{"id":7103,"date":"2022-02-17T09:35:36","date_gmt":"2022-02-17T00:35:36","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/eng\/?page_id=7103"},"modified":"2022-08-26T14:42:22","modified_gmt":"2022-08-26T05:42:22","slug":"yanagisawa2022-2-17","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2022year\/yanagisawa2022-2-17","title":{"rendered":"Tatsufumi Oka, Jun-Ya Kaimori, Yoshitaka Isaka \u226aNephrology, Inter-Organ Communication Research in Kidney Disease\u226b <span>Improving prognosis in chronic kidney disease<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li><a href=\"https:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2022year\/kaimori2022-2-17\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p><em><\/p>\n<p><span class=\"lineFrame\">Publish\u00a0<\/span> <em>Hypertension<\/em><\/p>\n<p><em>Researchers from Osaka University identify an association between mineralocorticoid receptor antagonist use and improved renal outcomes in patients with chronic kidney disease<\/em><\/p>\n<p class=\"figure\"><a href=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2022\/03\/oka_fig1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-7124 size-medium\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2022\/03\/oka_fig1-400x261.jpg?_t=1648097693\" alt=\"\" width=\"400\" height=\"261\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2022\/03\/oka_fig1-400x261.jpg 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2022\/03\/oka_fig1-768x502.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2022\/03\/oka_fig1.jpg 998w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><br \/>Figure1. Overview of the present study<\/p>\n<p>Just as a water filtration system acts to filter contaminants from the water you drink, your kidneys act to filter waste and excess fluid from your blood. In chronic kidney disease (CKD), kidney function is impaired over time, and the resultant build-up of excess fluid and waste has harmful repercussions on overall body function. Researchers in Japan conducted a study of real-world data from patients with CKD to evaluate the impact of a commonly prescribed medication on disease outcome.<\/p>\n<p>In a study published in <em>Hypertension<\/em>, researchers from Osaka University have demonstrated an association between the use of mineralocorticoid receptor antagonists (MRAs), a class of medicines that acts by suppressing the action of the steroid hormone aldosterone, and an improved renal prognosis in individuals with CKD.<\/p>\n<p>As CKD progresses, the initiation of renal replacement therapy (RRT), which includes dialysis and kidney transplantation, may be necessary for life support in kidney failure.. MRAs, which include spironolactone, eplerenone, and potassium canrenoate, are commonly used to reduce swelling, blood pressure, and urine protein levels in people with CKD. However, the association between MRA treatment and the initiation of RRT has not been fully explored in a real-world population, which spurred the research team from Osaka University to undertake a large-scale retrospective study of MRA use in people with CKD.<\/p>\n<p>\u201cWe conducted a retrospective analysis of clinical data from over 3100 individuals with CKD,\u201d says lead author Tatsufumi Oka. \u201cWe evaluated MRA treatment in various populations of people with CKD, including those with diabetes, heart disease, and severely impaired renal function.\u201d<\/p>\n<p>The research team employed a marginal structural model to analyze the association between MRA use and the initiation of RRT across multiple patient subgroups.<strong>\u00a0<\/strong><\/p>\n<p>\u201cOur analysis showed that MRA use was associated with a 28% lower rate of RRT initiation and a 24% lower rate of the combined outcomes of RRT initiation and death,\u201d says senior author Jun-Ya Kaimori.<\/p>\n<p>The research team observed a reduced risk for RRT initiation across various subgroups of people with CKD, including those with and without diabetes and those with severely impaired renal function. These findings highlight the association of MRA use and improved renal outcomes in a real-world population of CKD patients with varying health backgrounds. Overall, this study supports the use of MRAs in treatment plans for various groups of people with CKD who are not undergoing dialysis.<\/p>\n<p>###<\/p>\n<p>The article, \u201cMineralocorticoid receptor antagonist use and hard renal outcomes in real-world patients with chronic kidney disease,\u201d was published in Hypertension at DOI: <a href=\"https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.121.18360\">https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.121.18360<\/a><\/p>\n<p><strong>Summary: <\/strong>Researchers from Osaka University conducted a retrospective study of over 3100 people with chronic kidney disease to evaluate the association between mineralocorticoid receptor antagonist (MRA) use and renal outcomes. The analysis revealed an association between MRA use and a reduced risk for the initiation of renal replacement therapy across multiple subgroups of patients with chronic kidney disease. These findings reinforce the use of MRAs in treatment plans for various groups of people with chronic kidney disease who are not undergoing dialysis<\/p>\n<p><strong>Tweet:<\/strong>Researchers use real-world data to identify an association between mineralocorticoid receptor antagonists and improved outcomes in people with chronic kidney disease<\/p>\n<p><strong>Primary Keyword:<\/strong> Health and Medicine<br \/><strong>Additional Keywords: <\/strong>Kidney, Nephropathies, Renal failure, Drug therapy, Medications<\/p>\n<p><strong>Method of Research:<\/strong> Observational study<\/p>\n<p><strong>Subject of Research: <\/strong>People<\/p>\n<p class=\"figure\"><a href=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2022\/03\/oka_fig2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-7127 size-medium\" src=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2022\/03\/oka_fig2-396x400.jpg?_t=1648098280\" alt=\"\" width=\"396\" height=\"400\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2022\/03\/oka_fig2-396x400.jpg 396w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2022\/03\/oka_fig2-768x776.jpg 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2022\/03\/oka_fig2.jpg 814w\" sizes=\"(max-width: 396px) 100vw, 396px\" \/><\/a><br \/>Figure2.Marginal structural model<\/p>\n<p>Title:\u00a0\u00a0\u201cMineralocorticoid receptor antagonist use and hard renal outcomes in real-world patients with chronic kidney disease\u201d<\/p>\n<p>Journal: <em>Hypertension<\/em><\/p>\n<p>Authors: Tatsufumi Oka, Yusuke Sakaguchi, Koki Hattori, Yuta Asahina, Sachio Kajimoto, Yohei Doi, Jun-Ya Kaimori, and\u00a0Yoshitaka Isaka<\/p>\n<p>DOI: <a href=\"https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.121.18360\">10.1161\/HYPERTENSIONAHA.121.18360<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Publish\u00a0 Hypertension Researchers from Osaka University identify an association between miner [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7124,"parent":6951,"menu_order":191,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7103"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=7103"}],"version-history":[{"count":14,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7103\/revisions"}],"predecessor-version":[{"id":7569,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7103\/revisions\/7569"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/6951"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/7124"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=7103"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}