{"id":7486,"date":"2022-08-08T12:08:00","date_gmt":"2022-08-08T03:08:00","guid":{"rendered":"https:\/\/www.med.osaka-u.ac.jp\/eng\/?page_id=7486"},"modified":"2022-08-26T14:59:14","modified_gmt":"2022-08-26T05:59:14","slug":"yagi-ueda2019-2","status":"publish","type":"page","link":"https:\/\/www.med.osaka-u.ac.jp\/eng\/activities\/results\/2019year\/yagi-ueda2019-2","title":{"rendered":"Asami Yagi, Yutaka Ueda \u226aObstetrics and Gynecology\u226b <span>Japanese Study Finds Concerning Trends in Cervical Cancer and Treatment Response<\/span>"},"content":{"rendered":"<ul class=\"linkBar clearfix\">\n<li><a href=\"http:\/\/www.med.osaka-u.ac.jp\/activities\/results\/2019year\/yagi-ueda-201902\">Text in Japanese<\/a><\/li>\n<\/ul>\n<p>2018-02-04<br \/><em><em><\/p>\n<p><span class=\"lineFrame\">Publish\u00a0<\/span> <em>Cancer Research<\/em><\/p>\n<p><em>Osaka University-centered study examines large-scale population survey and identifies increase in cervical cancer rate, along with younger patients\u2019 surprising resistance to radiation therapy<\/em><\/p>\n<p class=\"figure\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-4543 size-medium\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/4c91d76fc4075d5b09d799ccb1e3fc4d-1-400x287.png?_t=1550801197\" alt=\"\" width=\"400\" height=\"287\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/4c91d76fc4075d5b09d799ccb1e3fc4d-1-400x287.png 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/4c91d76fc4075d5b09d799ccb1e3fc4d-1-768x550.png 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/4c91d76fc4075d5b09d799ccb1e3fc4d-1-1024x734.png 1024w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/4c91d76fc4075d5b09d799ccb1e3fc4d-1.png 1037w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/4c91d76fc4075d5b09d799ccb1e3fc4d-1.png\"> <span class=\"caption\">Fig.1 Age-adjusted incidence rate of cervical cancer in Japan, analyzed using a Japanese model population from 1985<\/span><span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Cervical cancer rates can be greatly reduced through preventive measures against the human papillomavirus (HPV) along with proactive cancer screening. Japan may be showing how ignoring that knowledge could prove hazardous, as it is the only advanced economy in which the cervical cancer rate is increasing. New research adds further nuance to this situation.<\/p>\n<p>Researchers centered at Osaka University examined 1976\u20132012 data on over 50,000 cervical and related cancer cases extracted from the Osaka Cancer Registry. They reported their findings in the journal <em>Cancer Research<\/em>.<\/p>\n<p>\u201cThe Osaka Cancer Registry gives us especially valuable insight on cancer trends because it\u2019s a large and accurately recorded cohort,\u201d study co-author Yutaka Ueda says. \u201cOsaka Prefecture accounts for about 10% of Japan\u2019s population, so the data are quite representative of the country.\u201d<\/p>\n<p>The researchers retroactively classified the cases by stage, age group, diagnosis period, and histological type using multiple imputation, a reliable method for estimating missing values to yield more-comprehensive data. They then calculated the age-adjusted (equal to those in a normally distributed population) incidence rates, and 5- and 10-year survival rates.<\/p>\n<p>They found that, from 1976 to 2000, Japan\u2019s age-adjusted rate of cervical cancer dropped profoundly. However, in the 21st century, it reversed course and started climbing. Japan\u2019s cervical cancer screening rate is a very low 40%, and although HPV vaccination was introduced in 2009, after just 4 years the government had stopped recommending it amid reports of supposed adverse events. Nevertheless, cervical cancer survival rates have mostly risen, thanks to more-effective treatment.<\/p>\n<p>The current findings are somewhat confounding, as the rising survival rates offset the increasing incidence. These survival rates likely owe to the success of concurrent chemotherapy and radiation therapy (CCRT) in place of radiation alone, and the official recommendation of CCRT\u2019s use.<\/p>\n<p>Additionally, and very interestingly, the researchers noted that age may <em>negatively<\/em> correlate with radiation therapy resistance. Predictably, younger people had better overall survival rates, but for localized cervical cancers, which are commonly treated with surgery or radiation, older people (60 years and above) had better survival rates than younger individuals (40\u201359 years) when undergoing radiation.<\/p>\n<p>\u201cIncreased survival rates are certainly a good sign, yet the increasing age-adjusted incidence is concerning,\u201d study lead author Asami Yagi says. \u201cThe finding that radiation may be less-effective in younger patients with localized cervical cancer is surprising, but could prove useful. Our results should serve as a strong indicator that better preventive measures are needed, and these results can also provide guidance on treatment choices.