capillary\/endocardial endothelium through   transmitting NRG-1\u03b2\/ErbB signaling in the postnatal heart. <\/p>\n<p class=\"mt25\"><span class=\"lineFrame\">URL<\/span> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/pub\/imed1\/medone\/\" target=\"_blank\">http:\/\/www.med.osaka-u.ac.jp\/pub\/imed1\/medone\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2007-7-2 Publish Journal of Clinical Investigation; 117, 1771-1781, 2007 I e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1815,"parent":464,"menu_order":134,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/645"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=645"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/645\/revisions"}],"predecessor-version":[{"id":2364,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/645\/revisions\/2364"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/464"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1815"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=645"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}