{"id":675,"date":"2017-03-14T11:54:03","date_gmt":"2017-03-14T02:54:03","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2012year\/murakami-masaaki"},"modified":"2017-04-28T16:10:12","modified_gmt":"2017-04-28T07:10:12","slug":"article01","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2012year\/article01","title":{"rendered":"MURAKAMI Masaaki \u226aDevelopmental Immunology\u226b <span>\u201cRegional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2012year\/article01\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1> \u6751\u4e0a&#12288;\u6b63\u6643\u226a\u514d\u75ab\u767a\u751f\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2012\/murakami20120203.jpeg\" target=\"_blank\" class=\"zoom\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2012\/murakami20120203.jpeg\" alt=\"\u514d\u75ab\u767a\u751f\u5b66\" height=\"324\" width=\"318\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2012-2-3<br \/>\n  <span class=\"lineFrame\">Publish<\/span>Cell, 148, 447&ndash;457 (2012)<\/p>\n<p><!-- \n\n<h3>\u5c40\u6240\u7684\u306a\u795e\u7d4c\u306e\u6d3b\u6027\u304c\u3001\u514d\u75ab\u7d30\u80de\u306e\u8840\u6db2\u8133\u95a2\u9580\u306e\u901a\u904e\u30b2\u30fc\u30c8\u3092\u5f62\u6210\u3059\u308b<\/h3>\n\n\n\n\n<p>\u4eca\u56de\u306e\u8ad6\u6587\u3067\u306f\u3001\u672b\u68a2\u795e\u7d4c\u7cfb\u304c\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u8133\u3084\u810a\u9ac4\uff08\u4e2d\u67a2\u795e\u7d4c\u7cfb\uff09\u306b\u514d\u75ab\u7d30\u80de\u306e\u5165\u308a\u53e3\u3068\u306a\u308b\u30b2\u30fc\u30c8\u304c\u3064\u304f\u3089\u308c\u3001\u305d\u306e\u30b2\u30fc\u30c8\u3092\u901a\u904e\u3057\u3066\u75c5\u539f\u6027\u306e\u3042\u308b\u514d\u75ab\u7d30\u80de\u304c\u8840\u7ba1\u304b\u3089\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u4fb5\u5165\u3057\u3001\u75c5\u6c17\u304c\u767a\u75c7\u3059\u308b\u3053\u3068\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u8840\u7ba1\u306f\u3001\u514d\u75ab\u7cfb\u306e\u7d30\u80de\u3092\u306f\u3058\u3081\u3001\u30a6\u30a4\u30eb\u30b9\u3084\u5927\u304d\u306a\u305f\u3093\u3071\u304f\u8cea\u3092\u8133\u3084\u810a\u9ac4\u306b\u901a\u904e\u3055\u305b\u306a\u3044\u3001\u8840\u6db2\u8133\u95a2\u9580\u3092\u5f62\u6210\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u3082\u30a6\u30a4\u30eb\u30b9\u304c\u611f\u67d3\u3059\u308b\u3053\u3068\u3084\u3001\u3055\u307e\u3056\u307e\u306a\u304c\u3093\u3001\u96e3\u75c5\u306a\u3069\u304c\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u3092\u5236\u5fa1\u3059\u308b\u305f\u3081\u306b\u8840\u6db2\u8133\u95a2\u9580\u306b\u3082\u514d\u75ab\u7d30\u80de\u306a\u3069\u306e\u5165\u308a\u53e3\u3068\u306a\u308b\u30b2\u30fc\u30c8\u304c\u3042\u308b\u3068\u4e88\u60f3\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3053\u306e\u30b2\u30fc\u30c8\u304c\u3069\u3053\u306b\u3042\u308b\u306e\u304b\u3001\u3069\u306e\u3088\u3046\u306a\u904e\u7a0b\u3084\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u6a5f\u80fd\u3059\u308b\u306e\u304b\u306f\u5168\u304f\u4e0d\u660e\u3067\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u96e3\u75c5\u3067\u3042\u308b\u591a\u767a\u6027\u786c\u5316\u75c7\u306e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u3001\u514d\u75ab\u7d30\u80de\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3078\u306e\u30b2\u30fc\u30c8\u306f\u3042\u308b\u7279\u5b9a\u306e\u90e8\u4f4d\u306b\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u3001\u307e\u305f\u305d\u306e\u5f62\u6210\u304c\u672b\u68a2\u795e\u7d4c\u7cfb\u306e\u6d3b\u6027\u5316\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u795e\u7d4c\u7cfb\u3068\u514d\u75ab\u7cfb\u306e\u95a2\u308f\u308a\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u660e\u3089\u304b\u306b\u3057\u305f\u3082\u306e\u3067\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u96e3\u75c5\u3084\u304c\u3093\u306a\u3069\u306b\u5bfe\u3059\u308b\u4e88\u9632\u6cd5\u3084\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u65b0\u305f\u306a\u53ef\u80fd\u6027\u3092\u4e0e\u3048\u307e\u3059\u3002\u307e\u305f\u3001\u30b9\u30c8\u30ec\u30b9\u306a\u3069\u306e\u7cbe\u795e\u72b6\u614b\u3068\u3055\u307e\u3056\u307e\u306a\u75c5\u6c17\u3068\u306e\u56e0\u679c\u95a2\u4fc2\u306e\u89e3\u660e\u306b\u3082\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n --><\/p>\n<p>Although it is believed that neural activations can affect immune responses, very little is known about the neuro-immune interactions involved, especially the key regulators for immune signals to reach from the blood to the CNS. We here describe dorsal blood vessels in the 5th lumbar-cord that show excess chemokine levels in a manner dependent on regional neural activations of the soleus-muscle. These responses appear to act as a gate for blood cell populations including immune cells to enter the CNS. This gate can promote pathogenic T cells inflammatory inflow, which risks autoimmune diseases like multiple sclerosis. Therefore, these regional neuro-immune interactions may offer new therapeutic targets for neurological diseases.Research highlights are;(1) A mouse multiple sclerosis model reveals a gateway through which T-cells enter the CNS, (2) T-cell entry occurs via dorsal blood vessels that contact a specific region of the spine, (3) Entry depends on high CCL20 chemokine output from the IL-6 amplifier in dorsal vessels, and (4) Leg soleus muscle activity enhances chemokine expression in dorsal blood vessels <\/p>\n<p><span class=\"mt25\"><span class=\"lineFrame\">URL<\/span> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/pub\/molonc\/www\/\" target=\"_blank\">http:\/\/www.med.osaka-u.ac.jp\/pub\/molonc\/www\/<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2012-2-3 PublishCell, 148, 447&ndash;457 (2012) Although it is believed that [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1786,"parent":459,"menu_order":134,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/675"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=675"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/675\/revisions"}],"predecessor-version":[{"id":2393,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/675\/revisions\/2393"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/459"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1786"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}