{"id":664,"date":"2017-03-14T11:52:11","date_gmt":"2017-03-14T02:52:11","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2010year\/nakano-atsushitakashima-seiji"},"modified":"2017-04-28T16:06:34","modified_gmt":"2017-04-28T07:06:34","slug":"article04","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2010year\/article04","title":{"rendered":"NAKANO Atsushi,TAKASHIMA Seiji \u226aMolecular Cardiology\u226b <span>\u201cAMPK controls the speed of microtubule polymerization and directional cell   migration via CLIP-170 phosphorylation.\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2010year\/article04\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1> \u4e2d\u91ce&#12288;\u6566\u3001\u9ad8\u5cf6&#12288;\u6210\u4e8c\u226a\u5206\u5b50\u5fc3\u8840\u7ba1\u533b\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2010\/takashima20100523.png\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2010\/takashima20100523.png\" alt=\"\u5206\u5b50\u5fc3\u8840\u7ba1\u533b\u5b66\" height=\"200\" width=\"138\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2010-5-23<br \/>\n  <span class=\"lineFrame\">Publish<\/span>Nature Cell Biology &nbsp;12(6), 583-590 (2010)<\/p>\n<p><!-- \n\n<h3>AMPK\u306fCLIP-170\u306e\u30ea\u30f3\u9178\u5316\u3092\u4ecb\u3057\u3066\u5fae\u5c0f\u7ba1\u4f38\u9577\u30b9\u30d4\u30fc\u30c9\u304a\u3088\u3073\u7d30\u80de\u904a\u8d70\u3092\u8abf\u6574\u3059\u308b<\/h3>\n\n\n\n\n<p>AMPK\u306fATP\u306e\u4f4e\u4e0b\u3092\u611f\u77e5\u3057\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\u30ea\u30f3\u9178\u5316\u9175\u7d20\u3042\u308b\u3002AMPK\u306f\u4f4e\u9178\u7d20\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u3055\u307e\u3056\u307e\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u7570\u5e38\u306b\u3088\u308a\u6d3b\u6027\u5316\u3055\u308c\u751f\u4f53\u3067\u306e\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002 <br \/>\n  \u3053\u308c\u3089\u306e\u904e\u7a0b\u306e\u4e2d\u3067\u3001AMPK\u306e\u6d3b\u6027\u5316\u306f\u7d30\u80de\u6975\u6027\u306e\u5f62\u6210\u306b\u3082\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u305f\u304c\u305d\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4e0d\u660e\u3067\u3042\u3063\u305f\u3002\u672c\u8ad6\u6587\u3067\u306fAMPK\u306e\u57fa\u8cea\u3067\u3042\u308bCLIP-170\u3092\u5fc3\u81d3\u7d44\u7e54\u304b\u3089\u65b0\u305f\u306b\u7cbe\u88fd\u540c\u5b9a\u3057\u3001AMPK\u306e\u7d30\u80de\u6975\u6027\u5f62\u6210\u306b\u304a\u3051\u308b\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002 <br \/>\n  &#12288;AMPK\u306b\u3088\u308bCLIP-170\u306e\u5fae\u5c0f\u7ba1\u904b\u52d5\u306e\u5236\u5fa1\u304c\u660e\u78ba\u306b\u793a\u3055\u308c\u305f\u3053\u3068\u3067\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u67af\u6e07\u72b6\u614b\u306b\u304a\u3051\u308b\u5fae\u5c0f\u7ba1\u52d5\u614b\u5236\u5fa1\u3068\u3044\u3046\u5168\u304f\u65b0\u3057\u3044\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u6a5f\u5e8f\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u305f\u3002<\/p>\n\n --><\/p>\n<p>AMPK  is a stress response kinase which is activated by ATP consuming cellular  conditions. In this process, AMPK plays an important role in the cellular polarity;  however its molecular mechanism has been unknown. <br \/>\n  In this work, we purified and identified the novel AMPK substrate  CLIP-170 and revealed the physiological importance in cell polarity by  AMPK-CLIP170 singling.<br \/>\n  These data  clarified the novel stress response via the regulation of microtubule polymerization  against energy consuming cellular conditions. <\/p>\n<p class=\"mt25\">&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2010-5-23 PublishNature Cell Biology &nbsp;12(6), 583-590 (2010) AMPK is a s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1801,"parent":461,"menu_order":171,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/664"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=664"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/664\/revisions"}],"predecessor-version":[{"id":2384,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/664\/revisions\/2384"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/461"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1801"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=664"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}