{"id":658,"date":"2017-03-14T11:51:31","date_gmt":"2017-03-14T02:51:31","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2009year\/iwaki-mitsuhiro-yanagida-toshio"},"modified":"2017-04-28T15:31:54","modified_gmt":"2017-04-28T06:31:54","slug":"article07","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2009year\/article07","title":{"rendered":"IWAKI Mitsuhiro, YANAGIDA Toshio \u226aMolecular Physiology\u226b <span>\u201cBrownian search-and-catch mechanism for myosin-VI steps\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2009year\/article07\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1>\u5ca9\u57ce \u5149\u5b8f\u3001\u67f3\u7530 \u654f\u96c4 \u226a\u5206\u5b50\u751f\u7406\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2009\/iwaki20090510.jpeg\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2009\/iwaki20090510.jpeg\" alt=\"\" height=\"130\" width=\"291\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2009-5-10<br \/>\n  <span class=\"lineFrame\">Publish<\/span> Nature Chemical Biology, 5(6), 403-405 (2009)<\/p>\n<p><!-- \n\n<h3>\u30df\u30aa\u30b7\u30f3VI\u306e\u4e00\u65b9\u5411\u904b\u52d5\u306e\u305f\u3081\u306e\u30d6\u30e9\u30a6\u30f3\u904b\u52d5\u6574\u6d41\u6a5f\u69cb <\/h3>\n\n\n\n\n<p>\u5206\u5b50\u30e2\u30fc\u30bf\u30fc\u3067\u3042\u308b\u30df\u30aa\u30b7\u30f3VI\u306f\u5e83\u7bc4\u306b\u5b58\u5728\u3057\u3001\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306a\u3069\u306e\u5c0f\u80de\u8f38\u9001\u3084\u7d30\u80de\u904b\u52d5\u3001\u819c\u5f35\u529b\u306e\u4fdd\u6301  \u3068\u3044\u3063\u305f\u52d5\u304d\u3084\u529b\u767a\u751f\u3092\u62c5\u3046\u3002\u7279\u306b\u5c0f\u80de\u8f38\u9001\u6642\u306b\u306f\u3001\uff21\uff34\uff30\u306e\u52a0\u6c34\u5206\u89e3\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u5229\u7528\u3057\u7d30\u80de\u9aa8\u683c\u306e\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u4e0a\u3067\u4e00\u65b9\u5411\u306e\u6b69\u884c\u904b\u52d5\u3092\u884c\u3046\u3002\u6b69\u884c  \u904b\u52d5\u306b\u304a\u3044\u3066\u3001\u30df\u30aa\u30b7\u30f3VI\u306e\uff12\u3064\u306e\u30e2\u30fc\u30bf\u30fc\u90e8\u4f4d\u306f\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u4e0a\u3067\u4ea4\u4e92\u306b\u30d6\u30e9\u30a6\u30f3\u904b\u52d5\u3092\u884c\u3044\u3001\u524d\u5f8c\u306e\u7d50\u5408\u4f4d\u7f6e\u3092\u63a2\u7d22\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u305f  \u304c\u3001\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u7d50\u5408\u4f4d\u7f6e\u3092\u6c7a\u5b9a\u3057\u3066\u3044\u308b\u304b\u308f\u304b\u3063\u3066\u3044\u306a\u304b\u3063\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u30ec\u30fc\u30b6\u30fc\u30c8\u30e9\u30c3\u30d7\u3092\u7528\u3044\u305f\uff11\u5206\u5b50\u64cd\u4f5c\u6280\u8853\u306b\u3088\u3063\u3066\u7d50\u5408\u4f4d\u7f6e\u3092\u63a2\u7d22\u4e2d\u306e\u30e2\u30fc  \u30bf\u30fc\u90e8\u4f4d\u306b\u64cd\u4f5c\u3092\u52a0\u3048\u3001\u7d50\u5408\u4f4d\u7f6e\u306e\u6c7a\u5b9a\u6a5f\u69cb\u3092\u8abf\u3079\u305f\u3002\u30df\u30aa\u30b7\u30f3VI\u306e\uff12\u3064\u306e\u30e2\u30fc\u30bf\u30fc\u90e8\u4f4d\u306f\u30cd\u30c3\u30af\u90e8\u4f4d\u3092\u4ecb\u3057\u3066\u9023\u7d50\u3055\u308c\u3066\u304a\u308a\u3001\u4ea4\u4e92\u306b\u30e2\u30fc\u30bf\u30fc\u3092\u524d\u65b9\u306b\u62bc\u3057  \u51fa\u3057\u306a\u304c\u3089\u6b69\u304f\u3068\u3001\u5206\u5b50\u5185\u3067\u6b6a\u307f\u304c\u52a0\u3048\u3089\u308c\u308b\u3002\u30d6\u30e9\u30a6\u30f3\u904b\u52d5\u306b\u3088\u3063\u3066\u7d50\u5408\u4f4d\u7f6e\u3092\u63a2\u7d22\u3057\u3066\u3044\u308b\u30e2\u30fc\u30bf\u30fc\u90e8\u4f4d\u306f\u3001\u524d\u65b9\u306e\u7d50\u5408\u4f4d\u7f6e\u3067\u52a0\u3048\u3089\u308c\u308b\u5206\u5b50\u5185\u6b6a\u307f\u3092\u611f\u3058  \u308b\u3068ATP\u306e\u52a0\u6c34\u5206\u89e3\u30b5\u30a4\u30af\u30eb\u3092\u9032\u3081\u3066\u30a2\u30af\u30c1\u30f3\u3068\u5f37\u304f\u7d50\u5408\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u3053\u306e\u6210\u679c\u306f\u3001\u6211\u3005\u304c\u3001\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb\u3067\u6a5f\u80fd\u3059\u308b\u5206\u5b50\u30e2\u30fc\u30bf\u30fc\u306e\u30d6\u30e9\u30a6\u30f3\u904b  \u52d5\u6574\u6d41\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u3002<\/p>\n\n --><\/p>\n<p> The cargo transporter myosin-VI processively walks along actin filaments using its two heads.   Here we  use single-molecule nanometry to show that the strong binding by myosin heads to actin is greatly accelerated (approximately 30-fold)   when backward strain is applied to weakly bound heads during the actin search. We propose that the  myosin head searches for the forward actin target by Brownian motion and  catches the actin in a strain-dependent manner.<\/p>\n<p class=\"mt25\"><span class=\"lineFrame\">URL<\/span> <a href=\"http:\/\/www.phys1.med.osaka-u.ac.jp\/\" target=\"_blank\">http:\/\/www.phys1.med.osaka-u.ac.jp:80\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2009-5-10 Publish Nature Chemical Biology, 5(6), 403-405 (2009) The cargo tr [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1809,"parent":462,"menu_order":183,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/658"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=658"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/658\/revisions"}],"predecessor-version":[{"id":2377,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/658\/revisions\/2377"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/462"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1809"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}