{"id":665,"date":"2017-03-14T11:52:11","date_gmt":"2017-03-14T02:52:11","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2010year\/hattori-tsuyoshi-ito-akirakatayama-taiichi-tohyama-masaya"},"modified":"2017-04-28T16:06:38","modified_gmt":"2017-04-28T07:06:38","slug":"article05","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2010year\/article05","title":{"rendered":"HATTORI Tsuyoshi, ITO Akira,KATAYAMA Taiichi,  TOHYAMA Masaya \u226aMolecular Neuropsychiatry\u226b <span>\u201cDISC1 regulates cell\u2013cell adhesion, cell\u2013matrix adhesion and neurite outgrowth.\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2010year\/article05\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1> \u670d\u90e8&#12288;\u525b\u5fd7\u3001\u4f0a\u85e4&#12288;\u5f70\u3001\u7247\u5c71&#12288;\u6cf0\u4e00\u3001\u9060\u5c71&#12288;\u6b63\u5f4c\u226a\u5206\u5b50\u7cbe\u795e\u795e\u7d4c\u5b66\uff08\u5927\u65e5\u672c\u4f4f\u53cb\u88fd\u85ac\uff09\u5bc4\u9644\u8b1b\u5ea7\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2010\/hattori20100518_s.png\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2010\/hattori20100518_s.png\" alt=\"\u5206\u5b50\u7cbe\u795e\u795e\u7d4c\u5b66\u5bc4\u9644\u8b1b\u5ea7\" height=\"154\" width=\"288\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2010-5-18<br \/>\n  <span class=\"lineFrame\">Publish<\/span>Molecular Psychiatry15 : 798&ndash;809  (2010)<\/p>\n<p><!-- \n\n<h3>\u7cbe\u795e\u75be\u60a3\u30ea\u30b9\u30af\u56e0\u5b50DISC1\u306f\u7d30\u80de\u9593\u63a5\u7740\u3001\u7d30\u80de\uff0d\u7d30\u80de\u5916\u57fa\u8cea\u9593\u63a5\u7740\u3001\u795e\u7d4c\u7a81\u8d77\u4f38\u5c55\u3092\u5236\u5fa1\u3059\u308b<br \/>\n<\/h3>\n\n\n\n\n<p>\u7cbe\u795e\u75be\u60a3\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3042\u308bDISC1\u306f\u795e\u7d4c\u7d30\u80de\u306e\u7a81\u8d77\u4f38\u5c55\u3001\u79fb\u52d5\u3001\u5897\u6b96\u306a\u3069\u8133\u795e\u7d4c\u767a\u9054\u306e\u904e\u7a0b\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002\u4eca\u56de\u3001\u6211\u3005\u306fDISC1\u304c\u7d30\u80de\u9593\u306e\u63a5\u7740\u306b\u50cd\u304fN-cadherin\u306e\u767a\u73fe\u91cf\u3092\u5897\u52a0\u3055\u305b\u3001\u305d\u306e\u3053\u3068\u306b\u3088\u308a\u7d30\u80de\u9593\u306e\u63a5\u7740\u3092\u4fc3\u9032\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u307e\u305f\u3001DISC1\u306f\u7d30\u80de\uff0d\u7d30\u80de\u5916\u57fa\u8cea\u3068\u306e\u63a5\u7740\u3092\u62c5\u3063\u3066\u3044\u308bb1-integrin\u306e\u767a\u73fe\u91cf\u3082\u5236\u5fa1\u3057\u3066\u304a\u308a\u3001DISC1\u304c\u7d30\u80de\u8868\u9762\u3084\u795e\u7d4c\u6210\u9577\u5186\u9310\u306eb1-integrin\u306e\u767a\u73fe\u91cf\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u795e\u7d4c\u7a81\u8d77\u4f38\u5c55\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u306b\u3088\u308a\u3001\u6211\u3005\u306fDISC1\u304cN-cadherin\u3068b1-integrin\u3068\u3044\u3046\u7d30\u80de\u63a5\u7740\u56e0\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u795e\u7d4c\u7d30\u80de\u6a5f\u80fd\u3092\u8abf\u7bc0\u3059\u308b\u3068\u3044\u3046\u65b0\u305f\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n\n --><\/p>\n<p> Disrupted-in-schizophrenia 1 (DISC1) is a promising susceptibility gene for major mental illness. Recent studies have implicated DISC1 in key neurodevelopmental processes, including neurite outgrowth, neuronal migration and proliferation. Here, we report that DISC1 regulates cell&ndash;cell and cell&ndash;matrix adhesion and neurite outgrowth. DISC1 overexpression increased expression of the adherence junction protein N-cadherin and enhanced cell&ndash;cell adhesion. The increased N-cadherin accumulated in the areas of cell&ndash;cell contact. DISC1 overexpression also enhanced cell&ndash;matrix adhesion by inducing expression of b1-integrin protein. In the presence of nerve growth factor (NGF), DISC1 overexpression increased&#12288;b1-integrin expression at the cell membrane and growth cone. NGF-induced neurite extension was enhanced by DISC1, and anti-b1-integrin antibody reduced the neurite outgrowth of DISC1-overexpressing cells to the control level. Furthermore, DISC1 also regulated N-cadherin and b1-integrin expression at the cell membrane in primary neurons. <\/p>\n<p class=\"mt25\">&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2010-5-18 PublishMolecular Psychiatry15 : 798&ndash;809 (2010) Disrupted-in- [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1802,"parent":461,"menu_order":177,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/665"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=665"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/665\/revisions"}],"predecessor-version":[{"id":2385,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/665\/revisions\/2385"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/461"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1802"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}