{"id":649,"date":"2017-03-14T11:50:54","date_gmt":"2017-03-14T02:50:54","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2008year\/murakami-masaaki-hirano-toshio"},"modified":"2017-04-28T15:30:56","modified_gmt":"2017-04-28T06:30:56","slug":"article01","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2008year\/article01","title":{"rendered":"MURAKAMI Masaaki, HIRANO Toshio \u226aDevelopmental Immunology\u226b <span>\u201cInterleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2008year\/article01\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1>\u6751\u4e0a \u6b63\u6643\u3001\u5e73\u91ce \u4fca\u592b \u226a\u514d\u75ab\u767a\u751f\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2008\/murakami20081017.jpeg\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2008\/murakami20081017.jpeg\" alt=\"\" height=\"200\" width=\"146\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2008-10-17<br \/>\n  <span class=\"lineFrame\">Publish<\/span> Immunity, 29: 628-636, 2008<\/p>\n<p><!-- \n\n<h3>Th17\u7d30\u80de\u306f\u7e4a\u7dad\u82bd\u7d30\u80de\u306b\u5b58\u5728\u3059\u308bIL-6\u5897\u5e45\u30eb\u30fc\u30d7\u3092\u6d3b\u6027\u5316\u3059\u308b\u4e8b\u3067\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3092\u8a98\u5c0e\u3059\u308b\uff1a\u514d\u75ab\u7d30\u80de  \u3068\u975e\u514d\u75ab\u7d30\u80de\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u81ea\u5df1\u514d\u75ab\u75c5\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b<\/h3>\n\n\n\n\n<p>\uff1c\u7814\u7a76\u306e\u80cc\u666f\u3068\u7d4c\u7def\uff1e<br \/>\n  Th17\u7d30\u80de\u306f\u3001\u6700\u8fd1\u767a\u898b\u3055\u308c\u305fTh1\u3001Th2\u7d30\u80de\u306b\u7d9a\u304f\u7b2c\uff13\u756a\u76ee\u306eCD4+\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\u306e\u7d30\u80de\u96c6\u56e3\u3067\u3001\u6d3b\u6027\u5316\u3059\u308b\u3068\u591a\u304f\u306eIL-17\u3092\u7523\u751f\u3059\u308b\u3002\u3053\u308c  \u307e\u3067\u306e\u7814\u7a76\u304b\u3089\u3001Th17\u7d30\u80de\u306f\u3001\u591a\u304f\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\uff08\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3001\u7cd6\u5c3f\u75c5\u3001\u81ea\u5df1\u514d\u75ab\u6027\u8133\u810a\u9ac4\u708e\u7b49\uff09\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304d\u305f\u3002\u3057\u304b\u3057\u3001Th17  \u304b\u3089\u7523\u751f\u3055\u308c\u308bIL-17\u304c\u3069\u306e\u3088\u3046\u306b\u591a\u304f\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3092\u8a98\u5c0e\u3059\u308b\u306e\u304b\u4e0d\u660e\u3067\u3042\u3063\u305f\u3002\u4e00\u65b9\u3001\u6211\u3005\u306f\u514d\u75ab\u7d30\u80de\u3068\u7e4a\u7dad\u82bd\u7d30\u80de\u7b49\u306e\u975e\u514d\u75ab\u7d30\u80de\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u81ea\u5df1  \u514d\u75ab\u75c5\u306e\u767a\u75c7\u306b\u91cd\u8981\u3067\u3042\u308b\u4e8b\u3092\u5831\u544a\u3057\u3066\u304d\u305f\uff08Sawa et al., JEM, 2006\uff09\u3002<\/p>\n\n\n\n\n<p>\uff1c\u672c\u7814\u7a76\u306e\u5185\u5bb9\uff1e<br \/>\n  \u4eca\u56de\u3001\u6211\u3005\u306fTh17\u7d30\u80de\u304b\u3089\u7523\u751f\u3055\u308c\u308bIL-17\u304cIL-6\u3068\u5354\u8abf\u3057\u3066\u7e4a\u7dad\u82bd\u7d30\u80de\uff08\uff11\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u967d\u6027\u7d30\u80de\uff09\u306b\u4f5c\u7528\u3057\u3066\u3001\u3055\u3089\u306b\u3001\u591a\u304f\u306eIL-6\u3092\u7523\u751f  \u3059\u308b\u3068\u3044\u3046\u201dIL-17\u8a98\u5c0e\u6027\u306eIL-6\u7523\u751f\u5897\u5e45\u30eb\u30fc\u30d7\u201d\u306e\u5b58\u5728\u3092\u793a\u3057\u305f\u3002\u3053\u306eIL-6\u5897\u5e45\u30eb\u30fc\u30d7\u306e\u66b4\u8d70\u304c\u81ea\u5df1\u514d\u75ab\u6027\u95a2\u7bc0\u708e(F759\u95a2\u7bc0\u708e\uff09\u304a\u3088\u3073\u81ea\u5df1  \u514d\u75ab\u6027\u8133\u810a\u9ac4\u708e\uff08EAE\uff09\u306b\u91cd\u8981\u3067\u3042\u308b\u4e8b\u3092\u30de\u30a6\u30b9\u306e\u751f\u4f53\u5185\u306b\u3066\u8a3c\u660e\u3057\u305f\u3002<\/p>\n\n\n\n\n<p>\uff1c\u4eca\u5f8c\u306e\u5c55\u958b\uff1e<br \/>\n  \u3053\u306eIL-6\u5897\u5e45\u30eb\u30fc\u30d7\u3092\u4eba\u70ba\u7684\u306b\u5897\u5f37\u3001\u6e1b\u5f31\u3059\u308b\u4e8b\u3067\u3001\u751f\u4f53\u306e\u514d\u75ab\u53cd\u5fdc\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u3066\u30ef\u30af\u30c1\u30f3\u3001\u764c\u6cbb\u7642\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u7b49\u3078\u306e\u5fdc\u7528\u3082\u53ef\u80fd\u3068\u306a\u308b\u3002<\/p>\n\n --><\/p>\n<p>Dysregulated cytokine expression and signaling are   major contributors to a number of autoimmune diseases. Interleukin-17A   (IL-17A) and IL-6 are important in many disorders characterized by   immune self-recognition, and IL-6 is known to induce the differentiation   of T helper 17 (Th17) cells. Here we described an IL-17A-triggered   positive-feedback loop of IL-6 signaling, which involved the activation   of the transcription factors nuclear factor (NF)-\u03baB and signal   transducer and activator of transcription 3 (STAT3) in fibroblasts.   Importantly, enhancement of this loop caused by disruption of suppressor   of cytokine signaling 3 (SOCS3)-dependent negative regulation of the   IL-6 signal transducer gp130 contributed to the development of   arthritis. Because this mechanism also enhanced experimental autoimmune   encephalomyelitis (EAE) in wild-type mice, it may be a general etiologic   process underlying other Th17 cell-mediated autoimmune diseases.<\/p>\n<p class=\"mt25\"><span class=\"lineFrame\">URL<\/span> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/pub\/molonc\/www\/\" target=\"_blank\">http:\/\/www.med.osaka-u.ac.jp\/pub\/molonc\/www\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2008-10-17 Publish Immunity, 29: 628-636, 2008 Dysregulated cytokine express [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1812,"parent":463,"menu_order":134,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/649"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=649"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/649\/revisions"}],"predecessor-version":[{"id":2368,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/649\/revisions\/2368"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/463"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1812"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}