{"id":689,"date":"2017-03-14T11:55:26","date_gmt":"2017-03-14T02:55:26","guid":{"rendered":"http:\/\/www2.med.osaka-u.ac.jp\/wwwmed\/eng\/activities\/results\/2015year\/takedakiyoshi"},"modified":"2018-01-24T11:24:16","modified_gmt":"2018-01-24T02:24:16","slug":"article02","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2015year\/article02","title":{"rendered":"TAKEDA Kiyoshi \u226aImmune Regulation\u226b <span>\u201cThe ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells\u201d<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li><a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2015year\/article02\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><!-- \n\n<h1>  \u7af9\u7530 \u6f54\u226a\u514d\u75ab\u5236\u5fa1\u5b66\u226b<\/h1>\n\n --><\/p>\n<p class=\"figure\"><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2015\/takeda20150217_s.jpeg\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/\/activities\/results\/2015\/takeda20150217_s.jpeg\" alt=\"\u514d\u75ab\u5236\u5fa1\u5b66-1\" width=\"446\" height=\"458\" \/><br \/> <span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>2015-2-17<br \/> <span class=\"lineFrame\">Publish<\/span>Immunity\uff082015\uff09 doi:10.1016\/j.immuni.2015.01.015<\/p>\n<p><!-- \n\n<h3>E-NPP3\u306f\u3001\u30de\u30b9\u30c8\u7d30\u80de\u30fb\u597d\u5869\u57fa\u7403\u306b\u3088\u308bATP\u4f9d\u5b58\u6027\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u8ca0\u306b\u5236\u5fa1\u3059\u308b<\/h3>\n\n\n\n\n<p> \u8fd1\u5e74\u60a3\u8005\u6570\u304c\u5897\u52a0\u306e\u4e00\u9014\u3092\u305f\u3069\u308b\u5598\u606f\u3084\u30a2\u30c8\u30d4\u30fc\u306a\u3069\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306f\u3001\u30de\u30b9\u30c8\u7d30\u80de\u30fb\u597d\u5869\u57fa\u7403\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30de\u30b9\u30c8\u7d30\u80de\u30fb\u597d\u5869\u57fa\u7403\u306e\u6d3b\u6027\u304c\u666e\u6bb5\u3069\u306e\u3088\u3046\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u30a2\u30ec\u30eb\u30b2\u30f3\u3067\u6d3b\u6027\u5316\u3055\u308c\u305f\u597d\u5869\u57fa\u7403\u3067\u767a\u73fe\u304c\u9ad8\u304f\u306a\u308b\u9175\u7d20E-NPP3 (CD203c)\u3092\u6b20\u640d\u3057\u305f\u30de\u30a6\u30b9\u3092\u4f5c\u6210\u3057\u305f\u3068\u3053\u308d\u3001\u30de\u30b9\u30c8\u7d30\u80de\u30fb\u597d\u5869\u57fa\u7403\u304c\u6d3b\u6027\u5316\u72b6\u614b\u306b\u306a\u308a\u3001\u76ae\u819a\u30a2\u30ec\u30eb\u30ae\u30fc\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u3001\u5598\u606f\u304c\u60aa\u5316\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001E-NPP3 \u306f\u30a2\u30c7\u30ce\u30b7\u30f3\u4e09\u30ea\u30f3\u9178(ATP) \u3092\u5206\u89e3\u3059\u308b\u819c\u578b\u9175\u7d20\u3067\u3042\u308a\u3001ATP\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u3078\u306e\u95a2\u4e0e\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u3067\u6d3b\u6027\u5316\u3055\u308c\u305f\u30de\u30b9\u30c8\u7d30\u80de\u30fb\u597d\u5869\u57fa\u7403\u306fATP\u3092\u5206\u6ccc\u3057\u3001\u5206\u6ccc\u3055\u308c\u305fATP\u304c\u30de\u30b9\u30c8\u7d30\u80de\u30fb\u597d\u5869\u57fa\u7403\u81ea\u8eab\u3092\u3055\u3089\u306b\u6d3b\u6027\u5316\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u60aa\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u4eca\u5f8c\u3001ATP\u3001 E-NPP3\u3092\u6a19\u7684\u3068\u3057\u305f\u5598\u606f\u3084\u76ae\u819a\u30a2\u30ec\u30eb\u30ae\u30fc\u3078\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br \/>\n<\/p>\n\n\n\n\n<p>&nbsp;<\/p>\n\n --><\/p>\n<p>Mast cells and basophils play mandatory roles in the pathogenesis of allergic diseases, such as bronchial asthma and atopic diseases. However, it remain unclear how the activity of mast cells\/basophils are regulated. We analyzed the function of E-NPP3 (CD203c), which is highly expressed in activated basophils. Mast cells\/basophils increased in number and are highly activated in mice lacking E-NPP3. Accordingly, E-NPP3-deficient mice suffered from severe skin allergic inflammation, allergic diarrhea, and bronchial asthma. Mast cells\/basophils were shown to secrete adenosine triphosphate (ATP) upon activation. In E-NPP3-deficient mast cells\/basophils, ATP level was increased and ATP activated E-NPP3-deficient mast cells\/basophils in an autocrine manner, leading to development of severe allergic inflammation. Thus, E-NPP3 suppresses the ATP-dependent activation of mast cells\/basophils, and thereby negatively regulates allergic responses.<\/p>\n<p><span class=\"lineFrame\">URL<\/span><a href=\"http:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/\">http:\/\/www.med.osaka-u.ac.jp\/pub\/ongene\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Click to enlarge 2015-2-17 PublishImmunity\uff082015\uff09 doi:10.1016\/j.immuni.2015.01.015 Mast cells  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1778,"parent":456,"menu_order":166,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/689"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=689"}],"version-history":[{"count":7,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/689\/revisions"}],"predecessor-version":[{"id":3251,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/689\/revisions\/3251"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/456"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/1778"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}