\u201d<\/p>\n<p>***<br \/>The article, \u201cEpidemiological and clinical analyses of cervical cancer using data from the population-based Osaka cancer registry\u201d was published in <em>Cancer Research <\/em>at DOI: <a href=\"https:\/\/doi.org\/10.1158\/0008-5472.CAN-18-3109\">https:\/\/doi.org\/10.1158\/0008-5472.CAN-18-3109<\/a>.<\/p>\n<p class=\"figure\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-4546 size-medium\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/f523dc7eb9d216d6d93339cee7e1a627-400x251.png?_t=1550801448\" alt=\"\" width=\"400\" height=\"251\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/f523dc7eb9d216d6d93339cee7e1a627-400x251.png 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/f523dc7eb9d216d6d93339cee7e1a627-768x483.png 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/f523dc7eb9d216d6d93339cee7e1a627-1024x644.png 1024w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/f523dc7eb9d216d6d93339cee7e1a627.png 1037w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/f523dc7eb9d216d6d93339cee7e1a627.png\">\u00a0<span class=\"caption\">Fig.2 Age-adjusted incidence rate of squamous cell carcinoma and adenocarcinoma in Japan, by age group \u00a0 <br \/><\/span><span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n<p class=\"figure\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-4574 size-medium\" src=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/07df9963e250f92e3548b42eb8a1a89b-400x206.png?_t=1550801651\" alt=\"\" width=\"400\" height=\"206\" srcset=\"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/07df9963e250f92e3548b42eb8a1a89b-400x206.png 400w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/07df9963e250f92e3548b42eb8a1a89b-768x396.png 768w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/07df9963e250f92e3548b42eb8a1a89b-1024x528.png 1024w, https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/07df9963e250f92e3548b42eb8a1a89b.png 1037w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><a href=\"http:\/\/www.med.osaka-u.ac.jp\/eng\/wp-content\/uploads\/2019\/02\/07df9963e250f92e3548b42eb8a1a89b.png\"> <span class=\"caption\">Fig.3 Five-year relative survival rate, by age group and treatment (1976\u20132010, localized) Surgery-based: surgery, surgery + radiation, surgery + radiation + chemotherapy Radiation: radiation, radiation + chemotherapy <\/span><span class=\"click\">Click to enlarge<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Article<\/strong>: Epidemiological and clinical analyses of cervical cancer using data from the population-based Osaka cancer registry<br \/><strong>Journal<\/strong>: <em>Cancer Research<br \/><\/em><strong>DOI<\/strong>: 10.1158\/0008-5472.CAN-18-3109<br \/><strong>Authors<\/strong>: Asami Yagi, Yutaka Ueda, Mamoru Kakuda, Yusuke Tanaka, Sayaka Ikeda, Shinya Matsuzaki, Eiji Kobayashi, Toshitaka Morishima, Isao Miyashiro, Keisuke Fukui, Yuri Ito, Tomio Nakayama and Tadashi Kimura<br \/><strong>Funding<\/strong>: Japanese Agency for Medical Research and Development (AMED)<\/p>\n<p><strong>Summary<\/strong>:\u00a0<br \/>Osaka University-centered research examined a large-scale Japanese data cohort for trends in cervical cancer prevalence, treatment, and survival. They identified a troubling increase in age-adjusted prevalence, especially among younger people. Japan is the only advanced economy to show such an increase. Additionally, and interestingly, the research found that, in localized cervical cancer, younger people had worse survival rates than older patients when undergoing radiation. The findings are useful for informing preventive measures and treatment choices.<\/p>\n<p><strong>Primary Keyword: <\/strong>Medicine\/Health<br \/><strong>Additional Keywords:<\/strong> Cancer, Epidemiology, Gynecology, Infectious\/Emerging Diseases, Public Health<br \/><strong>Categories<\/strong>: Medical<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Text in Japanese 2018-02-04 Publish\u00a0 Cancer Research Osaka University-centered study examines large-scale popu [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4543,"parent":4390,"menu_order":110,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7486"}],"collection":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=7486"}],"version-history":[{"count":2,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7486\/revisions"}],"predecessor-version":[{"id":7616,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/7486\/revisions\/7616"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/pages\/4390"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media\/4543"}],"wp:attachment":[{"href":"https:\/\/www.med.osaka-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=7486"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}