{"id":6834,"date":"2021-08-26T13:23:17","date_gmt":"2021-08-26T04:23:17","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/eng\/?page_id=6834"},"modified":"2022-08-26T14:45:04","modified_gmt":"2022-08-26T05:45:04","slug":"okada2021-08-26","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2021year\/okada2021-08-26","title":{"rendered":"Yoshihiko Tomofuji,  Yukinori Okada \u226aStatistical Genetics\u226b <span>Systemic lupus erythematosus linked to altered gut microbiome<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li><a href=\"https:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2021year\/okada2021-08-26\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><em><\/p>\n<p><span class=\"lineFrame\">Publish\u00a0<\/span> <em>Annals of the Rheumatic Diseases<\/em><\/p>\n<p><em>Researchers from Osaka University reveal changes in the components of the gut microbiome that are associated with the autoimmune disease systemic lupus erythematosis<\/em><\/p>\n<p class=\"figure\"><a href=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2021\/10\/tomofuji_pic1-e1635308410987.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6835 size-medium\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2021\/10\/tomofuji_pic1-400x240.jpg?_t=1635309223\" alt=\"\" width=\"400\" height=\"240\" \/><\/a><br \/>Figure1 : Overview of the study\u3000<\/p>\n<p>Systemic lupus erythematosis (SLE) is an autoimmune disease in which the immune system targets tissues of the body, causing widespread inflammation and affecting multiple organs such as the kidney and the brain. The gut \u201cmicrobiome\u201d\u2014all the micro-organisms that live in the human gut\u2014is known to be altered in SLE patients. Now, a research team at Osaka University has comprehensively profiled the associations between the gut microbiome and SLE.<\/p>\n<p>Healthy human intestines contain billions of micro-organisms that are essential for the normal functioning of the gut. They protect against pathogens, assist in the metabolism of food, and are also able to affect the immune response. Various diseases have been linked to disturbances of the gut bacteria leading to imbalance, or \u201cdysbiosis,\u201d including autoimmune conditions.<\/p>\n<p>The team isolated DNA from the intestinal microbiome using fecal samples, and then used a next-generation sequencing machine to carry out metagenome shotgun sequencing. This is a technique that allows the sequencing of all genes present in a complex sample by fragmenting all the genomes, sequencing the short fragments, and then reassembling the sequences. By collecting samples from both SLE patients and healthy comparisons, they could comprehensively assess the relationship between the gut microbiome and SLE. \u201cWe were able to show distinct changes to the gut microbiome in SLE patients,\u201d says lead author Yoshihiko Tomofuji, \u201cas we found that two species of <em>Streptococcus <\/em>bacteria, <em>Streptococcus anginosus<\/em> and <em>Streptococcus intermedius<\/em>, were significantly increased in the gut microbiome of patients with SLE.\u201d<\/p>\n<p>The gut microbiome can affect the wider functions of the body by altering the population of small molecules, or metabolites, circulating in the liquid part of the blood, called the plasma. The team therefore went on to integrate the gut microbiome data with data on the entire population of plasma metabolites, known as the plasma metabolome.<\/p>\n<p>\u201cOur analysis revealed interactions between the microbiome and the host that were mediated by the metabolome,\u201d explains senior author Yukinori Okada. \u201cA particular molecule known as acylcarnitine had a positive correlation with the SLE-associated bacterium.\u201d<\/p>\n<p>Acylcarnitine is known to induce inflammation and could therefore potentially act as a trigger for the overactivation of the immune system seen in SLE.<\/p>\n<p>This research reveals for the first time the specific microbial landscape of SLE patients, contributing to our understanding of the relationship between the gut microbiome and SLE and providing useful resources for future research.<\/p>\n<p>###<\/p>\n<p>The article, \u201cMetagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese\u201d, was published in <em>Annals of the Rheumatic Diseases<\/em> at DOI: <a href=\"about:blank\">https:\/\/doi.org\/10.1136\/annrheumdis-2021-220687<\/a><\/p>\n<p><strong>Summary: <\/strong>Osaka University researchers have identified alterations to the gut microbiome in patients with the autoimmune condition systemic lupus erythematosus (SLE). The SLE patients had increased levels of the bacteria <em>Streptococcus anginosus<\/em> and <em>Streptococcus intermedius<\/em>. The metabolites present in the blood plasma were also altered, indicating interactions between the microbiome and the host. This study, the first to illuminate the microbial landscape of SLE, adds to our knowledge of the gut microbiome and the immune system.<\/p>\n<p><strong>Tweet: <\/strong>Specific alterations to the gut micro-organisms shown in patients with systemic lupus erythematosus<\/p>\n<p><strong>Primary Keyword: <\/strong>Health and medicine<br \/><strong>Additional Keywords:<\/strong> Autoimmune disorders, Blood plasma, Gut microbiota, Human gut microbiota, Lupus, Metabolites, Microbiota, Shotgun sequencing, <em>Streptococcus<\/em>.<\/p>\n<p><strong>Method of Research:<\/strong> Data\/statistical analysis<\/p>\n<p><strong>Subject of Research:<\/strong> People<\/p>\n<p class=\"figure\"><a href=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2021\/10\/tomofuji_pic2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6836 size-medium\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2021\/10\/tomofuji_pic2-400x318.jpg?_t=1635309230\" alt=\"\" width=\"400\" height=\"318\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2021\/10\/tomofuji_pic2-400x318.jpg 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2021\/10\/tomofuji_pic2-768x611.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2021\/10\/tomofuji_pic2.jpg 977w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><br \/>Figure2 :Result of the case\u2013control comparison of the microbial taxa is indicated as a phylogenetic tree. <em>Streptococcus anginosus<\/em> and <em>Streptococcus intermedius<\/em> increased in the SLE patients, with a false discovery ratio &lt; 0.05.\u3000<\/p>\n<p>Title: \u201cMetagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese\u201d<br \/>Journal: <em>Annals of the Rheumatic Diseases<br \/><\/em>Authors: Yoshihiko Tomofuji, Yuichi Maeda, Eri Oguro-Igashira, Toshihiro Kishikawa, Kenichi Yamamoto, Kyuto Sonehara, Daisuke Motooka, Yuki Matsumoto, Hidetoshi Matsuoka, Maiko Yoshimura, Mayu Yagita, Takuro Nii, Shiro Ohshima, Shota Nakamura, Hidenori Inohara, Kiyoshi Takeda, Atsushi Kumanogoh, Yukinori Okada<br \/>DOI: 10.1136\/annrheumdis-2021-220687<br \/>Funded by: Japan Society for the Promotion of Science, Japan Agency for Medical Research and Development, Japan Science and Technology Agency, Takeda Science Foundation<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Publish\u00a0 Annals of the Rheumatic Diseases Researchers from Osaka University reveal changes in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6835,"parent":6480,"menu_order":66,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/6834"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=6834"}],"version-history":[{"count":12,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/6834\/revisions"}],"predecessor-version":[{"id":7577,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/6834\/revisions\/7577"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/6480"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/6835"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=6834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}