{"id":650,"date":"2017-03-14T11:50:54","date_gmt":"2017-03-14T02:50:54","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2008year\/takeda-kiyoshi-honda-kenya"},"modified":"2017-04-28T15:31:02","modified_gmt":"2017-04-28T06:31:02","slug":"article02","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2008year\/article02","title":{"rendered":"TAKEDA Kiyoshi, HONDA Kenya \u226aImmune Regulation\u226b <span>\u201cATP drives lamina proria TH17 cell differentiation.\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2008year\/article02\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1>\u7af9\u7530 \u6f54\u3001\u672c\u7530 \u8ce2\u4e5f \u226a\u514d\u75ab\u5236\u5fa1\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2008\/takeda20080820.jpeg\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2008\/takeda20080820.jpeg\" alt=\"\" height=\"163\" width=\"200\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2008-8-20<br \/>\n  <span class=\"lineFrame\">Publish<\/span> Nature,455: 808-812, 2008<\/p>\n<p><!-- \n\n<h3>\u8178\u5185\u7d30\u83cc\u7531\u6765\u306eATP\u304cTH17\u7d30\u80de\u5206\u5316\u306e\u8a98\u5c0e\u3092\u4fc3\u3059<\/h3>\n\n\n\n\n<p>\u6d88\u5316\u7ba1\u306b\u306f\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-17\u3092\u9ad8\u7523\u751f\u3059\u308bT\u7d30\u80de\u96c6\u56e3\uff08TH17\u7d30\u80de\u3068\u3088\u3070\u308c\u308b\uff09\u304c\u7279\u7570\u7684\u306b\u591a\u6570\u5b58\u5728\u3059\u308b\u3002\u3053\u306eTH17\u7d30\u80de\u306e\u7570\u5e38\u6d3b\u6027\u5316\u304c\u3001\u6f70\u760d\u6027\u5927\u8178\u708e\u3084\u30af\u30ed\u30fc\u30f3\u75c5\u306b\u4ee3\u8868\u3055\u308c\u308b\u708e\u75c7\u6027\u8178\u75be\u60a3\u306e\u539f\u56e0\u306e\u4e00\u3064\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u3053\u308c\u307e\u3067\u3001TH17  \u7d30\u80de\u304c\u306a\u305c\u6d88\u5316\u7ba1\u3067\u591a\u304f\u5b58\u5728\u3059\u308b\u306e\u304b\u3001\u8b0e\u3060\u3063\u305f\u3002\u6211\u3005\u306f\u3001\u8178\u5185\u5e38\u5728\u83cc\u7531\u6765\u306eATP (adenosine   5'-triphosphate)\u304c\u3001\u8178\u7ba1\u7c98\u819c\u56fa\u6709\u5c64\u306b\u7279\u7570\u7684\u306a\u6a39\u72b6\u7d30\u80de\u306b\u4f5c\u7528\u3057\u3001TH17\u7d30\u80de\u306e\u5206\u5316\u3092\u8a98\u5c0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\u3002<\/p>\n\n --><\/p>\n<p>High numbers of IL-17-producing TH17 cells are   selectively present in the intestinal lamina propria. Excessive   TH17-mediated responses lead to development of inflammatory bowel   diseases such as Crohn&#8217;s diseases and ulcerative colitis. However, it   remains totally unknown how TH17 cells differentiate in the intestine.   In this study, we demonstrate that adenosine 5&#8242;-triphophate (ATP)   derived from commensal bacteria acts on a unique subset of intestinal   dendritic cells to instruct development of TH17 cells.<\/p>\n<p class=\"mt25\"><span class=\"lineFrame\">URL<\/span> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/\" target=\"_blank\">http:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2008-8-20 Publish Nature,455: 808-812, 2008 High numbers of IL-17-producing  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1813,"parent":463,"menu_order":166,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/650"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=650"}],"version-history":[{"count":7,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/650\/revisions"}],"predecessor-version":[{"id":2369,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/650\/revisions\/2369"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/463"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1813"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=650"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}