{"id":7229,"date":"2022-04-27T16:05:37","date_gmt":"2022-04-27T07:05:37","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/eng\/?page_id=7229"},"modified":"2025-09-03T11:34:24","modified_gmt":"2025-09-03T02:34:24","slug":"high-guided","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/introduction\/research\/endowed\/high-guided","title":{"rendered":"High Precision Image-guided Puncture Therapy"},"content":{"rendered":"<ul class=\"linkBar clearfix\"><!-- \n\n<li><a href=\"#\" target=\"_blank\" rel=\"noopener\">\u7814\u7a76\u5ba4\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8<\/a><\/li>\n\n --><\/p>\n<li><a href=\"https:\/\/www.med.osaka-u.ac.jp\/introduction\/research-2\/endowed\/high-guided\">Text in Japanese<\/a><\/li>\n<p><!-- \n\n<li><a href=\"#\" target=\"_blank\" class=\"pdf\" rel=\"noopener\">\u5927\u5b66\u9662\u751f\u5411\u3051\u7814\u7a76\u6982\u8981<\/a><\/li>\n\n --><\/ul>\n<div class=\"index\">\n<div class=\"title\">Innovative therapy\/medical device development for interventional radiology (IVR) by translational research<\/div>\n<ul>\n<li>IVR focusing on tumor immunity\/metabolism: Molecular biology study for drug delivery of immune\/metabolism modulating agents by IVR<\/li>\n<li>Innovative liquid embolic material development: development of liquid embolic material that is non-adhesive and less reactive to foreign body unlike conventional ones<\/li>\n<li>Novel drug\/device development for non-vascular IVR: development of CT-guided marking agent and ablation device for small animal<\/li>\n<\/ul>\n<\/div>\n<p><!-- \/ .index --><!-- \n\n<div class=\"profile\">\n  \n\n<div class=\"clearfix\">\n    \n\n<div class=\"fl photo\"><img decoding=\"async\" src=\"https:\/\/www.med.osaka-u.ac.jp\/wp-content\/uploads\/\/introduction\/research\/endowed\/inflammatory_profile.png\" alt=\"\" \/><\/div>\n\n\n    \/ .photo\n    \n\n<div class=\"name\"><span class=\"position\">\u6559\u6388 <\/span>\u6c0f\u540d <\/div>\n\n\n    \/ .name\n    \n\n<div class=\"member\">\u6240\u5c5e<\/div>\n\n\n    \/ .member\n    \n\n<div class=\"description\">\u6982\u8981<\/div>\n\n\n    \/ .description\n  <\/div>\n\n\n  \/ .clearfix\n<\/div>\n\n --><!-- \/ .profile --><\/p>\n<h3>New development of sustained release DDS for immune checkpoint inhibitor<\/h3>\n<p>These are a part of our recent research themes.<\/p>\n<p>We are working on the development of new lipiodol emulsion for sustained release of an immune checkpoint inhibitor (anti-PD-L1 antibody). Anti-PD-L1 antibody is systemically administered to treat hepatocellular carcinoma (HCC) in cancer immunotherapy. However, its therapeutic effect is not satisfactory, suggesting that there is a more room for improvement. Recently, there has been a report on lipiodol-Pickering emulsion, a drug delivery system (DDS) with a high sustained-release performance.<\/p>\n<p>Therefore, in our research, we intend to develop lipiodol-Pickering emulsion that releases anti-PD-L1 antibody in a sustained manner and apply it to HCC treatment.<\/p>\n<p>As a result of in vitro study, we have successfully developed lipiodol-Pickering emulsion that is superior in sustained release of anti-PD-L1 antibody as shown below.<\/p>\n<p class=\"figure\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-38589 size-full\" src=\"https:\/\/www.med.osaka-u.ac.jp\/wp-content\/uploads\/2024\/02\/high-guided_fig.png\" alt=\"\" width=\"900\" height=\"826\" \/>\u00a0<\/p>\n<p>We will further advance the research by preparing a rat HCC model for hepatic arterial infusion using a catheter.<\/p>\n<p>Our final goal is to improve the prognosis of HCC patients by linking the study to the development of new cancer immunotherapy with higher efficacy and its clinical application.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese Innovative therapy\/medical device development for interventional radiology (IVR) by translati [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":90,"menu_order":223,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7229"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=7229"}],"version-history":[{"count":3,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7229\/revisions"}],"predecessor-version":[{"id":9276,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7229\/revisions\/9276"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/90"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=7229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}