{"id":659,"date":"2017-03-14T11:51:31","date_gmt":"2017-03-14T02:51:31","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2009year\/murakami-masaaki-hirano-toshio"},"modified":"2017-04-28T15:31:59","modified_gmt":"2017-04-28T06:31:59","slug":"article08","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2009year\/article08","title":{"rendered":"MURAKAMI Masaaki, HIRANO Toshio \u226aDevelopmental Immunology\u226b <span>\u201cHepatic Interleukin-7 Expression Regulates T Cell Responses\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2009year\/article08\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1>\u6751\u4e0a \u6b63\u6643\u3001\u5e73\u91ce \u4fca\u592b \u226a\u514d\u75ab\u767a\u751f\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2009\/sawa_immunity200903.jpeg\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2009\/sawa_immunity200903.jpeg\" alt=\"\" height=\"93\" width=\"200\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2009-3-12<br \/>\n  <span class=\"lineFrame\">Publish<\/span> Immunity 30, 447-457, 2009<\/p>\n<p><!-- \n\n<h3>\u611f\u67d3\u3067\u767a\u73fe\u3059\u308b\u809d\u81d3\u7531\u6765\u306eIL-7\u306b\u3088\u308bT\u7d30\u80de\u306e\u53cd\u5fdc\u6027\u306e\u5236\u5fa1<\/h3>\n\n\n\n\n<p>IL-7\u306fT\u7d30\u80de\u306e\u53cd\u5fdc\u6027\u3092\u898f\u5b9a\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u3057\u3066\u53e4\u304f\u304b\u3089\u77e5\u3089\u308c\u3066\u304d\u305f\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u304b  \u3089\u3001(i)IL-7\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3067\u306fT\u7d30\u80de\u304c\u307b\u3068\u3093\u3069\u5b58\u5728\u3057\u306a\u3044\u3053\u3068\u3001(ii)\u6d3b\u6027\u5316T\u7d30\u80de\u3067\u306fIL-7\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u304c\u975e\u5e38\u306b\u4f4e\u4e0b\u3059\u308b\u304c\u3001\u30e1\u30e2  \u30ea\u30fcT\u7d30\u80de\u3067\u306f\u9006\u306b\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u7b49\u306e\u5b9f\u9a13\u4e8b\u5b9f\u304b\u3089\u3001\u201c\u751f\u4f53\u5185\u3067\u306f\u3001IL-7\u306f\u5916\u6765\u523a\u6fc0\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\u4e8b\u306f\u7121\u304f\u3001T\u7d30\u80de\u3078\u306eIL-7\u306e\u523a\u6fc0\u306fIL-  7\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u5f37\u5ea6\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u201d\u3068\u4fe1\u3058\u3089\u308c\u3066\u304d\u305f\u3002\u4e00\u65b9\u3001\u809d\u81d3\u306f\u708e\u75c7\u306e\u30bb\u30f3\u30b5\u30fc\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u304d\u305f\u3002\u5b9f\u969b\u306b\u611f\u67d3\u7b49\u306b\u3088\u308b\u708e\u75c7\u5f8c\u306b\u7523\u751f\u3055\u308c\u308b  IL-6\u306f\u809d\u81d3\u306b\u4f5c\u7528\u3057\u3066CRP\u7b49\u306e\u6025\u6027\u671f\u30bf\u30f3\u30d1\u30af\u3092\u8840\u4e2d\u306b\u767a\u73fe\u3059\u308b\u3002CRP\u3092\u542b\u3080\u6025\u6027\u671f\u30bf\u30f3\u30d1\u30af\u306f\u3001\u4e00\u822c\u7684\u306a\u8840\u6db2\u691c\u67fb\u306b\u3082\u7528\u3044\u3089\u308c\u3066\u751f\u4f53\u5185\u306e\u708e\u75c7\u306e\u30de\u30fc  \u30ab\u30fc\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u307e\u3067\u306b\u6025\u6027\u671f\u30bf\u30f3\u30d1\u30af\u3067T\u7d30\u80de\u306b\u76f4\u63a5\u4f5c\u7528\u3059\u308b\u3082\u306e\u306f\u77e5\u3089\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u3002\u4eca\u56de\u3001\u6211\u3005\u306f\u3001\u611f\u67d3\u5f8c\u306eTLR\u4fe1\u53f7\u306b\u3066\u8a98\u5c0e  \u3055\u308c\u308b\uff11\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u304c\u809d\u7d30\u80de\u306b\u76f4\u63a5\u4f5c\u7528\u3057\u3066\u809d\u81d3\u304b\u3089\u8840\u4e2d\u306b\u591a\u304f\u306eIL-7\u304c\u5faa\u74b0\u3059\u308b\u3053\u3068\u3001\u3055\u3089\u306b\u3001\u305d\u306eIL-7\u304cCD4+T\u7d30\u80de\u304a\u3088\u3073CD8+T  \u7d30\u80de\u306e\u751f\u5b58\u3092\u8a98\u5c0e\u3057\u3066CD4+T\u7d30\u80de\u304a\u3088\u3073CD8+T\u7d30\u80de\u306e\u53cd\u5fdc\u6027\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u3064\u307e\u308a\u3001IL-7\u306f\u809d\u81d3\u304b\u3089\u611f\u67d3\u7b49\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u305f\u708e\u75c7  \u6642\u306b\u8a98\u5c0e\u3055\u308c\u308b\u6025\u6027\u671f\u30bf\u30f3\u30d1\u30af\u3067T\u7d30\u80de\u306b\u76f4\u63a5\u4f5c\u7528\u3057\u3066\u305d\u306e\u6a5f\u80fd\u3092\u5897\u5f37\u3057\u3066\u611f\u67d3\u7b49\u3092\u5236\u5fa1\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308b\u4e8b\u304c\u5224\u660e\u3057\u305f\u3002 <\/p>\n\n --><\/p>\n<p>TLR-mediated signals in a variety of inflammatory   cells, including dendritic cells, macrophages, neutrophils, and   nonhematopoietic cells, result in the production of proinflammatory   cytokines. These cytokines initiate various systemic responses and   \u201cacute-phase reactions,\u201d which are characterized by altered protein   expression profiles in hepatocytes, including the production of many   serum proteins, suggesting that the liver is a sensor of inflammation.  Interleukin-7 (IL-7), which is known to be important for T cell   homeostasis, is mainly produced by stromal cells. It is believed that   the production of IL-7 in stromal cells occurs at a constant rate in   vivo and is unaffected by most extrinsic stimuli. IL-7 expression in   vivo, which appears to limit the size of the lymphocyte pool, is thought   to be regulated by IL-7 receptor \u03b1 (IL-7R\u03b1)-mediated consumption rather   than the rate of IL-7 expression. We, however, showed that excessive   IL-6 signaling increased the amount of IL-7 expression in vivo, which   was followed by the development of autoimmune arthritis. We show that   IL-7, the production of which was thought to occur at a constant rate in   vivo, was a hepatically expressed protein that directly controled T   cell responses. Depletion of IL-7 expression in the liver abrogated   several TLR-mediated T cell events, including enhanced CD4+ T cell and   CD8+ T cell survival, augmented CD8+ T cell cytotoxic activity, and the   development of experimental autoimmune encephalitis, a Th17   cell-mediated autoimmune disease. Thus, T cell responses are regulated   by hepatocyte-derived IL-7, which is expressed in response to TLR   signaling in vivo. We suggested that TLR-induced IL-7 expression in the   liver, which is an acute-phase response, may be a good diagnostic and   therapeutic target for efficient vaccine developments and for conditions   characterized by TLR-mediated T cell dysregulation, including   autoimmune diseases. <\/p>\n<p class=\"mt25\"><span class=\"lineFrame\">URL<\/span> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/pub\/molonc\/www\/\" target=\"_blank\">http:\/\/www.med.osaka-u.ac.jp\/pub\/molonc\/www\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2009-3-12 Publish Immunity 30, 447-457, 2009 TLR-mediated signals in a varie [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1810,"parent":462,"menu_order":186,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/659"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=659"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/659\/revisions"}],"predecessor-version":[{"id":2378,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/659\/revisions\/2378"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/462"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1810"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}