{"id":673,"date":"2017-03-14T11:53:36","date_gmt":"2017-03-14T02:53:36","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2011year\/sasaki-tsutomu-kitagawa-kazuo"},"modified":"2017-04-28T16:08:19","modified_gmt":"2017-04-28T07:08:19","slug":"article06","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2011year\/article06","title":{"rendered":"SASAKI Tsutomu, KITAGAWA Kazuo \u226aNeurology\u226b <span>\u201cSIK2  Is a Key Regulator for Neuronal Survival after Ischemia via TORC1-CREB\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2011year\/article06\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1> \u4f50\u3005\u6728&#12288;\u52c9\u3001\u5317\u5ddd&#12288;\u4e00\u592b\u226a\u795e\u7d4c\u5185\u79d1\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2011\/sasaki20110113.png\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2011\/sasaki20110113.png\" alt=\"\u795e\u7d4c\u5185\u79d1\u5b66\" height=\"154\" width=\"288\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2011-1-13<br \/>\n  <span class=\"lineFrame\">Publish<\/span> Neuron&#12288;69(1):106-19(2011)<\/p>\n<p><!-- \n\n<h3>SIK2(\u5869\u8a98\u5c0e\u6027\u30ad\u30ca\u30fc\u305c2)\u306f\u3001\u8133\u865a\u8840\u306b\u969b\u3057\u3066CREB-TORC1\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u795e\u7d4c\u7d30\u80de\u969c\u5bb3\u3092\u5236\u5fa1\u3059\u308b<\/h3>\n\n\n\n\n<p>\u8ee2\u5199\u56e0\u5b50CREB(cAMP responsive element-binding protein)\u306f\u3001\u8133\u5185\u306b\u8c4a\u5bcc\u306b\u767a\u73fe\u3057\u3001\u8a18\u61b6\u3001\u795e\u7d4c\u53ef\u5851\u6027\u3001\u7d30\u80de\u751f\u5b58\u306a\u3069\u5e45\u5e83\u3044\u795e\u7d4c\u6a5f\u80fd\u3001\u6216\u3044\u306f\u75c5\u614b\u306b\u95a2\u4e0e\u3059\u308b\u3002\u4eca\u56de\u6211\u3005\u306f\u3001SIK2\u3001CREB-specific coactivator transducer of regulated CREB  activity 1(TORC1\/CRTC1)\u304c\u795e\u7d4c\u7d30\u80de\u306b\u8c4a\u5bcc\u306b\u767a\u73fe\u3057\u3001\u8133\u865a\u8840\u6642\u306b\u306fCa2+\/calmodulin-dependent protein  kinase(CaMK)1\/4 \u306e\u6d3b\u6027\u5316\u306b\u3088\u308a\u3001SIK2\u304c\u5206\u89e3\u3055\u308c\u3001TORC1-CREB\u3092\u4ecb\u3057\u3066\u4e0b\u6d41\u306e\u795e\u7d4c\u4fdd\u8b77\u56e0\u5b50\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u65b0\u898f\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u5831\u544a\u3057\u305f\u3002\u53c8\u3001\u8133\u865a\u8840\u6642\u795e\u7d4c\u7d30\u80de\u306b\u304a\u3044\u3066\u306fNMDA\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305fCa2+\u6d41\u5165\u304c\u91cd\u8981\u3067\u3042\u308b\u304c\u3001\u3068\u308a\u308f\u3051NMDA&#12288;NR2A\u30b5\u30d6\u30bf\u30a4\u30d7\u3001\u30b7\u30ca\u30d7\u30b9\u523a\u6fc0\u6642\u306e\u5185\u56e0\u6027\u4fdd\u8b77\u30b7\u30b0\u30ca\u30eb\u306b\u95a2\u4e0e\u3059\u308b\u7d4c\u8def\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u307e\u305f\u3001SIK2\u907a\u4f1d\u5b50\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306e\u3001\u795e\u7d4c\u7d30\u80de\u751f\u5b58\u4fc3\u9032\u52b9\u679c\u3001\u8133\u6897\u585e\u30b5\u30a4\u30ba\u306e\u7e2e\u5c0f\u3092\u8a8d\u3081\u305f\u3002\u4eca\u56de\u306e\u6210\u679c\u306f\u3001SIK2,TORC1\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u304c\u3001\u8133\u6897\u585e\u306e\u307f\u306a\u3089\u305a\u3001\u8a8d\u77e5\u75c7\u306a\u3069\u3092\u542b\u3081\u305f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u5bfe\u3057\u3066\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u306b\u7e4b\u304c\u308a\u3046\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n\n --><\/p>\n<p> The cAMP responsive  element-binding protein (CREB) functions in a broad array of biological and  pathophysiological processes. We found that salt-inducible kinase 2 (SIK2) was  abundantly expressed in neurons and suppressed CREB-mediated gene expression  after oxygen-glucose deprivation (OGD). OGD induced the degradation of SIK2  protein concomitantly with the dephosphorylation of the CREB-specific  coactivator transducer of regulated CREB activity 1 (TORC1), resulting in the  activation of CREB and its downstream gene targets. Ca(2+)\/calmodulin-dependent  protein kinase I\/IV are capable of phosphorylating SIK2 at Thr484, resulting in  SIK2 degradation in cortical neurons. Neuronal survival after OGD was significantly  increased in neurons isolated from sik2(-\/-) mice, and ischemic neuronal injury  was significantly reduced in the brains of sik2(-\/-) mice subjected to  transient focal ischemia. These findings suggest that SIK2 plays critical roles  in neuronal survival, is modulated by CaMK I\/IV, and regulates CREB via TORC1. <\/p>\n<p class=\"mt25\"><span class=\"lineFrame\">URL<\/span><a href=\"http:\/\/www.med.osaka-u.ac.jp\/pub\/neurol\/myweb6\/Top.html\">http:\/\/www.med.osaka-u.ac.jp\/pub\/neurol\/myweb6\/Top.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2011-1-13 Publish Neuron&#12288;69(1):106-19(2011) The cAMP responsive eleme [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1796,"parent":460,"menu_order":180,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/673"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=673"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/673\/revisions"}],"predecessor-version":[{"id":2391,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/673\/revisions\/2391"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/460"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1796"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}