{"id":687,"date":"2017-03-14T11:55:10","date_gmt":"2017-03-14T02:55:10","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2014year\/nishimura-junichi-yamamoto-masaki-kanakura-yuzuru"},"modified":"2017-04-28T16:11:35","modified_gmt":"2017-04-28T07:11:35","slug":"article03","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2014year\/article03","title":{"rendered":"NISHIMURA Junichi, YAMAMOTO Masaki, KANAKURA Yuzuru \u226aHematology and Oncology\u226b <span>\u201cGenetic Variants in C5 and Poor Response to Eculizumab  \u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li> <a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2014year\/article03\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1> \u897f\u6751 \u7d14\u4e00\u3001\u5c71\u672c \u6b63\u6a39\u3001\u91d1\u5009 \u8b72\u226a\u8840\u6db2\u30fb\u816b\u760d\u5185\u79d1\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2014\/Nishimura20140213_s.jpeg\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2014\/Nishimura20140213_s.jpeg\" alt=\"\u514d\u75ab\u5236\u5fa1\u5b66-1\" height=\"307\" width=\"501\" \/><br \/>\n  <span class=\"click\">Click to enlarge<\/span><\/a> <\/p>\n<p>2014-2-13<br \/>\n  <span class=\"lineFrame\">Publish<\/span>The New England Journal of Medicine(2014) doi:10.1056\/NEJMoa1311084\n<\/p>\n<p><!-- \n\n<h3>C5\u306e\u907a\u4f1d\u5b50\u591a\u69d8\u4f53\u3068\u30a8\u30af\u30ea\u30ba\u30de\u30d6\u306b\u5bfe\u3059\u308b\u53cd\u5fdc\u4e0d\u826f<\/h3>\n\n\n\n\n<p> \u88dc\u4f53\u86cb\u767dC5\u3092\u6a19\u7684\u3068\u3059\u308b\u30d2\u30c8\u5316\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308b\u30a8\u30af\u30ea\u30ba\u30de\u30d6\u306f\u3001\u767a\u4f5c\u6027\u591c\u9593\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u5c3f\u75c7\uff08PNH\uff09\u306b\u95a2\u9023\u3059\u308b\u7d42\u672b\u88dc\u4f53\u4ecb\u5728\u6027\u6eb6\u8840\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002<br \/>\n  \u6211\u3005\u306f\u3001C5\u306e\u672c\u6765\u306e\u6a5f\u80fd\u3067\u3042\u308b\u6eb6\u8840\u6d3b\u6027\u3092\u4fdd\u6301\u3057\u3064\u3064\u3001\u30a8\u30af\u30ea\u30ba\u30de\u30d6\u306b\u3088\u308b\u7d50\u5408\u3068\u305d\u308c\u306b\u5f15\u304d\u7d9a\u304f\u30a8\u30af\u30ea\u30ba\u30de\u30d6\u306b\u3088\u308b\u6eb6\u8840\u6291\u5236\u3092\u963b\u5bb3\u3059\u308bC5\u907a\u4f1d\u5b50\u591a\u578b\uff08c.2654G\u2192A\uff09\u3092\u3001\n  \u65e5\u672c\u4ebaPNH\u60a3\u8005\u306b\u304a\u3044\u3066\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002<br \/>\n  \u3053\u306e\u3053\u3068\u306f\u3001\u6a19\u7684\u86cb\u767d\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u591a\u578b\u304c\u3001\u69d8\u3005\u306a\u75be\u60a3\u306b\u5bfe\u3057\u3066\u7e41\u7528\u3055\u308c\u3066\u3044\u308b\u6297\u4f53\u7642\u6cd5\u306e\u53cd\u5fdc\u6027\u3092\u691c\u8a0e\u3059\u308b\u4e0a\u3067\u3001\u6975\u3081\u3066\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n --><\/p>\n<p> Eculizumab is a humanized monoclonal antibody that targets complement <br \/>\n  protein C5 and inhibits terminal complement-mediated hemolysis associated with PNH. We identified a C5 polymorphism (c.2654G\u2192A) <br \/>\n  in Japanese patients with PNH prevents binding and blockade by eculizumab, while retaining the functional capacity of the mutant C5 to cause hemolysis. <br \/>\n  Therefore, the polymorphism in the target protein might be important to consider in patients with a poor <br \/>\n  response to the antibody-based treatments for various diseases.<\/p>\n<p><span class=\"lineFrame\">URL<\/span><a href=\"http:\/\/www.hematology.pro\/\" target=\"_blank\">http:\/\/www.hematology.pro\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2014-2-13 PublishThe New England Journal of Medicine(2014) doi:10.1056\/NEJMo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1781,"parent":457,"menu_order":169,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/687"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=687"}],"version-history":[{"count":6,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/687\/revisions"}],"predecessor-version":[{"id":2405,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/687\/revisions\/2405"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/457"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1781"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=687"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}